Traceability of septic shock caused by phocaeicola vulgatus: a rare case report.

Background: Phocaeicola vulgatus (P.vulgatus) is a member of Bacteroides fragilis Group(BFG). Septic shock caused by P.

Stationary screen time, blood lipids, and atherosclerotic cardiovascular disease incidence.

Background And Aims: The associations between screen time exposure, blood lipids, and Atherosclerotic Cardiovascular Disease (ASCVD) incidence have been less studied. We aimed to examine the associations of exposure to screen time with blood total cholesterol (TC), HDL-C, LDL-C, triglycerides (TG), apolipoprotein A1 (ApoA1), apolipoprotein B (ApoB), and ASCVD risk score, and risk of subsequent ASCVD incidence.

Methods And Results: A nationwide sample of 7124 China Health and Nutrition Survey 2009 participants were followed up to 2015 for ASCVD incidence.

The impact of preoperative maintaining antithrombotic therapy in patients undergoing non-coronary endovascular interventions.

Background: Antithrombotic medications, including antiplatelet and anticoagulant therapies, are widely used to prevent thromboembolic events in patients with cardiovascular diseases. It is common for patients on antithrombotic medications to undergo endovascular interventions though potential complications remain unclear. This study investigated the impact of continuing antithrombotic medications before endovascular interventions on perioperative clinical outcomes, particularly intraoperative blood transfusion.

Proteomics-driven discovery of LCAT as a novel biomarker for liver metastasis in colorectal cancer.

Background: This study aimed to identify molecular markers that influence liver metastasis in colorectal cancer (CRC) and assess their clinical relevance.

Methods: Proteomic analysis compared differential protein expression between CRC patients with liver metastasis (CRLM) and those without (CRNLM). Bioinformatics and survival analyses identified key proteins and validated them using the TCGA database for expression and clinical significance.

Integrative analysis of transcriptome and metabolome reveal molecular mechanism of tolerance to salt stress in rice.

Background: Salt stress is considered to be one of the major abiotic stresses influencing rice growth and productivity. To improve rice crop productivity in saline soils, it is essential to choose a suitable variety for mitigating salt stress and gain a deep understanding of the underlying mechanisms. The current study explored the salt tolerance mechanism of wild rice 'HD96-1 (salt resistive)' and conventional rice 'IR29 (salt sensitive)' by evaluating morph-physiological, transcriptomic, and metabolomic approaches.

A global analysis of the burden of ischemic heart disease attributable to diet low in ω-3 fatty acids between 1990 and 2021.

Aim: Ischemic heart disease (IHD) is a major contributor to global mortality and disability, imposing a significant health and economic burden on patients and society. Despite existing treatment options including medications and surgeries, their effectiveness remains limited, with issues such as suboptimal treatment outcomes and high recurrence rates. This study aims to investigate the relationship between low dietary intake of ω-3 fatty acids and the burden of IHD, hoping to provide new insights into the prevention and treatment of IHD.

Comparison of remimazolam tosylate and propofol in hemodynamic stability, postoperative cognitive function, and recovery in general anesthesia combined with regional nerve blocks: a retrospective cohort study.

Background: General anesthesia (GA) combined with regional anesthesia (RA) is commonly used to enhance perioperative analgesia and hemodynamic stability. This study aimed to compare the hemodynamic effects and postoperative cognitive function between remimazolam tosylate and propofol in patients undergoing GA combined with RA.

Methods: A retrospective cohort study was conducted on 4408 patients who underwent elective upper or lower limb surgeries at our institution from January 2020 to June 2024.

Endoscopic treatment for gastroesophageal varices in patients with cirrhosis: a survey comparing between developed and developing countries.

Background: In this survey, we compared endoscopists' approach to treatment of gastroesophageal varices (GOV) in patients with cirrhosis between developed and developing countries. The objective of this study was to undertake a comparative analysis of the approaches employed by endoscopists in developed and developing countries with regard to the treatment of GOV in patients with cirrhosis.

Methods: Between Jan 2019 to Aug 2019, we administered a questionnaire-based online survey internationally via e-mail.

Lung Cancer Biomarker Database (LCBD): a comprehensive and curated repository of lung cancer biomarkers.

Background: Lung cancer remains a leading cause of cancer-related mortality, primarily because of the lack of effective diagnostic and therapeutic biomarkers. To address the issue of fragmented biomarker data across numerous publications, we have developed the Lung Cancer Biomarker Database (LCBD, http://lcbd.biomarkerdb.

Genome-wide exploration and characterization of the RALFs and analysis of its role in peanut (Arachis hypogaea L.).

Background: Rapid alkalinization factors (RALFs) are small peptides hormones that regulate plant growth and stress responses. Although RALFs have been identified in a broad range of land plant species, their roles in peanuts (Arachis hypogaea L.) remain largely unexplored.

Influences of gestational diabetes mellitus on the changes in the vaginal microbiota from antepartum to postpartum.

Background: No consensus has yet been reached concerning whether there were significant differences in the vaginal microbiota according to maternal gestational diabetes mellitus (GDM) status. This study aimed to compare the vaginal microbiota of women with GDM and normal blood glucose before and after delivery and to prospectively evaluate the influence of GDM on the dynamic changes of vaginal microbiota from antepartum to postpartum.

Methods: This study included 20 GDM patients and 31 average pregnant women who gave birth at the Shenzhen Baoan Women's and Children's Hospital.

Comprehensive Brain-wide Mapping of Afferent and Efferent Nuclei Associated with the Heart in the Mouse.

Normal heart function depends on complex regulation by the brain, and abnormalities in the brain‒heart axis affect various diseases, such as myocardial infarction and anxiety disorders. However, systematic tracking of the brain regions associated with the input and output of the heart is lacking. In this study, we injected retrograde transsynaptic pseudorabies virus (PRV) and anterograde transsynaptic herpes simplex virus (HSV) into the left ventricular wall of mice to identify the whole-brain regions associated with the input to and output from the heart.

On the Specific Status of Rhinogobius zhoui (Gobiiformes, Gobiidae) with mtDNA Characterization.

Rhinogobius zhoui is found only in streams on Lianhua Mountain, Guangdong Province, China. Juveniles of Rhinogobius zhoui bred in an artificial environment do not undergo a planktonic period and have a landlocked life history. At present, there is not much published literature regarding this species.

In vitro and in vivo assessment of diosmetin-loaded lactoferrin-modified liposomes for brain delivery in intracerebral hemorrhage therapy.

Intracerebral hemorrhage (ICH) is a serious cerebrovascular disease with high morbidity, mortality, and disability rates, largely due to neuroinflammation. Diosmetin, a natural flavonoid, has known neuroprotective effects in cerebral ischemia/reperfusion models but has been less studied in ICH. Our previous study developed diosmetin-loaded lactoferrin-modified long-circulating liposomes (Lf-Dios-Lcl), which penetrate the BBB and improve diosmetin bioavailability and brain distribution.

Inflammatory cytokines and oral cancer risk: an integrated study combining two-sample Mendelian randomization with experimental validation.

Objective: This study aimed to investigate the causal relationship between inflammatory cytokines and oral cavity cancer risk using Mendelian randomization analysis and experimental validation.

Methods: Two-sample Mendelian randomization was conducted using summary-level genome-wide association study data on 41 inflammatory cytokines and oral cavity cancer risk in Europeans. Single nucleotide polymorphisms associated with cytokines (p < 5 × 10-6) and oral cancer were selected as instrumental variables, excluding those in linkage disequilibrium.

The assembly of a Malus sieversii regulatory network reveals gene resistance against Alternaria alternata f. sp. mali when colonized by Trichoderma biofertilizer.

Trichoderma spp., as excellent biocontrol agents, can induce systemic resistance to protect plants from phytopathogen attacks. In a previous study, Trichoderma biofertilizer activated the MsERF105 transcription factor (TF), which further enhanced the resistance of Malus sieversii against Alternaria alternata f.

CBX3 promotes multidrug resistance by suppressing ferroptosis in colorectal carcinoma via the CUL3/NRF2/GPX2 axis.

Chemoresistance poses a significant challenge in colorectal cancer (CRC) treatment. However, the mechanisms underlying chemoresistance remain unclear. CBX3 promoted proliferation and metastasis in CRC.

The comparative efficacy of L-glutamine, celecoxib, and glucosamine sulfate in osteoarthritis management.

To explore the therapeutic efficacy of L-glutamine (L-Gln) on pathological progression and clinical symptoms of osteoarthritis (OA), and compare with glucosamine sulfate (GS), and celecoxib (CXB). Rats were administered sodium chloride, L-Gln, GS, or CXB via gavage for eight weeks starting from the fifth week after sham operation or Anterior Cruciate Ligament Transection (ACLT) + Medial Meniscectomy (MMx). Then the severity of knee OA in rats was evaluated by serological analysis, histological examination and imaging examination.

Soil quality changes in the Horqin sandy area under different ecological restoration patterns.

Ecological restoration is crucial for combatting desertification and mitigating grassland degradation. The assessment of changes in soil quality under different restoration patterns is beneficial for optimizing the development and implementation of local ecological restoration strategies. In this study, five typical restoration patterns of sample plots-plant regenerative sand-barrier land (S2), shrub planted afforested land (S3), aerially seeded afforested land (S4), artificially restored grassland (S5), fenced shrubland (S6), and a control plot (S1)-were selected as research objects in the Horqin sandy area.

Identification and validation of a major QTL, QFhb-6AL, for Fusarium head blight resistance on chromosome 6AL in wheat.

A novel major QTL, QFhb-6AL, accounting for 34.6% phenotypic variation for FHB resistance, was identified in the Chinese cultivar Xunong 029, and a near-diagnostic marker was developed for marker-assisted selection. Fusarium head blight (FHB) is a destructive disease in wheat (Triticum aestivum L.

Few-shot traffic classification based on autoencoder and deep graph convolutional networks.

Traffic classification is a crucial technique in network management that aims to identify and manage data packets to optimize network efficiency, ensure quality of service, enhance network security, and implement policy management. As graph convolutional networks (GCNs) take into account not only the features of the data itself, but also the relationships among sets of data during classification. Many researchers have proposed their own traffic classification methods based on GCN in recent years.

Hierarchical multi step Gray Wolf optimization algorithm for energy systems optimization.

Gray Wolf Optimization (GWO), inspired by the social hierarchy and cooperative hunting behavior of gray wolves, is a widely used metaheuristic algorithm for solving complex optimization problems in various domains, including engineering design, image processing, and machine learning. However, standard GWO can suffer from premature convergence and sensitivity to parameter settings. To address these limitations, this paper introduces the Hierarchical Multi-Step Gray Wolf Optimization (HMS-GWO) algorithm.

Structural basis of thymidine-rich DNA recognition by Drosophila P75 PWWP domain.

Drosophila P75 (dP75), a homolog of the human LEDGF/p75, is crucial for oogenesis by recruiting the histone kinase Jil-1 to euchromatin and impeding H3K9me2 spreading. Like LEDGF, dP75 binds transcriptionally active chromatin, but its precise mechanism remains unclear. Here we show that its PWWP domain prefers binding to thymidine-rich DNA over GC-rich sequences.

MLC2: Physiological Functions and Potential Roles in Tumorigenesis.

The myosin regulatory light chain 2 (MLC2) is a crucial regulator of myosin activity. Its phosphorylation, mediated by various kinases, plays a vital role in maintaining normal physiological functions in skeletal muscle, myocardium, smooth muscle, and nonmuscle cells. Moreover, MLC2 has been implicated in the development of many cancers through its phosphorylation.

Effect of Mn content on the corrosion behavior and biocompatibility of biodegradable Zn-Mn alloys.

Zinc-based alloys have attracted increasing attention as biodegradable metals by virtue of their excellent mechanical, degradable and biocompatible properties. By introducing different levels of manganese (0.1, 0.