Increased hip fracture risk in the patients with type 2 diabetes mellitus is correlated with urine albumin-to-creatinine ratio (ACR) and diabetes duration in men.

Patients with type 2 diabetes mellitus (T2DM) have increased hip fracture risk. And the association between urine albumin to creatinine ratio (ACR) and an increased risk of hip fracture in patients with T2DM remains controversial. This study aimed to investigate the association between urinary ACR and hip fracture risk in postmenopausal women and aged men with T2DM.

Dysregulated transfer RNA-derived small RNAs as potential gastric cancer biomarkers.

Gastric cancer (GC) is the kind of carcinoma that has the highest rates of morbidity and death worldwide. In the early stages of GC, there is currently an absence of sensitive and specific biomarkers. The newly-discovered class of non-coding RNAs (ncRNAs) known as transfer RNA-derived small RNAs (tsRNAs) is highly expressed in bodily fluids and neoplastic cells.

Optimization of substrate formulation for by replacing wood by straw and their effect on enzyme activities.

Introduction: China is rich in straw resources. The utilization of straw in the cultivation of edible fungi partially resolves the resource conflicts between mushroom cultivation and forest industry and also contributes to environmental protection.

Methods: In this study, based on the technology of replacing wood by grass, the straw formula for mycelial culture of was optimized with Simplex-lattice method commonly used in mixture design.

Identification and characterization of playing a positive role in the abiotic stress resistance of Chinese chestnut via an integrated strategy.

Chinese chestnut ( Blume) is an important economic forest tree species and mainly cultivated in mountainous areas and wastelands, subjecting it to various abiotic stresses. The protein phosphatase 2C (PP2C) genes contributes largely to stress responses in plants. However, the characteristics and functions of genes in remain unknown.

Identification and analysis of major latex protein () family genes in responsive to infection by RNA-seq approaches.

Roses () are among the most cherished ornamental plants globally, yet they are highly susceptible to infections by , the causative agent of gray mold disease. Here we inoculated the resistant rose variety 'Yellow Leisure Liness' with to investigate its resistance mechanisms against gray mold disease. Through transcriptome sequencing, we identified 578 differentially expressed genes (DEGs) that were significantly upregulated at 24, 48, and 72 hours post-inoculation, with these genes significantly enriched for three defense response-related GO terms.

Unveiling the molecular mechanism of sepal curvature in Section through full-length transcriptome and RNA-seq analysis.

Introduction: Orchids are renowned for their intricate floral structures, where sepals and petals contribute significantly to ornamental value and pollinator attraction. In Section , the distinctive curvature of these floral organs enhances both aesthetic appeal and pollination efficiency. However, the molecular and cellular mechanisms underlying this trait remain poorly understood.

Unemployment and mental health: a global study of unemployment's influence on diverse mental disorders.

Introduction: Globally, one in five individuals faces unemployment, which substantially increases their risk of developing mental disorders. Understanding the relationship between unemployment and specific mental health outcomes is crucial for formulating effective policy interventions.

Methods: This study examines the relationship between unemployment and mental disorders across 201 countries from 1970 to 2020.

The effect of activities of daily living on anxiety in older adult people: the mediating role of social participation.

Objective: Anxiety is a serious psychiatric illness in older adult people. Activities of daily living and social participation are important factors influencing anxiety in older adult people. Using social participation as a mediating variable, this study explored the influence of activities of daily living on anxiety in older adult people to provide scientific evidence for improving the psychological health of older adult people.

Investment strategies for sustainable safe development of Chinese coal mine employees driven by digital intelligence.

China's "14th Five-Year Plan" proposes the construction of a "Digital China," posing the challenge of digital transformation to coal mining enterprises. It is critical to compare the effectiveness of investing in digital devices with that of human capital. This study establishes a structural equation model based on the 'regulation-situation-behavior' theoretical framework.

HealthPass: a contactless check-in and adaptive access control system for lowering cluster infection risk in public health crisis.

Introduction: Ensuring effective measures against the spread of the virus is paramount for educational institutions and workplaces as they resume operations amidst the ongoing public health crisis. A touchless and privacy-conscious check-in procedure for visitor assessment is critical to safeguarding venues against potential virus transmission.

Methods: In our study, we developed an interaction-free entry system featuring anonymous visitors who voluntarily provide data.

Implementation and evaluation of whole-course-based Internet Hospital Outpatient Pharmacy Services: a cross-sectional study in western China.

Background: In recent years, the development of telemedicine and eHealth services has led to the rapid worldwide growth of Internet hospitals, which played a significant role during the coronavirus disease 2019 (COVID-19) pandemic. However, little is known about the characteristics and safety of Internet hospital outpatient pharmacy services (IHOPSs), which represent a new model of pharmaceutical services.

Objective: This study aimed to reveal the comprehensive characteristics and safety of whole-course-based IHOPSs in a general tertiary hospital in western China.

Analysis of genetic instability induced by radon exposure in iron mine processing workers in Shandong Province, Northern China.

Background: Radon, a colorless and odorless radioactive gas, poses serious health risks. It is the second leading cause of lung cancer and notably increases lung cancer risk in smokers. Although previous epidemiological studies have mainly examined lung cancer rates in miners, the effects of radon on genomic stability and its molecular mechanisms are not well understood.

Examining the role of intrinsic and extrinsic cues from service requirement narratives in web-based time banking participation decisions.

Introduction: Time banking, known as "Community/Neighborhood Pension," instantiates a form of co-creation that can provide a new solution to fulfil the unmet social service needs of community members with idle resources, which is a feasible solution to alleviate pension pressure. The sustainable operation of time banks relies on the co-creation and active participation of community members. Therefore, in this study, we investigate the motivation of members to participate in web-based time banks from a service requirement narrative perspective.

Prevalence and influencing factors of oral frailty in older adults: a systematic review and meta-analysis.

Objective: This study aimed to conduct a systematic review and meta-analysis, assessing the pooled prevalence and influencing factors of oral frailty in older people to assist healthcare professionals in enhancing their understanding of this condition and formulating efficient interventions.

Methods: This systematic review was performed based on the Preferred Reporting Items for Systematic Reviews and Meta-analyses Statement (PRISMA) guidelines. We searched PubMed, Web of Science, The Cochrane Library, Embase, CINAHL, ProQuest, the National Knowledge Infrastructure (CNKI), WAN FANG DATA, VIP Information, SinoMed and Scopus for literature published in English or Chinese from inception to June 19, 2024.

A study of the impact of internet use on the mental health of rural older adults-empirical analysis based on China General Social Survey 2021 data.

Background: In the context of the era of both digitalization and aging, Internet use plays an important role in supporting the rural older adults to actively integrate into the digital society and improve their mental health.

Purpose: To explore the impact of Internet use on the mental health of rural older adults and the mediating role of their social participation.

Methods: Based on the latest data from the China General Social Survey (CGSS) 2021, the study utilized linear regression analysis to explore the impact of Internet use on the mental health of rural older adults and the mediating role of their social participation.

Modification of gemcitabine with oxaliplatin in China for unresectable gallbladder cancer: a cost-effectiveness analysis.

Background: The incidence of gall bladder cancer (GBC), one of the most prevalent bile duct malignancies, differs with ethnicity and geographic location. To treat unresected GBC in the Chinese setting, this study aimed to assess the financial effectiveness of a combination of modified gemcitabine and oxaliplatin.

Methods: Data from a randomized controlled study in which individuals with metastatic GBC were treated with oxaliplatin and gemcitabine demonstrated improved survival.

Chronic impacts of natural infrastructure on the physical and psychological health of university students during and after COVID-19: a case study of Chengdu, China.

Introduction: The COVID-19 pandemic has underscored the health benefits of green spaces, yet research on how specific elements of natural infrastructure affect well-being during the pandemic has been limited.

Methods: This study, conducted at Sichuan Agricultural University with 300 students in 2022, investigated how urban natural infrastructure impacts physical and psychological well-being during the pandemic. Different aspects of natural infrastructure, such as thermal comfort, air quality (negative ion concentration), and noise and light levels, varied in their positive effects on students' health.

Effects of a flexibly delivered group-based acceptance and commitment therapy on reducing stress and enhancing psychological wellbeing in parents of school-age children during the COVID-19 pandemic: a quasi-experimental study.

Introduction: COVID-19 has increased parental stress and significantly impacted the psychological well-being of individuals, especially parents of school-age children. Acceptance and Commitment Therapy posits that individuals can accept their unchangeable inner experiences (thoughts and feelings) while acting in ways aligned with their personal values, demonstrating effectiveness in reducing stress and improving psychological well-being, especially among parents of children with chronic illness. This study aimed to test the effectiveness of a group-based ACT, delivered flexibly, in improving stress and psychological well-being in parents with school-age children, regardless of their children's chronic conditions, within a real-world context.

COVID-19 outbreaks caused by different SARS-CoV-2 variants: a descriptive, comparative study from China.

Objectives: To understand the epidemic characteristics of various SARS-CoV-2 variants, we mainly focus on analyzing general epidemic profiles, viral mutation, and evolution of COVID-19 outbreaks caused by different SARS-CoV-2 variants of concern (VOCs) in China as of August 2022.

Methods: We systematically sorted out the general epidemic profiles of outbreaks caused by various SARS-CoV-2 VOCs in China, compared the differences of outbreaks caused by Delta and Omicron VOCs, and analyzed the mutational changes of subvariants between the same outbreak and different outbreaks.

Findings: By 15 August 2022, a total of 2, 33, and 124 COVID-19 outbreaks caused by Alpha, Delta, and Omicron VOCs, respectively, were reported in different regions of China.

Study on regional differences and causes of emergency logistics responsiveness under the impact of public emergencies-findings from Chinese samples.

Introduction: In recent years, the frequency and intensity of natural disasters and public emergencies around the world have been steadily increasing. Emergency logistics plays an irreplaceable role in providing rapid material and service support in the aftermath of disasters. Therefore, systematically analyzing the differences in emergency logistics responsiveness across various regions of China and understanding their underlying causes are of great significance for optimizing emergency logistics systems and improving disaster responsiveness.

Examining the effects of psychological resilience and wellbeing on perceived stress and depressive symptoms among undergraduate nursing interns: testing a moderated mediation model.

Background: Perceived stress is recognized as a significant risk factor for depressive symptoms, while psychological resilience and wellbeing are considered crucial protective factors. However, the intricate relationships among these variables in undergraduate nursing interns remain largely unexplored. This study aims to investigate the mediating role of psychological resilience in the relationship between perceived stress and depressive symptoms, as well as the moderating influence of wellbeing on this mediation.

Socioeconomic inequalities in depression and the role of job conditions in China.

Background: The rising prevalence of depression in China, coupled with a tightening job market, highlights concern for the workforce's mental health. Although socioeconomic inequalities in depression have been well documented in high-income countries, the association between socioeconomic status (SES) and depression, along with its work-related mediators, has not been sufficiently studied in China.

Methods: The study participants are 6,536 non-agriculturally employed working adults from the 2020 China Family Panel Studies (CFPS).

The impact of university freshmen's mental health on academic performance: an empirical study based on M University in Fujian Province, China.

Objective: To investigate the impact of freshmen's mental health on their short-and long-term academic performance, as well as to provide empirical evidence for improving university students' mental health intervention tactics and higher education quality.

Methods: A multiple regression model was used to analyze student data from 3 years of enrollment at M University in Fujian Province.

Results: Different mental health problems have a significant impact on academic performance, which varies by gender, enrollment year, and subject.

A Magnetic-Responsive Biomimetic Nanosystem Coated with Glioma Stem Cell Membranes Effectively Targets and Eliminates Malignant Gliomas.

Glioblastoma multiforme (GBM) is among the most challenging malignant brain tumors, making the development of new treatment strategies highly necessary. Glioma stem cells (GSCs) markedly contribute to drug resistance, radiation resistance, and tumor recurrence in GBM. The therapeutic potential of nanomaterials targeting GSCs in GBM urgently needs to be explored.

Clinical Relevance and Drug Modulation of PPAR Signaling Pathway in Triple-Negative Breast Cancer: A Comprehensive Analysis.

Triple-negative breast cancer (TNBC) is highly heterogeneous and poses a significant medical challenge due to limited treatment options and poor outcomes. Peroxisome proliferator-activated receptors (PPARs) play a crucial role in regulating metabolism and cell fate. While the association between PPAR signal and human cancers has been a topic of concern, its specific relationship with TNBC remains unclear.