CAMKIIδ Reinforces Lipid Metabolism and Promotes the Development of B Cell Lymphoma.

The most prevalent types of lymphomas are B cell lymphomas (BCL). Newer therapies for BCL have improved the prognosis for many patients. However, approximately 30% with aggressive BCL either remain refractory or ultimately relapse.

Predicting Survival Rates in Brain Metastases Patients from Non-Small Cell Lung Cancer Using Radiomic Signatures Associated with Tumor Immune Heterogeneity.

Non-small cell lung cancer (NSCLC) frequently metastasizes to the brain, significantly worsened prognoses. This study aimed to develop an interpretable model for predicting survival in NSCLC patients with brain metastases (BM) integrating radiomic features and RNA sequencing data. 292 samples are collected and analyzed utilizing T1/T2 MRIs.

Superior Regional Control and Laryngeal Function Preservation With Radiotherapy Versus Partial Laryngectomy: A Propensity Score-Matched Analysis of 562 Early Glottic Cancer Patients.

Objectives: We aimed to compare the outcomes of patients with T1-T2N0M0 glottic squamous cell carcinoma who underwent either partial laryngectomy (PL) or radiotherapy (RT).

Methods: A retrospective analysis of 562 patients treated with RT (n = 151) or PL (n = 411) was conducted. The Kaplan-Meier method was used to estimate outcomes.

Acidity Reversal Enables Site-Specific Ring-Opening Polymerization of Epoxides from Biprotonic Compounds.

Polyethers are versatile materials extensively used in advanced as well as everyday applications. The incorporation of primary amine functionality into polyethers is particularly attractive due to its well-established coupling chemistries. However, the inherent nucleophilicity of amine group poses a challenge in the anionic ring-opening polymerization (ROP) of epoxides and requires the use of robust protecting groups that can withstand the harsh conditions of ROP without triggering undesirable side reactions.

Aprocitentan for Blood Pressure Reduction in Black Patients.

Background: Black individuals frequently present with resistant hypertension and disproportionately increased cardiovascular risk. We investigated the blood pressure (BP)-lowering effect of the dual endothelin receptor antagonist aprocitentan in Black individuals enrolled in the PRECISION study (Parallel-Group, Phase 3 Study with Aprocitentan in Subjects with Resistant Hypertension).

Methods: Patients with confirmed resistant hypertension were randomized to aprocitentan 12.

Unlocking Advanced Architectures of Single-Crystal Metal-Organic Frameworks.

The synthesis of metal-organic frameworks (MOFs) with diverse geometries has captivated considerable interest due to their manifestation of novel and extraordinary properties. While much progress has been made in shaping regular polyhedral single-crystal MOFs, the creation of more complex, topologically intricate nanostructures remains a largely unexplored frontier. Here, we present a refined site-specific anisotropic assembly and etching co-mediation approach to fabricate a series of hierarchical MOF nanohybrids and single-crystal MOFs.

2D Perovskite Heterojunction-Based Self-Powered Polarized Photodetectors with Controllable Polarization Ratio Enabled by Ferro-Pyro-Phototronic Effect.

Metal halide perovskites (MHPs) are commonly used in polarization-sensitive photodetectors (PDs) for applications such as polarization imaging, remote sensing, and optical communication. Although various methods exist to adjust the polarization-sensitive photocurrent, a universal and effective approach for continuous control of MHPs' optoelectronic and polarized properties is lacking. A universal strategy to electrically modulate the polarization ratio (PR) of self-powered polarized PDs using the ferro-pyro-phototronic effect (FPPE) in 2D perovskites is presented.

Exploring microfluidics-based organoid interactions through analysis of albumin secretion.

Organoids-on-a-chip exhibit significant potential for advancing disease modeling, drug screening, and precision medicine, largely due to their capacity to facilitate interactions among organoids. However, the influence of chip design on these interactions remains poorly understood, primarily due to our limited knowledge of the mediators of communication and the complexity of interaction dynamics. This study demonstrates that analyzing albumin secretion from liver organoids within an organoids-on-a-chip system can provide a measure of the interaction intensity among organoids, offering valuable insights into how chip design influences these interactions.

Exploring Social-Ecological Pathways From Sexual Identity to Sleep Among Chinese Women: Structural Equation Modeling Analysis.

Background: Women and sexual minority individuals have been found to be at higher risk for experiencing poor sleep health compared to their counterparts. However, research on the sleep health of sexual minority women (SMW) is lacking in China.

Objective: This study aimed to examine sleep quality and social support for Chinese women with varied sexual identities, and then investigate the in-depth relationships between sexual identity and sleep.

Nitrogen-doped graphene supported single-atom catalysts for efficient electrocatalytic oxidation of 5-hydroxymethylfurfural to 2,5-furandicarboxylic acid: a density functional theory study.

Electrocatalytic oxidation of 5-hydroxymethylfurfural (HMF) to 2,5-furandicarboxylic acid (FDCA) is a promising alternative for oxygen evolution reactions. The search for efficient catalysts has been attracting increasing scientific attention. This work explores the performance of nitrogen-doped graphene-supported single-atom catalysts (M-NC SACs) for the reaction.

Integrating transcriptomics, metabolomics, and network pharmacology to investigate multi-target effects of sporoderm-broken spores of on improving HFD-induced diabetic nephropathy rats.

Diabetes mellitus (DM) is a major metabolic disease endangering global health, with diabetic nephropathy (DN) as a primary complication lacking curative therapy. Sporoderm-broken spores of (GLP), an herbal medicine, has been used for the treatment of metabolic disorders. In this study, DN was induced in Sprague-Dawley rats using streptozotocin (STZ) and a high-fat diet (HFD), and the protective mechanisms of GLP were investigated through transcriptomic, metabolomic, and network pharmacology (NP) analyses.

Recent advances in bacterial outer membrane vesicles: Effects on the immune system, mechanisms and their usage for tumor treatment.

Tumor treatment remains a significant medical challenge, with many traditional therapies causing notable side effects. Recent research has led to the development of immunotherapy, which offers numerous advantages. Bacteria inherently possess motility, allowing them to preferentially colonize tumors and modulate the tumor immune microenvironment, thus influencing the efficacy of immunotherapy.

Lentinan-functionalized PBAE-G-nanodiamonds as an adjuvant to induce cGAS-STING pathway-mediated macrophage activation and immune enhancement.

A series of biodegradable nanoparticle-based drug delivery systems have been designed utilizing poly(β-amino ester)-guanidine-phenylboronic acid (PBAE-G) polymers. In this study, a novel Lentinan-Functionalized PBAE-G-nanodiamond system was developed to carry ovalbumin (LNT-PBAE-G-ND@OVA). The impact of this drug delivery system on the activation and maturation of macrophages was then assessed.

Platelet membrane biomimetic nanomedicine induces dual glutathione consumption for enhancing cancer radioimmunotherapy.

Radiotherapy (RT) is one of the most common treatments for cancer. However, intracellular glutathione (GSH) plays a key role in protecting cancer from radiation damage. Herein, we have developed a platelet membrane biomimetic nanomedicine (PMD) that induces double GSH consumption to enhance tumor radioimmunotherapy.

Utilizing Targeted Next-Generation Sequencing for Rapid, Accurate, and Cost-Effective Pathogen Detection in Lower Respiratory Tract Infections.

Objective: To evaluate the diagnostic performance and clinical impact of targeted next-generation sequencing (tNGS) in patients with suspected lower respiratory tract infections.

Methods: Following propensity score matching, we compared the diagnostic performances of tNGS and metagenomic next-generation sequencing (mNGS). Furthermore, the diagnostic performance of tNGS was compared with that of culture, and its clinical impact was assessed.

Coagulation Parameters in Elderly Patients with Severe Pneumonia: Correlation with Disease Severity and Prognosis.

Objective: This study aimed to investigate the levels of coagulation parameters in elderly patients with severe pneumonia and analyse their correlation with disease severity and prognosis.

Methods: A retrospective study was conducted on 207 elderly patients (aged ≥60 years) with severe pneumonia admitted to our hospital between January 2022 and December 2023. Demographic data, clinical characteristics and coagulation parameters, including prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time and fibrinogen (FIB), were collected.

An oral microbiota-based deep neural network model for risk stratification and prognosis prediction in gastric cancer.

Background: This study aims to develop an oral microbiota-based model for gastric cancer (GC) risk stratification and prognosis prediction.

Methods: Oral microbial markers for GC prognosis and risk stratification were identified from 99 GC patients, and their predictive potential was validated on an external dataset of 111 GC patients. The identified bacterial markers were used to construct a Deep Neural Network (DNN) model, a Random Forest (RF) model, and a Support Vector Machine (SVM) model for predicting GC prognosis.

Gesture-controlled reconfigurable metasurface system based on surface electromyography for real-time electromagnetic wave manipulation.

Gesture recognition plays a significant role in human-machine interaction (HMI) system. This paper proposes a gesture-controlled reconfigurable metasurface system based on surface electromyography (sEMG) for real-time beam deflection and polarization conversion. By recognizing the sEMG signals of user gestures through a pre-trained convolutional neural network (CNN) model, the system dynamically modulates the metasurface, enabling precise control of the deflection direction and polarization state of electromagnetic waves.

Auto-collimation diffraction of two-dimensional metal-dielectric grating with azimuth angle of 45°.

Grating under auto-collimation configuration with polarization-independent high diffraction efficiency plays an important role in the displacement measurement system, spectral beam combining system and so on. In this paper, we proposed, for the first time, a reflective two-dimensional metal-dielectric grating of which the (-1, -1) order beam is diffracted back along the input light direction, when the incident azimuth angle is 45°. With optimized structure, the (-1, -1) order diffraction efficiencies of transverse electric polarization (TE) and transverse magnetic polarization (TM) are 95.

Metacavities by harnessing the linear-crossing metamaterials.

The formed optical cavity mode intensively relies on the size and geometry of optical cavity. When the defect or impurity exists inside the cavity, the formed cavity mode will be destroyed. Here, we propose a metacavity consisting of arrays of linear-crossing metamaterials (LCMMs) with abnormal dispersion, where each LCMM offers both the directional propagation channel for all incident angles and the negative refraction across its neighboring LCMMs.

Measuring high-efficiency perfect composite vortex beams with reflective metasurfaces in microwave band.

Optical vortex beams carrying orbit angular momentum have attracted significant attention recently. Perfect vortex beams, characterized by their topological charge-independent intensity profile, have important applications in enhancing communication capacity and optimizing particle manipulation. In this paper, metal-insulator-metal copper-coin type reflective metasurfaces are proposed to generate perfect composite vortex beams in X-band.

Origins and conservation of topological polarization defects in resonant photonic-crystal diffraction.

We present a continuative definition of topological charge to depict the polarization defects on any resonant diffraction orders in photonic crystal slab regardless they are radiative or evanescent. By using such a generalized definition, we investigate the origins and conservation of polarization defects across the whole Brillouin zone. We found that the mode crossings due to Brillouin zone folding contribute to the emergence of polarization defects in the entire Brillouin zone.

F-FDG PET/CT findings in a mucosa-associated lymphoid tissue lymphoma patient coexisting with primary myelofibrosis.

A 61-year-old male presented with hematemesis and melena. Biopsy and immunohistochemistry confirmed mucosa-associated lymphoid tissue (MALT) lymphoma in the posterior wall of the gastric antrum, prompting further evaluation with F-fluorodeoxyglucose (F-FDG) positron emission tomography/computed tomography (PET/CT). In addition to elevated uptake in the gastric antrum, F-FDG PET/CT showed diffuse uptake in multiple bone marrow, initially suspected to indicate bone marrow involvement by lymphoma.

Systemic progression of primary cutaneous anaplastic large cell lymphoma in F-FDG PET/CT: a case report.

Primary cutaneous anaplastic large cell lymphoma (pcALCL) is a type of skin T-cell lymphoma with a favorable prognosis. Some patients may experience recurrence, but systemic involvement is rare. Some studies suggest that systemic progression is associated with poor prognosis.