[Chinese guidelines on response assessment and minimal residual disease monitoring in multiple myeloma (2024)].

The application of standardized criteria to evaluate treatment efficacy is crucial for guiding therapeutic decisions, assessing prognosis, and interpreting outcomes in treating multiple myeloma (MM). The unique characteristics of MM make its response assessment more complex compared with other malignancies. It primarily depends on serum and urine M protein levels, combined with the number of plasma cells in the bone marrow and comprehensive imaging findings.

Application of Augmented Reality for Accurate Punctures During Stage 1 Sacral Neuromodulation.

Purpose: Precise electrode placement is crucial for the success of sacral neuromodulation (SNM). The aim of this study was to explore a more accurate and convenient method for positioning punctures during the first stage of SNM.

Methods: This retrospective study compared preoperative baseline values, intraoperative indicators, postoperative scores, and other clinical data from 130 patients who underwent SNM electrode implantation at our department between 2018 and 2023.

Long-term Outcomes of Prostate Capsule-Sparing and Nerve-Sparing Radical Cystectomy With Neobladder: A Propensity Score-Matched Comparison.

Purpose: This study aimed to compare and analyze the feasibility and long-term efficacy of prostatic capsule-sparing (PCS) and nerve-sparing (NS) radical cystectomy in the treatment of bladder cancer.

Methods: From June 2004 to December 2021, our institution treated and followed 145 patients who underwent radical cystectomy with neobladder reconstruction for over a year. These patients were divided into 2 groups: PCS (n=74) and NS (n=71).

Predicting postoperative adhesive small bowel obstruction in infants under 3 months with intestinal malrotation: a random forest approach.

Objective: This study aimed to develop a predictive model using a random forest algorithm to determine the likelihood of postoperative adhesive small bowel obstruction (ASBO) in infants under 3 months with intestinal malrotation.

Methods: A machine learning model was used to predict postoperative adhesive small bowel obstruction using comprehensive clinical data extracted from 107 patients with a follow-up of at least 24 months. The Boruta algorithm was used for selecting clinical features, and nested cross-validation tuned and selected hyper-parameters for the random forest model.

Intravenous injection of PCSK9 gain-of-function mutation in C57BL/6J background mice on Angiotensin II-induced AAA.

Objective: This study was performed to compare the incidence of Angiotensin II (Ang II)-induced abdominal aortic aneurysms (AAA) between intravenous and intraperitoneal injection of AAV8.mPCSK9 in wild-type (WT) mice with C57BL/6J background and the pathological differences of above model in WT and ApoE mice.

Design: Male WT mice were injected intraperitoneally or intravenously with either a AAV8.

Reconciliation of wheat 660 K and 90 K SNP arrays and their utilization in dough rheological properties of bread wheat.

Introduction: High-density Wheat 660 K and 90 K SNP arrays are powerful tools for understanding the genetic basis of wheat traits. However, their inconsistantly physical positions that were caused by different versions of Chinese Spring genome during developing arrays are confused and inconvenient for further application.

Objective: With the repid development of wheat geonome sequencing, we aim to reconciliate Wheat 660 K and 90 K SNP arrays in modern cultivar and reveal the genetic basis of dough rheological properties in bread wheat.

School-based environment and physical activity in adolescents: A systematic review and meta-analysis.

Objective: This study aimed to evaluate the effectiveness of school environmental factors in promoting adolescents' physical activity.

Methods: A systematic search of five databases (PubMed, Embase, Web of Science, EBSCO, and Cochrane Library) was conducted from the earliest available records up to September 2023. Meta-analyses were performed for each school environmental factor, provided that at least two studies reported on the association between that factor and adolescents' physical activity.

Preparation, structural changes and functional properties of the covalent complexes of almond protein and phloretin.

Proteins and polyphenols exhibit distinct biological activities and functional properties. A comprehensive investigation into the formation mechanisms, structures, and functional properties of protein-polyphenol complexes will deepen our understanding of their interactions and establish a theoretical foundation and technical support for development of novel functional foods and pharmaceutical products. The almond protein-phloretin (AP-PHL) covalent complex was synthesized through the covalent binding of hydroxyl radicals to phloretin (PHL), utilizing almond protein (AP) as the raw material.

Integrating network pharmacology to investigate the mechanism of quercetin's action through AKT inhibition in co-expressed genes associated with polycystic ovary syndrome and endometrial cancer.

Endometrial cancer (EC) is a common gynecological malignancy for which polycystic ovarian syndrome (PCOS) has been identified as a significant risk factor. Quercetin, a widely distributed natural flavonoid, has demonstrated potential therapeutic effects in managing both PCOS and EC. However, the specific molecular targets of quercetin in the context of PCOS comorbid with EC (PCOS-EC) remain poorly defined.

One-step fabrication of dual-network cellulose-based hydrogel sensors with high flexibility and conductivity under ZnCl solvent method for flexible sensing properties.

Flexible smart sensing materials are gaining tremendous momentum in wearable and bionic smart electronics. To satisfy the growing demand for sustainability and eco-friendliness, biomass-based hydrogel sensors for green and biologically safe wearable sensors have attracted significant attention. In this work, we have prepared MCC/PAA/AgNWs/CNTs hydrogel sensors with excellent conductive sensing properties by a simple physical blending method.

A review of RNA nanoparticles for drug/gene/protein delivery in advanced therapies: Current state and future prospects.

Nanotechnology involves the utilization of materials with exceptional properties at the nanoscale. Over the past few years, nanotechnologies have demonstrated significant potential in improving human health, particularly in medical treatments. The self-assembly characteristic of RNA is a highly effective method for designing and constructing nanostructures using a combination of biological, chemical, and physical techniques from different fields.

Development and validation of a support vector machine-based nomogram for diagnosis of obstetric antiphospholipid syndrome.

Background: Antiphospholipid Syndrome (APS) is a systemic autoimmune disorder characterized by arterial or venous thrombosis and/or pregnancy complications. This study aims to develop a diagnostic model for Obstetric APS (OAPS) using the Support Vector Machine (SVM) algorithm.

Methods: Data were retrospectively collected from 102 patients with OAPS and 80 healthy controls (HC).

Identification of lactylation-associated fibroblast subclusters predicting prognosis and cancer immunotherapy response in colon cancer.

Background: Lactylation plays an important role in tumor progression. This study aimed to clarify the impact of lactylation on cancer-associated fibroblasts(CAFs).

Methods: Single-cell and bulk RNA sequence data, along with survival information, were obtained from TCGA and GEO datasets.

ISG15 increases the apoptosis of β cells in type 1 diabetes.

Type 1 diabetes (T1D) is an autoimmune disease characterized by hyperglycemia caused by the destruction of insulin-producing β cells. Viral infection is an important environmental factor which is associated with the islet autoimmunity in genetically susceptible individuals. Loss of β-cells and triggering of insulitis following viral infection could result from several non-exclusive mechanisms.

Neural markers of human aggression and cooperation are influenced by zero-sum or non-zero-sum groups.

Cooperation and competition in social interaction are important to social development. There are many studies examining the neural mechanism underlying these behaviors; however, little is known about the potential role of payoff norms in social interactions. This study introduced two distinct payoff norms: zero-sum (ZS) and non-zero-sum (NZS).

Evolving Paradigms in Spinal Surgery: A Systematic Review of the Learning Curves in Minimally Invasive Spine Techniques.

Our research examines the learning curves of various minimally invasive lumbar surgeries to determine the benefits and challenges they pose to both surgeons and patients. The advent of microsurgical techniques since the 1960s, including advances in fluoroscopic navigation and intraoperative computed tomography, has significantly shifted spinal surgery from open to minimally invasive methods. This study critically evaluates surgical duration, intraoperative conversions to open surgery, and complications as primary parameters to gauge these learning curves.

Reducing Postoperative Neurological Complications in Uniportal Full-Endoscopic Lumbar Interbody Fusion: Efficacy of the GUARD Technique Combined With Delayed Ligamentum Flavectomy.

Objective: Uniportal full-endoscopic transforaminal lumbar interbody fusion (FE-TLIF) carries a unique risk of nerve traction and abrasion injury during cage insertion. This study aims to evaluate the clinical efficacy of the GUARD technique and delayed ligamentum flavectomy in reducing postoperative radicular pain and neurapraxia in patients undergoing uniportal FE-TLIF.

Methods: A retrospective analysis was conducted on 45 patients with an average age of 53.

Innovative Nerve Root Protection in Full-Endoscopic Facet-Resecting Lumbar Interbody Fusion: Controlled Cage Glider Rotation Using the GUARD (Glider Used As a Rotary Device) Technique.

This video presents a case of L4-5 unstable spondylolisthesis treated with full-endoscopic transforaminal lumbar interbody fusion (Endo-TLIF), emphasizing the GUARD (Glider Used as a Rotary Device) technique for nerve root protection. This innovative approach involves controlled rotation of the cage glider before cage insertion to minimize the risk of nerve root injury, a significant complication in Endo-TLIF procedures. The GUARD technique, validated in previous cadaveric studies, provides enhanced safety during cage insertion by protecting the nerve root.

Hybrid Endoscopic Thoracic Discectomy Using Robotic Arm and Navigation for Highly Migrated Calcified Disc Herniation.

This video provides a step-by-step guide for performing the hybrid endoscopic thoracic discectomy using navigation and robotic arm for addressing high migrated calcified disc herniation. With the development of techniques, endoscopic spine surgery has emerged as a reliable treatment for thoracic myelopathy. This approach offers high-resolution, off-axis visualization of the surgical field.

Associations between multiple metabolic biomarkers with steatotic liver disease subcategories: A 5-year Chinese cohort study.

The effectiveness of established biomarkers for non-alcoholic fatty liver disease (NAFLD) within the updated framework of steatotic liver disease (SLD) remains uncertain. This cohort study examines the association of four metabolic biomarkers-retinol-binding protein 4 (RBP-4), fibroblast growth factor 21 (FGF-21), adiponectin, and osteocalcin-with SLD and its subtypes: metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction with alcohol-related liver disease (MetALD)/alcohol-related liver disease (ALD). Among 3,504 Chinese participants aged 55-70, 938 (26.

A review of polysorbate quantification and its degradation analysis by liquid chromatography coupled with charged aerosol detection.

Polysorbates (PS), as non-ionic surfactants, contribute significantly to the stability of proteins in formulations. However, their lack of chromophore groups makes them difficult to detect with high sensitivity and simplicity. The charged aerosol detector (CAD) is an emerging and universal detector that can provide highly sensitive response signals to non-volatile or semi-volatile substances, such as esters, acids, oxidized aldehydes, and contaminant ions in PS.

A review on molecularly imprinted magnetic solid phase extraction emphasizing the analysis of antibiotics in complex matrices:Design, preparation, and application.

Magnetic solid phase extraction (MSPE) has been widely employed in the isolation and enrichment of antibiotics in complex matrices because it presents various unique advantages over traditional SPE including simple operation, fast extraction procedure, low cost and eco-friendliness. In recently years, magnetic molecularly imprinted nanoparticles (MMINs) containing highly specific recognition performance have been widely used to specific extraction of antibiotics under the format of MSPE. In this connection, recent advances of MMINs in the analysis of antibiotic residues are reviewed.

Comparing efficacy and safety of transanal vs. laparoscopic total mesorectal excision for middle and low rectal cancer: Updated meta-analysis.

Objective: This study aimed to compare the efficacy and safety of transanal total mesorectal excision (TaTME) with laparoscopic total mesorectal excision (LaTME) in patients with middle and low rectal cancer.

Methods: A comprehensive search of PubMed, Embase, and Cochrane databases was conducted to identify studies evaluating TaTME and LaTME from inception to June 2023. An additional search update was conducted in November 2024 to capture recently published studies.

PreTKcat: A pre-trained representation learning and machine learning framework for predicting enzyme turnover number.

The enzyme turnover number (k) is crucial for understanding enzyme kinetics and optimizing biotechnological processes. However, experimentally measured k values are limited due to the high cost and labor intensity of wet-lab measurements, necessitating robust computational methods. To address this issue, we propose PreTKcat, a framework that integrates pre-trained representation learning and machine learning to predict k values.

A systematic review for non-targeted analysis of per- and polyfluoroalkyl substances (PFAS).

This review follows the PRISMA guidelines to provide a systematic review of 115 peer reviewed articles that used non-targeted analysis (NTA) methods to detect per- and polyfluoroalkylated substances (PFAS). This literature highlights the significant positive impact of NTA in understanding PFAS in the environment. Within the literature a geographical bias exists, with most NTA studies (∼60 %) conducted in the United States and China.