Theoretical model and experimental verification of seepage-transition-spontaneous imbibition in water migration of water-injected coal.

Coal seam water injection is widely applied to prevent mine disasters. In the traditional water migration model of water-injected coal, from ignoring capillary force in the seepage stage to generating the capillary dynamic during the spontaneous imbibition state, no transition state exists from 0 to generating capillary force. In this paper, on the basis of theoretical analysis, an equivalent capillary term is introduced to modify the Forchheimer model, and then a seepage-transition-spontaneous imbibition model that is suitable for water migration of water-injected coal is proposed.

Lysophosphatidylcholine promoting α-Synuclein aggregation in Parkinson's disease: disrupting GCase glycosylation and lysosomal α-Synuclein degradation.

In Parkinson's Disease (PD), elevated serum lysophosphatidylcholine (LPC) levels correlate with disease progression. However, the mechanisms by which abnormal LPC elevation contributes to PD-related neurotoxicity remain poorly understood. This study aims to investigate the pathogenic role of LPC in dopaminergic neuronal damage and elucidates its underlying mechanisms.

Development and usability of the "Cognitive Evergreenland" app to engage individuals at high risk of dementia in lifestyle interventions.

Multidomain lifestyle interventions can improve cognitive function and mobile health technologies can deliver cost-effective interventions. We developed the smartphone app, Cognitive Evergreenland, to promote cognitive health in people at high risk of dementia, and assessed its usability. Functional modules were selected using a behaviour change wheel (BCW) theory-based method.

Emerging trends in SERS-based veterinary drug detection: multifunctional substrates and intelligent data approaches.

Veterinary drug residues in poultry and livestock products present persistent challenges to food safety, necessitating precise and efficient detection methods. Surface-enhanced Raman scattering (SERS) has been identified as a powerful tool for veterinary drug residue analysis due to its high sensitivity and specificity. However, the development of reliable SERS substrates and the interpretation of complex spectral data remain significant obstacles.

Chromosome-level genome assembly of a critically endangered species Leuciscus chuanchicus.

Leuciscus chuanchicus, a critically endangered cyprinid endemic in the Yellow River, represents an evolutionary significant lineage within Leuciscinae. However, conservation efforts for this species have been hindered by the lack of genetic and genomic resources. Here we reported a high-quality chromosome-level genome of L.

Super-multiplexed imaging and coding in the range of radio frequency.

The era of the Internet has led to an information explosion, creating significant challenges for current techniques in information storage and access. High-performance strategies that expand existing methods offer a promising solution. Imaging-based approaches are vital for information perception but remain underexplored for information processing due to limited multiplexity.

Ecological restoration in the Yellow River Basin enhances hydropower potential.

Hydropower, an important renewable energy source worldwide, is threatened by reservoir sedimentation. Ecological restoration (ER) can mitigate this by reducing upstream sediment, thereby extending hydropower facilities' lifespan. However, ER may also reduce runoff, potentially diminishing energy generation and complicating its overall impact on hydropower potential.

Machine learning-based prediction models for renal impairment in Chinese adults with hyperuricaemia: risk factor analysis.

In hyperuricaemic populations, multiple factors may contribute to impaired renal function. This study aimed to establish a machine learning-based model to identify characteristic factors related to renal impairment in hyperuricaemic patients, determine dose‒response relationships, and facilitate early intervention strategies. Data were collected through the big data platform of Nanjing Hospital of Traditional Chinese Medicine, encompassing 2,705 patients with hyperuricaemia (1,577 with renal impairment, 828 without) from June 2019 to June 2022.

A greening Earth has reversed the trend of decreasing carbonate weathering under a warming climate.

The response of mineral weathering and its related Weathering Sink for atmospheric CO (WS) to global vegetation greening are not well understood. After applying different biogeochemical models and a field experiment to investigate the influence of vegetation greening and warming on the variations of carbonate weathering and WS on regional and global scales, here we show a significant positive relationship between global carbonate weathering intensity ([HCO] as a proxy) and vegetation greenness. During 1982-2018, under a warming climate, [HCO] and WS increase by 5.

METTL3-mA-mediated TGF-β signaling promotes Fuchs endothelial corneal dystrophy via regulating corneal endothelial-to-mesenchymal transition.

Fuchs endothelial corneal dystrophy (FECD) is the leading cause of vision-threatening corneal endothelial dystrophy without pharmacologic treatments. Corneal endothelial-mesenchymal transition (cEndMT), a specific cellular phenotypic transition, is implicated in the vicious cycle in FECD pathogenesis. Here, we investigated the reversible epigenetic regulation of N-methyladenosine (mA) during cEndMT process and FECD progression.

VM-UNet++ research on crack image segmentation based on improved VM-UNet.

Cracks are common defects in physical structures, and if not detected and addressed in a timely manner, they can pose a severe threat to the overall safety of the structure. In recent years, with advancements in deep learning, particularly the widespread use of Convolutional Neural Networks (CNNs) and Transformers, significant breakthroughs have been made in the field of crack detection. However, CNNs still face limitations in capturing global information due to their local receptive fields when processing images.

General synthesis of covalent organic frameworks under ambient condition within minutes via microplasma electrochemistry approach.

Covalent organic frameworks (COFs) are typically synthesized using solvothermal conditions with high temperature and long reaction time (≥120 °C, >72 h). Herein, we report a general and rapid microplasma electrochemistry strategy to synthesize COFs under ambient conditions. A series of flexible imine-bond COFs with high-crystallinity were prepared in minutes via this method, which showed 1000-fold higher space-time yield than solvothermal method.

Thyroid function and multiple sclerosis: a two-sample mendelian randomization study and mediation analysis.

Multiple sclerosis (MS) is a prevalent neurological disorder with a complex etiology, often associated with thyroid function. However, the causal relationship between these two conditions remains poorly understood. This study aimed to elucidate the causal relationship between thyroid function and MS using a bidirectional Mendelian randomization (MR) approach and to investigate the potential mediating role of immune cells.

Site-specific synergy in heterogeneous single atoms for efficient oxygen evolution.

Heterogeneous single-atom systems demonstrate potential to break performance limitations of single-atom catalysts through synergy interactions. The synergy in heterogeneous single atoms strongly dependes on their anchoring sites. Herein, we reveal the site-specific synergy in heterogeneous single atoms for oxygen evolution.

Reducing the road freight emissions through integrated strategy in the port cities.

Port cities, as crucial nodes in global supply chains, face challenges from both intense traffic emissions and vulnerability to climate-related extremes due to pollution density. Effective and near-term mitigation strategies for greener road freight are imperative to reverse the increasing trend of emissions. This study utilizes a high-resolution emission inventory from 1.

Lentinan suppresses the progression of neuroblastoma by inhibiting FOS-mediated transcription activation of VRK1 to stabilize p53 protein.

Neuroblastoma (NB) is a common malignant and solid pediatric tumor with unfavorable prognosis. Although studies have shown the anti-tumor efficacy of lentinan (LNT), molecular mechanism that contribute to the anti-tumor effect on NB remains unclear. The aim of this study is to unmask the anti-tumor role of LNT in NB and the specific molecular mechanism.

Pd-catalyzed deuteration of aryl halides with deuterium oxide.

Late-stage deuteration of aryl halides with deuterium oxide is a highly desirable but challenging transformation, primarily due to the difficulty of activating inert carbon-halogen bonds and the umpolung of deuterium oxide in the presence of various functional groups. To achieve this transformation, efforts have been made to develop photo-chemical, electro-chemical, or mechano-chemical strategies. However, these approaches often require specialized setups or activated substrates.

Genetic deletion of G protein-coupled receptor 56 aggravates traumatic brain injury through the microglial CCL3/4/5 upregulation targeted to CCR5.

Traumatic brain injury (TBI) is a significant global health concern that often results in death or disability, and effective pharmacological treatments are lacking. G protein-coupled receptor 56 (GPR56), a potential drug target, is crucial for neuronal and glial cell function and therefore plays important roles in various neurological diseases. Here, we investigated the potential role and mechanism of GPR56 in TBI-related damage to gain new insights into the pharmacological treatment of TBI.

Aggregation induced emission luminogen bacteria hybrid bionic robot for multimodal phototheranostics and immunotherapy.

Multimodal phototheranostics utilizing single molecules offer a "one-and-done" approach, presenting a convenient and effective strategy for cancer therapy. However, therapies based on conventional photosensitizers often suffer from limitations such as a single photosensitizing mechanism, restricted tumor penetration and retention, and the requirement for multiple irradiations, which significantly constrain their application. In this report, we present an aggregation-induced emission luminogen (AIEgen) bacteria hybrid bionic robot to address above issues.

DTIAM: a unified framework for predicting drug-target interactions, binding affinities and drug mechanisms.

Accurate and robust prediction of drug-target interactions (DTIs) plays a vital role in drug discovery but remains challenging due to limited labeled data, cold start problems, and insufficient understanding of mechanisms of action (MoA). Distinguishing activation and inhibition mechanisms is particularly critical in clinical applications. Here, we propose DTIAM, a unified framework for predicting interactions, binding affinities, and activation/inhibition mechanisms between drugs and targets.

Asymmetric reductive arylation and alkenylation to access S-chirogenic sulfinamides.

The study of the stereochemistry of organic sulfur compounds has been ongoing for over a century, with S-chirogenic pharmacophores playing an essential role in drug discovery within bioscience and medicinal chemistry. Traditionally, the synthesis of sulfinamides featuring stereogenic sulfur(IV) centers involves a complex, multistep process that often depends on chiral auxiliaries or kinetic resolution. Here, we introduce an effective and versatile method for synthesizing diverse classes of S-chirogenic sulfinamides through selective aryl and alkenyl addition to sulfinylamines.

Reprogramming aerobic metabolism mitigates Streptococcus pyogenes tissue damage in a mouse necrotizing skin infection model.

Disease tolerance is a host response to infection that limits collateral damage to host tissues while having a neutral effect on pathogen fitness. Previously, we found that the pathogenic lactic acid bacterium Streptococcus pyogenes manipulates disease tolerance using its aerobic mixed-acid fermentation pathway via the enzyme pyruvate dehydrogenase, but the microbe-derived molecules that mediate communication with the host's disease tolerance pathways remain elusive. Here we show in a murine model that aerobic mixed-acid fermentation inhibits the accumulation of inflammatory cells including neutrophils and macrophages, reduces the immunosuppressive cytokine interleukin-10, and delays bacterial clearance and wound healing.

Photothermal direct methane conversion to formaldehyde at the gas-solid interface under ambient pressure.

Photocatalytic direct oxidation of methane to C oxygenates offers a green alternative to conventional energy-intensive and high-carbon-footprint multi-step processes. However, current batch-type gas-liquid-solid reaction systems under high-pressure conditions face critical challenges in real-time product separation and concentration for industrial implementation. Here, we demonstrate a continuous-flow gas-solid photothermal catalytic route for methane conversion to formaldehyde under ambient pressure, where the generated gas-phase formaldehyde can be easily collected by water absorption.

Potential locations for non-invasive brain stimulation in treating ADHD: Results from a cross-dataset validation of functional connectivity analysis.

Noninvasive brain stimulation (NIBS) has emerged as a promising therapeutic approach for attention-deficit/hyperactivity disorder (ADHD), yet the inaccurate selection of stimulation sites may constrain its efficacy. This study aimed to identify novel NIBS targets for ADHD by integrating meta-analytic findings with cross-dataset validation of functional connectivity patterns. A meta-analysis including 124 functional magnetic resonance imaging (fMRI) studies was first conducted to delineate critical brain regions associated with ADHD, which were defined as regions of interest (ROIs).