L-serine metabolic regulation and host respiratory homeostasis.

LSerine, a non-essential amino acid (NEAA), can be obtained through diet or synthesis. Functionally, L-serine not only serves as the precursor of other amino acids, lipids, and nucleotides, but also participates in the folate/methionine cycle. An increasing number of studies have demonstrated that L-serine is widely used in the adjuvant therapy of many diseases (e.

Synergistic antifungal effects and mechanisms of amantadine hydrochloride combined with azole antifungal drugs on drug-resistant .

Introduction: The increasing resistance of () to conventional antifungal drugs poses a great challenge to the clinical treatment of infections caused by this yeast. Drug combinations are a potential therapeutic approach to overcome the drug- resistance of . This study explored the synergistic effects of amantadine hydrochloride (AMH) combined with azole antifungal drugs against drug-resistant and .

Monte Carlo simulation to optimize polymyxin B dosing regimens for the treatment of Gram-negative bacteremia.

Objective: This study aimed to predict and evaluate the efficacy of various polymyxin B dosing regimens for Gram-negative bacteremia using Monte Carlo simulation, with a specific focus on assessing the efficacy in patients receiving continuous renal replacement therapy (CRRT). The goal was to optimize clinical dosing regimens and guide rational polymyxin B use in practice.

Methods: A total of 1,939 Gram-negative bacterial strains were analyzed, collected between April 2019 and December 2021 through the China Bloodstream Gram-negative Pathogens Antimicrobial Resistance and Virulence Surveillance Network (CARVIS-NET).

Establishment and validation of a dual qPCR method for the detection of carbapenem-resistant in bloodstream infections.

Objective: Bloodstream infections(BSIs) caused by carbapenem-resistant (CRAB) have a high mortality rate due to the high levels of drug resistance. There is an urgent need to establish a sensitive and accurate detection method to rapidly detect CRAB in BSIs.

Methods: A new method was developed based on fluorescence quantitative PCR (qPCR) targeting the specific region of 16sRNA and OXA-23 gene from CRAB.

Injectable photosensitive bone cement enhancing angiogenesis and osteogenic differentiation for the treatment of bone nonunion.

Nonunion fractures present a significant clinical challenge because of their complex microenvironment, which includes poor vascularization, insufficient osteogenesis, infection, and separation of fracture ends. The current clinical treatments have certain limitations. Inspired by this phenomenon, sandcastle worms secrete adhesive proteins that bind sand grains, shell fragments, and mineral particles, thereby constructing their "castles.

Thermal and nutrient stress drove Permian-Triassic shallow marine extinctions.

The Permian-Triassic climate crisis can provide key insights into the potential impact of horizon threats to modern-day biodiversity. This crisis coincides with the same extensive environmental changes that threaten modern marine ecosystems (i.e.

Defining optimal electrospun membranes to enhance biological activities of human endometrial MSCs.

Introduction: Human endometrial mesenchymal stem cells (H-EMSCs) can inhibit endometrial fibrosis and repair damaged endometrium. However, direct cell injection into dam-aged endometrium shows limited cell survival. Cell seeding onto biomaterial-based electrospun membranes could improve H-EMSCs' survival and prolong their stay at the damaged endometrium.

The rational design, biofunctionalization and biological properties of orthopedic porous titanium implants: a review.

Porous titanium implants are becoming an important tool in orthopedic clinical applications. This review provides a comprehensive survey of recent advances in porous titanium implants for orthopedic use. First, the review briefly describes the characteristics of bone and the design requirements of orthopedic implants.

Regulatory T Cell Metabolism: A Promising Therapeutic Target for Cancer Treatment?

Regulatory T (Treg) cells are essential for maintaining immune homeostasis by suppressing excessive immune responses. In the context of cancer, however, Tregs promote immune evasion and tumor progression, particularly through their unique adaptations within the tumor microenvironment (TME). Recent research has emphasized how metabolic characteristics shape Treg activation, migration, and immunosuppressive function, revealing the impact of metabolic pathways on Treg fitness in homeostasis and within the TME.

The impact of family socioeconomic status on adolescent mental and physical health: the mediating role of parental involvement in youth sports.

Introduction: The physical and mental health of adolescents is a crucial cornerstone for social development. Therefore, this study aimed to examine whether family socioeconomic status made a difference in Chinese teenage mental and physical health and to disentangle the mediating role of parental involvement in youth sports in the process in which family socioeconomic status influenced adolescent health.

Methods: A quantitative analysis used a sample of approximately 11,000 adolescents from Chinese middle schools.

Parental smoking is associated with adolescent loneliness: evidence from 71 low- and middle-income countries.

Introduction: The association between parental smoking and adolescent mental health is not well understood. We aimed to examine the association between parental smoking and adolescent loneliness using global data collected from the Global School-based Student Health Survey (GSHS) between 2009 and 2019.

Methods: A total of 187,552 adolescents aged 12-15 years in 71 low- and middle-income countries (LMIC) from the GSHS with cross-sectional design were included in this study.

Examining how fiscal policies influence innovation in TCM enterprises: the role of R&D investment and executives with pharmaceutical backgrounds.

Introduction: Innovation is crucial to realize the modernization and industrialization of traditional Chinese medicine (TCM), so its incentive methods and influence mechanisms are worth exploring. Based on externality theory and imprinting theory, this paper demonstrates the significance of external support and internal resources in the innovation of TCM enterprises.

Methods: This study adopts a sample of listed TCM enterprises in China during 2007-2023 to examine the impacts and differences between innovation subsidies and tax incentives on TCM enterprise innovation.

Study on the impact of rural public sports facilities and instructors on residents' participation in sports activities in China.

Objective: This study aims to explore how rural public sports facilities and their instructors influence the participation of rural residents in sports activities under the background of China's rural revitalization strategy. The goal is to provide strategies for the effective use and management of rural sports facilities, thereby encouraging rural residents to actively participate in sports activities, improve their quality of life, and support comprehensive rural revitalization.

Methods: A cross-sectional study design was used, employing a stratified sampling method to distribute questionnaires to 5,000 residents in the eastern, central, western, and southern regions of China.

Assessment of radiation knowledge among medical personnel in nuclear emergency preparedness: a cross-sectional study.

Background: Radiation literacy, encompassing the understanding of basic principles, applications, risks, and protective measures related to ionizing radiation, is critical for medical personnel working in jobs that involve the use of radioactive materials or medical imaging. In the context of nuclear emergency preparedness, the level of radiation knowledge among healthcare professionals-such as doctors, nurses, and radiographers-directly influences the effectiveness and safety of emergency responses. This study aims to address this gap by evaluating the radiation knowledge of medical personnel and identifying areas for improvement in profession-specific training programs.

Understanding key factors contributing to mental health challenges among pediatric nurses: a systematic review.

Background: The mental health and wellbeing of nurses, particularly pediatric nurses, have garnered attention due to the increased risk of mental health challenges associated with their demanding profession. These nurses are especially vulnerable, yet their mental wellbeing is often understudied.

Objective: This systematic review aims to identify and analyze key factors associated with mental health challenges among pediatric nurses and explore how these factors interact to influence their wellbeing.

The impact of temperature changes on the health vulnerability of migrant workers: an empirical study based on the China family panel studies.

Introduction: Migrant workers constitute a significant portion of China's workforce, and their health directly affects labor supply and economic stability. Health vulnerability plays a crucial role in shaping the well-being of migrant workers, yet its determinants, particularly the impact of temperature change, remain underexplored. This study, based on the socio-ecological model, investigates how temperature variations influence the health vulnerability of migrant workers in China.

Multimorbidity characteristics in older adults and their associated factors in complex networks: a cross-sectional study.

Background: Multimorbidity of chronic diseases has become an increasingly serious public health problem. However, the research on the current situation of multimorbidity in the older adults in Jiangsu, China is relatively lacking.

Methods: We surveyed a total of 229,926 inpatients aged above 60 and with two or more chronic diseases in the First Affiliated Hospital with Nanjing Medical University from January 1, 2015 to December 31, 2021.

Daily physical activity, coffee and energy drink consumption, and sleep patterns among Chinese elite professional esports athletes: a case study of Zhejiang Regans Gaming.

Purpose: Esports is increasingly recognized as both a legitimate sport and profession. However, evidence on the health behaviors of esports athletes remains limited. Due to the nature of their activity, these athletes face occupational health risks associated with prolonged sedentary behavior, sleep deprivation, and excessive energy drink consumption.

Bridging accessibility gaps in urban community-based basic older adult care: a comprehensive framework validated in Xi'an, China.

Objectives: Accessibility is a critical factor in ensuring equitable public services. In urban older adult care systems, resource allocation and service disparities present unique challenges. The classical "5A" theory-availability, accessibility, affordability, adaptability, and acceptability-provides a robust framework for evaluating service delivery.

Global, regional and national burden of decubitus ulcers in 204 countries and territories from 1990 to 2021: a systematic analysis based on the global burden of disease study 2021.

Background: Decubitus ulcers, also known as pressure ulcers, pose a significant public health challenge due to their substantial impact on morbidity, mortality, and healthcare expenditures.

Methods: The number and age-standardized rates (ASRs) of prevalence, death, disability adjusted life-year (DALY), years of life lost (YLL), and years lived with disability (YLD) at the global, regional, and national levels were acquired from the GBD 2021 database. Trends were evaluated based on the estimated average percentage change (EAPC) of ASRs.

Health system delay and risk factors in pulmonary tuberculosis diagnosis before and during the COVID-19 epidemic: a multi-center survey in China.

Background: Understanding health system delay (HSD) in pulmonary tuberculosis (PTB) diagnosis aids in tailoring interventions for case detection and curbing transmission. However, recent nationwide studies on HSD in PTB diagnosis have been scarce. This study assesses HSD and its risk factors in China, taking into account the impact of the COVID-19 epidemic.

Healthcare workers' knowledge, attitudes, and practices on catheter-associated UTI prevention: influencing factors in an OB/GYN hospital.

Background: Catheter-associated urinary tract infection (CAUTI) is a leading cause of hospital-acquired infections globally, with a high prevalence in China, especially in high-risk settings like intensive care and post-operative environments. These infections are influenced by factors such as patient volume, healthcare worker training, and adherence to infection control protocols. Shanghai, as a major healthcare hub, faces unique challenges in CAUTI prevention.

Spatio-temporal evolution and driving factors of the coupling and coordinated development of China's digital economy and older adult care services.

Background: This study aims to examine the level of coupled and coordinated development between China's digital economy and older adult care services, analyzing their spatiotemporal evolution characteristics and key influencing factors, with the goal of providing feasible recommendations and scientific bases for the development of the digital economy and older adult care services in China.

Methods: This study uses publicly available panel data from China for the years 2015-2022. It employs the entropy method to measure the weights of various indicators in the digital economy and older adult care services.

Gender differences in preferences, gateway effects, and potential motivations among e-cigarette users in China.

Objective: A cross-sectional survey was conducted to investigate the differences in preferences, gateway effects, and potential motivations for e-cigarette use among different genders of e-cigarette users in China, thereby providing ideas for the development of public prevention and intervention measures for e-cigarettes.

Methods: This study adopted a combination of online web questionnaires and offline distribution questionnaires to survey 640 e-cigarette users by snowball sampling and convenience sampling in China in 2023. We used the Potential E-Cigarette Dependence Scale, the E-Cigarette Preference Scale, and the General Information Scale to conduct the survey and assessment, and surveyed 360 individuals of those who only used traditional cigarettes for comparison.

Lactate Dehydrogenase Indicates Development From Fulminant Myocarditis to Chronic Persistent Myocarditis: A Multicenter Retrospective Cohort Study in China.

Background: Fulminant myocarditis (FM) is a critical manifestation of myocarditis. However, the clinical features and risk factors associated with its adverse outcomes are not fully understood. Given the high mortality and potential for long-term complications, it is crucial to identify factors that could predict the progression of FM to chronic persistent myocarditis.