Overlooked Role of Photogenerated Holes in Persistent Free Radical Formation on Hematite.

Persistent free radicals (PFRs) have garnered considerable attention due to their long lifetime and high reactivity. However, the roles of photogenerated carriers in PFR formation remain underexplored. We compared and analyzed the PFR formation on hematite-SiO loaded catechol, combining experimental and theoretical investigations.

Genome-wide identification of the SmPHR gene family in Salvia miltiorrhiza and SmPHR7-mediated response to phosphate starvation in Arabidopsis thaliana.

This study reveals the transcripts of S. miltiorrhiza in response to phosphate deficiency, identifies 18 SmPHRs in the genome, and tentatively establishes a role for SmPHR7 in regulating phosphate starvation. Phosphorus is essential for plant growth and development, and phosphate deficiency is a common nutritional stress.

Comparison of Myringitis Incidence in Cartilage Myringoplasty With and Without External Ear Canal Packing For the Repair of Chronic Tympanic Membrane Perforations.

We compared the long-term efficacy and incidence of myringitis after cartilage graft underlay myringoplasty for chronic tympanic membrane (TM) perforations with and without external ear canal (EAC) packing. : In total, 129 patients who met the inclusion criteria were allocated to either the EAC packing (packing) group or the no-EAC packing (no-packing) group. All patients underwent endoscopic cartilage graft underlay myringoplasty.

The impact of cold spells and heat waves frequencies on the prevalence and incidence of stroke in middle-to-elderly age population in China: evidence from the China Health and Retirement Longitudinal Study (CHARLS).

Stroke, a key cardiovascular disease, is impacted by cold spells and heat waves. However, limited sample size and unclear impact on the aging population's prevalence and incidence remain concerns. We aim to explore the association between cold spells and heat waves frequency and stroke in middle-aged and elderly people in China.

Long noncoding RNA MATN1-AS1 contributes to oxaliplatin resistance of gastric cancer cells through miR-518b/ZNF281 axis.

Chemoresistance leads to poor outcomes of patients with gastric cancer (GC). Long non-coding RNAs (lncRNAs) have been demonstrated as novel gene modulators in various carcinomas and chemoresistance. Our study aimed to investigate the role and underlying modulatory mechanism of lncRNA MATN1-AS1 in GC chemoresistance.

Molecular Insights into the Rhamnolipid-Promoted Enzymatic Performance on Removing Phenolic Pollutants.

Horseradish peroxidase (HRP) is a metalloenzyme widely used in various biochemical applications but is susceptible to activity loss and instability under suboptimal conditions. In this study, rhamnolipid (RL) was, for the first time, employed as an additive to enhance the catalytic performance of HRP, including in a dual-enzyme cascade system with glucose oxidase (GOx). We carried out catalytic experiments on phenol degradation and showed that protecting HRP from deactivation is critical in maintaining the high catalytic effect in the dual-enzyme cascade.

Artificial intelligence-based automated surgical workflow recognition in esophageal endoscopic submucosal dissection: an international multicenter study (with video).

Background: Endoscopic submucosal dissection (ESD) is a crucial yet challenging multi-phase procedure for treating early gastrointestinal cancers. This study developed an artificial intelligence (AI)-based automated surgical workflow recognition model for esophageal ESD and proposed an innovative training program based on esophageal ESD videos with or without AI labels to evaluate its effectiveness for trainees.

Methods: We retrospectively analyzed complete ESD videos collected from seven hospitals worldwide between 2016 and 2024.

New perspectives on the taste mechanisms of umami and bitter peptides in low-salt fermented fish sauce based on peptidomics, molecular docking and molecular dynamics.

Umami and bitter peptides generated by microbial metabolism are essential to the taste of low-salt fish sauce. However, the uncertain taste mechanisms of peptides hinder the efficient identification of high-intensity taste peptides in fish sauce. Our study investigated the taste mechanisms of umami or bitter peptides from low-salt fish sauce fermented with .

Photosensitive resistive switching in parylene-PbTe nanocomposite memristors for neuromorphic computing.

Resistive switching (RS) memory devices with incorporated capabilities of data sensing, storing and processing are promising for artificial intelligence applications. In this respect, controlling resistance not only by electrical but also optical stimulations provides attractive opportunities for the development of novel neuromorphic sensing and computing systems. Here, we demonstrate the RS of Cu/parylene-PbTe/ITO memristive devices and the dependence of RS on optical excitation for efficient neuromorphic computing with high classification accuracy.

Development and validation of a nomogram model based on vascular entry sign for predicting lymphovascular invasion in gastric cancer.

Background: To evaluate the predictive value of a nomogram based on the vascular entry sign for lymphovascular invasion in gastric cancer.

Methods: A total of 135 patients with histopathologically confirmed gastric cancer from August 2021 to November 2022 were enrolled. All patients underwent contrast-enhanced CT scans.

MAP4K4 aggravates microvascular anomalies in diabetic retinopathy in a YTHDF2-dependent manner.

Aims/hypothesis: Signalling pathways that regulate endothelial cell (EC) dysfunction, ischaemia and inflammation play a crucial role in retinal microangiopathy such as diabetic retinopathy. MAP4K4 is highly expressed in ECs. However, the involvement of MAP4K4 in retinal vasculopathy of diabetic retinopathy remains unclear.

Intrapancreatic adipocytes and beta cell dedifferentiation in human type 2 diabetes.

Aims/hypothesis: Fat deposition in the pancreas is implicated in beta cell dysfunction and the progress of type 2 diabetes. However, there is limited evidence to confirm the correlation and explore how pancreatic fat links with beta cell dysfunction in human type 2 diabetes. This study aimed to examine the spatial relationship between pancreatic fat and islets in human pancreases.

Environmentally Persistent Free Radical Emissions from Indoor Burning of Pelletized Biofuels.

Pelletization of biomass fuels has been promoted as an effective alternative to mitigate particulate matter (PM) emissions from the residential burning of raw biomass materials; however, environmentally persistent free radicals (EPFRs), a class of harmful components in PM, from the biomass pellet burning have been rarely studied yet. Here, laboratory-based combustion experiments were conducted to characterize EPFRs for different pellets burned in cooking and heating stoves and compared with those for the corresponding uncompressed biofuels. Emission factors (EFs) of EPFRs for biomass pellets ranged from 2.

The effect of H occupancy modes in small and large cages of H-tetrahydrofuran hydrates on the hydrates' stability and H storage capacity.

Hydrogen storage as hydrates is one of the most environmentally benign approaches to store hydrogen as it requires only water and traces of promoters. However, the scalability of storing hydrogen hydrate formation is hindered by the limited understanding of the structure, dynamics and energetics of hydrogen and promoters in the hydrate cages. In this study, molecular dynamics simulation configurations with different occupancy modes of H and tetrahydrofuran (THF) in the hydrate cages are investigated under the following scenarios: (i) two H molecules occupying the small cages, (ii) occupancy of H molecules in the THF-free large cages, and (iii) co-occupancy of H and THF in one large cage.

Preparation of capecitabine-poly(p-dioxanone) electrospraying nanoparticles and influence of particle size on their colorectal cancer inhibitive efficiency.

Colorectal cancer is the fourth leading cause of cancer-related deaths worldwide. Capecitabine is a chemotherapeutic agent commonly used for the treatment of colon cancer. To realize local sustained release, promote efficient local intracellular transport, and mitigate the systemic toxic effects of capecitabine, a capecitabine prodrug, capecitabine-poly (p-dioxanone) (Cap-PPDO), was successfully synthesized.

Quantum Well Superlattice Heteronanostructures for Efficient Photocatalytic Hydrogen Evolution.

In this study, we construct a quantum well effect-based two-dimensional Z-scheme superlattice heteronanostructure photocatalyst constructed from hydrogen-bonded porphyrin organic frameworks (HOFs) and carbon nitride. Porphyrin HOFs extend spectral absorption, while their π-conjugation and electron density variations significantly enhance charge separation and exhibit favorable alignment with the energy levels of carbon nitride, thereby enabling efficient charge transfer. Carboxylic acid channels in the HOFs further promote the decomposition of water molecules, thereby boosting hydrogen production.

Low-Cost, Facile, and Scalable Manufacturing of Single-Molecule-Integrated Catalytic Electrodes.

To surmount the shortcomings of powder-based catalysts and small electrode sizes, the development of meter-scale integrated electrode materials is essential for practical electrocatalytic applications, which requires fine control over the effective surface grafting of catalytic active sites on large-size electrodes as well as addressing the challenge of balancing cost-effective and large-scale manufacturing with highly active and stable operation. Herein, we report a low-cost, facile, and scalable method for directly constructing meter-scale single-molecule-integrated catalytic electrodes using commercially available, flexible, and size-tailored conductive carbon textiles (e.g.

Statistical inference on change points in generalized semiparametric segmented models.

The segmented model has significant applications in scientific research when the change-point effect exists. In this article, we propose a comprehensive semiparametric framework in segmented models to test the existence and estimate the location of change points in the generalized outcome setting. The proposed framework is based on a semismooth estimating equation for the change-point estimation and an average score-type test for hypothesis testing.

Two-Year Hypertension Incidence Risk Prediction in Populations in the Desert Regions of Northwest China: Prospective Cohort Study.

Background: Hypertension is a major global health issue and a significant modifiable risk factor for cardiovascular diseases, contributing to a substantial socioeconomic burden due to its high prevalence. In China, particularly among populations living near desert regions, hypertension is even more prevalent due to unique environmental and lifestyle conditions, exacerbating the disease burden in these areas, underscoring the urgent need for effective early detection and intervention strategies.

Objective: This study aims to develop, calibrate, and prospectively validate a 2-year hypertension risk prediction model by using large-scale health examination data collected from populations residing in 4 regions surrounding the Taklamakan Desert of northwest China.

Protein-ligand interaction prediction based on heterogeneity maps and data enhancement.

Prediction of protein-ligand interactions is critical for drug discovery and repositioning. Traditional prediction methods are computationally intensive and limited in modeling structural changes. In contrast, data-driven deep learning methods significantly reduce computational costs and offer a more efficient approach for drug discovery.

Optimized Porous KTi(PO)@N-Doped Carbon Electrode for Enhanced Sodium/Potassium-Storage and Accelerated Activation Process.

Porous KTi(PO) nanoparticles are synthesized via a solvothermal method and subsequently modified with nitrogen-doped carbon layers by using polydopamine as the carbon source. The resultant KTi(PO)@N-doped carbon composite (KTP@NC) exhibits a preserved porous structure with abundant pores, facilitating ion diffusion and electrolyte infiltration. Various characterizations, including X-ray diffraction, scanning electron microscopy, transmission electron microscopy, and Raman spectroscopy, reveal the successful formation of an interconnected nitrogen-doped carbon network.

Position-dependent resource competition within inflorescences of Sagittaria trifolia.

Resource competition among flowers is expected to influence variation in seed output within inflorescences, but the extent to which flower position affects competitive interactions is still incompletely understood. To investigate position effects on seed output in the perennial, monoecious macrophyte Sagittaria trifolia, we compared components of seed production (fruit set, seed number per fruit, and seed size) in control inflorescences to that in inflorescences from which half of the female flowers were experimentally removed, either from basal positions, from upper positions, or from across the inflorescence. Basal and upper flower removal reduced total seed output per inflorescence, while the throughout removal treatment maintained a seed yield comparable to the control.

A sensitive and rapid visual method of chicken sexing based on LAMP-CRISPR/Cas12a system.

1. Accurate sex identification of one-day-old chicks is crucial in layer poultry production. Establishing an early sexing method during the chicken embryonic period is essential for animal welfare.