Efficacy, safety and treatment satisfaction of transition to a regimen of insulin degludec/aspart: A pilot study.

Background: There is a lack of clinical evidence on the efficacy and safety of transitioning from a thrice-daily pre-mixed insulin or basal-prandial regimen to insulin deglu-dec/aspart (IDegAsp) therapy, with insufficient data from the Chinese popu-lation.

Aim: To demonstrate the efficacy, safety, and treatment satisfaction associated with the transition to IDegAsp in type 2 diabetes mellitus (T2DM).

Methods: In this 12-week open-label, non-randomized, single-center, pilot study, patients with T2DM receiving thrice-daily insulin or intensive insulin treatment were transitioned to twice-daily injections of insulin IDegAsp.

Unveiling mitochondrial mysteries: Exploring novel tRNA variants in type 2 diabetes mellitus.

The recent study of Ding provides valuable insights into the functional implications of novel mitochondrial tRNA and tRNA variants in type 2 diabetes mellitus (T2DM). This editorial explores their findings, highlighting the role of mitochondrial dysfunction in the pathogenesis of T2DM. By examining the molecular mechanisms through which these tRNA variants contribute to disease progression, the study introduces new targets for therapeutic strategies.

Application of Dorzagliatin in peritoneal dialysis patients with type 2 diabetes mellitus: A case report.

Background: Treating diabetes in dialysis patients remains a challenge, with many hypoglycemic drugs requiring dose adjustments or avoidance in these patients.

Case Summary: This report describes an 83-year-old female patient with a 30-year history of type 2 diabetes (T2DM) who had struggled to control her blood sugar for more than a year. She had a history of high blood pressure for 30 years, had undergone continuous ambulatory peritoneal dialysis for more than two years, was 163 cm tall, weighed 77 kg, and had a body mass index of 28.

Protein nanoparticles as potent delivery vehicles for polycytosine RNA-binding protein one.

Ma recently reported in the that ferroptosis occurs in osteoblasts under high glucose conditions, reflecting diabetes pathology. This condition could be protected by the upregulation of the gene encoding polycytosine RNA-binding protein 1 (PCBP1). Additionally, Ma used a lentivirus infection system to express PCBP1.

Role of macrophage polarization in diabetic foot ulcer healing: A bibliometric study.

Background: Diabetic foot ulcers (DFUs) are a significant contributor to disability and mortality in diabetic patients. Macrophage polarization and functional regulation are promising areas of research and show therapeutic potential in the field of DFU healing. However, the complex mechanism, the difficulty in clinical translation, and the large heterogeneity present significant challenges.

Intestinal glucagon-like peptide-1: A new regulator of impaired counterregulatory responses to hypoglycemia in type 1 diabetes mellitus.

In this article, we review the study by Jin , which examined the role of intestinal glucagon-like peptide-1 (GLP-1) in counterregulatory responses to hypoglycemia in patients with type 1 diabetes mellitus (T1DM). With the global rise of T1DM, there is an increased burden on society and healthcare systems. Due to insulin therapy and islet dysfunction, T1DM patients are highly vulnerable to severe hypoglycemia, a leading cause of mortality.

Two new species of the genus (Coleoptera, Elmidae) from Guizhou, China.

The riffle beetle genus Jäch & Boukal, 1995 (Elminae, Macronychini) includes only three species from East Asia. In this paper, two new species, and , are described from Guizhou Province, China. Illustrations of the new species and a key to all five species are also provided.

Descriptions of four species of Polyxenida Verhoeff, 1934 (Diplopoda, Penicillata) from China, including one new species and one new record.

This study describes a new species of Polyxenida from China, , along with a species newly recorded from China: (Miyosi, 1947), and provides additional descriptions of Ishii & Liang, 1990 and Ishii & Liang, 1990. The study conducted mitochondrial cytochrome oxidase subunit I (COI) sequencing for all four species and constructed a phylogenetic tree based on the molecular data. The comprehensive morphological descriptions and molecular analyses confirm the addition of one new species and one newly recorded species for the Polyxenida fauna of China, elevating the total number of known Polyxenida species in the country from 10 to 12.

A new species of Gray, 1827 (Squamata, Gekkonidae) from Yunnan Nangunhe National Nature Reserve, China.

A new forest-dwelling species of the group is described from southwestern Yunnan Province, China. Phylogenetically, it was recovered as the sister species of , with a genetic distance of 9.2% in the ND2 gene.

Revision of the orb-weaving spider genus Archer, 1960 (Araneae, Araneidae) from China.

The orb-weaver spider genus Archer, 1960 from China is revised, and three species, including two new species, are recognized: Mi & Wang, (♂♀) from Xizang and Mi & Wang, (♂♀) from Hainan; the type species, (Strand, 1906) (♂♀), is redescribed based on specimens from Guizhou and Hubei. A distributional map of the studied specimens is also provided.

The BEN domain protein LIN-14 coordinates neuromuscular positioning during epidermal maturation.

Development and function of an organism depend on coordinated inter-tissue interaction. How such interactions are maintained during tissue renewal and reorganization remains poorly understood. Here, we find that BEN domain transcription factor LIN-14 is required in epidermis for maintaining the position of motor neurons and muscles during developmental tissue reorganization.

Chemical proteomic profiling of lysine crotonylation using minimalist bioorthogonal probes in mammalian cells.

Protein lysine crotonylation has been found to be closely related to the occurrence and development of various diseases. Currently, site identification of crotonylation is mainly dependent on antibody enrichment; however, due to the cost, heterogeneity, and specificity of antibodies, it is desired to develop an alternative chemical tool to detect crotonylation. Herein, we report an alkynyl-functionalized bioorthogonal chemical probe, Cr-alkyne, for the detection and identification of protein lysine crotonylation in mammalian cells.

What Kinds of Computations Can Young Children Perform Over Non-Symbolic Representations of Small Quantities?

Children can manipulate non-symbolic representations of both small quantities of objects (about four or fewer, represented by the parallel individuation system) and large quantities of objects (represented by the analog magnitude system, or AMS). Previous work has shown that children can perform a variety of non-symbolic operations over AMS representations (like summing and solving for an unknown addend), but are not able to perform further operations on the derived solutions of such non-symbolic operations. However, while the computational capacity of AMS has been studied extensively in early childhood, less is known about the computational capacity of the parallel individuation system.

and antimalarial activities of the ethanol extract of stem bark used for the treatment of malaria in the Western Region of Cameroon.

Background: Malaria is one of the leading causes of morbidity and/or mortality in tropical Africa. The spread and development of resistance to chemical antimalarial drugs and the relatively high cost of the latter are problems associated with malaria control and are reasons to promote the use of plants to meet healthcare needs to treat malaria. The aim of this study was to evaluate antiplasmodial activities of extracts of (Mah quat), which is traditionally used for the treatment of malaria in the western region of Cameroon.

Schistosomiasis endemicity and its role in sexually transmitted infections - a systematic review and meta-analysis.

Introduction: Schistosomiasis, a tropical parasitic disease, affects 779 million people globally, with 85% of cases in Africa. The interplay between schistosomiasis and other sexually transmitted infections (STIs) can exacerbate health burdens, but most attention has focused on interactions with HIV, neglecting coinfections with other STIs. This systematic review and meta-analysis aims to understand the role infections play in STIs within schistosomiasis-endemic populations.

Application Value of STOP-Bang Questionnaire in Predicting Abnormal Metabolites.

Objective: To evaluate the application value of STOP-Bang questionnaire (SBQ) in predicting abnormal metabolites.

Methods: Totally 121 patients were included into the study and filled the questionnaires, and their clinical data were collected at the same time. These patients were grouped according to the questionnaire scores.

New species and records of (Botryosphaeriales, Botryosphaeriaceae) from in China.

During the fungal investigations of hosts in China, ten isolates of were obtained from dead and dying branches. Morphological characteristics and phylogenetic analyses of combined ITS, LSU, and loci revealed the presence of two new species, and , as well as two new host records for and from . In this study, we provide descriptions and illustrations of these species, thereby enriching the diversity within the taxa.

Two new species of (Xylariaceae, Ascomycota) associated with fallen leaves in Hainan Tropical Rainforest National Park, China.

is a large and complex genus of macrofungi, playing a critical role in ecosystems as decomposers and possessing antimicrobial, anticancer, and antioxidant properties. This paper described two new species discovered on fallen leaves in Hainan Tropical Rainforest National Park, based on morphological characteristics and genetic sequences. Detailed color illustrations and comparisons with similar species were provided.

Curcumin in gastric cancer treatment: A commentary on mechanistic insights and future directions.

The study by Yang presents a comprehensive investigation into the therapeutic potential of curcumin for gastric cancer (GC). Using network pharmacology, the researchers identified 48 curcumin-related genes, 31 of which overlap with GC targets. Key genes, including , , , , , and , are linked to poor survival in GC patients.

Coagulation indices and fibrinogen degradation products as predictive biomarkers for tumor-node-metastasis staging and metastasis in gastric cancer.

Background: Gastric cancer (GC) is a prevalent malignancy with a substantial health burden and high mortality rate, despite advances in prevention, early detection, and treatment. Compared with the global average, Asia, notably China, reports disproportionately high GC incidences. The disease often progresses asymptomatically in the early stages, leading to delayed diagnosis and compromised outcomes.

Association between autoimmune gastritis and gastric polyps: Clinical characteristics and risk factors.

Background: The relationship between autoimmune gastritis (AIG) and gastric polyps (GPs) is not well understood.

Aim: To explore the clinical characteristics and risk factors of AIG with GPs in patients.

Methods: This double center retrospective study included 530 patients diagnosed with AIG from July 2019 to July 2023.

Exosomes as promising frontier approaches in future cancer therapy.

In this editorial, we will discuss the article by Tang published in the recent issue of the . They explored an innovative approach to enhancing gemcitabine (GEM) delivery and efficacy using human bone marrow mesenchymal stem cells (HU-BMSCs)-derived exosomes. The manufacture of GEM-loaded HU-BMSCs-derived exosomes (Exo-GEM) has been optimized.

TRIPLET combined with microwave ablation: A novel treatment for advanced hepatocellular carcinoma.

This editorial comments on a study by Zuo . The focus is on the efficacy of hepatic arterial infusion chemotherapy combined with camrelizumab and apatinib (the TRIPLET regimen), alongside microwave ablation therapy, in treating advanced hepatocellular carcinoma (HCC). The potential application of this combination therapy for patients with advanced HCC is evaluated.

Advancing treatment strategies: Insights from network meta-analysis of hepatic arterial infusion chemotherapy for advanced hepatocellular carcinoma.

This study examines the pivotal findings of the network meta-analysis of Zhou , which evaluated the efficacy of hepatic arterial infusion chemotherapy and combination therapies for advanced hepatocellular carcinoma (HCC). This meta-analysis suggests that therapeutic combinations have greater efficacy than do standard treatments. The article highlights the key insights that have the potential to shift current clinical practice and enhance outcomes for patients with advanced HCC.

Multiparameter magnetic resonance imaging-based radiomics model for the prediction of rectal cancer metachronous liver metastasis.

Background: The liver, as the main target organ for hematogenous metastasis of colorectal cancer, early and accurate prediction of liver metastasis is crucial for the diagnosis and treatment of patients. Herein, this study aims to investigate the application value of a combined machine learning (ML) based model based on the multiparameter magnetic resonance imaging for prediction of rectal metachronous liver metastasis (MLM).

Aim: To investigate the efficacy of radiomics based on multiparametric magnetic resonance imaging images of preoperative first diagnosed rectal cancer in predicting MLM from rectal cancer.