The Correlation Between Symptom Clusters and Quality of Life in Patients with Systemic Lupus Erythematosus: A Cross-Sectional Study.

Background: Systemic lupus erythematosus (SLE) is characterized by a range of symptoms that often cluster together, impacting the quality of life (QoL) of affected individuals.

Objective: To delineate the composition of symptom clusters in patients with SLE and analyze their correlation with QoL, thus providing a basis for symptom management.

Methods: Using convenience sampling, 201 patients were recruited.

Effectiveness of psychological interventions in reducing post-traumatic stress among post-myocardial infarction patients: a systematic review and meta-analysis.

Aims: Myocardial infarction (MI) can lead to post-traumatic stress disorder (PTSD) which frequently occurs with anxiety and depression, impairing daily functioning and increasing the risk of recurrent cardiovascular events. While psychological interventions have shown promise in reducing anxiety and depression, their effectiveness for PTSD in post-MI patients remains unexplored. This systematic review and meta-analysis aim to evaluate the effectiveness of psychological interventions on PTSD, anxiety, and depression in post-MI patients.

Antioxidant activities of three enzymatic hydrolysates from on HaCaT cells and zebrafish .

To explore the antioxidant activity of enzymatic hydrolysates of from Dalian and preliminarily elucidate their mechanisms of action both and . Samples were hydrolysed using alcalase, protamex, and neutrase. 2,2-diphenyl-1-(2,4,6-trinitrophenyl)hydrazyl (DPPH) and 2,2'-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid (ABTS) radical scavenging assays showed that the alcalase hydrolysate had the highest antioxidant activity, with IC values of 4.

Ultrasonic/microwave-assisted extraction and properties of polysaccharides from .

This study aimed to optimize the ultrasonic/microwave-assisted extraction (UAME) technique of polysaccharides (EAP-UM) by response surface methodology (RSM). The optimum conditions include: solid-liquid ratio of 1:23 g/mL, ultrasonic power of 252 W, microwave power of 417 W, and extraction time of 11 min. Under these conditions, the yield of polysaccharides reached 7.

Characteristic Structure of the Relationships Among Depression, Maladaptive Cognition, and Internet Addiction and Its Temporal Evolution in University Students: A Network Analysis.

This study explored the structure and temporal evolution of the relationship among depression, maladaptive cognition, and internet addiction (DMI) among university students by focusing on topological and dynamic properties in a network analysis. A 3-year longitudinal survey was conducted with 873 university students (M = 18.32, SD = 0.

A multi-omics study of the association between insomnia with objective short sleep duration phenotype and high blood pressure.

Study Objectives: Insomnia with objective short sleep duration is associated with increased hypertension risk. We aimed to explore the mechanism underlying the association between objective short sleep duration and hypertension in patients with chronic insomnia disorder (CID) by multi-omics.

Methods: CID was defined according to International Classification of Sleep Disorders-3, and objective short sleep was based on the median value of total sleep time of the overall subjects during an overnight polysomnography.

Inhibition of Retinal Neovascularization by BEZ235: Targeting the Akt/4EBP1/Cyclin D1 Pathway in Endothelial Cells.

Purpose: To investigate the therapeutic efficacy of BEZ235, a dual PI3K/mTOR inhibitor, in suppressing pathological neovascularization in an oxygen-induced retinopathy (OIR) mouse model and explore the role of cyclin D1 in endothelial cell cycle regulation.

Methods: Single-cell RNA sequencing was performed to analyze gene expression and cell-cycle alterations in retinal endothelial cells under normoxic and OIR conditions. The effects of BEZ235 on human umbilical vein endothelial cells (HUVECs) and human retinal microvascular endothelial cells (HRMECs) were evaluated by assessing cell viability, cell-cycle progression, proliferation, migration, and tube formation.

Data pharmacovigilance analysis of medroxyprogesterone-related adverse events in the FDA adverse event reporting system.

Objectives: Medroxyprogesterone acetate (MPA), a steroid progesterone, is widely used to treat endometriosis, menstrual disorders, and uterine bleeding in clinical practice. However, the safety profile of MPA requires comprehensive evaluation.

Methods: This study performed a retrospective analysis using real-world data extracted from the US Food and Drug Administration Adverse Event Reporting System (FAERS) database.

The Digital Health Competencies in Medical Education Framework: An International Consensus Statement Based on a Delphi Study.

Importance: Rapid digitalization of health care and a dearth of digital health education for medical students and junior physicians worldwide means there is an imperative for more training in this dynamic and evolving field.

Objective: To develop an evidence-informed, consensus-guided, adaptable digital health competencies framework for the design and development of digital health curricula in medical institutions globally.

Evidence Review: A core group was assembled to oversee the development of the Digital Health Competencies in Medical Education (DECODE) framework.

Incidence trends of pediatric psoriasis in 1990-2021: findings from the Global Burden of Disease Study 2021.

Background: Pediatric psoriasis is a chronic inflammatory skin disease that poses unique challenges in diagnosis and management. While studies from high-income countries have reported rising incidence trends, global data on the incidence of pediatric psoriasis remain scarce.

Objective: To provide a comprehensive description of pediatric psoriasis incidence at the global, regional, and national levels.

Application of artificial intelligence to ultrasound imaging for benign gynecological disorders: systematic review.

Objective: Although artificial intelligence (AI) is increasingly being applied to ultrasound imaging in gynecology, efforts to synthesize the available evidence have been inadequate. The aim of this systematic review was to summarize and evaluate the literature on the role of AI applied to ultrasound imaging in benign gynecological disorders.

Methods: Web of Science, PubMed and Scopus databases were searched from inception until August 2024.

Stress Relaxation and Creep Response of Glassy Hydrogels with Dense Physical Associations.

Various glassy hydrogels are developed by forming dense physical associations within the matrices, which exhibit forced elastic deformation and possess high stiffness, strength, and toughness. Here, the viscoplastic behaviors of the glassy hydrogel of poly(methacrylamide--methacrylic acid) are investigated by stress relaxation and creep measurements. We found that the characteristic time of stress relaxation of the glassy gel is much smaller than that of amorphous polymers.

Three-Dimensionally Printed Ionogel-Coated Ceramic Electrolytes for Solid-State Lithium Batteries.

Stereolithography three-dimensional (3D) printing technology enables the customization of ceramic-based solid electrolyte structures with desired electrochemical properties; however, formulating slurries that both are highly ceramic-loaded and have low viscosity for printing poses a challenge. Here, we propose an ionogel-coated ceramic approach to prepare a shear-thinning fast-ion conductor ceramic (LiLaZrTaO) slurry, which possesses both a high ceramic content of 50 wt % and a low viscosity of 1.53 Pa·s.

Detection of Mycoplasma pneumoniae in hospitalized pediatric patients presenting with acute lower respiratory tract infections utilizing targeted next-generation sequencing.

Background: Mycoplasma pneumoniae is a prevalent pathogen in pediatric community-acquired pneumonia. Currently, limited literature exists on the clinical utilization of pathogen-targeted sequencing technologies.

Methods: Targeted next-generation sequencing (tNGS) technology was employed to analyze bronchoalveolar lavage fluid (BALF) from 1,070 hospitalized pediatric patients with acute lower respiratory tract infections.

Dynamic proportional loss of functional connectivity revealed change of left superior frontal gyrus in subjective cognitive decline: an explanatory study based on Chinese and Western cohorts.

Brain network dynamics have been extensively explored in patients with subjective cognitive decline (SCD). However, these studies are susceptible to individual differences, scanning parameters, and other confounding factors. Therefore, how to reveal subtle SCD-related subtle changes remains unclear.

Progression of the Residual Lesion in Cavernous Sinus Extra-Axial Cavernous Hemangioma After Surgery.

Our study aimed to investigate the factors associated with residual cavernous sinus extra-axial cavernous hemangiomas (ECHs) progression after surgery. This retrospective study consecutively included patients of cavernous sinus ECHs with incomplete lesion resection from February 2012 to January 2024. The progression of the lesions was defined as new lesions or a growth of residual lesion (≥ 10% increase in volume).

The Bidirectional Relations Between Parental Autonomy Support, Gratitude and Academic Engagement in Chinese Adolescents.

Abundant evidence highlights the benefits of self-determined motivation (e.g., parental autonomy support as internalized extrinsic motivation, gratitude as intrinsic motivation) on academic engagement during adolescence, yet the potential mutual relations remain relatively unexplored.

Novel Cellulosic Fiber Composites with Integrated Multi-Band Electromagnetic Interference Shielding and Energy Storage Functionalities.

In an era where technological advancement and sustainability converge, developing renewable materials with multifunctional integration is increasingly in demand. This study filled a crucial gap by integrating energy storage, multi-band electromagnetic interference (EMI) shielding, and structural design into bio-based materials. Specifically, conductive polymer layers were formed within the 2,2,6,6-tetramethylpiperidine-1-oxide (TEMPO)-oxidized cellulose fiber skeleton, where a mild TEMPO-mediated oxidation system was applied to endow it with abundant macropores that could be utilized as active sites (specific surface area of 105.

Phylogeographic Characterization of Aedes albopictus (Skuse, 1894) in Algeria.

Purpose: Aedes albopictus, known as the Asian tiger mosquito, is an extensively studied mosquito species recognized for its rapid global expansion and its capacity to transmit a range of viruses such as dengue, chikungunya, Zika, and yellow fever viruses. In 2010, Ae. albopictus was observed for the first time in Tizi-Ouzou, Algeria, and since then has colonized all the northern part of the country until the semi-arid areas.

Transition Metal Carbonitride MXenes Anchored with Pt Sub-Nanometer Clusters to Achieve High-Performance Hydrogen Evolution Reaction at All pH Range.

Transition metal carbides, known as MXenes, particularly TiCT, have been extensively explored as promising materials for electrochemical reactions. However, transition metal carbonitride MXenes with high nitrogen content for electrochemical reactions are rarely reported. In this work, transition metal carbonitride MXenes incorporated with Pt-based electrocatalysts, ranging from single atoms to sub-nanometer dimensions, are explored for hydrogen evolution reaction (HER).

Comparison of different surgical techniques and anastomosis methods in short-term outcomes of right colon cancer: a network meta-analysis of open surgery, laparoscopic, and robot-assisted techniques with extracorporeal and intracorporeal anastomosis.

With the rapid development of minimally invasive surgical techniques, there remains considerable controversy regarding the choice of surgical approach and anastomosis method for patients with right-sded colon cancer (RSCC). This meta-analysis compared the short-term outcomes of open right colectomies (ORC), laparoscopic right colectomies with intracorporeal and extracorporeal anastomosis (LRC-IA and LRC-EA), as well as robot right colectomies with intracorporeal and extracorporeal anastomosis (RRC-IA and RRC-EA). A systematic search was conducted across PubMed (n = 549), Web of Science (n = 821), Embase (n = 591), and the Cochrane Central Register (n = 86) from January 2000 to August 2024.

Discovery of natural products as influenza neuraminidase inhibitors: in silico screening, in vitro validation, and molecular dynamic simulation studies.

Influenza is a highly contagious respiratory illness that imposes a significant global burden. Antiviral neuraminidase inhibitors (NAIs) such as oseltamivir (OC) have been proven essential, but the emergence of resistant viral strains necessitates the development of novel therapies. This study explored the potential of natural products as alternative NAIs.

Promoting the design of future indoor environmental to improve air pollution: Based on the analysis of hazardous substances in indoor PM pollution in cold regions.

People spend about 90% of their day indoors and are at increased risk of exposure to metal elements (MEs), water-soluble ions (WSIs) and polycyclic aromatic hydrocarbons (PAHs) contained in indoor PM. Therefore, firstly this study investigated indoor PM pollution to explore the distribution characteristics of MEs, WSIs and PAHs. Secondly, the carcinogenic risk of MEs and PAH to the population was analyzed using health risk assessment models.

Advanced Bismuth-Based Anode Materials for Efficient Potassium Storage: Structural Features, Storage Mechanisms and Modification Strategies.

Potassium-ion batteries (PIBs) are considered as a promising energy storage system owing to its abundant potassium resources. As an important part of the battery composition, anode materials play a vital role in the future development of PIBs. Bismuth-based anode materials demonstrate great potential for storing potassium ions (K) due to their layered structure, high theoretical capacity based on the alloying reaction mechanism, and safe operating voltage.

Applicability of Ni@ZnO polymer nanocomposite as an adsorbent for removal of methylene blue dye from synthetic wastewater: Batch studies and multilinear regression (MLR) modeling.

Synthetic organic dye such as methylene blue (MB) is non-biodegradable and highly toxic, released from textile wastewater. This work investigates the applicability of Ni@ZnO polymer nanocomposite for MB removal from the wastewater. To understand their differences before and after MB adsorption, composites' surface morphology was characterized by various techniques including scanning electron microscope (SEM), thermogravimetric analysis (TGA), X-ray diffraction (XRD), energy dispersive spectroscopy (EDS), Fourier transformation infrared (FT-IR) and UV-Vis spectrophotometer.