Preoperative Computed Tomography Radiomics-Based Models for Predicting Microvascular Invasion of Intrahepatic Mass-Forming Cholangiocarcinoma.

Objectives: The aim of the study is to investigate the ability of preoperative CT (Computed Tomography)-based radiomics signature to predict microvascular invasion (MVI) of intrahepatic mass-forming cholangiocarcinoma (IMCC) and develop radiomics-based prediction models.

Materials And Methods: Preoperative clinical data, basic CT features, and radiomics features of 121 IMCC patients (44 with MVI and 77 without MVI) were retrospectively reviewed. The loading and display of CT images, delineation of the volume of interest, and feature extraction were performed using 3D Slicer.

Benchmark of Density Functional Theory in the Prediction of C Chemical Shielding Anisotropies for Anisotropic Nuclear Magnetic Resonance-Based Structural Elucidation.

Density functional theory (DFT) calculations have emerged as a powerful theoretical toolbox for interpreting and analyzing the experimental nuclear magnetic resonance (NMR) spectra of chemical compounds. While DFT has been extensively used and benchmarked for isotropic NMR observables, the evaluation of the full chemical shielding tensor, which is necessary for interpreting residual chemical shift anisotropy (RCSA), has received much less attention, despite its recent applications in the structural elucidation of organic molecules. In this study, we present a comprehensive benchmark of carbon shielding anisotropies based on coupled cluster reference tensors taken from the NS372 benchmark data set.

Enhanced Anti-Interference Photoelectrochemical DNA Bioassay: Grafting a Peptide-Conjugated Hairpin DNA Probe on a COF-Based Photocathode.

Precise and sensitive analysis of specific DNA in actual human bodily fluids is crucial for the early diagnosis of major diseases and for a deeper understanding of DNA functions. Herein, by grafting a peptide-conjugated hairpin DNA probe to a covalent organic framework (COF)-based photocathode, a robust anti-interference photoelectrochemical (PEC) DNA bioassay was explored, which could specifically resist potential interference from nonspecific proteins and reducing species. Human immunodeficiency virus (HIV) DNA was used as the target DNA (tDNA) for the PEC DNA bioassay.

Uncommon Breast Metastasis From Rectal Carcinoma Clearly Revealed on 68Ga-FAPI-04 PET/CT.

Breast metastasis from rectal carcinoma is very rare. We report a case of imaging findings of breast metastasis in a 31-year-old woman who underwent laparoscopic radical tumor resection 8 months ago. 68Ga-FAPI-04 PET/CT and 18F-FDG PET/CT showed 4 small breast nodules with intense 68Ga-FAPI uptake (SUVmax, 9.

68Ga-Pentixafor PET in Combination With MRI Improves the Differential Diagnosis of Glioblastoma and Primary Central Nervous System Lymphoma.

Purposes: This study aims to investigate the diagnostic performance of combining 68Ga-pentixafor PET with MRI to differentiate primary central nervous system lymphoma (PCNSL) from glioblastoma (GBM), particularly focusing on atypical lymphoma identification.

Patients And Methods: Seventy-one PCNSL and 53 GBM patients who underwent both 68Ga-pentixafor PET/CT and MRI were retrospectively included. We evaluated the quantitative imaging parameters and MRI features of positive lesions, identifying atypical PCNSL by hemorrhage, necrosis, or heterogeneous enhancement.

Solar-Driven Nanofluidic Ion Regulation for Fractional Salt Crystallization and Reutilization.

Solar water evaporation (SWE) has emerged as an appealing method for water and salt recovery from hypersaline wastewater. However, different ions usually transfer and accumulate uncontrollably during ion-water separation, making salt fractionalization impractical for conventional SWE, and the resulting mixed salts are hard to use and still require significant costs for disposal. To achieve salt fractionalization and reutilization, achieving ion-water and ion-ion separation simultaneously are crucial in advancing SWE toward sustainability.

Microbial perspective of multidisciplinary collaborative weight management approach: may serve as a key target for weight loss.

Changes in the gut microbiota are associated with obesity and may influence weight loss. We are currently implementing a sustained multidisciplinary collaborative weight management (MCWM) approach to weight loss. We report significant improvements in participant health status after 6 months, along with alterations in the structure, interactions, and metabolic functions of the microbiota.

Association between pre-stroke frailty and post-discharge destination in acute stroke among Chinese older adults.

Aims: To investigate the association between pre-stroke frailty and discharge destination in hospitalized older adults in China.

Methods: We conducted this prospective cohort study in a tertiary care hospital in China. We enrolled patients aged 60 years and older admitted to the hospital for acute stroke from January 2022 to May 2022.

Resveratrol amplifies the anti-tumor effect of α-PD-1 by altering the intestinal microbiome and PGD2 content.

The anti-PD-1 mAb may be further considered along with PGD2 or active molecules that can promote PGD2 synthesis to enhance the anti-tumor immune response.

Distinct and interdependent functions of three RING proteins regulate recombination during mammalian meiosis.

During meiosis, each pair of homologous chromosomes becomes connected by at least one crossover, as required for accurate segregation, and adjacent crossovers are widely separated thereby limiting total numbers. In coarsening models, this crossover patterning results from nascent recombination sites competing to accrue a limiting pro-crossover RING-domain protein (COR) that diffuses between synapsed chromosomes. Here, we delineate the localization dynamics of three mammalian CORs in the mouse and determine their interdependencies.

Characterizing progenitor cells in developing and injured spinal cord: Insights from single-nucleus transcriptomics and lineage tracing.

Various mature tissue-resident cells exhibit progenitor characteristics following injury. However, the existence of endogenous stem cells with multiple lineage potentials in the adult spinal cord remains a compelling area of research. In this study, we present a cross-species investigation that extends from development to injury.

Proton Accumulation Modulated Surface Potential in Proton Conducting Ceramics Revealed by Near-Ambient Pressure X-ray Photoelectron Spectroscopy.

Proton conducting electrochemical cells (PCECs) are efficient and clean intermediate-temperature energy conversion devices. The proton concentration across the PCECs is often nonuniform, and characterizing the distribution of proton concentration can help to locate the position of rate-limiting reactions. However, the determination of the local proton concentration under operating conditions remains challenging.

Targeting KAT6A/B as a New Therapeutic Strategy for Cancer Therapy.

The lysine acetyltransferase 6A (KAT6A, MOZ, MYST3) is a member of the MYST family of protein acetyltransferases, which are essential for different biological processes such as craniofacial, embryonic, stem cell development, and hematopoiesis. KAT6A is an oncogene in human acute myeloid leukemia (AML), and KAT6A overexpression in AML is associated with metastases and poor prognoses. Furthermore, KAT6A mutations play an important role in cancer formation and progression and result in therapeutic resistance in both hematopoietic malignancies and solid tumors.

Patient-Reported Outcome Scale for Allergic Rhinitis (AR-PRO): Development and Validation in China.

Background: Patient-reported outcomes (PROs) have become indispensable measures in allergic rhinitis (AR) clinical trials. However, there is currently no scale specifically designed for the Chinese population. This study aimed to develop and validate the patient-reported outcome scale for allergic rhinitis (AR-PRO) to provide a reliable tool for AR patients in China.

Charge Arrangement Determines the Sensitivity of Aggregation Patterns between Peptide-Chains to the Surrounding Ionic Environment.

The molecular basis for the liquid-liquid phase separation (LLPS) behavior of various biomolecular components in the cell is the formation of multivalent and low-affinity interactions. When the content of these components exceeds a certain critical concentration, the molecules will spontaneously coalesce to form a new liquid phase; i.e.

Benchmark of Data Integration in Single-Cell Proteomics.

Single-cell proteomics (SCP) detected based on different technologies always involves batch-specific variations because of differences in sample processing and other potential biases. How to integrate SCP data effectively has become a great challenge. Integration of SCP data not only requires the conservation of true biological variances, but also realizes the removal of unwanted batch effects.

Simultaneous determination of twelve microcystins in algal supplements on the Chinese market and possible risks to exposed populations.

Algae supplements are widely recognized for their nutritional benefits and are commonly marketed as natural health products. However, concerns regarding contamination with cyanobacterial toxins have been raised. Moreover, there is very little data regarding the potential contamination of algal supplements on the Chinese market by these toxins.

Accelerated Screening of Highly Sensitive Gas Sensor Materials for Greenhouse Gases Based on DFT and Machine Learning Methods.

Greenhouse gases (GHGs) have caused great harm to the ecological environment, so it is necessary to screen gas sensor materials for detecting GHGs. In this study, we propose an ideal gas sensor design strategy with high screening efficiency and low cost targeting four typical GHGs (CO, CH, NO, SF). This strategy introduces machine learning (ML) methods based on density functional theory (DFT) to achieve accurate and rapid screening from a large number of candidate gas sensor materials.

Residue depletion and withdrawal time estimation of tilmicosin in black-bone silky fowls after administration via drinking water.

In this study, residue depletion and withdrawal time estimation of tilmicosin were examined in Taihe black-bone silky fowls (TBSFs) after oral administration for three consecutive days at a dose of 75 mg/L in water. The tilmicosin concentrations in liver, kidney, muscle, and skin/fat of TBSFs collected from different time points (0.16, 1, 3, 5, 7, 9, 12, 20, 30, 40 days after last administration) were determined by UPLC-MS/MS.

Physicochemical characterization, bioactive compounds, and in vitro digestion characteristics of Moringa oleifera seed oil: a comprehensive investigation.

Background: Moringa oleifera is a wild plant belonging to the genus Moringa and the family Moringaceae, which possesses valuable nutritional and medicinal properties and is inexpensive. The present study aimed to provide a comprehensive assessment of the potential of M. oleifera seed oil (MoSO) as a food ingredient by investigating its physicochemical properties, bioactivity, and in vitro digestion characteristics.

Research on quantitative evaluation of medical insurance fraud supervision policy based on 'Antecedents-Process-Outcomes' framework.

Fraud in medical insurance is a serious problem that threatens the safety and sustainability of medical insurance funds. The process of reducing or even eliminating the impact of fraud is related to maintaining the balance of payments for medical insurance funds and reforming the payment system based on total amount control. As a result of reviewing the policy background of medical insurance fraud in China, combined with the policy evaluation model in the area of public management, this paper develops a conceptual framework of 'Antecedents-Process-Outcomes' that emphasizes the fraud and governance of medical insurance funds.

ESG rating disagreement and bank loan availability: Evidence from China.

Environmental, social, and governance (ESG) ratings are receiving increasing attention in credit markets. However, ESG rating disagreement erects obstacles for companies in obtaining capital resources. This study investigates the impact of ESG rating disagreement on bank loan availability uses data of Chinese listed firms from 2014 to 2022, and employs models with multiple regression analyses and fixed effects.