Newly isolated bacterium and arbuscular mycorrhizal fungus effectively reduce the root cadmium concentration and increase the root biomass of Ophiopogon japonicus.

Soil cadmium (Cd) contamination is one of the major challenges in food production. This has led to above-maximum threshold accumulation of Cd in O. japonicus roots.

Metagenomic insights into efficiency and mechanism of antibiotic resistome reduction by electronic mediators-enhanced microbial electrochemical system.

Electronic mediators are an effective means of enhancing the efficiency of microbial electrochemical electron transfer; however, there are still gaps in understanding the strengthening mechanisms and the efficiency of removing antibiotic resistance genes (ARGs) and antibiotic-resistant bacteria (ARB). This study systematically elucidates the effects of various electron mediators on bioelectrochemical processes, electron transfer efficiency, and the underlying mechanisms that inhibit ARG propagation within sediment microbial fuel cell systems (SMFCs). The results indicate that the addition of electron mediators significantly increased the output voltage (33.

Microcosm experiments deciphered resistome coalescence, risks and source-sink relationship of antibiotic resistance in the soil irrigated with reclaimed water.

Reclaimed water is widely used in agriculture irrigation to alleviate water scarcity, whereas the dissemination of antibiotic resistance genes (ARGs) in the soil it introduces has attracted widespread attention. Currently, few studies have systematically elucidated the coalescence of the resistome originating from reclaimed water with the soil's native community. Also, the effects and mechanisms of irrigation on the dissemination of ARGs in soils have yet to be demonstrated.

Introducing internal allocation factors for assessing aggregate pesticide exposure across multiple pathways and routes.

In the health risk assessment of pesticides, methods for external exposure assessment have been well developed. However, quantifying the contribution of various exposure pathways or routes to internal dose remains challenging. This study introduced the internal allocation factor (IAF) for 319 pesticides to investigate the impact of different exposure pathways and routes on chemical distribution within the human body.

The inhibition of anammox system under Cu stress and mechanisms of biochar-mediated recovery.

Copper (Cu)-containing wastewater has proven difficult to effectively treat using the anammox process. In this study, the nitrogen removal efficiency (NRE), sludge characteristics, microbial community and recovery mechanisms of biochar-mediated anammox under Cu stress were elucidated. At a Custress of 5 mg/L, a 73.

Ionic liquid-modified magnetic covalent organic framework for the extraction of four pyrethroids in traditional Chinese herbs.

Efficient enrichment of analytes and purification of matrices are crucial for the highly sensitive detection and monitoring of pesticides in traditional Chinese herbs. This work prepared magnetic ionic liquid-controlled covalent organic framework (IL-COF@FeO) as the sorbent via a simple in-situ precipitation polymerization and thiolene "click" strategy. The IL-COF@FeO exhibited remarkable adsorption performance towards pyrethroids within 5 min.

TRIM29 reverses lenvatinib resistance in liver cancer cells by ubiquitinating and degrading YBX1 to inhibit the PI3K/AKT pathway.

Sorafenib and lenvatinib are frontline treatments for advanced hepatocellular carcinoma (HCC). While lenvatinib surpasses sorafenib in efficacy and tolerability, resistance remains a significant clinical challenge. Recent research highlights the potential of TRIM family proteins in modulating lenvatinib resistance in HCC, necessitating a deeper understanding of their specific mechanisms.

Nomogram vs. Depth of invasion for predicting occult lymph node metastasis in cT1-2N0 buccal squamous cell carcinoma.

Objective: To develop a nomogram prediction model for occult lymph node metastasis (LNM) in patients with cT1-2N0 buccal squamous cell carcinoma (BSCC), then to compare its predictive efficacy against depth of invasion (DOI).

Methods: Clinical data were retrieved for patients undergoing primary tumor resection and neck dissection from June 2020 to August 2024. Based on the risk factors screened by Lasso regression, we established four candidate models: logistic regression, random forest, support vector machine, and XGboost.

Low folate biomarker concentrations are associated with increase the risk and severity of periodontitis in adults: A cross-sectional study based on the National Health and Nutrition Examination Survey 2009-2014.

We sought to test the hypothesis that adult folate biomarker concentrations are negatively associated with the risk and severity of periodontitis. Data were pooled from the National Health and Nutrition Examination Survey (NHANES) 2009 to 2014. A total of 9252 dentate adult subjects aged 30 years and older who received a periodontal examination and had complete folate biomarker data were included in the analysis.

A randomized controlled trial of an intervention for unmet supportive care needs addressing colorectal cancer couples.

Purpose: Supported by the Supportive Care Needs Framework (SCNF), we developed a colorectal cancer (CRC) couple-based unmet supportive care needs (USCNs) intervention program, which has been proven to be feasible. The intention was to assess what the clinical efficacy of this intervention would be in CRC couples.

Methods: One hundred and sixty-eight CRC couples were randomly assigned to one of two groups: a control group (receiving normal care) or an intervention group (receiving normal care plus a five-week USCNs intervention).

Comprehensive comparison on different wavelength selection methods using several near-infrared spectral datasets with different dimensionalities.

NIR spectroscopy is widely used in chemical analysis, agricultural science, food safety, and other fields, but its high dimensionality and data redundancy bring analytical challenges. This study aims to compare the performance of different wavelength selection methods in NIR spectral datasets with different dimensionalities to provide a reference for researchers. The wavelength selection methods in this study were classified into four categories according to their principles, which are partial least squares (PLS) parameter-based methods, intelligent optimization algorithms (IOA)-based methods, model population analysis (MPA)-based methods and wavelength interval selection (WIS) methods.

Synthesis and characteristics of type 3 resistant waxy corn starch by removal of starch granule surface proteins and heat-moisture treatment.

The type 3 resistant waxy corn starch (RS3) was synthesized by removing starch granule surface proteins and subjecting it to heat-moisture treatment at -20°C, 4°C, and 25°C. Upon applying the dual modification, a significant reduction in particle size and in vitro digestion was observed, while the gelatinization enthalpy, relative crystallinity, and resistant starch content increased. Notably, RS3 treated at 4°C demonstrated the lowest digestion rate of 3.

Household energy transition and its crucial role in saving infant lives in developing countries.

This study estimates the impact of reducing household solid fuel dependence on the infant mortality rate (IMR) in developing countries, where traditional solid fuels such as firewood and coal are widely used. Utilizing panel data from 76 developing countries over the period 1990 to 2020, our findings indicate that IMR drops substantially as household reliance on solid fuels decreases. A 1% reduction in per capita solid fuel consumption is linked to an average 0.

Ingestion of melamine cleaning sponges-derived microplastic fibers affects the survival and reproduction of Daphnia magna.

The abrasion of melamine cleaning sponges release microplastic fibers (MPFs) into the environment, yet the potential risks remain unknown. Here, we evaluated the ingestion, elimination, and toxic effects of melamine MPFs on Daphnia magna through acute and chronic exposures. This new type of MPFs displayed different morphology (a combination of linear and branched fibers with a length ranging from 10 to 157 μm) from the widely-studied MPFs released from textiles (longer and thicker linear fibers but no branched fibers).

Multiple token rearrangement Transformer network with explicit superpixel constraint for segmentation of echocardiography.

Diagnostic cardiologists have considerable clinical demand for precise segmentation of echocardiography to diagnose cardiovascular disease. The paradox is that manual segmentation of echocardiography is a time-consuming and operator-dependent task. Computer-aided segmentation can reduce the workflow greatly.

Identifying risk factors and developing a nomogram for HFNC failure in patients with hypercapnic acute respiratory failure.

Background: Currently, there is a deficiency in nomograms specifically designed for predicting the failure of high-flow nasal cannula (HFNC) oxygen therapy in patients with hypercapnic acute respiratory failure (hypercapnic ARF). The aim of this retrospective study is to develop and evaluate a nomogram that assesses the risk of HFNC failure in this patient population.

Methods: Patients with ARF and hypercapnia (PaCO ≥ 45 mmHg in the initial arterial blood gas) who received HFNC in the intensive care unit (ICU) from January 1, 2020 to December 31, 2023 were enrolled in this study.

Transcriptome analysis of nitrate enhanced tobacco resistance to aphid infestation.

Tobacco is an economic crop that primarily relies on nitrate (NO) as its nitrogen source, and tobacco aphid is one of the significant pests that harm its growth. However, the impact of NO supply on the resistance of tobacco to aphids remains unclear. Present study investigated the effects of different NO concentrations supply on the reproductive capacity of tobacco aphids, impact of aphid infestation on tobacco growth, secondary metabolic and transcription changes.

Morphological, physiological and transcriptional analyses provide insights into the biosynthesis of phenolics in Juniperus rigida under UV-B treatment.

Phenolics play a crucial role in plant defense mechanisms against increased UV-B radiation. Due to their significant medicinal properties, the phenolic compounds produced by Juniperus rigida have great potential as valuable sources for medicine. However, the process of synthesizing J.

Electromagnetism and thermostability of CrCsynthesised with high-temperature and high-pressure quenching method.

The interactions between the carbon skeleton and the metal atoms of a binary transition metal carbide (BTMC) are particular interest for industrial applications with openning physics and chemitry questions, especially in magnetoelectric (ME) functional materials and cemented carbides. Chromium and carbon BTMCs are a series of intermetallic compounds with typical chemical formulas and sharepolycrystalline powder c somehromium special characteristics.and carbon as precursors, In this paper,and synthesized s we usedingle-phase bluk Cr7C3 (orthorhombic, with space group: Pnma) with high density and good crystallinity by means of high-temperature and high-pressure quenching method (HTHPQM).

An attenuated live strain of HY9901 mutant Δgr provides protection against Vibrio alginolyticus in pearl gentian grouper (♀Epinephelus fuscoguttatus × ♂Epinephelus lanceolatu).

Vibrio alginolyticus is a serious aquaculture bacterial pathogen, which is widely distributed in the ocean and rivers, and cause vibriosis in aquaculture. Therefore, it is imperative to develop effective vaccine to prevent vibriosis. In this study, the efficacy of gr deletion strain (Δgr) of V.

Association between ambient temperature and couple fecundity: Insights from a large-scale cohort study in Yunnan, China.

Background: Direct evidence linking ambient temperature to human fecundity is sparse. We aimed to evaluate the potential impact of ambient temperature on time to pregnancy (TTP) and identify the optimal temperature range for initiating conception attempts.

Methods: Our analysis included 576 927 couples from the Chinese National Free Preconception Health Examination Project (NFPHEP) in Yunnan Province, with a one-year follow-up post-enrollment.

Design, synthesis and structure-activity relationship of novel 1,2,4-triazolopyrimidin-5-one derivatives targeting GABA and Na1.2 with antiepileptic activity.

A novel class of 7-phenyl-[1,2,4]triazol-5(4H)-one derivatives was designed and synthesized, and their in vivo anticonvulsant activities were evaluated using subcutaneous pentylenetetrazole (Sc-PTZ) and maximal electroshock (MES) tests. Compounds 3u, 4f and 4k exhibited significant anticonvulsant activities in the Sc-PTZ model with ED values of 23.7, 17.

Exploiting synthetic lethality in PDAC with antibody drug conjugates and ATR inhibition.

Pancreatic ductal adenocarcinoma (PDAC) remains a highly lethal malignancy with poor prognosis. Antibody-drug conjugates (ADCs) and their combinations with various anti-tumor drugs have made great progress. Camptothecin, and its derivatives (Dxd, SN-38 or exatecan) targeted TOP1 are effective payloads due to their potent anti-tumor activity.

How far do we still need to go with antibiotics in aquatic environments? Antibiotic occurrence, chemical-free or chemical-limited strategies, key challenges, and future perspectives.

Global consumption and progressive migration of antibiotics through aquatic systems have contributed to their rapid spread, posing significant threats to environmental and human health, and antibiotics have been recognized as emerging pollutants. Hence, extensive approaches have been proposed for antibiotic treatment in water, yielding great achievements. This review systematically summarized current knowledge from contamination characteristics to treatment strategies.

The impact of bisphenol A on gill health: A focus on mitochondrial dysfunction induced disorders of energy metabolism and apoptosis in Meretrix petechialis.

Bisphenol A (BPA), a well-known chemical compound used in various daily goods, has been associated with adverse effects on animal metabolic processes. However, the specific impacts of BPA exposure on clam gills remain largely unexplored. To investigate the effects of BPA on energy metabolism and apoptosis in Meretrix petechialis gills, clams were exposed to varying concentrations of BPA (1, 10, and 100 μg/L) for 21 days.