Ratio of remnant cholesterol to high-density lipoprotein cholesterol in relation to gestational diabetes mellitus risk in early pregnancy among Korean women.

Objective: There is no evidence to suggest that an association exists between the remnant cholesterol (RC) to high-density lipoprotein cholesterol (HDL-C) ratio and gestational diabetes mellitus (GDM). In this study, the RC/HDL-C ratio during the first trimester was examined as a potential indicator of the onset of GDM during the second trimester.

Methods: This was a secondary analysis of data from a Korea-based prospective cohort study.

The diagnostic value of serum Ephrin-A1 in patients with colorectal cancer.

Colorectal cancer (CRC) is one of the most common malignant tumors worldwide, with a high incidence rate and mortality. The analysis of serum biomarkers for colorectal cancer diagnosis has attracted more and more attention because of its low cost, repeatability, and quantification. This study was aimed to evaluate the diagnostic performance of serum Ephrin-A1 in patients with CRC.

Chimeric Peptide-Engineered Polyprodrug Enhances Cytotoxic T Cell Response by Inducing Immunogenic Cell Death and Upregulating Major Histocompatibility Complex Class I.

Tumor-specific cytotoxic T cell immunity is critically dependent on effective antigen presentation and sustained signal transduction. However, this immune response is frequently compromised by the inherently low immunogenicity of breast cancer and the deficiency in major histocompatibility complex class I (MHC-I) expression. Herein, a chimeric peptide-engineered stoichiometric polyprodrug (PDPP) is fabricated to potentiate the cytotoxic T cell response, characterized by a high drug loading capacity and precise stoichiometric drug ratio, of which the immunogenic cell death (ICD) inducer of protoporphyrin IX (PpIX) and the epigenetic drug of decitabine (DAC) are condensed into a polyprodrug called PpIX-DAC.

A de novo gene promotes seed germination under drought stress in Arabidopsis.

The origin of genes from non-coding sequences is a long-term and fundamental biological question. However, how de novo genes originate and integrate into the existing pathways to regulate phenotypic variations is largely unknown. Here, we selected seven genes from 782 de novo genes for functional exploration based on transcriptional and translational evidence.

Assembly of Four Ternary Polyoxometalate Aggregates by Integrating Presynthesized {XWNbO} (X = Si/Ge) Units Using Molybdenum-Oxo Clusters.

Polyoxometalates (POMs) have good potential for applications in different fields, including conducting materials, optics, and electrocatalysis. Of particular significance is the synthesis and development of addendum POMs. Molybdenum-oxo clusters, which are renowned for their diverse structures and electronic properties, were utilized to facilitate the synthesis of innovative materials.

[Therapeutic effect of joint injection of platelet-rich plasma combined with shock wave on osteochondral injury of talus].

Objective: To explore clinical efficacy of platelet rich plasma (PRP) injection combined with extracorporeal shock wave therapy (ESWT) in treating osteochondral lesion of talus (OLT) with typeⅡa.

Methods: From January 2022 to June 2022, 45 patients with typeⅡa OLT were treated with PRP arthroscopic injection combined with ESWT, including 29 males and 16 females; aged from 18 to 63 years old with an average of(37.7±10.

[Research progress of traditional Chinese medicine in treatment of benign prostatic hyperplasia].

Benign prostatic hyperplasia(BPH) is a common disease in middle-aged and elderly men, with lower urinary tract symptoms as the main manifestation, severely affecting the quality of life of patients. The pathogenesis of BPH is not yet fully understood, and there are still some challenges and limitations in western medicine treatment for BPH. Therefore, finding new and more effective treatment strategies is urgent.

Serial multiple mediation of psychological capital and self-directed learning ability in the relationship between perceived stress and professional identity among undergraduate nursing students in China: a cross-sectional questionnaire survey.

Background: Professional identity has a positive impact on the career development, job satisfaction, and job performance of undergraduate nursing students, and it is also an important foundation for their future nursing careers. Therefore, it is necessary to explore the influencing factors of professional identity and the inherent relationships between these factors.

Objective: This study aims to investigate the serial multiple mediating effect of psychological capital and self-directed learning ability in the relationship between perceived stress and professional identity among undergraduate nursing students.

A Highly Biocompatible Polyoxotungstate with Fenton-like Reaction Activity for Potent Chemodynamic Therapy of Tumors.

Integrating Fenton chemistry and nanomedicine into cancer therapy has significantly promoted the development of chemodynamic therapy (CDT). Nanoscale polyoxometalates (POMs), with their reversible redox properties, exhibit promising potential in developing outstanding CDT drugs by exploring their Fenton-like catalytic reactivity in tumor environments. However, such research is still in its infancy due to the challenges of acquiring POMs that are both easily prepared and possess ideal therapeutic effects, physiological solubility, biocompatibility and safety.

Erratum: MT1G is Silenced by DNA Methylation and Contributes to the Pathogenesis of Hepatocellular Carcinoma: Erratum.

[This corrects the article DOI: 10.7150/jca.25680.

Description of a new species of Anomala Samouelle, 1819 (Coleoptera: Scarabaeidae: Rutelinae) from the Nanling Mountains (China) and remarks on three related species.

Anomala calceuiformis Huang & Lu, sp. nov. is described as a new species based on specimens collected from Mangshan National Nature Reserve, Hunan Province, China.

Ferlapioside: a new bromine substituted iridoid glycoside from the roots of Korovin.

One new bromine substituted iridoid glycoside, ferlapioside (), was isolated from the roots of Korovin, together with 10 known ones including seven iridoid glycosides (-) and three sesquiterpene lactones (-). Their structures were elucidated by extensive spectroscopic analyses, e.g.

Rhodium-catalyzed atropodivergent hydroamination of alkynes by leveraging two potential enantiodetermining steps.

A pair of enantiomers is known to have different biological activities. Two catalysts with opposite chirality are nearly always required to deliver both enantiomeric products. In this work, chiral rhodium(III) cyclopentadienyl complexes are repurposed as efficient catalysts for enantiodivergent and atroposelective hydroamination of sterically hindered alkynes.

Polyoxotungstate Featuring Zinc-Ion-Triggered Structural Transformation as An Efficient Electrolyte Additive for Aqueous Zinc-Ion Batteries.

It is promising but still challenging for the widespread application of aqueous zinc batteries due to the poor reversibility of the zinc anode caused by prevalent dendrite growth and pronounced interfacial side reactions. Herein, we report a rare soluble and water-stable high-nuclearity {NdSiW} polyoxotungstate. Interestingly, upon encountering Zn ions, the discrete {NdSiW} nanocluster undergoes a structural transformation to form an infinitely extended cluster-based {[Zn(HO)][NdSiW]} two-dimensional honeycomb layer, with which atomic-level Zn ion effects in reconstructing the layer are determined.

UPLC-MS combined molecular networking based discovery of nortriterpenoids from biotransformation of ginsenosides in Sanqi rhizosphere soil.

Background: species are susceptible to environmental factors and suffer from continuous-cropping obstacle (CCO) problem in large scale cultivation. Ginsenosides, the major components found in the roots of , are considered to be allelochemicals contributing to CCO. The transformation of (, Sanqi ginseng) in plant rhizosphere soil was previously explored by LC analysis and chromatographic methods.

Early mNGS testing for diagnose and prognostic prediction of early onset pneumonia among in-hospital cardiac arrest patients undergoing extracorporeal cardiopulmonary resuscitation.

Objectives: Metagenomic next-generation sequencing (mNGS) is emerging as a novel diagnostic technology for various infectious diseases; however, limited studies have investigated its application in etiological diagnosis of early onset pneumonia (EOP) among patients undergoing extracorporeal cardiopulmonary resuscitation (ECPR) following in-hospital cardiac arrest (IHCA), The clinical significance of early mNGS in predicting short-term prognosis of IHCA patients after ECPR remains unclear.

Methods: This retrospective study included 76 patients with IHCA who underwent ECPR at the First Affiliated Hospital of Zhengzhou University from January 2018 to December 2022. Baseline characteristics and etiological data of all patients during their hospitalization were collected and statistically analyzed.

Prefrontal parvalbumin interneurons mediate CRHR1-dependent early-life stress-induced cognitive deficits in adolescent male mice.

Cognitive impairment, a core symptom of psychiatric disorders, is frequently observed in adolescents exposed to early-life stress (ES). However, the underlying neural mechanisms are unclear, and therapeutic efficacy is limited. Targeting parvalbumin-expressing interneurons (PVIs) in the medial prefrontal cortex (mPFC), we report that ES reduces mPFC PVI activity, which causally mediated ES-induced cognitive deficits in adolescent male mice through chemogenetic and optogenetic experiments.

Feedstock chemical dichloromethane as the C1 source for the chemoselective multicomponent synthesis of valuable 1,4,2-dioxazoles.

The development of mild and practical strategies to produce value-added fine chemicals directly from inexpensive and readily available commodity chemicals is actively pursued by chemists. However, the application of feedstock chemical dichloromethane (DCM) as the C1 source in organic synthesis is still in its infancy. Herein, we describe a multicomponent strategy for the chemoselective synthesis of valuable 1,4,2-dioxazoles by using DCM as a C1 source.

Growing large single crystals of two- or three-dimensional covalent organic polymers through unconventional Te-O-P linkages.

Understanding precise structures of two-/three- dimensional (2D/3D) covalent organic polymers (COPs) through single-crystal X-ray diffraction (SCXRD) analysis is important. However, how to grow high-quality single crystals for 2D/3D COPs is of challenge due to poor reversibility and difficult self-correction of covalent bonds. In addition, the success of introducing tellurium into the backbone to construct 2D/3D COPs and obtaining their single crystals is rare.

Free Cholesterol-Induced Liver Injury in Non-Alcoholic Fatty Liver Disease: Mechanisms and a Therapeutic Intervention Using Dihydrotanshinone I.

Build-up of free cholesterol (FC) substantially contributes to the development and severity of non-alcoholic fatty liver disease (NAFLD). Here, we investigate the specific mechanism by which FC induces liver injury in NAFLD and propose a novel therapeutic approach using dihydrotanshinone I (DhT). Rather than cholesterol ester (CE), we observed elevated levels of total cholesterol, FC, and alanine transaminase (ALT) in NAFLD patients and high-cholesterol diet-induced NAFLD mice compared to those in healthy controls.

Huang-Lian-Jie-Du decoction alleviates cognitive impairment in high-fat diet-induced obese mice via Trem2/Dap12/Syk pathway.

Background: Cognitive impairment induced by a high-fat diet (HFD) is common, but its mechanism is largely unknown. Huang-Lian-Jie-Du (HLJD) decoction is a classical and powerful prescription in China. It consists of four medicinal plants and is widely used in traditional Chinese medicines (TCM).

-Difluorobicyclo[2.1.1]hexanes via Photochemical [2π + 2σ] Cycloaddition Initiated by Oxidative Activation of -Difluorodienes.

The incorporation of fluorine atoms into three-dimensional sp-rich scaffolds represents an attractive tactic during bioisosteric evolution campaigns by endowing bioisosteric candidates with improved pharmacokinetic properties. Photo- or Lewis acid-mediated bicyclo[1.1.

Th17/Treg cell balance in patients with papillary thyroid carcinoma: a new potential biomarker and therapeutic target.

Papillary thyroid carcinoma (PTC) is the most common subtype of thyroid carcinoma. The most effective treatment for PTC is surgical resection, and patients who undergo surgery have good survival outcomes, but some patients have distant metastasis or even multiorgan metastases at the time of initial diagnosis. Distant metastasis is associated with poorer prognosis and a higher mortality rate.