Asymmetric Coordination Engineering of Tin Single-Atom Catalysts Toward CO Electroreduction: the Crucial Role of Charge Capacity in Selectivity.

Electrochemical reduction of CO is an efficient strategy for CO utilization under mild conditions. Tin (Sn) single-atom catalysts (SACs) are promising candidates due to their controllable CO/formate generation via asymmetric coordination engineering. Nevertheless, the factors that govern the selectivity remain unclear.

Enhancing cadmium stress resilience in chickpea ( L.) via exogenous melatonin application.

Chickpea ( L.) productivity is hindered by biotic and abiotic stresses, particularly heavy metal toxicity. The pot experiment was carried out at the botanical garden of The Islamia University of Bahawalpur, Bahawalpur-Pakistan.

Linear Enhanced 3D Nanofluid Force-Electric Conversion Device.

The inherent trade-off between permeability and selectivity has constrained further improvement of passive linear force-electric conversion performance in nanofluidic pressure sensors. To overcome this limitation, a 3D nanofluidic membrane with high mechanical strength utilizing aramid nanofibers/carbon nanofiber (ANF/CNF) dual crosslinking is developed. Due to the abundant surface functional groups of CNF and the high mechanical strength of ANF, this large-scale integrated 3D nanofluidic membrane exhibits advantages of high flux, high porosity, and short ion transport path, demonstrating superior force-electric response compared to conventional 1D and 2D configurations.

Expression and clinical significance of 25-hydroxyvitamin D, insulin-like growth factor 1, and beta-2 microglobulin in cognitive dysfunction after ischemic stroke in the elderly.

We aimed to unveil the clinical significance of serum 25-hydroxyvitamin D (25-OH-VD), insulin-like growth factor 1 (IGF-1), and beta-2 microglobulin (β2-MG) levels in cognitive dysfunction after ischemic stroke (IS) in the elderly. A total of 160 geriatric IS patients admitted to our hospital were retrospectively collected. The patients' serum 25-OH-VD, IGF-1, and β2-MG levels were detected, and the correlation between the three levels and the patients' National Institutes of Health Stroke Scale (NIHSS) and Montreal Cognitive Assessment (MoCA) scores was tested by the Pearson test.

Aperiodic Pupil Fluctuations at Rest Predict Orienting of Visual Attention.

The aperiodic exponent of the power spectrum of signals in several neuroimaging modalities has been found to be related to the excitation/inhibition balance of the neural system. Leveraging the rich temporal dynamics of resting-state pupil fluctuations, the present study investigated the association between the aperiodic exponent of pupil fluctuations and the neural excitation/inhibition balance in attentional processing. In separate phases, we recorded participants' pupil size during resting state and assessed their attentional orienting using the Posner cueing tasks with different cue validities (i.

Transformation-Invariant Laplacian Metadevices Robust to Environmental Variation.

As one of the typical applications of metamaterials, the invisibility cloak has raised vast research interests. After many years' research efforts, the invisibility cloak has extended its applicability from optics and acoustics to electrostatics and thermal diffusion. One scientific challenge that has significantly restricted the practical application of the invisibility cloak is the strong background dependence, that is, all passive cloaking devices realized thus far are unable to resist variation in the background refractive index.

Hsf1 is essential for proteotoxic stress response in smyd1b-deficient embryos and fish survival under heat shock.

Molecular chaperones play critical roles in post-translational maintenance in protein homeostasis. Previous studies have shown that loss of Smyd1b function results in defective myofibril organization and dramatic upregulation of heat shock protein gene (hsp) expression in muscle cells of zebrafish embryos. To investigate the molecular mechanisms and functional importance of this stress response, we characterized changes of gene expression in smyd1b knockdown and knockout embryos using RNA-seq.

Palladium-catalyzed -arylation of (hetero)aryl chlorides with pyrroles and their analogues.

We present a mild and efficient method for the arylation of N-H heteroarenes using a low-loading Pd/keYPhos catalyst (0.8 mol%). This approach employs inexpensive and structurally diverse aryl chlorides as electrophiles in reactions with indoles, pyrroles, and carbazole, enabling the construction of a wide range of -arylated products.

Spatial Transcriptomics: Biotechnologies, Computational Tools, and Neuroscience Applications.

Spatial transcriptomics (ST) represents a revolutionary approach in molecular biology, providing unprecedented insights into the spatial organization of gene expression within tissues. This review aims to elucidate advancements in ST technologies, their computational tools, and their pivotal applications in neuroscience. It is begun with a historical overview, tracing the evolution from early image-based techniques to contemporary sequence-based methods.

Tumor Mutation Signature Reveals the Risk Factors of Lung Adenocarcinoma with or Mutation.

Introduction: and mutations are frequently detected in lung adenocarcinoma (LUAD). Tumor mutational signature (TMS) determination is an approach to identify somatic mutational patterns associated with pathogenic factors. In this study, through the analysis of TMS, the underlying pathogenic factors of LUAD with and mutations were traced.

The trajectory of attention deficit hyperactivity disorder symptoms and its dynamic relationship with inhibitory control.

Background: Attention Deficit Hyperactivity Disorder (ADHD) is a prevalent neurodevelopmental disorder in childhood, characterized by symptoms of inattention, hyperactivity, and impulsivity. Impaired inhibitory control is observed in the majority of individuals with ADHD. Understanding the relationship between inhibitory control and the developmental trajectory of ADHD is essential for informing clinical prognosis and guiding early interventions.

Development of smart packaging halochromic films embedded with anthocyanin pigments; recent advances.

Nowadays, innovative biodegradable packaging based on pH-sensitive natural dyes is being developed. These smart systems quickly inform the food quality to the consumer and monitor fresh foods in real-time. Smart packaging protects food against ambiance risks and simultaneously sends information to users for variations and alterations in the packaging settings.

Effectiveness of Outpatient Chronic Pain Management for Middle-Aged Patients by Internet Hospitals: Retrospective Cohort Study.

Background: Chronic pain is widespread and carries a heavy disease burden, and there is a lack of effective outpatient pain management. As an emerging internet medical platform in China, internet hospitals have been successfully applied for the management of chronic diseases. There are also a certain number of patients with chronic pain that use internet hospitals for pain management.

Single-Cell RNA Sequencing Uncovers Molecular Features Underlying the Disrupted Neurogenesis Following Traumatic Brain Injury.

Traumatic brain injury (TBI) is a leading cause of death and disability worldwide, with limited effective treatment strategies. Endogenous neural stem cells (NSCs) give rise to neurons and glial cells throughout life. However, NSCs are more likely to differentiate into glial cells rather than neurons at the lesion site after TBI and the underlying molecular mechanism remains largely unknown.

Influence of nutritional guidance during pregnancy on nutritional status and pregnancy outcome of pregnant women.

This study was an original article, mainly aimed to explore the influence of nutritional guidance during pregnancy on nutritional status and pregnancy outcome of pregnant women. Two hundred (200) pregnant women were admitted to the Nanjing General Hospital of Nanjing Military Command from May 2021 to May 2023. They were randomly sub-divided into a control group and an intervention group.

A new way of the Coombs test using flow cytometry-based assay to assess erythrocytes-bound IgG antibodies in the human and rabbit model.

The Coombs test is important in hematology for detecting erythrocyte-bound IgG antibodies or in serm through agglutination methods, but its sensitivity and specificity are limited. Flow cytometry provides a more precise and sensitive alternative for quantitatively assessing RBC-bound IgG antibodies. This assessment is crucial for evaluating the risk of hemolytic reactions and ensuring safe transfusions.

Structure-Guided Development of ClpP Agonists with Potent Therapeutic Activities against Infection.

Peritonitis caused by poses a severe threat to patients with end-stage renal failure. Treating multidrug-resistant infections requires the use of antibiotics with diverse mechanisms of action. Caseinolytic protease P (ClpP) is a promising antibacterial target; however, selective activation of (ClpP) over human ClpP (ClpP) remains challenging.

Research Progress in 3D Printed Biobased and Biodegradable Polyester/Ceramic Composite Materials: Applications and Challenges in Bone Tissue Engineering.

Transplantation of bone implants is currently recognized as one of the most effective means of treating bone defects. Biobased and biodegradable polyester composites combine the good mechanical and degradable properties of polyester, thereby providing an alternative for bone implant materials. Bone tissue engineering (BTE) accelerates bone defect repair by simulating the bone microenvironment.

Highly-Efficient Differentiation of Reactive Lymphocytes in Peripheral Blood Using Multi-Object Detection Network With Large Kernels.

Reactive lymphocytes are an important type of leukocytes, which are morphologically transformed from lymphocytes. The increase in these cells is usually a sign of certain virus infections, so their detection plays an important role in the fight against diseases. Manual detection of reactive lymphocytes is undoubtedly time-consuming and labor-intensive, requiring a high level of professional knowledge.

Chinese Translation and Measurement of the Heart Failure Needs Assessment Questionnaire in Mainland China.

The management of heart failure in patients presents a significant challenge to global public health, marked by an increase in unaddressed needs due to the extended deterioration of health. It is crucial to conduct comprehensive assessments of patients with heart failure, thereby providing personalized care. The purpose of this study was to translate, adapt, and validate the Needs Assessment Questionnaire for people with heart failure in Mainland China and to evaluate its reliability and validity within a population of people with heart failure.

Inhibition of ASIC1a reduces ferroptosis in rheumatoid arthritis articular chondrocytes via the p53/NRF2/SLC7A11 pathway.

The activation of acid-sensing ion channel 1a (ASIC1a) in response to extracellular acidification leads to an increase in extracellular calcium influx, thereby exacerbating the degeneration of articular chondrocytes in rheumatoid arthritis (RA). It has been suggested that the inhibition of extracellular calcium influx could potentially impede chondrocyte ferroptosis. The cystine transporter, solute carrier family 7 member 11 (SLC7A11), is recognized as a key regulator of ferroptosis.

The Influence of Surface Treatment on the Color of Enamel and Dentin: An In Vitro Study Using Machine Learning-Based Analysis.

Objective: To investigate how surface treatment affects the color of enamel and dentin, and to evaluate whether the color differences are acceptable.

Materials And Methods: Freshly extracted premolars were prepared using diamond burs (blue, red, and yellow tapes). Tooth surfaces were divided into control and acid-etched areas and treated with phosphoric acid (5, 15, 30, 45, and 60 s).

Biglycan stimulates retinal pathological angiogenesis via up-regulation of CXCL12 expression in pericytes.

Retinal pathological angiogenesis (PA) is a common hallmark in proliferative retinopathies, including age-related macular degeneration (AMD), proliferative diabetic retinopathy (PDR), and retinopathy of prematurity (ROP). The mechanisms underlying PA is complex and incompletely understood. In this study, we investigated the role of extracellular matrix (ECM) protein biglycan (BGN) in PA using an oxygen-induced retinopathy (OIR) mouse model, along with hypoxia (1% O) conditions for incubating pericytes and endothelial cells in vitro.