Bioinformatics identifies key genes and potential therapeutic targets in the pathological mechanism of oxidative stress in Randall's plaque.

Randall's plaque (RP) is recognized as a precursor lesion for kidney stones, with its formation and progression potentially linked to oxidative stress. Previous studies have provided limited insights into the underlying mechanisms of RP, failing to fully elucidate its molecular pathways. To investigate the relationship between oxidative stress and RP, we employed bioinformatics approaches to identify key genes, predict associated pathways and drug molecules, analyze variations in immune cell populations, and construct diagnostic models.

Hybrids of copper cysteamine nanosheets and silver nanocluster ensure superior bactericidal capability via enhanced photodynamic effect.

Over the past decades, bacterial infections resulting from the misuse of antibiotics have garnered significant attention. Among the alternative antibacterial strategies, photodynamic therapy (PDT) has emerged as a promising non-antibiotic approach. However, persistent bacterial biofilms, particularly those composed of gram-negative bacteria with their protective outer membranes, have exhibited remarkable resilience to PDT.

Hemodynamic comparisons of different shunt positions and geometrical model simplification strategies in the simulation of transjugular intrahepatic portosystemic shunt (TIPS).

Transjugular intrahepatic portosystemic shunt (TIPS) is a widely used surgery for portal hypertensive patients, whose potential postoperative complications are closely related to the hemodynamic condition of the portal venous system. The selection of shunt position in the surgery may affect the postoperative hemodynamics; however, it is difficult for clinical studies to investigate the influence. Therefore, this study aims to employ the computational model simulating TIPS to compare the hemodynamic differences resulting from different shunt positions, and also to investigate the influences of different geometrical model simplification strategies used in the TIPS simulation.

Mechanical prediction method of strata movement and surface subsidence in backfill-strip mining.

Underground coal excavation has caused a series of geological disasters and environmental problems, especially coal mining subsidence. Backfill-strip mining, which combines the advantages of strip mining and backfill mining, can reduce subsidence and improve the recovery rate of coal. Therefore, predicting the impact of backfill-strip mining on the surface environment and strata structure is essential for the better development of backfill-strip mining technology.

The mediating effects of death reflection on death literacy and death anxiety among Chinese nurses: a cross-sectional study.

The purpose of this study was to investigate the mediating effect of death reflection on death literacy and death anxiety in clinical nurses. A sample of 2,882 nurses in China were selected by convenience sampling. A socio-demographic questionnaire, a death literacy scale, a death reflection scale, and a death anxiety scale were used to investigate.

Development and validation of a prediction model for intrapartum fever related to chorioamnionitis in parturients undergoing epidural analgesia.

Intrapartum fever is a common complication in parturients undergoing epidural analgesia (EA), significantly increasing the incidence of maternal and infant complications. This study aims to develop and validate a prediction model for intrapartum fever related to chorioamnionitis (IFTC) in parturients undergoing epidural analgesia. A total of 596 parturients with fever (axillary temperature ≥ 38℃) who received EA from January 2020 to December 2023 were included and randomly assigned to the training set (N = 417) and the validation set (N = 179) according to the ratio of 7:3.

Development and assessment of a novel single-drive variable angle spraying machine.

Traditional sprayers are limited to applying spray mixture solely to the upper surfaces of crops. To overcome this limitation, a variable angle spraying machine (VASM) was designed using a linkage system. This machine enables the adjustment of both the spray position and angle through a single input signal, facilitating multi-directional spraying from the top to the bottom of crops.

Propensity score matching analysis of the association between physical activity and multimorbidity in middle-aged and elderly Chinese.

In the context of an aging population, older adults increasingly face the challenge of managing multiple chronic conditions simultaneously. This study utilized analytical methods such as propensity score matching (PSM) and multivariate logistic regression, to explore the relationship between physical activity and the number of chronic diseases as well as the risk of developing co-morbidities among middle-aged and elderly Chinese individuals using data from the 2020 China Health and Retirement Longitudinal Survey. The PSM results showed that physical activity decreased the number of chronic diseases in middle-aged and elderly people by 0.

Altered neurovascular coupling and structure-function coupling in Moyamoya disease affect postoperative collateral formation.

Chronic ischemia in moyamoya disease (MMD) impaired white matter microstructure and neural functional network. However, the coupling between cerebral blood flow (CBF) and functional connectivity and the association between structural and functional network are largely unknown. 38 MMD patients and 20 sex/age-matched healthy controls (HC) were included for T1-weighted imaging, arterial spin labeling imaging, resting-state functional MRI and diffusion tensor imaging.

CPDM: Content-preserving diffusion model for underwater image enhancement.

Underwater image enhancement (UIE) is challenging since image degradation in aquatic environments is complicated and changing over time. Existing mainstream methods rely on either physical-model or data-driven, suffering from performance bottlenecks due to changes in imaging conditions or training instability. In this article, we attempt to adapt the diffusion model to the UIE task and propose a Content-Preserving Diffusion Model (CPDM) to address the above challenges.

Re-evaluation of the relationship between PrPc expression and patient prognosis in primary esophageal squamous cell carcinoma and primary hepatocellular carcinoma.

PrPc is expressed in various tumors and is associated with cancer progression, but previous studies have shown conflicting results regarding its relationship with patient prognosis-potentially due to differences in the antibodies used. This study aimed to clarify the relationship between PrPc expression and primary esophageal squamous cell carcinoma (ESCC) and primary hepatocellular carcinoma (HCC) using a novel anti-PrPc antibody, 4AA-m, noted for its high specificity and sensitivity. We used flow cytometry to detect PrPc expression in ESCC and HCC cell lines.

Radiomics models based on thoracic and upper lumbar spine in chest LDCT to predict low bone mineral density.

This study aims to develop and validate different radiomics models based on thoracic and upper lumbar spine in chest low-dose computed tomography (LDCT) to predict low bone mineral density (BMD) using quantitative computed tomography (QCT) as standard of reference. A total of 905 participants underwent chest LDCT and paired QCT BMD examination were retrospectively included from August 2018 and June 2019. The patients with low BMD (n = 388) and the normal (n = 517) were randomly divided into a training set (n = 622) and a validation set (n = 283).

A time series study of the association between extreme temperature and ozone on varicella incidence.

This study aimed to discuss the effects of extreme temperatures and ozone on the incidence of varicella in Shijiazhuang City from 2014 to 2022, which provides new ideas for preventing public health events. METHODS We collected varicella cases in Shijiazhuang, China, from 2014 to 2022 and evaluated the relationship between temperature extremes and ozone on varicella incidence by building distributional lag nonlinear models. The analysis was stratified by age and sex, with 19,188 varicella cases reported.

Curcumin liposomes alleviate senescence of bone marrow mesenchymal stem cells by activating mitophagy.

The senescence of mesenchymal stem cells (MSCs) is closely related to aging and degenerative diseases. Curcumin exhibits antioxidant and anti-inflammatory effects and has been extensively used in anti-cancer and anti-aging applications. Studies have shown that curcumin can promote osteogenic differentiation, autophagy and proliferation of MSCs.

The effect of toluene sulfonic acid remimazolam on postoperative delirium in elderly patients undergoing painless bronchoscopy.

Toluene sulfonic acid remimazolam is a novel benzodiazepine that differs from traditional benzodiazepines (BZDs) due to its rapid onset, swift metabolism, and lack of hepatic or renal metabolism, as well as its reduced effects on cardiac and cerebral functions. Despite its potential advantages, clinical experience with this agent remains limited. This study investigated the effect of remizolam on postoperative delirium in elderly patients undergoing painless bronchoscopy.

IQGAP3 activates Hedgehog signaling to confer stemness and metastasis via up-regulating GLI1 in lung cancer.

Lung cancer ranks as the most prevalent malignant neoplasm worldwide, contributing significantly to cancer-related mortality. Stemness is a well-recognized factor underlying radiotherapy resistance, recurrence and metastasis in non-small-cell lung cancer (NSCLC) patients. Our prior investigations have established the role of IQ motif containing GTPase-activating protein 3 (IQGAP3) in mediating radiotherapy resistance in lung cancer, but its impact on lung cancer stemness remains unexplored.

Effects of vegetation restoration on soil aggregate characteristics and soil erodibility at gully head in Loess hilly and gully region.

Vegetation restoration can be effective in containing gully head advance. However, the effect of vegetation restoration type on soil aggregate stability and erosion resistance at the head of the gully is unclear. In this study, five types of vegetation restoration-Pinus tabulaeformis (PT), Prunus sibirica (PS), Caragana korshinskii (CKS), Hippophae rhamnoides (HR), and natural grassland (NG, the dominant species is Leymus chinensis)-in the gully head were studied.

Interspecific competition and survival pressures in endangered Barringtonia racemosa populations of Mainland China.

This study evaluates the growth, survival pressures, and community dynamics of Barringtonia racemosa (L.) Spreng. populations in Jiulong Mountain and Suixi County, Guangdong Province.

Identification of allelochemicals under continuous cropping of Morchella mushrooms.

Continuous cropping obstacle has been becoming the bottleneck for the stable development of morel cultivation. The allelopathic effect of soil allelochemicals may play an instrumental role in the morel soil sickness. In this study, the allelochemicals were identified by gas chromatography-mass spectrometry (GC-MS) combined with in vitro bioassay.

Short-chain fatty acids play a key role in antibody response to SARS-CoV-2 infection in people living with HIV.

High SARS-CoV-2-specific antibody levels can protect against SARS-CoV-2 reinfection. The gut microbiome can affect a host's immune response. However, its role in the antibody response to SARS-CoV-2 in people living with HIV (PLWH) remains poorly understood.

Single-nucleus transcriptomic profiling of the diaphragm during mechanical ventilation.

Mechanical ventilation contributes to diaphragm atrophy and muscle weakness, which is referred to as ventilator-induced diaphragmatic dysfunction (VIDD). The pathogenesis of VIDD has not been fully understood until recently. The aim of this study was to investigate the effects of 24 h of mechanical ventilation on fibro-adipogenic progenitor (FAP) proliferation, endothelial-mesenchymal transition (EndMT), and immune cell infiltration driving diaphragm fibrosis in a rabbit model.

Spatiotemporal dynamics and spatial correlation patterns of urban ecological resilience across the Yellow River Basin in China.

Addressing the need to harmonize environment conservation and sustainable economic development within the Yellow River Basin (YRB) requires a profound comprehension of the spatiotemporal dynamics of urban ecosystem resilience. This study developed an index system utilizing the resistance-adaptability-recovery framework to measure these dynamics. By applying the advanced multi-attribute boundary area comparison method and a spatial autocorrelation model, we investigated the spatiotemporal variations and spatial correlation patterns of urban ecological resilience across the YRB.

The effect of Internet+ -based extracurricular running exercise on students' physical fitness.

The application of the Internet combined with extracurricular running exercise plays an important role in promoting the reform of school physical education teaching and the healthy development of students' physical fitness. 2379 students of Guilin Medical College used the Flash Campus APP for 30 weeks of running exercise during the school period, and the Wilcoxon test and t-test were used to statistically test the data of 50 m, standing long jump, lung capacity, seated forward bending, height, and body weight; men's pull-ups, 1,000 m; and women's sit-ups, 800 m pre- and post-tests. The Z/t values of men's 50 m, standing long jump, pull-ups, and lung capacity; women's 50 m running, standing long jump, sit-ups, lung capacity, and sitting prone flexion after extracurricular running exercise were - 3.

The performance of a novel diagnostic criteria for neurosyphilis in HIV-negative patients.

Diagnosing neurosyphilis in clinical settings poses significant challenges due to the absence of highly efficient diagnostic criteria. Our objective was to enhance the existing diagnostic criteria and assess their sensitivity and specificity for identifying neurosyphilis in HIV-negative patients. We conducted a retrospective review of patient records from a cross-sectional study carried out between December 2019 and May 2023.

Impaired visual attention and numerical processing in children with anisometropic amblyopia and after visual acuity recovery.

Amblyopia affects more than visual acuity. To compare the performances of visual selective attention and numerical processing in children with anisometropic amblyopia and children with normal vision, and investigate whether performance would be improved after visual acuity recovery, we performed 3 visual attention tasks (identifying number location task, numerical comparison task, and specific number comparison task) in children with anisometropic amblyopia, children who had recovered from anisometropic amblyopia, and children with normal vision in 6-8 and 9-11 years groups. The numerical processing ability, visual selective attention, and numerical distance effect were assessed by their reaction time of different tasks.