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3,391,514 results match your criteria: "China; Research Institute of Microbiology[Affiliation]"
Eur J Cancer
March 2025
Mount Sinai Health System, New York, NY, USA. Electronic address:
Lung cancer screening implementation has led to expanded imaging of the chest in older, tobacco-exposed populations. Growing numbers of screening cases are also found to have CT-detectable emphysema or elevated levels of coronary calcium, indicating the presence of coronary artery disease. Early interventions based on these additional findings, especially with coronary calcium, are emerging and follow established protocols.
View Article and Find Full Text PDFVaccine
March 2025
Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China; Vaccine Research Center, School of Public Health, Peking University, Beijing 100191, China; Center for Infectious Diseases and Policy Research & Global Health and Infectious Diseases Group, Peking University, Beijing, 100191, China; Key Laboratory of Epidemiology of Major Diseases (Peking University), Ministry of Education, China; Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety, Beijing 100191, China. Electronic address:
Background: Compared to other vaccines recommended for the elderly, the effectiveness of health education in improving the willingness to vaccinate the herpes zoster vaccine (HZV) in low-come residents remains unclear.
Methods: We recruited elderly participants from villages in Lingcheng District, and assigned each village to one of three health education interventions: oral health education, brochure-based health education, or video health education. The follow-up surveys were conducted immediately after each intervention.
Hum Immunol
March 2025
Department of Rheumatology and Immunology, The Affiliated Hospital of Southwest Medical University, Luzhou, China; Stem Cell Immunity and Regeneration Key Laboratory of Luzhou, China. Electronic address:
Systemic lupus erythematosus (SLE) is an autoimmune disease with complex underlying mechanisms that have not been fully elucidated. Tumor necrosis factor-α induces protein 3 (TNFAIP3) has been identified as an SLE susceptibility gene. This study aimed to investigate the association between TNFAIP3 levels in peripheral blood mononuclear cells (PBMCs), TNFAIP3 single nucleotide polymorphisms (SNPs), and SLE genetic susceptibility.
View Article and Find Full Text PDFFood Chem
March 2025
Key Laboratory of Coarse Cereal Processing, Ministry of Agriculture and Rural Affairs, Sichuan Engineering & Technology Research Center of Coarse Cereal Industralization, School of Food and Biological Engineering, Chengdu University, Chengdu 610106, China; Chengdu Agricultural College, Chengdu, Sichuan 611130, China. Electronic address:
Since the 21st century, chronic diseases have become a worldwide health problem due to their high morbidity and mortality. Soybean bioactive substances, especially soybean peptides, are considered to have health benefits beyond nutritional effects. As the most studied peptide in soybean, lunasin has been proven to exert beneficial effects on various chronic disorders.
View Article and Find Full Text PDFFood Chem
March 2025
SKL of Marine Food Processing & Safety Control, National Engineering Research Center of Seafood, Collaborative Innovation Center of Seafood Deep Processing, School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, China. Electronic address:
Mitigating food spoilage from microbial infections remains a critical challenge in food preservation. Although Zn ions are used as chemical bactericides, their use alone often requires high doses. A novel nanomaterial, Zn@MNPs, combining photothermal properties with the controlled release of Zn, was synthesized through a coordination of Zn with melanin nanoparticles (MNPs) derived from cuttlefish ink.
View Article and Find Full Text PDFFood Chem
March 2025
Sericultural & Agri-Food Research Institute Guangdong Academy of Agricultural Sciences, Key Laboratory of Functional Foods, Ministry of Agriculture and Rural Affairs, Guangdong Key Laboratory of Agricultural Products Processing, Guangzhou 510610, PR China. Electronic address:
Brown rice is nutritious but with low acceptance due to its cooking inconvenience and poor taste. This study investigated the effect of cyclic trace enzymatic hydrolysis (CEH) on brown rice refining and compared it with other two treatments: cyclic trace water infiltration (CWI) and disposable enzymatic hydrolysis (DEH). As results, CEH increased the moisture content of brown rice with a relatively low crack rate.
View Article and Find Full Text PDFFood Chem
March 2025
Zhejiang-Malaysia Joint Research Laboratory for Agricultural Product Processing and Nutrition, College of Food Science and Engineering, Ningbo University, Ningbo 315832, China. Electronic address:
This study aims to evaluate the different processing methods, soaking-high-temperature pressure cooking (SHPC) and un-soaking-high-temperature pressure cooking (USHPC), on the quality of Basa (Pangasius bocourti) fish maw (BFM). Compared to traditionally cooked BFM, SHPC and USHPC treated BFM exhibited more severe disruption of collagen fibrils and network structure, significantly decreased texture, shear force and water holding capacity of BFM with the increase of HPC time, indicating that HPC could effectively reduce soaking time of BFM. Besides, as time HPC was 30 min, USHPC almost showed similar texture results to SHPC, and the former had the higher in vitro digestibility.
View Article and Find Full Text PDFFood Chem
March 2025
College of Food Science and Engineering/Collaborative Innovation Center for Modern Grain Circulation and Safety, Nanjing University of Finance and Economics, Nanjing 210046, China; Beth Israel Deaconess Medical Center/Harvard Medical School, Boston 02215, United States of America. Electronic address:
Moringa oleifera leaf-derived natural products offer diverse health benefits in metabolic disorders. However, the structural attributes of M. oleifera leaf polysaccharides, their transformations during gastrointestinal digestion, and their influence on gut microbiota and hypoglycemic activity remain insufficiently understood.
View Article and Find Full Text PDFBurns
January 2025
Department of Plastic Surgery, The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, Gansu 730030, China. Electronic address:
Virology
March 2025
China Institute of Veterinary Drug Control, Beijing, 100081, China. Electronic address:
The impact of Foot-and-Mouth Disease Virus (FMDV) on memory immune responses has not been thoroughly investigated due to limited availability of immunological research tools. Using single-cell RNA sequencing, we identified specific gene markers for the majority of T and B cell subsets in the spleens of mice. Our findings indicate that FMDV infection significantly reduces the proportions of memory cell populations (e.
View Article and Find Full Text PDFArch Oral Biol
March 2025
Department of Rehabilitation Medicine, The Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China; Department of Rehabilitation Medicine, Sijing Hospital of the Songjiang District of Shanghai, Shanghai 201600, China. Electronic address:
Objectives: This study aimed to establish a reproducible and minimally invasive rat model of temporomandibular joint osteoarthritis (TMJ-OA) using intra-articular monoiodoacetic acid (MIA) injection, and to investigate the pathological mechanisms underlying TMJ-OA development, aimed at providing insights for potential clinical treatments.
Design: We compared the effects of single versus multiple MIA injections on body weight, pain behaviour, and condylar pathology in female Sprague-Dawley rats. We longitudinally assessed the progression of TMJ-OA over 5 weeks by evaluating condylar pathology and immunohistochemical staining.
Colloids Surf B Biointerfaces
March 2025
Academy of Chinese Medicine Sciences, Henan University of Chinese Medicine, Zhengzhou 450046, China; Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-Yao, Zhengzhou, Henan Province 450046, China. Electronic address:
Triptolide (TP, an active ingredient from Tripterygium wilfordii) demonstrates significant efficacy in treating rheumatoid arthritis, but its low bioavailability and multi-organ toxicity limit its application. Herein, we developed a PEGylated retinoate self-assembled nanomicelles (FA-TP@VA NPs) modified with folic acid (FA) for inflammatory macrophage-targeted delivery of TP. FA-TP@VA NPs showed an appropriate size (192.
View Article and Find Full Text PDFColloids Surf B Biointerfaces
March 2025
Outpatient Department, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou 121000, China. Electronic address:
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by joint inflammation, pain, and progressive joint damage. Current treatments, while effective, are limited by their potential side effects, particularly in long-term use. This study introduces a novel nanoemulsion-based therapeutic approach combining rapamycin, an mTOR inhibitor, with SS31, a mitochondrial-targeting antioxidant peptide.
View Article and Find Full Text PDFEpilepsy Behav
March 2025
Department of Neurology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
Objective: Electroencephalography (EEG) microstate analysis is widely used in the study of various neurological and psychiatric disorders. We aim to assess whether EEG microstates are altered in TLE patients with and without cognitive decline.
Methods: This study included a total of 47 temporal lobe epilepsy (TLE) patients with or without cognitive decline and 14 healthy controls (HCs).
Ecotoxicol Environ Saf
March 2025
School of Public Health, Hangzhou Medical College, Hangzhou, Zhejiang 310013, China; Huzhou Key Laboratory of Precise Prevention and Control of Major Chronic Diseases, School of Medicine, and the First Affiliated Hospital, Huzhou University, Huzhou, Zhejiang 313000, China. Electronic address:
Hexavalent chromium [Cr(VI)] exposure poses substantial environmental and health risks, especially in occupational settings, where it has been linked to genomic instability. Our previous research demonstrated that Cr(VI) exposure could induce DNA copy number (CN) variation. Here, we examined the role of Ubiquitin A-52 ribosomal protein fusion product 1 (UBA52) in stabilizing rDNA CN under Cr(VI) exposure by analyzing data from Cr(VI)-exposed workers and matched controls.
View Article and Find Full Text PDFEcotoxicol Environ Saf
March 2025
Shandong Academy of Agricultural Sciences, State Key Laboratory of Nutrient Use and Management, North Industrial Road 202, Jinan 250100, China. Electronic address:
In saline alkaline soils, microplastics inevitably form a combined stress with NaCl to limit crop growth, but the molecular mechanisms of their toxic effects remain vague and inadequate. We analyzed the molecular mechanisms underlying the response of maize seedlings to single or combined stresses of MPs and NaCl by means of combined metabolomic and transcriptomic analyses. MPs and NaCl single or combined stresses reduced plant fresh weight by 36.
View Article and Find Full Text PDFEcotoxicol Environ Saf
March 2025
School of Public Health, the Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Guizhou Medical University, Guiyang 561113, PR China; College of Life Science and Oceanography, Shenzhen University, Shenzhen 518060, PR China. Electronic address:
Arsenic (As) is an environmental toxicant and human carcinogen, long-term exposure to As can lead to varying degrees of liver injury. In this study, the liver injury model of As poisoned Sprague-Dawley (SD) rats was established, and the potential mechanism was investigated by metabonomics and ionomics. A total of 164 differential expressed metabolites (DEMs) were identified between the As poisoned group and the control group, which mainly involved in nicotinate and nicotinamide metabolism, steroid hormone biosynthesis, taurine and hypotaurine metabolism, and porphyrin metabolism.
View Article and Find Full Text PDFEcotoxicol Environ Saf
March 2025
State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, Institute of Plant Protection and Microbiology, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China. Electronic address:
Pomacea canaliculata is one of the most destructive threats to the safe production of rice. Molluscicides are the primary measure for controlling this pest species. Tea saponin (TS) is a plant secondary metabolite with a high snail-killing activity.
View Article and Find Full Text PDFUltrason Sonochem
March 2025
School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China; Guangdong Technology Research Center for Advanced Chinese Medicine, Guangzhou 510006, China. Electronic address:
Amomum villosum Lour. (A. villosum) is widely utilized in culinary and medicinal contexts due to its rich diversity of bioactive compounds.
View Article and Find Full Text PDFUltrason Sonochem
March 2025
School of Food Science and Technology, National Engineering Research Center of Seafood, Dalian Polytechnic University, Dalian 116034 Liaoning, China; Engineering Research Center of Seafood of Ministry of Education of China, Dalian 116034 Liaoning, China; Collaborative Innovation Center of Seafood Deep Processing, Dalian Polytechnic University, Dalian 116034 Liaoning, China; SKL of Marine Food Processing & Safety Control, Dalian Polytechnic University, Dalian 116034, China. Electronic address:
Curing is a technological process that improves the tenderness, water retention, and overall quality of canned food. This study aimed to evaluate the effects of different exogenous additives, specifically sodium tripolyphosphate and lysine, on the quality of chicken breast meat in canned assorted vegetables and diced chicken using different curing methods: static curing, ultrasonic curing, vacuum tumbling curing, and ultrasonic combined with vacuum tumbling curing. The texture, moisture mobility and distribution, microstructure, and sensory acceptability of the chicken meat were evaluated.
View Article and Find Full Text PDFPlacenta
March 2025
Department of Obstetrics and Gynecology, Tangdu Hospital, Air Force Medical University, Xi'an, Shaanxi Province, China. Electronic address:
Introduction: Fetal growth restriction (FGR) is a common pregnancy complication with significant impact on obstetric and birth outcomes. Increasing evidence shows that the inhibition of placental mechanistic target of rapamycin (mTOR) signaling is closely related to FGR. However, the pathogenesis of FGR is not fully consistent presently, which is subject to the methodological divergence.
View Article and Find Full Text PDFJ Reprod Immunol
March 2025
Animal Science and Technology College, Beijing University of Agriculture, Beijing, China; Veterinary Science (Traditional Chinese Medicine)-Municipal Laboratory of Beijing, Beijing University of Agriculture, Beijing, China. Electronic address:
Bovine endometritis can lead to abnormal endometrial function and fibrosis, resulting in difficulties in successful embryo implantation and intrauterine adhesions. Melatonin is well known for its profitable effects against inflammation and pathological fibrosis in discrepant organs. Considering the potential therapeutic benefits of melatonin, this study aimed to investigate its effects on endometrial fibrosis in cows with endometritis.
View Article and Find Full Text PDFBioorg Chem
March 2025
School of Pharmacy, Fudan University; 826 Zhangheng Road, Pudong Zone, Shanghai 201203, China.
Selective inhibition of Class I HDACs has emerged as a promising approach for cancer therapy. Building on our previous work with Largazole (a member of the natural depsipeptide family), we have applied a similar fluorination modification to Romidepsin and synthesized its fluoro analog (12) in 12 steps. This analog exhibits potent inhibitory activity against Class I HDACs but shows no inhibitory effect on HDAC6, confirming its selectivity as a Class I HDAC inhibitor (IC50 HDAC1 0.
View Article and Find Full Text PDFBioorg Chem
March 2025
Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. Electronic address:
IMB5046, a microtubule inhibitor discovered by our team, served as the lead compound for designing a series of selenium-containing benzoates and benzamides. Among these, compound 2g emerged as a lead candidate, demonstrating potent antiproliferative activity. Mechanistic studies revealed that 2g bound to the colchicine site of tubulin, caused G2/M cell cycle arrest, and generated ROS.
View Article and Find Full Text PDFWater Res
March 2025
School of Engineering, Hangzhou Normal University, Hangzhou 311121, PR China. Electronic address:
The response mechanism of microorganisms in partial denitrification (PD) system under antibiotic stress, particularly microbial energy metabolism and electron transfer, remain inadequately understood. This knowledge gap hinders the establishment of ecological links between microbial dynamics and macro-level reactor performance. To address this, moving bed biofilm reactors were employed to investigate the dynamic changes of microbial community and metabolism under sulfadiazine (SDZ) and ciprofloxacin (CIP) stress.
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