Exploring prognosis and therapeutic strategies for HBV-HCC patients based on disulfidptosis-related genes.

Background: Hepatocellular carcinoma (HCC) accounts for over 80% of primary liver cancers and is the third leading cause of cancer-related deaths worldwide. Hepatitis B virus (HBV) infection is the primary etiological factor. Disulfidptosis is a newly discovered form of regulated cell death.

Identification of key miRNAs and target genes in extracellular vesicles derived from low-intensity pulsed ultrasound-treated stem cells.

Objectives: This study aimed to investigate the impact of low-intensity pulsed ultrasound (LIPUS) treatment on the miRNA and mRNA profiles of stem cell-derived extracellular vesicles (EVs). Specifically, it sought to identify key miRNAs and their target mRNAs associated with enhanced therapeutic efficacy in LIPUS-treated stem cell-derived EVs.

Methods: Utilizing miRNA deep-sequencing data from the Gene Expression Omnibus database, differential gene analysis was performed.

Clinical and radiological outcomes of lumbar endoscopic decompression for treating lumbar spinal stenosis and degenerative lumbar scoliosis: a retrospective study at mean 4.4 years follow-up.

Purpose: To assess the clinical and radiological outcomes of lumbar endoscopic decompression for the treatment of lumbar spinal stenosis (LSS) with concurrent degenerative lumbar scoliosis (DLS).

Methods: This study retrospectively reviewed 97 patients with LSS and DLS who underwent lumbar endoscopic decompression between 2016 and 2021. The average follow-up duration was 52.

Comparison of clinical efficacy of different internal fixation methods in older adult patients with osteoporotic fractures of proximal humerus.

Objective: To compare the efficacy of three treatment methods for older adult patients with osteoporotic proximal humerus fractures: proximal humerus locking plate (PHILOS) combined with calcium sulfate injection, PHILOS plate alone, and artificial hemi-shoulder joint replacement.

Methods: The clinical data of 48 older adult patients with osteoporotic proximal humerus fractures admitted to the Shoulder and Elbow Surgery Department of Zhongshan Hospital Affiliated with Dalian University from February 2018-August 2021 were retrospectively analyzed. The patients comprised 18 males and 30 females, with a mean age of (68.

Association between oxidative balance score and all-cause, CVD and respiratory-related mortality in the US older adults of asthma patients with diabetes.

Background: This study aims to investigate the correlation between oxidative balance score (OBS) and all-cause, cardiovascular disease (CVD) and respiratory-related mortality within a cohort that includes older asthma patients with diabetes.

Methods: Data from the National Health and Nutrition Examination Survey (NHANES) spanning from 2001 to 2018, which included 611 participants, were analyzed. Mortality outcomes were determined by linking the data to National Death Index (NDI) records through December 31, 2019.

Global burden of chronic kidney disease due to dietary factors.

Background: We aimed to assess the global impact of chronic kidney disease (CKD) attributable to dietary risk factors.

Methods: The research utilized data from the Global Burden of Disease Study 2021 to evaluate age-standardized mortality rates (ASMR), disability-adjusted life years (DALYs), and estimated annual percentage changes (EAPCs) linked to CKD resulting from dietary risk factors.

Results: From 1990 to 2021, both the ASMR and age-standardized DALY rate (ASDR) for CKD attributable to dietary risk factors exhibited an overall increasing trend globally.

Analysis of study Global Burden of Disease in 2021: global, regional, and national burden of nutritional deficiency from 1990 to 2021.

Background: Nutrient deficiency disorders (NDs) harm growth, causing economic losses. Addressing NDs is a global priority, yet recent data is limited. This study examines latest NDs data across 204 countries and 21 regions from 1990 to 2021.

Association between controlling nutritional status score and the prognosis of patients with acute myocardial infarction: a systematic review and meta-analysis.

Background: Recent studies have reported growing evidence supporting applying the controlling nutritional status (CONUT) score in acute myocardial infarction (AMI) patients. This investigation intended to ascertain the link between CONUT scores and the prognosis in the AMI population.

Methods: Multiple electronic databases, encompassing PubMed, Web of Science, Embase, and the Cochrane Library, were retrieved from the inception of the databases until July 20, 2024, to explore the link between CONUT scores and adverse clinical outcomes in individuals with AMI.

Genetically predicted causal link between the plasma lipidome and pancreatic diseases: a bidirectional Mendelian randomization study.

Background: Recent studies have increasingly emphasized the strong correlation between the lipidome and the risk of pancreatic diseases. To determine causality, a Mendelian randomization (MR) analysis was performed to identify connections between the lipidome and pancreatic diseases.

Methods: Statistics from a genome-wide association study of the plasma lipidome, which included a diverse array of 179 lipid species, were obtained from the GeneRISK cohort study with 7,174 participants.

Global trends in the burden of ischemic heart disease attributable to smoking from 1990 to 2021: A systematic analysis of the Global Burden of Disease Study 2021.

Introduction: Ischemic heart disease (IHD) remains a leading cause of death and disability worldwide. This study evaluates the trends in IHD burden attributable to smoking, utilizing Global Burden of Disease Study 2021 (GBD 2021) data, across 204 countries and territories from 1990 to 2021. By examining age-standardized death rates (ASDR) and disability-adjusted life years (ASRDALYs), the study provides insights into the spatiotemporal variations associated with smokingattributable IHD in different sociodemographic regions.

'Disappeared balloon': the trap of transseptal puncture for a large closure device of atrial septal defect-a case report.

Background: Several studies have demonstrated a notable increase in the incidence of atrial arrhythmias among individuals with atrial septal defect (ASD) occluder. Although the sequential dilation technique has been proposed as the mainstream technique for transseptal puncture with ASD occluder, it is associated with substantial risks and technical difficulties.

Case Summary: We report a patient who underwent catheter ablation for atrial fibrillation and had a large ASD occluder.

Multidimensional structural analyses revealed a correlation between thalamic atrophy and white matter degeneration in idiopathic dystonia.

Although aberrant changes in grey and white matter are core features of idiopathic dystonia, few studies have explored the correlation between grey and white matter changes in this disease. This study aimed to investigate the coupling correlation between morphological and microstructural alterations in patients with idiopathic dystonia. Structural T1 imaging and diffusion tensor imaging were performed on a relatively large cohort of patients.

Cardiac resynchronization therapy via left bundle branch pacing in heart failure with complete left bundle branch block: is the defibrillator needed?

Aims: This retrospective cohort study aimed to investigate the efficacy of dual-chamber left Bundle branch pacing (LBBP) as an alternative therapy for heart failure patients with complete left bundle branch block (CLBBB) and indications for defibrillator with cardiac resynchronization therapy (CRT-D).

Methods: 34 patients met inclusion criteria were enrolled in the study. These criteria included a left ventricular ejection fraction (LVEF) of lower than 35%, a New York Heart Association functional class of II-IV, CLBBB meeting Strauss's criteria, intraventricular dyssynchrony, and confirmed correction of CLBBB during LBBP.

Efficient removal of Cr(iii) by microbially induced calcium carbonate precipitation.

Microbially induced calcium carbonate precipitation (MICP) has emerged as a promising technique for environmental remediation, particularly for heavy metal removal. This study explores the potential of MICP for Cr(iii) removal, analyzing the effects of temperature, pH, calcium source addition, and initial Cr(iii) concentration on removal efficiency. The results show that Cr(iii) can be efficiently removed with a removal rate approaching 100% under optimal conditions (25 °C, pH 7.

DNA dendrimer-based nanocarriers for targeted Co-delivery and controlled release of multiple chemotherapeutic drugs.

DNA-based nanomaterials have attracted increasing attention over the past decades due to their incomparable programmability and functionality. In particular, dendritic DNA nanostructures are ideal for constructing drug carriers due to their highly branched structure. In this study, an intelligent drug delivery system was constructed based on DNA dendrimers, in which the DNA duplexes were utilized for simultaneously loading both hydrophilic and hydrophobic small molecule drugs.

Electron paramagnetic resonance and photoluminescence study on local structure of Gd ions in Gd-doped CaF crystals.

Employing electron paramagnetic resonance (EPR) and excitation and photoluminescence (PL) spectra, changes of the local structure of Gd ions were investigated for the CaF crystals containing 0.00015, 0.17, 1.

Synthesis and non-isothermal crystallization kinetics of polyamide 66 copolymers containing alicyclic structures.

To further improve the performance of PA66 and expand its applications, a new strategy was proposed to introduce an alicyclic structure into PA66 chain by the copolymerization method. Initially, 3,3'-dimethyl-4,4'-diaminodicyclohexylmethane (MACM) was reacted with 1,6-adipic acid to form MACM6 salt, and then, it was copolymerized with PA66 salt to synthesize PA66/MACM6 copolymers with alicyclic structures. PA66/MACM6 copolymers exhibited good thermal stabilities, and the presence of alicyclic structure had no significant effect on their thermal stabilities.

Facile synthesis of an α-FeO-TiO-MXene heterojunction for enhanced acetone gas sensors.

Acetone is harmful to the environment and human health. Therefore, research on acetone sensors for its high-efficiency detection is necessary. Herein, an α-FeO-TiO-MXene heterojunction was synthesized using a simple precipitation method, and its sensitivity towards acetone was systematically investigated.

Interaction between nitrate and trichloroethene bioreduction in mixed anaerobic cultures.

Bioremediation of trichloroethene (TCE)-contaminated sites often leads to groundwater acidification, while nitrate-polluted sites tend to generate alkalization. TCE and nitrate often coexist at contaminated sites; however, the pH variation caused by nitrate self-alkalization and TCE self-acidification and how these processes affect nitrate reduction and reductive dichlorination, have not been studied. This study investigated the interaction between nitrate and TCE, two common groundwater co-contaminants, during bioreduction in serum bottles containing synthetic mineral salt media and microbial consortia.

Potential geographical distribution of and its two hosts in China under climate change.

Introduction: The fungus is both edible and medicinal.

Methods: To acquire a thorough comprehension of its distribution in China, two host insects, and , were selected as biological factors potentially associated with its distribution, the ENMTools program was utilized to ascertain the principal environmental factors affecting the distribution of potentially suitable habitats. The possible geographic distributions in the present as well as in the 2030s, 2050s, and 2070s were then predicted using the optimized MaxEnt model.

Nanomaterials-plants-microbes interaction: plant growth promotion and stress mitigation.

Soil salinization, extreme climate conditions, and phytopathogens are abiotic and biotic stressors that remarkably reduce agricultural productivity. Recently, nanomaterials have gained attention as effective agents for agricultural applications to mitigate such stresses. This review aims to critically appraise the available literature on interactions involving nanomaterials, plants, and microorganisms.

Development of a colloidal gold immunochromatographic assay utilizing dual-antibody sandwich method for detecting .

A colloidal gold immunochromatographic assay (ICA) based on a dual-antibody sandwich method was developed for the rapid and convenient detection of () antigens in the early stages of infection. Monoclonal antibodies designed as 5B3 targeting the conserved region of 56 kDa outer membrane protein in various strains of were generated through cell fusion and screening techniques and combined with previously prepared polyclonal antibodies as detection antibodies to establish the ICA. Colloidal gold and polyclonal antibody-colloidal gold complexes were synthesized under optimized conditions.

Tracing microbial community across endophyte-to-saprotroph continuum of (L.) Presl leaves considering priority effect of endophyte on litter decomposition.

Endophytes typically coexist with plants in symbiosis and transition into the saprobic system as plant tissues senesce, participating in the decomposition process of litter. However, the dynamic changes of endophytic communities during this process and their role in litter decomposition remain unclear. This study tracked the microbial composition across the transition from live leaves to litter in (L.

Transcriptional activity of ammonia oxidisers in response to soil temperature, moisture and nitrogen amendment.

The contrasting response of AOA, AOB, and comammox transcript abundance to temperature, moisture, and nitrogen was investigated using soil microcosms. The moisture, temperature, and nitrogen treatments were selected to represent conditions typically found in a New Zealand (NZ) dairy farm. AOB dominated all synthetic urine treated soils.