Nanomaterials and clinical SERS technology: broad applications in disease diagnosis.

The critical need for rapid cancer diagnosis and related illnesses is growing alongside the current healthcare challenges, unfavorable prognosis, and constraints in diagnostic timing. As a result, emphasis on surface-enhanced Raman spectroscopy (SERS) diagnostic methods, including both label-free and labelled approaches, holds significant promise in fields such as analytical chemistry, biomedical science, and physics, due to the user-friendly nature of SERS. Over time, the SERS detection sensitivity and specificity with nanostructured materials for SERS applications (NMs-SERS) in different media have been remarkable.

Pentraxin-3 as a novel prognostic biomarker in non-neutropenic invasive pulmonary aspergillosis patients.

The incidence of invasive pulmonary aspergillosis (IPA) in non-neutropenic patients is increasing. This study aimed to evaluate the clinical outcomes and risk factors for mortality in non-neutropenic IPA patients. We conducted a prospective, multicenter study from August 2020 to February 2024, enrolling 565 patients with suspected IPA.

Current views and trends of nanomaterials as vectors for gene delivery since the 21st century: a bibliometric analysis.

Background: Gene therapy is garnering increasing support due to its potential for a "once-delivered, lifelong benefit." The limitations of traditional gene delivery methods have spurred the advancement of bionanomaterials. Despite this progress, a thorough analysis of the evolution, current state, key contributors, focal studies, and future directions of nanomaterials in gene delivery remains absent.

Long-range ordered high-entropy intermetallics enable stable and efficient hydrogen evolution in seawater.

Long-range ordered high-entropy intermetallics (HEIs) were synthesized a thermodynamically-driven atomic ordering strategy. The (FeCoNi)(RuPt) HEI achieves 200 mA cm at an overpotential of 56 mV and a remarkable low Tafel slope of 50.4 mV dec in alkaline seawater.

Multi-omics analysis reveals distinct gene regulatory mechanisms between primary and organoid-derived human hepatocytes.

Hepatic organoid cultures are a powerful model to study liver development and diseases in vitro. However, hepatocyte-like cells differentiated from these organoids remain immature compared to primary human hepatocytes (PHHs), which are the benchmark in the field. Here, we applied integrative single-cell transcriptome and chromatin accessibility analysis to reveal gene regulatory mechanisms underlying these differences.

Reconstruction of vibration noise in plate structures based on Data-Physics driven model and transfer learning.

The identification of vibration and reconstruction of sound fields of plate structures are important for understanding the vibroacoustic characteristics of complex structures. This paper presents a data-physics driven (DPD) model integrated with transfer learning (DPDT) for high-precision identification and reconstruction of vibration and noise radiation of plate structures. The model combines the Kirchhoff-Helmholtz integral equation with convolutional neural networks, leveraging physical information to reduce the need for extensive data.

Estimating in vivo power deposition density in thermotherapies based on ultrasound thermal strain imaging.

In thermal therapies, accurate estimation of in-tissue power deposition density (PDD) is essential for predicting temperature distributions over time or regularizing temperature imaging. Based on our previous work on ultrasound thermometry, namely, multi-thread thermal strain imaging (MT-TSI), this work develops an in vivo PDD estimation method. Specifically, by combining the TSI model infinitesimal echo strain filter with the bio-heat transfer theory (the Pennes equation), a finite-difference time-domain model is established to allow online extraction of the PDD.

Population pharmacokinetics and pulmonary modeling of eravacycline and the determination of microbiological breakpoint and cutoff of PK/PD.

Eravacycline is a broad-spectrum fluorocycline currently approved for complicated intra-abdominal infections (cIAIs). In lung-infection models, it is effective against methicillin-resistant (MRSA) and tetracycline-resistant MRSA. As such, we aimed to develop a population pharmacokinetic/pharmacodynamic (PK/PD) model to evaluate eravacycline's pulmonary distribution and kinetics.

Diversity and dynamics of multiple symbionts contribute to early development of broadcast spawning reef-building coral .

Sexual reproduction and recruitment enhance the genetic diversity and evolution of reef-building corals for population recovery and coral reef conservation under climate change. However, new recruits are vulnerable to physical changes and the mechanisms of symbiosis establishment remain poorly understood. Here, , a broadcast spawning hermaphrodite reef-building coral, was subjected to settlement and juvenile growth in flow-through seawater at 27.

Spermidine enhances the heat tolerance of by promoting mitochondrial respiration driven by fatty acid β-oxidation.

Unlabelled: High temperature is an unavoidable environmental stress that generally exerts detrimental effects on organisms and has widespread effects on metabolism. Spermidine is an important member of the polyamines family and is involved in a range of abiotic stress responses in plants. Mitochondria play an essential role in cellular homeostasis and are key components of the stress response.

A comprehensive review of current insights into the virulence factors of SARS-CoV-2.

The evolution of SARS-CoV-2 pathogenicity has been a major focus of attention. However, the determinants of pathogenicity are still unclear. Various hypotheses have attempted to elucidate the mechanisms underlying the evolution of viral pathogenicity, but a definitive conclusion has yet to be reached.

Genome sequence of ZAPR22R, isolated from calla lily in China.

Here, we present the complete genome sequence of strain ZAPR22R, isolated from the petiole and tuber of calla lily (), infected with soft rot. The genome consists of a single chromosome (4,528,722 bp) with a G+C content of 41.1%.

In-Depth Analysis of Soil Microbial Community Succession Model Construction under Microplastics Stress.

Although microplastics (MPs) toxicity to soil microorganisms has been preliminarily explored, the underlying reasons affecting the direction of microbial community succession are unclear. This study aimed to investigate the impacts of MPs infer community assembly mechanisms through phylogenetic bin-based null model analysis, network models, and protein function prediction in five typical Northeast China five typical soils. The results show that microbial communities in soils with high organic matter exhibit a stronger response to MPs, with enhanced protein functionality, network regulation, and assembly processes.

Design a functional graphene with decoration of dual transition metal dopants for hydrogen evolution electrocatalysis.

Since hydrogen is a promising alternative to fossil fuels due to its high energy density and environmental friendliness, water electrolysis for hydrogen production has received widespread attentions wherein the development of active and stable catalytic materials is a key research direction. This article designs a dual transition metal doped functional graphene for hydrogen evolution reaction via density functional theory calculations. Among varied combinations, 16 candidates are screened out that are expected to be stable as reflected by the criterion of formation energy Ef < 0 and active due to its free energy of hydrogen adsorption ∆GH within the window of ±0.

Integrated Two-in-one Strategy for Efficient Neutral Hydrogen Peroxide Electrosynthesis via Phosphorous Doping in 2D Mesoporous Carbon Carriers.

Herein, we demonstrate a two-in-one strategy for efficient neutral electrosynthesis of H2O2 via two-electron oxygen reduction reaction (2e-ORR), achieved by synergistically fine-modulating both the local microenvironment and electronic structure of indium (In) single atom (SA) sites. Through a series of finite elemental simulations and experimental analysis, we highlight the significant impact of phosphorous (P) doping on an optimized 2D mesoporous carbon carrier, which fosters a favorable microenvironment by improving the mass transfer and O2 enrichment, subsequently leading to an increased local pH levels. Consequently, an outstanding 2e-ORR performance is observed in neutral electrolytes, achieving over 95% selectivity for H2O2 across a broad voltage range of 0.

Regulating Interphase Chemistry by Targeted Functionalization of Hard Carbon Anode in Ester-based Electrolytes for High-Performance Sodium-Ion Batteries.

Commercial hard carbon (HC) anode suffers from unexpected interphase chemistry rooted in the parasitic reactions between surface oxygen-functional groups and ester-based electrolytes. Herein, an innovative strategy is proposed to regulate interphase chemistry by tailoring targeted functional groups on the HC surface, where highly active undesirable oxygen-functional groups are skillfully converted into a Si-O-Si molecular layer favorable for anchoring anions. Then, an inorganic/organic hybrid solid electrolyte interphase with low interfacial charge transfer resistance and enhanced cycling durability is constructed successfully.

PEBP1 amplifies mitochondrial dysfunction-induced integrated stress response.

Mitochondrial dysfunction is involved in numerous diseases and the aging process. The integrated stress response (ISR) serves as a critical adaptation mechanism to a variety of stresses, including those originating from mitochondria. By utilizing mass spectrometry-based cellular thermal shift assay (MS-CETSA), we uncovered that phosphatidylethanolamine-binding protein 1 (PEBP1), also known as Raf kinase inhibitory protein (RKIP), is thermally stabilized by stresses which induce mitochondrial ISR.

Vascular Healing After Biodegradable Polymer Sirolimus-Eluting Versus Durable Polymer Everolimus-Eluting Stents in Chronic Total Occlusions.

Background: Biodegradable polymer stents may reduce the risk of neoatherosclerosis and stent thrombosis. Limited data is available for biodegradable polymer sirolimus-eluting stent (BP-SES) and durable polymer drug-eluting stents (DP-EES) in chronic total occlusions (CTO).

Aim: This study was to evaluate healing patterns of BP-SES versus DP-EES in CTO at 3 and 13 months based on optical coherence tomography (OCT).

Novel De Novo Intronic Variant of SYNGAP1 Associated With the Neurodevelopmental Disorders.

Background: SYNGAP1 encodes a Ras/Rap GTPase-activating protein that is predominantly expressed in the brain with the functional roles in regulating synaptic plasticity, spine morphogenesis, and cognition function. Pathogenic variants in SYNGAP1 have been associated with a spectrum of neurodevelopmental disorders characterized by developmental delays, intellectual disabilities, epilepsy, hypotonia, and the features of autism spectrum disorder. The aim of this study was to identify a novel SYNGAP1 gene variant linked to neurodevelopmental disorders and to evaluate the pathogenicity of the detected variant.

Pd-Catalyzed Asymmetric Synthesis of Chiral 2-Trifluoromethyl-4-(indol-3-yl)-4-chromene Derivatives.

This paper presents a new strategy for the construction of the chiral 4-chromene skeleton. A series of chiral 2-trifluoromethyl-4-(indol-3-yl)-4-chromenes were synthesized in moderate to good yields (60-92%) with excellent enantioselectivity (up to 97% ee) through the palladium-catalyzed asymmetric condensation of 2-chromenes and indoles. These trifluoromethylated, stereochemically rich building blocks hold potential value in medicinal chemistry.

Transcriptome-Wide Association Study Identified Novel Blood Tissue Gene Biomarkers for Prostate Cancer Risk.

Objective: A number of susceptibility genes in prostate tissue have been identified to be associated with prostate cancer (PCa) risk. However, the reported genes based on assessing prostate tissue could not fully explain PCa genetic susceptibility. It is believed that genes functioning in the immune system may fill in the gap of some missing heritability.

Large Electromechanical Response and Field-Induced Shape Memory Effect in Ferroelectric Ceramics.

Electric-field-induced shape memory effect has potential applications in electromechanical actuator. Here, this study proposes the a phase structure design routine in (1-x)(75NaBiTiO-25SrTiO)-xPbTiO ceramics to obtain large electromechanical response and shape memory effect. It is found that the shape memory effect is closely related to the bending deformation induced by asymmetric polarization between positive and negative electrodes, which is resulted from the reductions of Bi and Pb because of electron injection from negative electrode.

CTCs Detection Methods In Vivo and In Vitro and Their Application in Tumor Immunotherapy.

Circulating tumor cells (CTCs) are tumor cells that detach from the primary tumor site and enter the bloodstream. They hold significant value for the early detection, diagnosis, and treatment of tumors. CTC detection methods can be classified into in vivo and in vitro techniques.

Late-Onset Krabbe Disease: Case Report of Two Patients in a Chinese Family and Literature Review.

Background: Krabbe disease (KD; globoid cell leucodystrophy) is a rare autosomal recessive lipid storage disorder that affects the white matter of the peripheral and central nervous. Late-onset KD is less frequently diagnosed and often presents with milder symptoms, making accurate diagnosis challenging, especially when distinguishing it from peripheral neuropathy. In this report, we present two cases of late-onset KD in a Chinese family.