Global perspectives and hotspots of VEGF signaling pathway in liver disease from 2008 to 2023: A bibliometric analysis and visualization.

Background: The vascular endothelial growth factor (VEGF) signaling pathway is closely related to pathological angiogenesis in liver disease. Anti-angiogenesis is an effective intervention in the clinical treatment of liver disease. Some antiangiogenic drugs are resistant and have limitations in clinical use.

LncRNA TUG1 mitigates chronic kidney disease through miR-542-3p/HIF-1α/VEGF axis.

Renal interstitial fibrosis (RIF) is a common pathway in chronic kidney disease (CKD) that ultimately leads to end-stage renal failure, worsening both glomerulosclerosis and interstitial fibrosis. Ten percent of the adult population in the world suffers from CKD, and as the ageing population continues to rise, it is increasingly regarded as a global threat-a silent epidemic. CKD has been discovered to be closely associated with both long noncoding RNAs (lncRNAs) and microRNAs (miRNAs), while the precise molecular processes behind this relationship are still unclear.

Analysis of HFE impact of COVID-19 on OHS in construction enterprises.

Human factors are critical to Occupational Health and Safety (OHS) in construction enterprises. However, comprehensive industry-wide recognition remains challenging, underscoring the need for Human Factors Engineering (HFE) research. This study develops an optimized HFE evaluation model based on fundamental HFE principles.

Eugenol inhibits NEAT1 as a ceRNA in pre-cancerous breast lesions.

Objective: Eugenol (EU) from cloves is highly effective against different tumors. The long noncoding ribonucleic acids (lncRNAs), which play a role of competing endogenous RNAs (ceRNAs), suppress microRNAs (miRNAs) involved in post-transcriptional regulatory networks. The present work focused on analyzing how EU affected pre-cancerous breast lesions (PBL).

Research on the basic theory and application of enhanced recovery in tight sandstone gas reservoirs.

Tight sandstone gas reservoirs are characterized by high water saturation, significant seepage resistance, low single-well productivity, rapid decline, and low gas recovery. Enhancing the recovery rate of tight sandstone gas reservoirs is a complex engineering challenge that necessitates thorough, refined, and systematic research into its fundamental theories. This study employs a comprehensive approach integrating mercury injection, nuclear magnetic resonance, micro-model visualization, and simulation experiments of displacement and inter-layer seepage flow, alongside foundational seepage theories, to systematically explore the characteristics of tight sandstone gas reservoirs, seepage patterns, and methods for improving gas recovery.

Curing cryptoglandular anal fistulas-Is it possible without surgery?

Background: Empirical reviews suggested that cryptoglandular anal fistulas require surgical resolution. However, some reports have indicated the possibility of nonsurgical and conservative treatment, which is discussed in this review.

Methods: This review explores the potential of nonsurgical approaches for curing anal fistulas through bacterial inhibition and immunomodulation.

Associations between fear of COVID-19 and mental health in Ghana: A sequential mediation model.

Introduction: Although the coronavirus disease 2019 (COVID-19) pandemic has ceased globally, individuals may still suffer from various psychological burdens in the post-COVID-19 era. The present observational cross-sectional study investigated how fear of COVID-19 can affect mental health through mediators including stress, perceived stigma, and preventive behaviors among young adults in Ghana.

Methods: A total of 635 participants aged between 18 and 29 years (mean age = 20.

Fluid volume status detection model for patients with heart failure based on machine learning methods.

Backgroud: Fluid volume abnormalities are a major cause of exacerbations in heart failure patients. However, there is few efficient, rapid, or cost-effective clinical approach for determining volume status, resulting in inadequate or unsatisfactory treatment. The aim was to develop an early fluid volume detection model for heart failure patients utilizing a machine learning stratification.

Altered interactions between attentional networks in older adults with mild cognitive impairment.

Previous research using the Attention Network Test (ANT) paradigm has indicated that older adults with mild cognitive impairment (MCI) experience declines in attentional performance across the three core networks: alerting, orienting, and executive control, primarily focusing on main effects. The present study sought to expand these findings by exploring whether interactions between these networks are also affected in the presence of MCI. To achieve this, we used the Revised Attention Network Test (ANT-R) to examine both the individual attentional networks and their interactions in 21 older adults with MCI and 27 healthy controls (HCs) matched on demographic variables.

Postoperative Tongqi Formula ameliorates postoperative ileus via p38 MAPK signaling pathway and metabolic disorder.

Aim Of The Study: This study investigated the mechanism by which the Postoperative Tongqi Formula (PTQF) treats postoperative ileus (POI) through regulation of the p38 MAPK signaling pathway, Zona occludens 1 (ZO-1) protein, and metabolism.

Methods: The primary components of PTQF were characterized using UHPLC-Q-TOF-MS/MS. The identified compounds subsequently employed network pharmacology to predict the signaling pathways associated with the inflammatory phase of POI.

Complex management of GS (Good's syndrome) with persistent COVID-19 infection and polymicrobial infections: A case report.

This case report highlights the diagnostic and therapeutic complexities faced by a 56-year-old female with Good's syndrome (GS), who presented with persistent Coronavirus Disease 2019 (COVID-19) infection alongside spp, , and co-infection, which collectively contributed to severe pulmonary involvement. The report further emphasizes a multifaceted treatment approach, incorporating antivirals, antifungals, antimicrobials, immunoglobulins, and antifibrotic therapy, which ultimately led to an improvement in the patient's condition. It underscored the intricate challenges of managing immunocompromised patients with multiple concurrent infections.

Bibliometric analysis of laryngeal cancer treatment literature (2003-2023).

Background: Despite advancements in medical science, the 5-year survival rate for laryngeal squamous cell carcinoma remains low, posing significant challenges in clinical management. This study explores the evolution of key topics and trends in laryngeal cancer research. Bibliometric and knowledge graph analysis are utilized to assess contributions in treating this carcinoma and to forecast emerging research hotspots that may enhance future clinical outcomes.

Study on the law of air leakage in goaf under the influence of double-series coal seam mining.

In order to solve the engineering problem of a large amount of wind leakage in the 8106 comprehensive mining working face of the Carboniferous System under the influence of overlapping mining of two coal seams in Yongdingzhuang Mine, Datong Mining Area, this paper utilizes finite element numerical simulation software to study the wind leakage characteristics of the 8106 working face and the distribution range of the spontaneous combustion "three zones" of the mining area. The results show that, under the condition of external air leakage, the internal pressure of the goaf is greater than the external pressure, the upper pressure is greater than the lower pressure, and the seepage direction is from the top down and from the inside out. Under the condition of no external air leakage, the air leakage source is mainly concentrated in the air inlet lane.

T cell receptor signaling pathway subgroups and construction of a novel prognostic model in osteosarcoma.

Background: T cell receptor (TCR) signaling pathway is closely related to tumor progress and immunotherapy. This study aimed to explore the clinical significance, prognosis, immune infiltration and chemotherapy sensitivity of TCR in osteosarcoma (OS).

Material And Methods: OS data were obtained from TARGET and GEO database.

Assessing the impact of public perception and willingness-to-pay on reducing smog in Pakistan: Evidence from Lahore City.

Smog pollution is a major global issue affecting Pakistan's major cities, particularly Lahore. The study aims to explore the public perception and willingness to pay (WTP) for smog reduction via the Contingent Valuation Method (CVM). This study uses a structured interview schedule and interval regression model to analyse the public perception and willingness to pay for smog reduction.

TRIM26 exacerbates pathological cardiac hypertrophy by activating TAK1.

Pathological myocardial hypertrophy can induce heart failure with high mortality, it is necessary to explore its pathogenesis. Tripartite motif-containing 26 (TRIM26) belongs to the multidomain E3 ubiquitin ligase family. We observed increased expression of TRIM26 in the myocardium of C57BL/6 mice subjected to transverse aortic constriction (TAC) surgery and neonatal rat cardiomyocytes (NRCMs) treated with phenylephrine (PE).

Wallerian degeneration: From mechanism to disease to imaging.

Wallerian degeneration (WD) was first discovered by Augustus Waller in 1850 in a transection of the glossopharyngeal and hypoglossal nerves in frogs. Initial studies suggested that the formation mechanism of WD is related to the nutrition of neuronal cell bodies to axons. However, with the wide application of transgenic mice in experiments, the latest studies have found that the mechanism of WD is related to axonal degeneration, myelin clearance and extracellular matrix.

Duodenum and ascending colonal perforation due to biliary stent migration.

Introduction: Bowel perforation due to migrated biliary stent is a rare complication. Here, we report a case of duodenal and ascending colonal perforation due to biliary stent migration.

Case Presentation: A 35-year-old man is complaining of right upper abdominal pain presented to the gastroenterology department.

Isoviolanthin promotes Schwann cells activity in peripheral nerve regeneration via Fhl3-mediated epithelial-mesenchymal transition-like process: An in vitro study.

Schwann cells, as crucial regenerative cells, possess the ability to facilitate axon growth following peripheral nerve injury. However, the regeneration efficiency dominated by Schwann cells is impaired by factors such as the severity of peripheral nervous injury, aging, and metabolic disease. Cause the limitations of clinical treatments, it is necessary to urgently search for new substances that could reinforce the functionality of Schwann cells and promote nerve regeneration.

The therapeutic potential of apigenin against atherosclerosis.

Apigenin is a natural flavonoid abundantly found in fruits, vegetables, and medicinal plants. It possesses protective effects against cancer, metabolic syndrome, dyslipidemia, etc. Atherosclerosis, a chronic immune-mediated inflammatory disease, is the underlying cause of coronary heart disease, stroke, and myocardial infarction.

Immunotherapy in colorectal cancer: Statuses and strategies.

Colorectal cancer (CRC) is widely recognized as the third most prevalent malignancy globally and the second leading cause of cancer-related mortality. Traditional treatment modalities for CRC, including surgery, chemotherapy, and radiotherapy, can be utilized either individually or in combination. However, these treatments frequently result in significant side effects due to their non-specificity and cytotoxicity affecting all cells.

Partial intestinal obstruction caused by duodenal obstruction by the superior mesenteric artery and abdominal aorta in a middle-aged woman: A case report.

A 55-year-old woman with non-small cell lung carcinoma complained of epigastric pain, bloating, anorexia and postprandial nausea and vomiting over a five-year period. An upper gastrointestinal pan-glucosamine contrast examination revealed a distinctive large, hook-shaped, ptotic gastric lumen with normal motility. The contrast agent demonstrated an abnormal round-trip flow anterior to the spine at the duodenal level, with pooling and gradual passage through this region in strands after prolonged retention.

Risk propagation in emergency supply chain during public health events - From a reliability perspective.

The emergency supply chain is a vital component of the emergency management system and serves as the cornerstone for delivering relief during emergencies. This paper focuses on investigating the propagation mechanism of supply chain risks in public health emergencies. Firstly, by analyzing the characteristics of emergency supply chains, this study enhances the formation mechanism of scale-free networks in emergency supply chains from a reliability perspective through the utilization of Decision Experimentation and Evaluation Laboratory (DEMATEL) and Analytic Network Process (ANP) methods.

Decreased Choriocapillaris Vessel Density in the Ipsilateral Eye after Carotid Artery Revascularization Detected by Widefield Swept-Source OCT Angiography.

Objective: To investigate the short-term blood flow changes and image features of the retina and choroid in patients who underwent carotid artery revascularization (CAR) for severe carotid artery stenosis using widefield swept-source OCT angiography (OCTA).

Design: Prospective study.

Participants: This prospective study included 112 eyes (56 eyes on the ipsilateral side and 56 eyes on the contralateral side) of 56 participants with severe carotid artery stenosis.

Rituximab as a first-line therapy in children with new-onset idiopathic nephrotic syndrome.

Background: Idiopathic nephrotic syndrome (INS) in children, commonly treated with steroids, poses challenges due to associated side effects. Rituximab, known for its efficacy in reducing relapse frequency in difficult-to-treat cases, emerges a potential first-line therapy for pediatric new-onset INS.

Method: This is a single-center, retrospective, observational study to evaluate the efficacy and safety of rituximab as a first-line therapy for pediatric INS.