A multi-domain feature fusion epilepsy seizure detection method based on spike matching and PLV functional networks.

The identification of spikes, as a typical characteristic wave of epilepsy, is crucial for diagnosing and locating the epileptogenic region. The traditional seizure detection methods lack spike features and have low sample richness. This paper proposes a seizure detection method with spike-based phase locking value (PLV) functional brain networks and multi-domain fused features.

Interactive segmentation for accurately isolating metastatic lesions from low-resolution, large-size bone scintigrams.

Bone is a common site for the metastasis of malignant tumors, and Single Photon Emission Computed Tomography (SPECT) is widely used to detect these metastases. Accurate delineation of metastatic bone lesions in SPECT images is essential for developing treatment plans. However, current clinical practices rely on manual delineation by physicians, which is prone to variability and subjective interpretation.

Development and validation of a risk stratification model for stroke recurrence after acute ischemic stroke in young adults: A nomogram-based, multicenter retrospective study.

Objective: The prevalence of ischemic stroke in young adults has increased dramatically. However, factors associated with prognosis in this cohort have not been well studied. This study primary aimed to construct and validate a nomogram for predicting stroke recurrence and to achieve risk stratification of young adults after acute ischemic stroke (AIS).

Advanced cortisol detection: A cMWCNTs-enhanced MB@Zr-MOF ratiometric electrochemical aptasensor.

A ratiometric electrochemical aptasensor was developed for ultra-sensitive detection of cortisol using aptamer (Apt) as recognition element, methylene blue (MB) as signal probe, and zirconium metal-organic framework (Zr-MOF) as carrier loaded with abundant MB for signal amplification. The carboxylated multi-walled carbon nanotubes (cMWCNTs)-modified Au electrode showed excellent electrochemical performance to immobilize complementary DNA (cDNA) for hybridizing with MB@Zr-MOF-Apt via amide bonds. In the presence of cortisol, it would compete with cDNA for binding the Apt, resulting in the detachment of MB@Zr-MOF-Apt complex from the electrode surface, and the electrochemical signal of MB was decreased, while that of [Fe(CN)] was basically unchanged.

Quantifying the sources and health risks of groundwater nitrate via dual NO isotopes and Monte Carlo simulations in a developed planting-breeding area.

Nitrate (NO) pollution in groundwater is a worldwide environmental issue, particularly in developed planting-breeding areas where there is a substantial presence of nitrogen-related sources. Here, we explored the key sources and potential health risks of NO in a typical planting-breeding area in the North China Plain based on dual stable isotopes and Monte Carlo simulations. The analysis results revealed that the NO concentration ranged from 0.

Adverse multigeneration combined effects of nano-sized plastics and mercury on growth and reproduction in a planktonic copepod Pseudodiaptomus annandalei.

Nano-plastics (NPs) and heavy metals have attracted growing scientific attention because of both pollutants' wide distribution and ecotoxicity. However, the long-term combined toxicity of NPs and mercury (Hg) on planktonic copepods, a crucial presence in marine environments, is unknown. Here, our study aimed to investigate the multigenerational phenotypic responses of the planktonic copepod Pseudodiaptomus annandalei to polystyrene NPs (about 50 nm) and Hg (alone or combined) at environmentally realistic concentrations (23 μg/L for NPs and 1 μg/L for Hg), and the underlying molecular mechanisms were explored.

Background-free luminescent and chromatic assay for strong visual detection of creatinine.

Creatinine is an essential biomarker for the clinical diagnosis and treatment of renal insufficiency. Although fluorescent methods are powerful tools for creatinine detection, almost all reported fluorescent probes rely on short-wavelength excitation and a single fluorescent signal, making them susceptible to environmental and operational conditions. In this study, a near-infrared excited, highly sensitive, and multi-output signal sensing system was established using upconversion nanoparticles and 3,5-dinitrobenzoic acid (DNBA) for synergistic luminescent and colorimetric assay for strong visual detection of creatinine.

Immunological characteristics of peripheral T cells as prognostic markers for Camrelizumab and Apatinib combination therapy in advanced squamous non-small-cell lung cancer.

Purpose: To determine the characteristic changes of peripheral blood T cells and identify potential biomarkers that associated with the clinical efficacy of combined immunotherapy and anti-angiogenic therapy in patients with advanced squamous non-small cell lung cancer (NSCLC).

Methods: We performed a comprehensive immunological assessment of peripheral blood mononuclear cell samples from advanced squamous NSCLC patients before and after combination of immunotherapy (Camrelizumab) and anti-angiogenic therapy (Apatinib) using spectral flow cytometry. Correlations between these immunological features and clinical efficacy were analyzed.

Modulation of γδ T cells by USF3: Implications for liver fibrosis and immune regulation.

Previous studies have established that γδ T cells play a significant role in liver fibrosis. However, their specific functions and mechanisms in fibrotic liver tissue remain unclear. Using online microarray expression profiles, we observed that USF3 was upregulated in patients with liver fibrosis and was associated with immune cells.

Scopoletin alleviates acetaminophen-induced hepatotoxicity through modulation of NLRP3 inflammasome activation and Nrf2/HMGB1/TLR4/NF-κB signaling pathway.

Scopoleitin (SP), a bioactive compound from many edible plants and fruits, exerts a wide range of biological activities, however the role and mechanism of SP in acetaminophen (APAP)-induced hepatotoxicity remains unclear. In this study, we verified the protective effect of SP on APAP-induced liver injury (AILI) hepatotoxicity and explore the underlying molecular mechanisms. Here, we showed that SP alleviated AILI by reducing serum alanine transaminase (ALT) and aspartate aminotransferase (AST) levels, hepatic histopathological damage, inflammation, and liver cell apoptosis.

The combined immunization of cervical cancer therapeutic vaccine based on Listeria balanced lethal system has a significant therapeutic effect on tumor model mice.

Cervical cancer is the fourth most common cancer and the fourth leading cause of cancer death in women. Effective treatment of cervical cancer is urgently needed. Tumor therapeutic vaccine is a research hotspot in tumor immunotherapy, and the tumor therapeutic vaccine based on attenuated live bacteria carrier has clinical application prospect because of its clear action site and high safety.

Primary squamous cell carcinoma of the pancreas: A case report.

Introduction: Primary squamous cell carcinoma (SCC) is a rare type of pancreatic cancer with an extremely low incidence rate and a prognosis that is poorer than that of pancreatic ductal adenocarcinoma.

Presentation Of Case: We report a case of pure pancreatic SCC in an 80-year-old man. Based on the examination before surgical resection, we did not detect any SCC lesions that might have metastasized to the pancreas.

ManiNeg: Manifestation-guided multimodal pretraining for mammography screening.

Breast cancer poses a significant health threat worldwide. Contrastive learning has emerged as an effective method to extract critical lesion features from mammograms, thereby offering a potent tool for breast cancer screening and analysis. A crucial aspect of contrastive learning is negative sampling, where the selection of hard negative samples is essential for driving representations to retain detailed lesion information.

Recombinant nanobody expressed by transgenic chimeric chickens eliminated vertical transmission of avian leukosis virus subgroup J.

Because of the vertical transmission of avian leukosis virus subgroup J (ALV-J), control of ALV-J in breed of chicken is still a serious issue. Blocking vertical transmission using antibodies is a potential strategy, but its high cost limits its application. We artificially designed recombinant nanobody (Nb) and efficiently expressed and secreted them in three primary chicken cells cultured in vitro by adenovirus delivery.

Riverine songbirds capture high levels of atmospheric mercury pollution from brown food webs in forests by mercury isotopic evidence.

Elevated methylmercury (MeHg) exposure poses significant risks to bird health, behavior, and reproduction. Still, the risk of MeHg exposure to forest birds, accounting for over 80 % of the world's bird species, is poorly understood. This study combines Hg isotopes and video analysis, aiming to assess MeHg exposure risks to a forest riverine songbird, the spotted forktail (Enicurus maculatus) from a remote subtropical montane forest.

Exposure profiles, determinants, and health risks of chemicals in personal care products among healthy older adults from the China BAPE study.

Personal care products (PCPs) are ubiquitously present in the environment, and the associated health risks have been increasingly concerned worldwide. However, knowledge regarding exposure assessments of older adults to these chemicals and their health risks remains largely limited. In the present study, five repeated surveys involving 76 healthy older adults in Jinan, Shandong Province, were performed to quantify urinary exposure levels of 14 chemicals in PCPs.

Quantification of micro- and nano-plastics in atmospheric fine particles by pyrolysis-gas chromatography-mass spectrometry with chromatographic peak reconstruction.

The effects of micro- and nano-plastics (MNPs) on human health are of global concern because MNPs are ubiquitous, persistent, and potentially toxic, particularly when bound to atmospheric fine particles (PM). Traditional quantitative analysis of MNPs by pyrolysis-gas chromatography-mass spectrometry (Py-GC/MS) is often inaccurate because of false positive signals caused by similar polymers and organic compounds. In this study, a reliable analytical strategy combining HNO digestion and chromatographic peak reconstruction was developed to improve the precision of pyrolysis-gas chromatography-mass spectrometry analysis of multiple MNPs bound to PM.

Bimetallic synergy in non-precious metal Mn/Ba-SSZ-13 zeolite for improving NO storage capacity at low temperatures.

Pd-zeolite is considered one of the most promising passive NO adsorber (PNA) materials for NO purification in diesel vehicles during cold start. Nevertheless, the scarcity and high cost of the precious metal Pd restrict the industrialisation of Pd-zeolites as PNA. This work developed a bimetallic Mn and Ba co-modified SSZ-13 as non-precious metal PNA material.

p-Phenylenediamines and their derived quinones: A review of their environmental fate, human exposure, and biological toxicity.

p-Phenylenediamines (PPDs) are widely used as antioxidants in numerous rubber products to prevent or delay oxidation and corrosion. However, their derived quinones (PPD-Qs), generated through reactions with ozone, are ubiquitous in the environment and raise significant health and toxicity concerns. This review summarizes the current state of knowledge on environmental distribution and fate, human exposure, and biological toxicity of PPDs and PPD-Qs, and makes recommendations for future research directions.

Polystyrene microplastics attenuated the impact of perfluorobutanoic acid on Chlorella sorokiniana: Hetero-aggregation, bioavailability, physiology, and transcriptomics.

Microplastics (MPs) and perfluorobutanoic acid (PFBA), emerging contaminants, are ubiquitous in the environment and toxic to organisms. The interaction of MPs with other contaminants can affect their toxicity. However, the impact of MPs on PFBA toxicity remains unknown.

Unveiling the degradation mechanism of 3,5-dichloroaniline: Activated sludge acclimation, strain isolation and gene cloning.

3,5-Dichloroaniline (3,5-DCA) is extensively used in synthesizing dicarboximide fungicides, medical compounds and dyes. Due to its widespread use in agriculture and industry, 3,5-DCA is often detected in groundwater, wastewater, sediments and soil, posing great risk to animals and humans. However, the genes and enzymes involved in 3,5-DCA degradation remain unidentified.

Psychosocial interventions for children and adolescents with adverse childhood experiences: A systematic review and meta-analysis.

Backgrounds: Exposure to adverse childhood experiences (ACEs) is associated with adverse neurobiological, developmental, cognitive, behavioral, psychological, and social consequences among children and adolescents. Psychosocial interventions hold promise for mitigating the negative impacts of ACEs, but there is a lack of updated and comprehensive evidence summarizing their effects qualitatively and quantitatively.

Aims: We performed a systematic review and meta-analysis of existing evidence on the effectiveness of psychosocial interventions on children's outcomes, including internalizing and externalizing problems.

The protective effect of wearing hearing protection devices in noise-induced hearing loss and its potential influencing factors in the Chinese adult population.

Background: Noise is a threat to human auditory system, hearing protection devices (HPDs) are widely used to prevent noise-induced hearing loss (NIHL). However, the role of wearing HPDs on NIHL and the complex relationship between them are still unclear. This study aims to explore such relationship and identify the associated influencing pathways.

A solar-powered electrocoagulation process with a novel CNT/silver nanowire coated basalt fabric cathode for effective oil/water separation: From fundamentals to application.

Electrocoagulation (EC) has proven its high efficiency and environmental sustainability for treating several types of wastewaters. However, the primary drawbacks of the conventional EC process are the suitable electrode materials and the relatively high cost due to the requirement for electric energy. To overcome these practical challenges, this study investigated effective oil/water separation by a solar-powered electrocoagulation (SPEC) process using a novel highly conductive basalt fabric (BF) cathode.

Ultrasensitive point-of-care multiplex diagnosis for influenza virus based robust quantum dot microsphere-lateral flow immunoassay.

Influenza A virus (IAV) and influenza B virus (IBV) with similar symptoms of infection caused a serious disease burden and economic losses in annual epidemic season, so it is important to quickly and accurately detect and distinguish between IAV and IBV during influenza season. Herein, the quantum dot microspheres (QDMS) were synthesized and applied to lateral flow immunoassays (LFIA), and a point-of-care (POC) biosensor that can discriminately and simultaneously diagnose IAV and IBV within 10 min was established. A double-sandwich QDMS nanotags was synthesized by immobilizing hydrophobic quantum dots (QDs) with chemical bonding method on a silica sphere template with an outer silica shell protection showed excellent stability and high fluorescence.