Programmable 2H-MoTe FGFET-Based CMOS Array.

A programmable 2H-MoTe floating-gate field-effect transistor (FGFET)-based complementary metal oxide semiconductor (CMOS) array has been fabricated on the grown substrate. Coplanar grown metallic 1T'-MoTe serves as the source and drain electrodes. The conductive type of the 2H-MoTe channel is manipulated by a top-gate engineering method.

Association Between Body Fat Percentage and Urinary Flow Rate in US Adults: Analysis of the National Health and Nutrition Examination Survey 2011-2018.

To assess the relationship between total body fat percentage(TBFP), trunk fat percentage(TFP), and urinary flow rate(UFR).We stratified by age and sex and hypothesize that TBFP and TFP are negatively associated with UFR across all groups.The study utilized data from the National Health and Nutrition Examination Survey (NHANES), which includes a series of nationally representative cross-sectional surveys.

Modulating the Hydrogen Bond for a Stable Zinc Anode with a Wide Temperature Range via the Sucrose and Polyacrylamide Synergistic Effect.

Zinc-ion batteries become a major research focus in energy storage, valued for their low cost and high safety. However, their widespread application is hindered by poor zinc anode stability caused by dendrites, side reactions, and poor performance across a wide temperature range at a strong hydrogen bond network aqueous electrolyte. In this study, we propose a strategy for the synergistic combination of a polyacrylamide hydrogel with sucrose.

A 71-Year-Old Man With Gas Accumulation in the Left Atrium.

A 71-year-old man with a history of atrial fibrillation presented to the emergency department with sudden unconsciousness after finishing lunch. Just 4 weeks ago, the patient underwent radiofrequency ablation for atrial fibrillation and regularly took rivaroxaban for anticoagulant therapy. According to the medical history, the patient suffered recurrent chest tightness and heartburn after radiofrequency ablation without other discomforts.

In situ global mapping of protein perturbations via protein abundance and conformation analysis.

Background: Traditional studies of protein responses to external stimuli primarily focus on changes in protein abundance, often overlooking the critical role of protein conformational alterations. To address this gap, we developed Protein Abundance and Conformation Analysis (PACA), an integrative method that quantifies both protein abundance and conformational changes. PACA combines conventional quantitative proteomics for abundance measurements with Target Response Accessibility Profiling (TRAP), a technique that captures conformational changes in situ by applying reductive dimethylation to label accessible lysine residues in living cells before lysis.

In-situ quantitative detection of hypochlorous acid in food samples by employing a near-infrared fluorescent probe in association with a portable optical data acquisition system.

Background: Hypochlorous acid (HClO) is a crucial disinfectant in the food industry. It can be used to soak perishable foods like vegetables, fruits, eggs, fish, and raw meat before processing and storage, eliminating microorganisms, bacteria, fungi, and pathogens to ensure food safety. HClO also helps preserve vegetables and fruits by reducing ethylene production, delaying rotting, decreasing cell membrane permeability, inhibiting polyphenol oxidase activity, and postponing discoloration.

One-step colorimetric immunosensing of foodborne bacteria using static magnet driven magnetophoretic separation and dual noble metal decorated magnetic nanobeads.

Background: Immunomagnetic separation is essential for screening pathogenic bacteria to prevent food poisoning. However, free immunomagnetic nanobeads (IMNBs) coexist with IMNB-bacteria conjugates (IBCs) after traditional immunomagnetic separation resulting in the infeasibility for IMNBs on IBCs to further act as signal label in bacterial detection. Although we have demonstrated that magnetophoretic separation at a high flowrate could separate IBCs from IMNBs, partial IMNBs were still found with IBCs due to chaotic flows and resulted in inevitable interferences.

Application of chemical pattern recognition and similarity evaluation in electrochemical and HPLC-DAD fingerprints for quality consistency study of herbal medicines.

Background: Herbal medicines and their preparations play a significant role in healthcare systems, yet concerns remain about their quality consistency. Chemical fingerprinting and multi-component quantitative analysis are the commonly used analytical methods and are widely applied in the quality analysis of herbal medicines. The study uses Gegen Qinlian tablets (GQTs) as a case to propose a comprehensive quality consistency evaluation system.

Simultaneous monitoring of creatinine and urea in diversified clinical samples based on SERS-active PDMS-flower-like ZIF-67@Ag nanoparticles.

The sensitive, efficient, and simultaneous assay of creatinine and urea in different body fluid is crucial for the daily detection and treatment of chronic kidney disease. Here, we exploited a versatile composite surface enhanced Raman scattering (SERS) substrate of polydimethylsiloxane (PDMS)-flower-like ZIF-67@Ag nanoparticles (NPs) based on simple in-situ growth and ion sputtering strategies. The plasmonic Ag NPs assembled on the three-dimensional anisotropic ZIF-67 matrix, facilitating numerous resonant electromagnetic "hotspots".

Flexible microcolumn array-based silk fibroin for sweat glucose monitoring.

Flexible sweat sensors possess the special potential for continuous non-invasive monitoring of human blood glucose. We put forward a flexible microcolumn array sensor, which is designed for health monitoring by means of detecting glucose levels in sweat and capturing physiological signals related to human movement. With the combination of silk fibroin (SF), waterborne polyurethane (PU), and multi-walled carbon nanotubes (MWCNT), this microcolumn film electrode is able to effectively function as a strain sensor benefiting from the superior mechanical performance of PU.

Paper-immobilized liquid-phase microextraction for direct paper spray mass spectrometry and immuno-detection of atropine in baby food, buckwheat cereals, and edible oils at regulatory levels.

Background: Atropine is a strictly regulated natural toxin. Monitoring for atropine is thus important, but often expensive and time-consuming. Moreover, the range of relevant matrices, and corresponding differences in required detection limits for atropine vary.

Mass spectrometric monitoring of redox transformation and arylation of tryptophan.

Tryptophan (Trp) is an essential amino acid obtained from human diet. It is involved not only in de novo biosynthesis of proteins but also in complex metabolic pathways. Redox transformation of tryptophan is under-explored in comparison with kynurenine, serotonin and indole pyruvate pathways.

Ratio fluorescence and smartphone-assisted colorimetry dual-mode detection of creatinine based on F, B, N-doped of red fluorescent carbon dots.

Background: Creatinine is a small molecule disease biomarker that reflects kidney function, accurate and effective detection of creatinine will play an important role in the prevention and treatment of diseases. Currently, commonly used creatinine detection methods are limited by expensive instruments, complex sample preparation, many interference factors from biological samples, and environmental factors that can affect the accuracy of the measurement. Therefore, developing a fast, simple, inexpensive, sensitive analysis method that can eliminate background interference and provide multi-detection modes has strong attraction and value.

Fabrication of tailored imprinted layer and cladded layer on magnetic nanomaterials with enhanced specificity for recognition of PFOS.

Background: Perfluorooctane sulfonate (PFOS) is a persistent organic pollutant with significant risks to ecosystems and human health. Magnetic molecularly imprinted polymers (MIPs) provide a promising solution for selectively extracting PFOS from contaminated water. However, while bifunctional monomer imprinting improves the imprinting effect by introducing diverse functional groups, it can also increase non-specific adsorption.

Exploration of crucial stromal risk genes associated with prognostic significance and chemotherapeutic opportunities in invasive ductal breast carcinoma.

Background: Few studies revealed that stromal genes regulate the tumor microenvironment (TME). However, identification of key-risk genes in the invasive ductal breast carcinoma-associated stroma (IDBCS) and their associations with the prediction of risk group remains lacking.

Methods: This study used the GSE9014, GSE10797, GSE8977, GSE33692, and TGGA BRCA datasets.

Latent dimensions of brain asymmetry.

Functional lateralization represents a fundamental aspect of brain organization, where certain cognitive functions are specialized in one hemisphere over the other. Deviations from typical patterns of lateralization often manifest in various brain disorders, such as autism spectrum disorder, schizophrenia, and dyslexia. However, despite its importance, uncovering the intrinsic properties of brain lateralization and its underlying structural basis remains challenging.

The Role of Mitochondrial DNA Copy Number in Venous Thromboembolism: Insights from a 2-Sample Mendelian Randomization Study.

Background: Venous thromboembolism (VTE), including pulmonary embolism (PE) and deep vein thrombosis (DVT), is the third most common cardiovascular disease. A low amount of mitochondrial DNA copy number (mtDNA-CN) reflects mitochondrial dysfunctions and has been associations with arterial cardiovascular diseases. However, the role of mtDNA-CN in venous cardiovascular disease was unclear.

Assessing the link of malnutrition with diabetes and mortality risk in heart failure patients.

Aims: Malnutrition is increasingly recognized as a significant factor influencing the clinical outcomes of patients with heart failure (HF). Diabetes exacerbates risks like hospitalizations and mortality due to cardiovascular complications. The aim of this study was to explore the association of malnutrition with diabetes and its prognostic impact on all-cause and cardiovascular mortality in patients with HF, using the nutritional assessment tools, controlling nutritional status (CONUT) score and geriatric nutritional risk index (GNRI).

Effect of Home-based Virtual Reality Training on Upper Extremity Recovery in Patients with Stroke: Systematic Review.

Background: Stroke is a leading cause of long-term disability, often resulting in upper extremity dysfunction. Traditional rehabilitation methods often face challenges such as limited patient access to resources and lack of sustained motivation. Home-based virtual reality (VR) training is gaining traction as an innovative, sustainable and interactive alternative.