Effects of different feeding strategies on egg production, eggshell quality, tibial mass and intestinal calcium transporter expression in laying hens.

1. This study examined feeding practices that could affect the expression of intestinal calcium transporter gene, tibial mass, eggshell quality and production performance in 25-week-old Hy-Line Brown Laying Hens.2.

Multi-omics uncover acute stress vulnerability through gut-hypothalamic communication in ducks.

1. The avian gut hosts a complex and dynamic microbial ecosystem, which is essential for regulating host organ function. However, the relationship between the gut microbiota and the hypothalamic axis in acute stress vulnerability in ducks remains unclear.

Magnetically targeted delivery of probiotics for controlled residence and accumulation in the intestine.

The effectiveness of orally delivered probiotics in treating gastrointestinal diseases is restricted by inadequate gut retention. In this study, we present a magnetically controlled strategy for probiotic delivery, which enables controlled accumulation and residence of probiotics in the intestine. The magnetically controlled probiotic is established by attaching amino-modified iron oxide (FeO-NH NPs) to polydopamine-coated GG (LGG@P) through electrostatic self-assembly and named as LGG@P@FeO.

Evaluation of the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 15 Palliative Care and the Functional Assessment of Chronic Illness Therapy-Palliative in assessing the quality of life in patients with advanced cancer.

Purpose Of Review: Two widely validated health-related quality of life (HR-QoL) tools, specifically designed for patients with advanced cancer, are the European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire Core 15 Palliative Care (EORTC QLQ-C15-PAL) and the Functional Assessment of Chronic Illness Therapy-Palliative (FACIT-Pal-14). This systematic review aims to evaluate the use of EORTC QLQ-C15-PAL and FACIT-Pal-14 in prospective studies in patients with advanced cancer, focusing on study types, clinical settings, additional HR-QoL tools used, and completion rates.

Recent Findings: Sixty studies were included in the analysis.

Lifei Qingchang Tang attenuates acute lung injury the NF-κB and MAPK signaling pathways.

Acute lung injury (ALI) has high morbidity and mortality. Lifei Qingchang Tang (LFQCT), a traditional Chinese medicine, has antioxidant and anti-inflammatory properties but its mechanism in ALI remains unclear. , LFQCT reduced intracellular Ca, ROS, and NO in LPS-induced RAW 264.

A Novel Model for Cornea Power Shift in Eyes Wearing Orthokeratology Lenses With Different Back Optic Zone Diameters for Myopia Control.

Purpose: The purpose of this study was to quantify the corneal power changes after wearing orthokeratology lenses of different back optic zone diameters (BOZDs) and to propose a novel 4-parameter model capable of revealing the associations between each parameter and axial length growth (ALG).

Methods: A prospective self-controlled study was conducted between June 2022 and December 2023. One eye in each subject (N = 33) was randomly assigned to wear a lens with a BOZD of either 5 mm (5 oz) or 6 mm (6 oz).

Prognostic Impact of Fluorescent Lymphography on Gastric Cancer After Neoadjuvant Chemotherapy.

Importance: Indocyanine green (ICG)-guided lymphadenectomy has been increasingly used to treat gastric cancer. However, its oncologic impact remains unclear.

Objective: To investigate the effect of ICG tracing on long-term outcomes in patients diagnosed with locally advanced gastric cancer undergoing neoadjuvant chemotherapy (NAC) followed by laparoscopic radical gastrectomy.

Effect of spermidine on cuproptosis in follicular granulosa cells.

1. A study was conducted to investigate the effect of spermidine on cuproptosis in granulosa cells of goose ovarian follicles. Granulosa cells from F2-F5 grade follicles of Sichuan white geese were isolated and cultured.

HGF-DPSCs ameliorate asthma by regulating CCR1 Th2 cells responses in mice pulmonary mucosa.

Asthma, a prevalent allergic disease affecting approximately 300 million individuals globally, remains a significant public health challenge. Mesenchymal stromal cells (MSCs) and hepatocyte growth factor (HGF), both recognized for their immunomodulatory properties, hold therapeutic potential for asthma. However, their precise mechanisms remain underexplored.

Construction and Application Research of a Perioperative Inspection Checklist for Acute Upper Gastrointestinal Bleeding.

Purpose: To enhance patient safety and improve communication and response times during the perioperative management of patients with acute upper gastrointestinal bleeding, a checklist was developed, tested for psychometric properties, and implemented in clinical practice.

Design: This is a methodological study.

Methods: A perioperative checklist for acute upper gastrointestinal bleeding was developed using a literature review and the Delphi method.

Disease Burden, Temporal Trends, and Cross-Country Inequality Associated with Sociodemographic Indicators in Alzheimer's Disease and Other Dementias.

Introduction: The purpose of this article is to describe the global burden and temporal trends of Alzheimer's disease and other dementias from 1990 to 2021 and explore cross-country inequality associated with sociodemographic development-related factors.

Methods: The disability-adjusted life years of Alzheimer's disease and other dementias and sociodemographic index were extracted from the Global Burden of Disease 2021 study, and other sociodemographic development-related factors, including government expenditure on education (% of GDP), net national income per capita, health expenditure per capita, and fertility rate, were sourced from World Bank Data. Disability-adjusted life years of Alzheimer's disease and other dementias across 204 countries/territories and global age-sex distribution in 2021 were illustrated.

Diagnostic and Therapeutic Potential of Photo-Responsive Nanomaterials in Osteoarthritis.

Osteoarthritis (OA) is the most common musculoskeletal disease globally and is the main reason for the chronic pain and disability in people over sixty-five worldwide. Degradation of the articular cartilage, synovial inflammation and osteophyte formation are widely acknowledged as the primary pathological manifestations of OA. OA affects more than 300 million people all over the world, bringing extremely large socioeconomic burden.

CD16CD56 NK Cells: A Protective NK Cell Subset for Progression and Prognosis in Amyotrophic Lateral Sclerosis.

Amyotrophic lateral sclerosis (ALS) is a non-neuron-autonomous disease where peripheral immune dysregulation significantly impacts disease progression. However, the immunopathological mechanisms of natural killer (NK) cells in ALS remain largely unexplored. This study enrolled 241 ALS patients and 102 healthy controls (HC), analyzing lymphocyte subsets, including T cells, B cells, and NK cells.

Decoding Microglial Polarization and Metabolic Reprogramming in Neurodegenerative Diseases: Implications for Disease Progression and Therapy.

As the resident macrophages of the brain, microglia are crucial immune cells specific to the central nervous system (CNS). They constantly surveil their surroundings and trigger immunological reactions, playing a key role in various neurodegenerative diseases (ND). As illnesses progress, microglia exhibit multiple phenotypes.

Trifluoroacetic Acid Induced a Cyclophilin D-Dependent Cognitive Impairment in Mice.

Studies have linked inhalation anesthesia and surgery to increased cognitive impairment, particularly in the elderly. Our previous research showed that isoflurane, but not desflurane, affected cognitive function in mice by modulating cyclophilin D (CypD), a key regulator of the mitochondrial permeability transition pore (mPTP) and mitochondrial function. Both anesthetics metabolize into trifluoroacetic acid (TFA), which is associated with cognitive deficits.

Cellular Senescence in the Regenerative Niche Hampers Skeletal Muscle Repair.

With the growing interest in skeletal muscle diseases, understanding the processes, factors, and treatments associated with muscle regeneration is crucial. Skeletal muscle regeneration is a complex process that largely depends on the niche composed of cell populations, such as satellite cells, and their microenvironment. Cellular senescence is associated with various physiological processes and age-related diseases and plays a significant role in the muscle regeneration niche.

Gut Microbiota Modulation of Dementia Related Complications.

Recent advances in microbial pathogen research have highlighted the potential of gut microbe-based microbial medicine. One of the most extensively studied biological pathways is the gut-brain axis, which has been shown to reverse neurological disorders. Evidence from animal-based studies of dysbiosis suggest complex behavioral changes, such as alterations in sociability and anxiety, can be modulated through gut microbiota.

Nanozyme-Based Strategies in Cancer Immunotherapy: Overcoming Resistance to Enhance Therapeutic Efficacy.

Nanozymes, which are nanomaterials that replicate the catalytic activities of natural enzymes in biological systems, have recently demonstrated considerable potential in improving cancer immunotherapy by altering the tumor microenvironment. Nanozyme-driven immune responses represent an innovative therapeutic modality with high effectiveness and minimal side effects. These nanozymes activate the immune system to specifically recognize and destroy cancer cells.

New Insight into the Mechanism of Neurochemical Imbalance in Multiple Sclerosis: Abnormal Transportation of Brain Extracellular Space.

Neurochemical imbalance is a contributing factor to neurological symptoms in multiple sclerosis (MS). The matured myelin sheath is crucial for substance transportation within the extracellular space (ECS) and for maintaining local homeostasis. Therefore, we hypothesize that disturbed ECS transportation following demyelinating lesions might lead to neurochemical imbalance in MS.

The mechanisms of resistance, epidemiological characteristics, and molecular evolution of carbapenem-resistant hypervirulent Klebsiella pneumoniae.

Introduction: Carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKP) is a highly pathogenic, drug-resistant, and transmissible "superbug" that causes infections in hospitals and communities. Because of the lack of effective antimicrobial treatment options, morbidity and mortality from CR-hvKP infections have increased dramatically, and outbreaks and the rapid spread of CR-hvKP in hospitals have become a major global public health challenge.

Methods: The mechanisms of molecular evolution in CR-hvKP include the acquisition of a hypervirulent plasmid encoding a virulence gene by carbapenemase-producing K pneumoniae, the horizontal transfer of plasmids carrying carbapenem resistance genes to hvKP, and the acquisition of fusion plasmids carrying both carbapenem resistance genes and hypervirulent genes by classic K pneumoniae.

Association between vitamin D level and risk of type 2 diabetes: a systematic review of Mendelian Randomization studies.

This study aims to review the evidence from Mendelian randomization (MR) studies on the causal role of vitamin D in type 2 diabetes (T2D). A systematic search (registered on PROSPERO (CRD42024551731)) was performed in PubMed, Embase and Web of Science for publications up to June 2024. MR studies including vitamin D as the exposure and T2D as the outcome were included.

Higher life's essential 8 score is associated with reduced risk of related surgery and all-cause mortality among 3,232 individuals with inflammatory bowel disease in a longitudinal cohort study.

Background: Previous studies indicated discrete lifestyle health metrics that benefit cardiovascular health are associated with better prognosis in inflammatory bowel disease (IBD), while evidence regarding the comprehensive impact of cardiovascular health remains limited. This study aimed to investigate the association between the overall cardiovascular health indicator, Life's Essential 8 (LE8), and the adverse outcomes of IBD.

Materials And Methods: We included 3,232 IBD participants recruited from the UK Biobank between 2006 and 2010.

Pressure-Induced Phase Transitions in Bismutotantalite (BiTaO): Insights from Single-Crystal Diffraction and Raman Spectroscopy.

In situ high-pressure single-crystal X-ray diffraction and Raman spectroscopy analyses were performed on a natural bismutotantalite with an α-BiTaO structure. The results indicate that α-BiTaO transforms into an orthorhombic phase (HP γ-BiTaO), likely through an intermediate orthorhombic phase (HP β-BiTaO). The transition pressures are 11.

A new pyrrolopyrazine alkaloid from the fruit of .

A new pyrrolopyrazine alkaloid, named lycipyrazine A (), alone with seven known alkaloids (-), were isolated from the fruit of The structure of new compound was determined using extensive 1D and 2D spectroscopic analyses, while its absolute configuration was determined by comparison of its experimental and calculated ECD spectra. Their -glucosidase inhibitory activity was screened using acarbose as a positive control. Compound showed strong inhibitory activity against -glucosidase (IC = 3.