The SwiftScan step-and-shoot continuous mode improves SPECT scanning efficiency: a preliminary phantom and clinical test.

Purpose: The aim of the study was to investigate the value of SwiftScan Step-and-Shoot Continuous (SSC) scanning mode in enhancing image quality and to explore appropriate scanning parameters for reducing scan time.

Methods: This study was composed of a phantom study and two clinical tests. The differences in visual image quality scores, coefficient of variance (COV) of the background, image signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR), and recovery coefficient (RC) of the sphere were compared between SSC mode and traditional Step-and-Shoot (SS) mode in the phantom study.

In Vivo Clonal Analysis Using MADM with Spatiotemporal Specificity.

Mosaic analysis with double markers (MADM) is a powerful in vivo lineage tracing technique. It utilizes Cre recombinase-dependent interchromosomal recombination to restore the stable expression of two fluorescent proteins sparsely in individual dividing stem or progenitor cells and their progenies. Here, we describe the application of this technique for quantitative lineage analysis of radial glial progenitors in the developing mouse neocortex at the single-cell resolution.

Effects of water and sediment chemistry variables on aquatic macroinvertebrate community structuring in a subtropical Austral river system.

Riverine physical and chemical characteristics are influencing ecosystem integrity while shaping and impacting species richness and diversity. Changes in these factors could potentially influence community structuring through competition, predation and localised species extinctions. In this study, eight sampling sites over multiple seasons were assessed along the streams draining the City of Nelspruit, South Africa, to examine river health based on water and sediment quality, while using macroinvertebrates as bioindicators for pollution.

Canonical and noncanonical NOTCH signaling in the nongenetic resistance of cancer: distinct and concerted control.

Therapeutic resistance in cancer is responsible for numerous cancer deaths in clinical practice. While target mutations are well recognized as the basis of genetic resistance to targeted therapy, nontarget mutation resistance (or nongenetic resistance) remains poorly characterized. Despite its complex and unintegrated mechanisms in the literature, nongenetic resistance is considered from our perspective to be a collective response of innate or acquired resistant subpopulations in heterogeneous tumors to therapy.

Diagnosis and treatment recommendations for glucose transporter 1 deficiency syndrome.

Background: Glucose transporter 1 deficiency syndrome (Glut1DS) was initially reported by De Vivo and colleagues in 1991. This disease arises from mutations in the SLC2A1 and presents with a broad clinical spectrum. It is a treatable neuro-metabolic condition, where prompt diagnosis and initiation of ketogenic dietary therapy can markedly enhance the prognosis.

Nongenetic risk factors for thyroid cancer: an umbrella review of evidence.

Background: The incidence of thyroid cancer has increased annually, but the risk factors for thyroid cancer are still unclear. In this umbrella review, we aimed to identify associations between nongenetic risk factors and thyroid cancer incidence, and assess the quality and validity of the evidence.

Methods: PubMed, Embase and the Cochrane Database of Systematic Reviews were searched to identify related meta-analyses or systematic reviews of epidemiological studies.

Programmable Food-Derived Peptide Coassembly Strategies for Boosting Targeted Colitis Therapy by Enhancing Oral Bioavailability and Restoring Gut Microenvironment Homeostasis.

Orally targeting nanostrategies of multiple nutraceuticals have attracted increasing attention in ulcerative colitis (UC) therapy for superior patient compliance, cost-effectiveness, and biocompatibility. However, the actual targeting delivery and bioefficacy of nutraceuticals are extremely restricted by their poor solubility, interior gastrointestinal retention, and base permeability. Herein, we developed controllable colon-targeting nanoparticles (NPs) composed of a quaternary ammonium chitosan (HTCC) shell and succinic acid-modified γ-cyclodextrin (SACD) core for precise UC treatment.

A 280 bp SINE insertion within the pig PLA2G16 could potentially modify gene expression through integration with its transcript.

In our previous study, we identified a Short Interspersed Nuclear Element Retrotransposon Insertion Polymorphism (SINE-RIP) within the 3' untranslated region (3'UTR) of the Phospholipase A2 Group XVI (PLA2G16) gene, which is essential in lipid metabolism. In this study, we confirmed the presence of this 280 bp SINE insertion and examined its distribution across ten distinct pig breeds using PCR and sequencing. Subsequently, RT-PCR was employed to determine its potential for co-transcription.

Systematic review of repetitive transcranial magnetic stimulation for post-stroke hemiplegic shoulder pain.

Background: Repetitive transcranial magnetic stimulation (rTMS) has shown potential in alleviating hemiplegic shoulder pain (HSP) and improving upper limb function, yet its efficacy remains debated. This study aims to assess the effectiveness of rTMS for HSP through a systematic review and meta-analysis.

Methods: Four databases were searched with the keywords "rTMS" and "HSP".

Subregional alterations in corpus callosum is associated with different symptoms in early-stage parkinson's disease.

Objective: Corpus callosum (CC) damage is the most consistent and typical change in early Parkinson's disease (PD), and is associated with various PD symptoms. However, the precise relationship between CC subregions and specific PD symptoms have not been identified comprehensively. In this study, we investigated the association between specific CC subregion alterations and PD symptoms using diffusion-weighted imaging.

Three new terpenes with potential antibacterial and anti-COVID-19 activities from the stems of R. Br.

The extract of the stems of R. Br. yielded three new terpenes () including two diterpenes and one triterpene, named euryachins C-E, as well as three known diterpenes ().

Facile preparation of a hydrophilic Eu-based ratiometric fluorescent nanosensor for Cu ion detection and imaging in living cells.

In this work, a hydrophilic Eu-based ratiometric fluorescent nanosensor (PAAC-Eu) was developed for Cu ion detection in aqueous solutions and imaging in living cells. The sensor was prepared a simple one-step reaction at room temperature, leveraging the synergistic coordination of commercially accessible polyacrylic acid (PAA) and coumarin-3-carboxylic acid (CCAH) with Eu ions. PAAC-Eu was easy to disperse in aqueous media and exhibited two characteristic emission bands at 406 nm and 618 nm, respectively, upon excitation at 350 nm.

Confined Flash Pt/WC inside Carbon Nanotubes for Efficient and Durable Electrocatalysis.

Exploiting cost-effective hydrogen evolution reaction (HER) catalysts is crucial for sustainable hydrogen production. However, currently reported nanocatalysts usually cannot simultaneously sustain high catalytic activity and long-term durability. Here, we report the efficient synthesis and activity tailoring of a chainmail catalyst, isolated platinum atom anchored tungsten carbide nanocrystals encapsulated inside carbon nanotubes (Pt/WC@CNTs), by confined flash Joule heating technique.

Kir5.1 regulates Kir4.2 expression and is a key component of the 50-pS inwardly-rectifying potassium channel in basolateral membrane of mouse proximal tubules.

Kir5.1 encoded by is an inwardly-rectifying K channel-subunit and it possibly interacts with Kir4.2-subunit encoded by for assembling a Kir4.

Surface-enhanced Raman scattering of R6G dimerization during self-healing of gel.

Traditional surface-enhanced Raman scattering (SERS) substrates seeking uniformity and reproducibility of the Raman signal often assume and require that hot spots remain consistently stable during Raman testing. Recently, the non-uniform accumulation in SERS sample pre-concentration strategies have inspired the direct use of self-healing noble metal aerogels (NMAs), as the sample pretreatment presented in this work, and uncovered more diverse Raman information of substances during the dynamic process of laser irradiation. Rare characteristic peaks such as 820 cm⁻ for R6G within a specific concentration range were observed, and potential processes including R6G dimerization and desorption were analyzed.

An Ultrastable Integrated Anode with ∼95 wt.% SiO via In Situ Electrode-Scale Conformal Coating.

SiO-based anodes, considered the most promising candidate for high-energy density batteries, have long been bothered by mechanical integrity issues. Research efforts focus on particle modifications, often overlooking the enhancement of interparticle connections, which can reduce the active material content within the electrode. Herein, an integrated electrode with strong covalent bonding at the electrode scale is designed, achieving excellent mechanical stability with ∼95 wt.

Aggregation-Induced Emission Luminogens Realizing High-Contrast Bioimaging.

A revolutionary transformation in biomedical imaging is unfolding with the advent of aggregation-induced emission luminogens (AIEgens). These cutting-edge molecules not only overcome the limitations of traditional fluorescent probes but also improve the boundaries of high-contrast imaging. Unlike conventional fluorophores suffering from aggregation-caused quenching, AIEgens exhibit enhanced luminescence when aggregated, enabling superior imaging performance.

Exploring the potential of the combined diagnostic model of ADC value and bp-MRI VI-RADS in the evaluation of muscle invasion in bladder Cancer.

Objective: This study investigates the diagnostic value of Vesical Imaging Reporting and Data System (VI-RADS) in biparametric MRI (bp-MRI) for the detection of muscular infiltration in bladder cancer, and to investigate whether apparent diffusion coefficient (ADC) value can function as a potential indicator of bp-MRI VI-RADS for patient benefit.

Materials And Methods: This single-center retrospective study enrolled 81 patients with pathologically confirmed bladder cancer from October 2019 to November 2021. Two readers independently scored the T2-weighted images and diffusion-weighted images of each index lesion based on the VI-RADS criteria, subsequently deriving the bp-MRI VI-RADS scores.

Ultrasound-guided percutaneous core-needle biopsy for the diagnosis of type 1 autoimmune pancreatitis.

Purpose: This study aimed to investigate the usefulness of ultrasound-guided core-needle biopsy (US-CNB) for diagnosing type 1 AIP and evaluate the radiological outcomes following steroid therapy.

Materials And Methods: From January 2017 to June 2023, patients with pathology results containing "lymphoplasmacytic infiltration" and "fibrosis" were enrolled. The detection rate of level 1 histology by International Consensus Diagnostic Criteria (ICDC) and the contribution of US-CNB were assessed.

Preliminary evaluation of a novel PSMA-targeting radiopharmaceutical [Ga]Ga/[Lu]Lu-NYM032 for theranostic use in prostate cancer.

Purpose: A novel theranostic radiopharmaceutical targeting prostate-specific membrane antigen (PSMA), [Ga]Ga/[Lu]Lu-NYM032, was developed and its diagnostic and therapeutic potential in the treatment of prostate cancer (PCa) was preliminarily evaluated.

Methods: The diagnostic efficacy of the PET tracer [Ga]Ga-NYM032 was first evaluated in PSMA-positive xenograft-bearing models (LNCaP models), followed by evaluation in 10 PCa patients using [Ga]Ga-PSMA617 a comparator. Finally, the therapeutic potential of [Lu]Lu-NYM032 was evaluated in LNCaP models.

Euchrestifolines A-O, fifteen novel carbazole alkaloids with potent anti-ferroptotic activity from Murraya euchrestifolia.

Fifteen novel carbazole alkaloids, euchrestifolines A-O (1-15), were obtained from Murraya euchrestifolia. Their structures were elucidated by spectroscopic analysis, Mosher's ester, calculated ECD, and transition metal complex ECD methods. Notably, euchrestifolines A-C (1-3) are the first naturally occurring pyrrolidone carbazoles to be identified, while euchrestifolines D-F (4-6) represent rare carbazole alkaloids containing a phenylpropanyl moiety; euchrestifoline G (7) features a unique benzopyranocarbazole skeleton.

Circular RNAs in the pathogenesis of SARS-CoV-2: potential diagnostic biomarkers and therapeutic targets.

Since December 2019, the global dissemination of a novel coronavirus has precipitated a notable public health crisis, prompting considerable interest and scrutiny from governmental and scholarly entities. Substantial research efforts have been dedicated to exploring diverse facets of this novel coronavirus, encompassing its pathogenesis, transmission dynamics, and therapeutic interventions. Recent findings suggest that circular RNAs (circRNAs) exert a pivotal influence on modulating viral infectivity and immune defense mechanisms.

A cross-tissue transcriptome-wide association study identifies new susceptibility genes for insomnia.

Despite a significant genetic component to insomnia (heritability: 22-25%), the genetic loci that modulate insomnia risk remain limited. We employed the Unified Test for Molecular Markers (UTMOST) for transcriptome-wide association studies (TWAS) across various tissues, integrating summary statistics from a Genome-Wide Association Study (GWAS) of 462,341 European participants with gene expression data from the Genotype-Tissue Expression (GTEx) project. Three validation methods (FUSION, FOCUS, and MAGMA) were used to confirm important genes.