Integrated Network Pharmacology, Machine Learning and Experimental Validation to Identify the Key Targets and Compounds of for the Treatment of Breast Cancer.

Background: TiaoShenGongJian (TSGJ) decoction, a traditional Chinese medicine for breast cancer, has unknown active compounds, targets, and mechanisms. This study identifies TSGJ's key targets and compounds for breast cancer treatment through network pharmacology, machine learning, and experimental validation.

Methods: Bioactive components and targets of TSGJ were identified from the TCMSP database, and breast cancer-related targets from GeneCards, PharmGkb, and RNA-seq datasets.

Single-Cell Analysis Integrated With Machine Learning Elucidates the Mechanisms of Nucleus Pulposus Cells Apoptosis in Intervertebral Disc Degeneration and Therapeutic Interventions.

Background: The molecular of intervertebral disc degeneration (IVDD) is still unclear. When it comes to treating decoction, traditional Chinese medicine is effective. In particular, the Duhuo (Radix Angelicae Biseratae) may be particularly helpful.

The role of vitamin D in slipped capital femoral epiphysis in children and adolescents: a retrospective case-control study.

Objective: To explore the correlation between vitamin D levels, related endocrine/metabolic factors, and the risk of slipped capital femoral epiphysis (SCFE) in children and adolescents, and to assess whether vitamin D levels are associated with SCFE severity.

Methods: A retrospective case-control study was conducted from March 2014 to October 2023 in Shengjing hospital. Patients diagnosed with SCFE were categorized as the SCFE group.

Transoral endoscopic thyroid lobectomy and ipsilateral central neck lymph node dissection vestibular approach: analysis of the learning curve and clinical outcomes evaluation.

Purpose: The transoral endoscopic thyroidectomy vestibular approach (TOETVA) is distinguished by its ability to leave no visible scars on the body's surface. Currently, there is still a lack of single-center large sample size analysis on the learning curve of TOETVA, especially for the treatment of thyroid cancer. This study aims to fill this void by presenting a comprehensive analysis of the learning curve and assessing the procedure's feasibility in managing thyroid cancer.

Corrigendum: Relationship between vitamin D deficiency and gestational diabetes: a narrative review.

[This corrects the article DOI: 10.3389/fendo.2024.

Associations of neutrophil/high-density lipoprotein cholesterol ratio with frailty and its mortality.

Background: Frailty is an increasingly important determinant in the field of health, and its identification has important clinical significance in the field of critical care medicine. However, there are still a large number of challenges in quick and accurate identification of frailty. This study aims to evaluate the value of the neutrophil/high-density lipoprotein cholesterol ratio (NHR) in frailty and its long-term survival.

Antidiabetic agent use and clinical outcomes in patients with diabetes hospitalized for COVID-19: a systematic review and meta-analysis.

Background: The effect of antidiabetic agents on mortality outcomes is unclear for individuals with diabetes mellitus (DM) who are hospitalized for COVID-19.

Purpose: To examine the relationship between antidiabetic agent use and clinical outcomes in individuals with DM hospitalized for COVID-19.

Methods: A systematic review of the literature (2020-2024) was performed across five databases.

Positive association of triglyceride glucose index and gestational diabetes mellitus: a retrospective cohort study.

Background: Gestational diabetes mellitus (GDM) is a common metabolic disorder with important health implications for both mother and offspring. This study aims to assess the relationship between the Triglyceride Glucose (TyG) index and GDM and explore its clinical significance.

Methods: A retrospective cohort study included 631 singleton pregnant women.

Unveiling the mystery of hepatic epithelioid angiomyolipoma: A unique case report with literature review.

Hepatic epithelioid angiomyolipoma is a rare mesenchymal liver tumor within the perivascular epithelioid cell tumor family, known for its uncertain malignancy and potential for aggressive behavior. Clinical presentation, laboratory findings, and imaging results lack specificity, making pathological examination critical for definitive diagnosis. This case report presents a 61-year-old male patient with a single tumor in the right liver lobe, measuring approximately 101 mm × 99 mm.

Dias-Logan syndrome with a p.Leu360Profs*212 heterozygous pathogenic variant of in a Chinese patient: A case report.

Dias-Logan syndrome, also known as intellectual developmental disorder with persistence of fetal hemoglobin (HbF), or -related intellectual developmental disorder, is an extremely rare neurogenetic disorder characterized by intellectual disability (ID), delayed psychomotor development, variable dysmorphic features, and asymptomatic persistence of fetal hemoglobin. The prevalence and incidence of this condition are currently unknown. We report an 8-year-old Han Chinese male patient with Dias-Logan syndrome who carries a heterozygous pathogenic variant, c.

The application of One Health concept in China and its practice and innovation in cross-sector cooperation.

Background: This study explores the opportunities and challenges associated with the One Health concept in China. Taking the practice of multi-sector health collaboration in China as an example, this study analyses the possible obstacles and opportunities.

Methods: From June to August 2023, 30 semi-structured interviews were conducted with experts from the Health Commission, Centre for Disease Control and Prevention, Department of Ecology and Environment, Ministry of Agriculture and Rural Affairs, Department of Transportation, Administration for Market Regulation, and other departments.

generation and conversion of a half-zirconocene catalyst for the synthesis of -acylpyrazoles.

Pyrazoles are an important class of five-membered nitrogen heterocyclic compounds that have been widely used in agriculture and medicine. Exploring their synthesis methods under mild conditions has always been a hot research topic. Herein, a new strategy was developed to enhance the activity of a zirconium metal centre for the synthesis of -acylpyrazole derivatives using CpZrCl as a pre-catalyst.

Green one-pot synthesis of quinoxaline derivatives using sulfo-anthranilic acid functionalized alginate-MCFeO nanostructures: a novel superparamagnetic catalyst with antiproliferative potential.

This study reports a green, multi-component synthesis of 2-aminoimidazole-linked quinoxaline Schiff bases using a novel superparamagnetic acid catalyst. The catalyst consists of sulfo-anthranilic acid (SAA) immobilized on MnCoFeO@alginate magnetic nanorods (MNRs), achieving high SAA loading (1.8 mmol g) and product yields (91-97%).

2D VC MXene/2D g-CN nanosheet heterojunctions constructed a one-pot method for remedying water pollution through high-efficient adsorption together with photocatalytic degradation.

With the development of modern industry, the problems of water pollution have become increasingly serious. There is a strong need to develop highly efficient and environmentally friendly technologies to address water pollution. In this work, a novel 2D VC MXene/2D g-CN nanosheet heterojunction was constructed a one-pot method.

Plasmonic Cu-supported amorphous RuP for efficient photothermal CO hydrogenation to CO.

The hydrogenation of carbon dioxide into profitable chemicals is a viable path toward achieving the objective of carbon neutrality. However, the typical approach for hydrogenation of CO heavily relies on thermally driven catalysis at high temperatures, which is not aligned with the goals of carbon neutrality. Thus, there is a critical need to explore new catalytic methods for the high-efficiency conversion of CO.

Full-component extract of and its effect on epidermal regeneration.

As a well-known aromatic herb rich in various bioactive molecules, the extract of is widely used in cosmetics. However, the extraction process for is far from perfect. Moreover, the water- and oil-soluble components are too complex to be compatible with each other.

Pre-pregnancy fertility guidance for women of childbearing age with epilepsy: A scoping review.

Background: Epilepsy is one of the most common neurological conditions affecting women of reproductive age. Epilepsy management during pregnancy is a clinical conundrum, requiring a balance between seizure control and risk minimization for women with epilepsy, as well as for their fetuses.

Objective: In this review, we aimed to systematically search, evaluate, and summarize relevant evidence on perinatal fertility guidance for women with epilepsy to provide a basis for medical staff to offer comprehensive fertility counseling.

Effects of upper extremity blood flow restriction training on muscle strength and hypertrophy: a systematic review and meta-analysis.

Background: Low load resistance training with blood flow restriction (LL-BFRT) has been shown to improve muscle strength and hypertrophic function. The effect of LL-BFRT on lower extremity muscle improvement has been widely discussed. However, no studies have discussed the effect of this training method on the upper extremity muscles until now.

Characterization of the ligand-binding properties of odorant-binding protein 38 from when interacting with soybean volatiles.

Background: (Fabricius) (Hemiptera: Alydidae) is a major soybean pest throughout East Asia that relies on its advanced olfactory system for the perception of plant-derived volatile compounds and aggregation pheromones for conspecific and host plant localization. Odorant binding proteins (OBPs) facilitate the transport of odorant compounds across the sensillum lymph within the insect olfactory system, enabling their interaction with odorant receptors (ORs).

Methods: Real-time quantitative PCR (qRT-PCR) analyses, fluorescence-based competitive binding assays, and molecular docking analyses were applied to assess the expression and ligand-binding properties of OBP38 from .

Altered lumbo-pelvic-hip complex muscle morphometry and contraction change in postpartum pelvic girdle pain and asymptomatic subjects: a cross-sectional study.

Objective: Lumbo-pelvic-hip complex muscle training is considered a crucial component of exercise rehabilitation for postpartum women with pelvic girdle pain (PGP). However, there is a paucity of research evidence regarding the morphological changes and contraction function of these muscles in postpartum women with PGP. Understanding the alterations in lumbo-pelvic-hip complex muscles function associated with PGP, is crucial for tailoring effective rehabilitation strategies and promoting optimal postpartum recovery.

What do we know: positive impact of hip-hop pedagogy on student's learning effects.

Over the last decade, hip-hop pedagogy has received a lot of attention in the field of education because of its significance in improving students' learning effects. This review articulates the current understanding of the positive impact of hip-hop pedagogy on students' learning effects within publications, an under-researched area. Based on a review of previous studies, this review innovatively examines six major elements of hip-hop pedagogy (DJ, MC, cypher, breakdance, knowledge, and graffiti) and concludes that the six major elements of hip-hop pedagogy can, in terms of the four dimensions of learning motivation, engagement, learning and memorization, and critical thinking, improve students' learning effects.

Carbonic Anhydrase IX Targeted Polyaspartamide fluorescent Probes for Tumor imaging.

Background: Precise intraoperative tumor delineation is essential for successful surgical outcomes. However, conventional methods are often incompetent to provide intraoperative guidance due to lack specificity and sensitivity. Recently fluorescence-guided surgery for tumors to delineate between cancerous and healthy tissues has attracted widespread attention.

Exosomes: Key Messengers Mediating the Interaction Between Tumor Cells and CD8 T Cells in the Tumor Microenvironment.

In recent years, with an increasingly profound comprehension of the tumor microenvironment, it has been discovered that the constituent cells within the immune microenvironment, such as macrophages, CD4T cells, and CD8T cells, interact with tumor cells in manners conducive to tumorigenesis and progression. Exosomes play a pivotal role as essential mediators for intercellular material exchange and signal transmission in this context. Tumor cell-derived exosomes carrying cargo such as PD-L1 and ncRNAs engage with CD8T cells to induce cytotoxic responses and facilitate immune evasion, thereby promoting tumor advancement.

Naringenin induces ferroptosis in osteosarcoma cells through the STAT3-MGST2 signaling pathway.

Osteosarcoma is a common malignant tumor found in adolescents, characterized by a high metastatic potential and poor prognosis, but it is sensitive to radiotherapy and chemotherapy. Ferroptosis is a novel form of regulated cell death induced by excessive iron accumulation, leading to lipid peroxidation that results in cellular dysfunction and death. Naringenin is a flavonoid known for its anti-cancer properties, yet its role in osteosarcoma has not been thoroughly studied.