Optimizing Acidic Oxygen Evolution with Manganese-Doped Ruthenium Dioxide Assembly.

Ruthenium dioxide (RuO) is one of the promising catalysts for the acidic oxygen evolution reaction (OER). However, designing RuO catalysts with good activity and stability remains a significant challenge. In this work, we propose the manganese (Mn)-doped RuO assembly as a catalyst for the OER with improved activity and stability.

Constructing Bridge Hydroxyl Groups on the Ru/MO/HZSM-5 (M = W, Mo) Catalysts to Promote the Hydrolysis Oxidation of Multicomponent VOCs.

Chlorinated and oxygenated volatile organic compounds (CVOCs and OVOCs) pose a significant threat to human health. Catalytic oxidation effectively removes these pollutants, but catalyst deactivation is a challenge. Our study focused on the hydrolysis oxidation of chlorobenzene (CB) and ethyl acetate (EA) over Ru/MO/HZSM-5 (M = W, Mo).

Synchronization cluster bursting in adaptive oscillator networks.

Adaptive dynamical networks are ubiquitous in real-world systems. This paper aims to explore the synchronization dynamics in networks of adaptive oscillators based on a paradigmatic system of adaptively coupled phase oscillators. Our numerical observations reveal the emergence of synchronization cluster bursting, characterized by periodic transitions between cluster synchronization and global synchronization.

Dynamical modeling and analysis of epileptic discharges transition caused by glutamate release with metabolism processes regulation from astrocyte.

Glutamate (Glu) is a crucial excitatory neurotransmitter in the central nervous system that transmits brain information by activating excitatory receptors on neuronal membranes. Physiological studies have demonstrated that abnormal Glu metabolism in astrocytes is closely related to the pathogenesis of epilepsy. The astrocyte metabolism processes mainly involve the Glu uptake through astrocyte EAAT2, the Glu-glutamine (Gln) conversion, and the Glu release.

Therapeutic Effects of Human Placental Extracts Eye Drops in Experimental Dry Eye and Alkali Burn.

To evaluate the efficacy of human placental extract (HPE) eye drops compared to that of carboxymethylcellulose (CMC) and human peripheral blood serum (HPBS) eye drops in a mouse model of experimental dry eye (EDE) and corneal alkali burns. EDE and alkali burn models were induced in C57BL/6 mice using desiccating stress and NaOH, respectively. In both the EDE and alkali burn models, treatment groups received CMC, HPBS, or HPE eye drops.

Whether temporal discounting is domain-specific between health outcomes and money: a systematic review and meta-analysis.

Background: Temporal discounting, the preference for immediate over delayed rewards, affects decision-making in domains like health and finance. Understanding the differences in how people discount health outcomes compared to monetary rewards is crucial to shaping health policy and technology assessments.

Aim: This systematic review and meta-analysis aimed to compare temporal discounting parameters between health outcomes and monetary rewards and evaluate their overall relationship.

How Perceptions of the Accuracy of Parental Praise and Criticism Link With Child Adjustment: The Mediating Role of Perfectionism.

Accurate parental praise and criticism congruent with child performance-often ignored-might have lasting impacts on child development. This study explored whether the levels of the accuracy (from deflated to accurate to inflated) of parental praise and criticism perceived by children linked to a risk for their maladjustment (i.e.

JZL-184 Alleviate Neurological Impairment through Regulation of Mitochondrial Transfer and Lipid Droplet Accumulation after Cardiac Arrest.

Astrocytes are abundant glial cells in the central nervous system (CNS) that play important roles in brain injury following cardiac arrest (CA). Following brain ischemia, astrocytes trigger endogenous neuroprotective mechanisms, such as fatty acid transport. Lipid droplets (LDs) are cellular structures involved in neutral lipid storage and play essential roles in many biological processes.

GALNT6 drives lenvatinib resistance in hepatocellular carcinoma through autophagy and cancer-associated fibroblast activation.

Background: Hepatocellular carcinoma (HCC) remains a significant global health challenge with limited treatment options. Lenvatinib, a tyrosine kinase inhibitor, has shown promise but is often undermined by the development of drug resistance.

Methods: Utilizing high-throughput sequencing, we investigated the molecular mechanisms underlying lenvatinib resistance in HCC cells, with a focus on metabolic pathways.

The survival prediction analysis and preliminary study of the biological function of YEATS2 in hepatocellular carcinoma.

Purpose: Our study aims to develop and validate a novel molecular marker for the prognosis and diagnosis of hepatocellular carcinoma (HCC) MATERIALS & METHODS: We retrospectively analyzed mRNA expression profile and clinicopathological data of HCC patients fetched from The Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO) and The International Cancer Genome Consortium (ICGC) datasets. Univariate Cox regression analysis was performed to collect differentially expressed mRNA (DEmRNAs) from HCC and non-tumor tissues, and YEATS2, a prognostic marker, was identified by further analysis. ROC curve, survival analysis and multivariate Cox regression analysis as well as nomograms were used to evaluate the prognosis of this gene.

Repurposing pinaverium bromide against Staphylococcus and its biofilms with new mechanisms.

Antibiotic resistance by methicillin-resistant Staphylococcus aureus (MRSA) is an urgent threat to human health. The biofilm and persister cells formation ability of MRSA and Staphylococcus epidermidis often companied with extremely high antimicrobial resistance. Pinaverium bromide (PVB) is an antispasmodic compound mainly used for irritable bowel syndrome.

Association between malnutrition, depression, anxiety and fatigue after stroke in older adults: a cross-lagged panel analysis.

Background: Malnutrition, post-stroke depression (PSD), post-stroke anxiety (PSA), and post-stroke fatigue (PSF) in stroke survivors have complex relationships and are associated with adverse stroke outcomes.

Aims: This research aims to explore the temporal and directional relationships between malnutrition, PSD, PSA, and PSF after stroke in older adults.

Methods: Patients aged 65 years and older with their first ischemic stroke from two centers were selected and assessed at baseline, 3 months and 12 months.

β-Asarone Inhibits Carboplatin Resistance in Retinoblastoma Cells Through the UCA1/miR-206/NRP1 Axis.

Retinoblastoma (RB) is an aggressive form of eye cancer. β-Asarone is a bioactive component isolated from the medicinal plant Acorus tatarinowii Schott and has anticancer effects on various human cancers. However, reports regarding the role of β-Asarone in RB remain limited.

The Impact of Metaphoric Language Intervention on Psychological Perceptions of Students with Autism.

This study aimed to investigate the influence of metaphoric language intervention (MLI) on students' psychological perception in bilingual learning, focusing on both autistic and students with non-autism. Students with autism often exhibit apprehension toward engaging in bilingual learning with their peers, resulting in reduced enjoyment and unfavorable language learning outcomes. A cohort of 108 students with autism and 102 students with non-autism, who demonstrated psychological perception engagement through MLI, was recruited for the study.

Application of extended immunotherapy in advanced clear cell renal cell carcinoma treated with first-line combination of immune-checkpoint inhibitor and tyrosine kinase inhibitor.

Purpose: To evaluate the efficacy and safety of extended immunotherapy in first-line immune checkpoint inhibitors (ICIs)-tyrosine kinase inhibitors (TKIs) combination treatment for advanced renal cell carcinoma (RCC).

Patients And Methods: We retrospectively analyzed data from patients with advanced RCC who received first-line ICIs-TKIs combination treatment at West China Hospital of Sichuan University between October 2018 and July 2024. Patients who are assessed as having a disease control status after 2 years of continuous treatment will continue to receive immune checkpoint inhibitors until the inhibitors are discontinued due to disease progression or death.

Curzerenone inactivates the nuclear factor-kappa B signaling to suppress malignancy and immune evasion in cervical cancer by targeting CSNK2B.

Curzerenone is a major component of the traditional herbal medicine Curcumae Rhizoma with potential cancer-suppressing effects. This study aims to investigate the treatment effect of Curzerenone on cervical cancer cells and the underpinning mechanism. HeLa and SiHa cells were treated with Curzerenone.

Impacts of carbon dioxide emissions on agricultural production indicators in Sub-Saharan African countries: new perspectives from static and dynamic panel models.

Agricultural productivity remains pivotal to the sustenance of the economies and livelihoods of Sub-Saharan African (SSA) countries. However, the emerging threat of climate change poses a significant challenge to these agricultural-dependent economies. Sub-Saharan African countries are at risk of experiencing the severe effects of climate change on their agricultural productivity.

Machine Learning Model for Risk Prediction of Prolonged Intensive Care Unit in Patients Receiving Intra-aortic Balloon Pump Therapy during Coronary Artery Bypass Graft Surgery.

This study aimed to construct machine learning models and predict prolonged intensive care units (ICU) stay in patients receiving perioperative intra-aortic balloon pump (IABP) therapy during cardiac surgery. 236 patients were divided into the normal (≤ 14 days) and prolonged (> 14 days) ICU groups based on the 75th percentile of ICU duration across the entire cohort. Seven machine learning models were trained and validated.

Yttrium-doped LiTiO nanoparticles as anode for high-rate and high-energy lithium-ion batteries.

LiTiO (LTO) batteries are known for safety and long lifespan due to zero-strain and stable lattice. However, their low specific capacity and lithium-ion diffusion limit practical use. This study explored modifying LTO through yttrium doping by hydrothermal method to form LiYTiO nanoparticles.

Accumulation of microtubule-associated protein tau promotes hepatocellular carcinogenesis through inhibiting autophagosome-lysosome fusion.

Dysregulated expression of microtubule-associated protein tau (MAPT) has been reported in a variety of human cancers. However, whether and how Tau influences hepatocellular carcinogenesis remains elusive. This study was aimed to investigate the role and the underlying mechanism of Tau in the proliferation, invasion, migration and sorafenib sensitivity of hepatocellular carcinoma (HCC) cells.

Enhancing cardiac regeneration: direct reprogramming of fibroblasts into myocardial-like cells using extracellular vesicles secreted by cardiomyocytes.

To investigate the promoting effect of extracellular vesicles derived from myocardial cells (CM-EVs) on the reprogramming of cardiac fibroblasts (CFs) into cardiomyocyte-like cells (iCMs) and their therapeutic effect on myocardial infarction (MI) in rats. Cell experiments: The differential adhesion method was used to obtain Sprague Dawley (SD) suckling rat CFs and cardiomyocytes (CMs), while the ultracentrifugation method was used to obtain CM-EVs. Transmission electron microscopy and nanoparticle tracking technology were used to analyze and determine the morphology and particle size of CM-EVs.