3,292,797 results match your criteria: "China; and ††Rhode Island Hospital[Affiliation]"

Valence-engineering modulation of MoS clusters for enhancing biocatalytic activity.

Nanoscale

December 2024

Tianjin Key Laboratory of Brain Science and Neural Engineering, Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin 300072, China.

Earth-abundant MoS with the advantages of a stable structure, tunable bandgap, and easy shear has great potential for applications in the fields of catalysis, biomedicine, and so on. However, the biocatalytic activity of MoS remains little investigated and is insufficient for biomedical applications. In this work, we develop ultra-small and water-soluble MoS clusters with superior antioxidant activity and enzyme-like activity valence-engineering modulation with Ce doping.

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Unveiling the Photoluminescence Mechanism of Carbonized Polymer Dots: Evolution and Synergistic Photoluminescence of Multiple Molecular Fluorophores.

Angew Chem Int Ed Engl

December 2024

State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, NO.2699 Qianjin Street, Chaoyang District, 130000, Changchun, CHINA.

Carbonized polymer dots (CPDs) are a class of exceptional fluorescent materials with diverse applications. However, their photoluminescence (PL) mechanism remained enigmatic and controversial, hindering further development and application. While molecular fluorophores explain primary fluorescence in some CPDs, the overall PL of CPDs still cannot be fully explained, such as their excitation-dependent behaviors, let alone the modulation of PL.

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Limited meta-analytical research has examined the epidemiology of child sexual abuse (CSA) victimization among Chinese children and adolescents over the past two decades. It is crucial to evaluate how the incidence of CSA has changed over time in response to the significant policy and sociocultural changes since 2013. This study employed a cross-temporal meta-analysis to explore the trend of CSA victimization among Chinese children and adolescents from 2000 to 2022.

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The functions of graphene have garnered significant attention in recent research. A profound understanding of the principles of temperature-dependent electromagnetic responses is crucial for guiding the design of advanced functional materials and devices. From this perspective, the thermally tailored mechanisms of polarization genes and conduction genes are emphasized.

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Background: Uric acid (UA) plays an important role in cardiovascular diseases, yet its implications in elderly patients remains incompletely understood. This study aimed to explore the impact of UA on the prognosis in advanced-age patients with acute coronary syndrome (ACS).

Methods: We included 526 patients aged 80 and older who were diagnosed with ACS.

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In this study, five catalysts with Pd particle sizes ranging from single atoms to nanoclusters and nanoparticles were synthesized by controlling the Pd loading amount and preparation methods, and applied in the hydrogenation of FDCA to THFDCA. Furthermore, kinetic models were established. Notably, the nanocluster catalyst demonstrated relatively high hydrogenation activity.

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Endometriosis and adenomyosis are debilitating gynecological conditions that severely affect the quality of life of women. Traditional diagnostic and treatment methods, including laparoscopic surgery and hormonal therapy, face significant limitations such as incomplete lesion detection, high recurrence rates, and adverse side effects. Emerging bioengineering technologies offer promising solutions for precise diagnosis and therapy of these diseases.

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Background: The Yunnan-Guizhou Plateau's high-altitude setting is characterized by intense solar ultraviolet radiation, a significant environmental stressor that frequently leads to skin barrier damage. This damage presents clinically as erythema, itching, and desquamation, underscoring the need for effective reparative interventions.

Aims: The objective of this study was to assess the therapeutic efficacy of a novel treatment protocol that integrates non-crosslinked hyaluronic acid (HA) injection with microneedle application of human epidermal growth factor (hEGF) for the restoration of skin barrier function in regions of high altitude.

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Intensity correlations in the Wigner representation.

Philos Trans A Math Phys Eng Sci

December 2024

Max-Planck-Institut für die Physik des Lichts, Erlangen 91058, Germany.

We derive a compact expression for the second-order correlation function [Formula: see text] of a quantum state in terms of its Wigner function, thereby establishing a direct link between [Formula: see text] and the state's shape in phase space. We conduct an experiment that simultaneously measures [Formula: see text] through direct photocounting and reconstructs the Wigner function via homodyne tomography. The results confirm our theoretical predictions.

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Reversible and irreversible retention of heavy metals in saturated porous media: association with kaolin.

Environ Sci Process Impacts

December 2024

Anhui Bossco Environmental Protection Technology Co., Ltd, Ningguo, Anhui, 242301, China.

Contamination of heavy metals (HMs) has caused increasing concern due to their ecological toxicities and difficulties in degradation. The transport, retention, and release of HMs in porous media are highly related to their environmental fate and risk to groundwater. Column transport experiments and numerical simulations were conducted to investigate the retention and release behaviors of Cu, Pb, Cd, and Zn in the presence and absence of kaolin under varying ionic strengths and cation types.

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Association between muscular atrophy and mortality risk in patients with COPD: a systematic review.

Ther Adv Respir Dis

December 2024

Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Background: Muscular atrophy often can be seen at the end of stage in many chronic diseases. It will also negatively influence patients' outcomes. Different studies showed that the association between muscular atrophy and mortality in patients with chronic obstructive pulmonary disease (COPD) was unclear.

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Parkinson's disease (PD) is a common neurodegenerative disease affecting nearly 10 million people worldwide and placing a heavy medical burden on both society and families. However, due to the complexity of its pathological mechanisms, current treatments for PD can only alleviate patients' symptoms. Therefore, novel therapeutic strategies are urgently sought in clinical practice.

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Background: Lymph node metastasis is closely associated with the prognosis of patients with non-small cell lung cancer (NSCLC). This study aimed to evaluate the role of preoperative 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) parameters in mediastinal lymph node metastasis in NSCLC.

Methods: One hundred patients with NSCLC who underwent surgery, systematic lymph node dissection, who had undergone 18FFDG PET/CT for initial staging were divided into two groups: lymph node metastasis and non-metastasis.

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Prospects for potential therapy targeting immune‑associated factors in endometriosis (Review).

Mol Med Rep

March 2025

Key Laboratory for Experimental Teratology of Ministry of Education, Department of Histology and Embryology, School of Basic Medical Sciences, Shandong University, Jinan, Shandong 250012, P.R. China.

Endometriosis (EM) is a chronic inflammatory disease that is one of the most common causes of gynecological systemic lesions in women before menopause. The most representative histological feature of EM is that the endometrium appears outside of the uterine cavity, often in the ovary. Although it is generally accepted that the epithelial and stromal cells of the ectopic endometrium are not malignant, they still have numerous similarities to malignant tumors, including considerable changes to the immune microenvironment (immune monitoring disorder), the creation of a specific hormone environment, high levels of oxidative stress, chronic inflammation and abnormal immune cell regulation.

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As a nonlinear optical phenomenon, upconversion (UC) occurs when two or more low-energy excitation photons are sequentially absorbed and emitted. Upconversion nanomaterials exhibit superior photostability, non-invasiveness, a unique near-infrared anti-Stokes shift, and enhanced tissue penetration capability. However, general upconversion nanomaterials typically utilize visible light (400-700 nm) for excitation, leading to limited tissue penetration, background signal interference, limited excitation efficiency and imaging quality issues due to tissue absorption and scattering.

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The incidence of hyperuricemia has increased recently, posing a serious threat to public health. Hyperuricemia is associated with an increased risk of gout, chronic kidney disease (CKD), obesity, metabolic syndrome, type 2 diabetes mellitus, hypertension, hypertriglyceridaemia, metabolic dysfunction‑associated steatotic liver disease, acute kidney injury, coronary heart disease and cardiovascular disease (CVD). These diseases are commonly accompanied by varying degrees of kidney damage.

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Following the publication of this paper, it was drawn to the Editors' attention by a concerned reader that certain of the TUNEL assay data shown in Fig. 4B were strikingly similar to data appearing in different form in another article written by different authors at different research institutes that had already been submitted for publication to the journal (which has subsequently been retracted). Owing to the fact that these contentious data had already apparently been submitted for publication prior to the receipt of this paper to , the Editor has decided that this paper should be retracted from the Journal.

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Recent advances in nanomaterials for the detection of mycobacterium tuberculosis (Review).

Int J Mol Med

March 2025

Orthopedics of Chun'an First People's Hospital, Zhejiang Provincial People's Hospital Chun'an Branch, Affiliated Chun'an Hospital of Hangzhou Medical College, Hangzhou, Zhejiang 311700, P.R. China.

The world's leading infectious disease killer tuberculosis (TB) has >10 million new cases and ~1.5 million mortalities yearly. Effective TB control and management depends on accurate and timely diagnosis to improve treatment, curb transmission and reduce the burden on the medical system.

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Thermodynamics and models for small nanoparticles upon protein adsorption.

Phys Chem Chem Phys

December 2024

College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, PR China.

Proteins are some of the most important components in living organisms. When nanoparticles enter a living system, they swiftly interact with proteins to produce the so-called "protein corona", which depicts the adsorption of proteins on large nanoparticles (normally tens to hundreds of nanometers). However, the sizes of small nanoparticles (typically, fluorescent nanomaterials such as quantum dots, noble metal nanoclusters, carbon dots, ) are less than 10 nm, which are comparable or even much smaller than those of proteins.

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Osteoarthritis (OA) is a common joint disorder involving the cartilage and other joint tissues. Quercetin (QCT) serves a protective role in the development of OA. However, to the best of our knowledge, the regulatory mechanisms of QCT in the progression of OA have not yet been fully elucidated.

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Research progress on the molecular mechanisms of Saikosaponin D in various diseases (Review).

Int J Mol Med

March 2025

Department of Gastroenterology, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200071, P.R. China.

Bupleurum, a Traditional Chinese Medicine (TCM) herb, is widely used in China and other Asian countries to manage chronic liver inflammation and viral hepatitis. Saikosaponin D (SSD), a triterpenoid saponin extracted from Bupleurum, exhibits extensive pharmacological properties, including anti‑inflammatory, antioxidant, anti‑apoptotic, anti‑fibrotic and anti‑cancer effects, making it a therapeutic candidate for numerous diseases. Clarifying the targets and molecular mechanisms underlying TCM compounds is essential for scientifically validating TCM's therapeutic roles in disease prevention and treatment, as well as for identifying novel therapeutic targets and lead compounds.

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Sevoflurane (Sev) has a cardioprotective role in myocardial ischemia/reperfusion injury (MI/RI), but its mechanism has not been fully elucidated. This study aimed to investigate whether the circ_CDR1as/miR-671-5p/HMGA1 axis mediates the cardioprotective effect of Sev in MI/RI. Cardiomyocytes underwent hypoxia/reoxygenation (H/R) treatment was used to simulate MI/RI in vitro.

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Our previous research identified that lncRNA PVT1 is upregulated in patients with IA. However, the precise functions of PVT1 in IA remain unclear. We compared the levels of PVT1, caspase-3, caspase-1, and NLRP3 in normal and IA patients.

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Combination of inorganic nitrate and vitamin C prevents collagen-induced arthritis in rats by inhibiting pyroptosis.

Food Funct

December 2024

Department of Oral and Maxillofacial & Head and Neck Oncology, Beijing Stomatological Hospital, Capital Medical University, Tian Tan Xi Li No. 4, Beijing, 100050, China.

Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease characterized by synovial inflammation, cartilage damage, and bone loss. Although effective treatments are currently lacking, early interventions hold promise for alleviating RA symptoms. Inorganic nitrates and vitamin C (VC) are essential bioactive substances abundant in fruits and vegetables.

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To evaluate the relationship between the muscle mass-to-fat ratio (MMFR) at the third lumbar spine (L3) and overall survival (OS) as well as related complications after pancreaticoduodenectomy (PD) for pancreatic cancer. Patients who underwent PD for pancreatic cancer between March 2017 and May 2023 at the Second Affiliated Hospital of Soochow University were included. Muscle mass and fat content at the L3 were measured by computed tomography.

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