The Multifaceted Roles of BACH1 in Disease: Implications for Biological Functions and Therapeutic Applications.

BTB domain and CNC homolog 1 (BACH1) belongs to the family of basic leucine zipper proteins and is expressed in most mammalian tissues. It can regulate its own expression and play a role in transcriptionally activating or inhibiting downstream target genes. It has a crucial role in various biological processes, such as oxidative stress, cell cycle, heme homeostasis, and immune regulation.

Clinical and Genetic Characteristics of Pediatric Colorectal Cancer.

Background: Compared to colorectal cancer (CRC) in adults, CRC in children is extremely rare. Although its incidence has increased recently, there is a lack of clinical research on the disease. Inherited cancer susceptibility syndromes (ICSS), a group of disorders in which patients are predisposed to susceptibility to a wide range of tumors as a result of pathogenic mutations in genes in their germ line, are an important cause of CRC in children.

Combination of Metabolomics and Bioinformatics to Reveal the Mechanism of Luteolin in the Treatment of Cervical Cancer.

The incidence of cervical cancer is high among women globally. The potential therapeutic efficacy of luteolin in the treatment of cervical cancer has been identified. Therefore, we aim to elucidate the mechanism of action of luteolin in the treatment of cervical cancer through a comprehensive approach that integrates metabolomics with bioinformatics.

Decoding the Implications of Zinc in the Development and Therapy of Leukemia.

Zinc plays a central role in the hematological development. Therapeutic interventions with zinc are shown to improve the health status of patients with malignancies by stimulating the immune system and reducing side effects. Despite the abnormal zinc homeostasis in leukemia, the role and mechanisms of zinc signaling in leukemia development remain poorly understood.

Active Water Optimization in Different Electrolyte Systems for Stable Zinc Anodes.

Zinc (Zn) metal, with abundant resources, intrinsic safety, and environmental benignity, presents an attractive prospect as a novel electrode material. However, many substantial challenges remain in realizing the widespread application of aqueous Zn-ion batteries (AZIBs) technologies. These encompass significant material corrosion challenges (This can lead to battery failure in an unloaded state.

In Operando Raman Spectroscopy Reveals Li-Ion Solvation in Lithium Metal Batteries.

Inhomogeneous lithium (Li) deposition and unstable solid electrolyte interphase are the main causes of short cycle life and safety issues in Li metal batteries (LMBs). Developing a 3D structured matrix current collector and novel electrolyte are feasible strategies to tackle these issues. Ether-based electrolytes are widely used in LMBs.

Triazole Drives Hole Localization and Superoxide Radical Formation for Enhancive Photocatalytic Cascade Isomerization/C─C Bond Scission of Biomass to Lactic Acid.

Chemocatalytic synthesis of lactic acid (LA) from biomass sugars involves heat-absorbing multistep cascade reactions mediated by different active sites, often encountering unsatisfactory selectivity. Here, a hole-localized carbon nitride-based photocatalyst (C-CNN) is constructed by covalent binding of heptazine and triazole skeleton via C─N bonds and further conjugated interaction with activated carbon, achieving the complete conversion of various biomass sugars to LA (up to 98.6% selectivity) at room temperature for 2 h.

Copper Depletion in Tumors Boosts Immunotherapy.

Copper depletion is being billed as a viable approach for cancer treatment. Vittorio and co-workers successfully demonstrated that Cuprior, an FDA-approved drug that binds with copper, effectively enhances anti-GD2 immunotherapy and improves the responses for neuroblastoma patients. These findings highlight the important role of copper chelation in modulating the tumor microenvironment.

Natural variation in CTF1 conferring cold tolerance at the flowering stage in rice.

Improving cold tolerance at the flowering stage (CTF) in rice is crucial for minimising yield loss, making the identification and application of cold-tolerant genes and QTLs imperative for effective molecular breeding. The long lead time, dependence on cold treatment conditions, and the inherent complexity of the trait make studying the genetic basis of CTF in rice challenging. To date, the fine-mapping or cloning of QTLs specific to CTF has not yet been achieved.

Intermittent theta burst stimulation for negative symptoms in schizophrenia patients with moderate to severe cognitive impairment: A randomized controlled trial.

Aims: This study aims to assess the therapeutic effects of intermittent theta burst stimulation (iTBS) targeting the bilateral dorsomedial prefrontal cortex (DMPFC) on negative symptoms in patients with schizophrenia, utilizing functional near-infrared spectroscopy for evaluation.

Methods: Thirty-five schizophrenia patients with negative symptoms and moderate to severe cognitive impairment were randomly assigned to a treatment group (n = 18) or a control group (n = 17). The treatment group received iTBS via bilateral DMPFC.

Color-shifting Crystalline Colloidal Arrays from Polymers With Upper Critical Solution Temperature.

Crystalline colloidal arrays (CCAs) composed of core-shell microspheres with thermoresponsive structural iridescence governed by Bragg's law have garnered significant attention for diverse applications. While core-shell microspheres with lower critical solution temperature (LCST) properties are extensively studied, upper critical solution temperature (UCST) counterparts remain unexplored, offering the potential to expand the application scope of thermoresponsive CCAs. In this study, poly(N-acryloyl glycinamide) (PNAGA), a UCST homopolymer, is employed for the first time to synthesize core-shell microspheres.

An Occult Primary Thymic Mucosa-Associated Lymphoid Tissue Lymphoma With Sjögren's Syndrome Revealed by CXCR4 Targeted Ga-Pentixafor PET/CT.

Mucosa-associated lymphoid tissue (MALT) lymphoma is an extranodal low-grade non-Hodgkin lymphoma that extremely rarely localises to the mediastinum. A 34-year-old female with chronic arthralgia, sicca and rash was found to have a well-demarcated mediastinal cystic mass with equivocal nodular enhancement within the cystic wall on chest CT during a workup for Sjögren's syndrome. Subsequent Ga-Pentixafor-PET/CT revealed focal uptake increase within the cystic capsule.

Ablation of Premature Ventricular Contractions With Prepotentials Mapped Inside Coronary Cusps: When to Go Infra-Valvular?

Background: Discrete prepotentials (DPPs) mapped inside aortic sinuses of Valsalva (ASVs) are deemed as reliable targets for ablation of premature ventricular contractions (PVCs). Nevertheless, ablation may still fail, necessitating further investigation. This study aimed to investigate the electrophysiological features and ablation approaches for PVCs with failed ablation inside ASVs, despite identified DPPs.

Defect-Engineered Biomimetic Piezoelectric Nanocomposites With Enhanced ROS Production, Macrophage Re-polarization, and Ca Channel Activation for Therapy of MRSA-Infected Wounds and Osteomyelitis.

Antibiotic-resistant bacteria often cause lethal infections in both the surficial and deep organs of humans. Failure of antibiotics in resistant infections leads to more effective alternative therapies, like spatiotemporally controllable piezodynamic therapy (PZDT) with deep penetration. Currently, PZDT demands further investigation for improved treatment outcomes and the corresponding therapeutic mechanisms.

Inverse Relationship Between Serum Carotenoid Levels and Cardiovascular-Kidney-Metabolic Syndrome Among the General Adult Population.

Objective: To examine the relationship between serum carotenoid levels and cardiovascular-kidney-metabolic (CKM) syndrome in a representative sample of US adults.

Methods: Data from the fasting subsample of the NHANES 2017-2018 were analyzed using a survey-weighted approach to ensure the findings are representative of the broader US adult population. Serum levels of α-carotene, β-carotene, β-cryptoxanthin, lutein/zeaxanthin, and lycopene were measured using high-performance liquid chromatography.

Bio-Based Surfactants via Borrowing Hydrogen Catalysis.

A borrowing hydrogen approach to produce bio-based surfactants is described. The process utilizes ubiquitous amino acids and common alcohols without protecting group manipulations. Surfactants are synthesized in a single step using a commercially available ruthenium-based catalyst in a waste-free manner with nearly ideal atom economy.

Low-dimensional Hetero-interlayer Enabling Sub-bandgap Photovoltaic Conversion for Perovskite Solar Cells.

Actualizing sub-bandgap photovoltaic conversion is effective in remitting energy loss and pushing theoretical efficiency limits for perovskite solar cells (PSCs). Herein, a zero-dimensional organic metal halide based on hydroxyquinoline (HQ) is developed to sensitize PSCs for near-infrared region gain to implement sub-bandgap photovoltaic conversion for enhancing power-conversion-efficiency (PCE) of PSCs. [ZnI4]2- skeletons containing heavy atoms intensify the direct singlet-to-triplet state transition of organic chromophores HQ, Meanwhile, the triplet energy of HQ is close to resonance with perovskite bandgap, favoring the energy transfer to perovskite and exciting the additional electron-hole pairs, which was observed by transient absorption spectroscopy, confirming the sensitization of perovskite to increase sub-bandgap photocurrent.

Target gene selection for sprayable dsRNA-based biopesticide against Tetranychus urticae Koch (Acari: Tetranychidae).

Background: Because of the excessive use of synthetic chemicals, the two-spotted spider mite, Tetranychus urticae Koch, a highly polyphagous pest, has developed comprehensive resistance to a broad spectrum of pesticides with diverse modes of action, raising severe concerns over agroecosystems and human health. To resolve this emerging issue, we initiated a project to develop double-stranded RNA (dsRNA)-based biopesticides against T. urticae, aiming for a species-specific and sustainable pest management alternative.

Gelatin-Induced Synthesis of Strain-Engineered Spherical CuO Nanoparticles for Efficient Nitrate Reduction to Ammonia.

The electrochemical reduction of nitrate to ammonia offers an environmentally sustainable pathway for nitrogen fixation. However, achieving both efficiency and selectivity in nitrate reduction presents a formidable challenge, due to the involvement of sluggish multielectron transfer processes. Herein, the successful synthesis of spherical Cu₂O nanoparticles (s-Cu₂O) exhibiting significant compressive strain effects, achieved through a one-pot method using gelatin as a structural modifier, is reported.

Prescribing DNA origami barrel-directed subtractive patterning of nanoparticles for crystalline superstructure assembly.

Long-range ordered lattices formed by the directed arrangement of colloidal particles hold significant promise for applications such as photonic crystals, plasmonic metamaterials, and semiconductor electronics. Harnessing regioselective interactions through DNA-mediated assembly is a promising approach to advancing colloidal assembly. Despite efforts to engineer microscale patchy particles using sequence-specific binding properties of DNA, controlling patch formation on nanoscale isotropic spherical nanoparticles remains challenging.

Perioperative management of a neonate with congenital biliary atresia complicated by severe pneumonia undergoing hepatic hilar jejunostomy: A case report.

The earlier a child with biliary atresia undergoes surgery after diagnosis, the better the prognosis. However, newborns often present with additional symptoms, most commonly pneumonia, which complicate in stabilizing the child's internal environment preoperatively, challenges anaesthetic management during surgery and hampers postoperative recovery. In current clinical practice, nursing care tends to focus more on symptomatic treatment rather than on a comprehensive pre- and postoperative assessment.

Effects of Porphyromonas gingivalis Outer Membrane Vesicles (OMVs) on Macrophages in Periodontitis.

Objective: To review the effect of outer membrane vesicles (OMVs) of the periodontal pathogen Porphyromonas gingivalis (P. gingivalis) on macrophages during periodontitis development.

Method: Literature pertaining to P.

Progress in Double Dearomatization Reactions.

Dearomatization reactions are among the most straightforward and efficient methods for creating sp3-rich cyclic systems from simple, readily available arenes. These reactions have been widely applied in the total synthesis of natural products, medicinal chemistry, and material sciences. The fruitful development of dearomatization strategies and methodologies targeting single aromatic substrate over the past decades has paved the way for more sophisticated multiple dearomatization processes, which offer greater advantages in constructing molecular complexity.