Colonoscopic administration of probiotics to treat irritable bowel syndrome with predominant diarrhea: a randomized placebo-controlled clinical trial.

Background: To investigate the effects of colonoscopic administration of probiotics on patients with irritable bowel syndrome with predominant diarrhea (IBS-D) by a single-center, randomized-controlled trial.

Methods: Consecutive outpatients at the First Affiliated Hospital of Fujian Medical University who met the Rome IV diagnostic criteria for IBS-D (n = 22) and healthy subjects (n = 10) from January 2017 to January 2018 were enrolled. IBS-D patients were randomly divided into either the probiotics or the placebo group.

Liver resection in stage 0-A HCC in segments 7/8: a propensity-matched analysis comparing open, laparoscopic, and robotic approach.

Background: Both laparoscopic hepatectomy (LH) and robotic hepatectomy (RH) have been performed for tumors in nearly all liver segments. However, few studies have compared the outcomes of patients who underwent open hepatectomy (OH), LH and RH for the treatment of Barcelona Clinic Liver Cancer (BCLC) stage 0-A HCC in S7/8.

Methods: The clinical data of patients who underwent S7/8 resection for the treatment of BCLC stage 0-A HCC in the First Affiliated Hospital of Guangxi Medical University from July 2017 to July 2023 were retrospectively collected.

Approaches for estimating the unsaturated hydraulic conductivity of compacted quartz sand via particle packing theory.

The unsaturated hydraulic conductivity (K) is one of the most important properties for evaluating moisture and gas migration in soil. However, the precise measurement of K in the laboratory often requires considerable time and economic costs. Currently, the most commonly used method to calculate K is to obtain it from the soil-water characteristic curve (SWCC) and saturated hydraulic conductivity.

The association of gut microbiota, immunocyte dynamics, and protein-protein ratios with tuberculosis susceptibility: a Mendelian randomization analysis.

This study focused on the relationships among gut microbiota, plasma protein ratios, and tuberculosis. Given the unclear causal relationship between gut microbiota and tuberculosis and the scarcity of research on relevant plasma protein ratios in tuberculosis, Mendelian randomization analysis (MR) was employed for in-depth exploration. By analyzing the GWAS data of individuals with European ancestry (the FinnGen dataset included 409,568 controls and 2613 cases), using the two-sample MR method, we focused on evaluating the impact of immunocyte-mediated gut microbiota on tuberculosis and the associations between 2821 plasma protein-to-protein ratios and tuberculosis.

The longitudinal association between multiple cardiometabolic diseases, socioeconomic status, and depressive symptoms in China.

The aim of this study is to investigate the effect of cardiometabolic diseases (CMDs) on the development of depressive symptoms and to determine whether socioeconomic status (SES) moderates this effect. A total of 6,455 individual free from depressive symptoms were selected from the China Health and Retirement Longitudinal Study (CHARLS). CMDs and SES were self-reported.

Risk effects of environmental factors on human brucellosis in Aksu Prefecture, Xinjiang, China, 2014-2023.

The context of rapid global environmental change underscores the pressing necessity to investigate the environmental factors and high-risk areas that contribute to the occurrence of brucellosis. In this study, a maximum entropy (MaxEnt) model was employed to analyze the factors influencing brucellosis in the Aksu Prefecture from 2014 to 2023. A distributed lag nonlinear model (DLNM) was employed to investigate the lagged effect of meteorological factors on the occurrence of brucellosis.

Correlation analysis between epicardial adipose tissue and acute coronary syndrome.

To investigate the correlation between the density and volume of epicardial adipose tissue(EAT)and acute coronary syndrome (ACS). This study included 355 subjects (mean age: 60.65 ± 9.

Evaluation of contralateral arterial flow compensation using transcranial Doppler in acute internal carotid artery occlusion and implications for neurological outcome.

Acute internal carotid artery occlusion (AICAO) can result in malignant cerebral edema and unfavorable patient outcomes. This study evaluated the utility of transcranial Doppler (TCD) in assessing contralateral flow compensation and predicting outcomes in patients with AICAO. We enrolled 51 patients within 6 h of symptom onset and conducted TCD examinations to evaluate collateral circulation.

Analysis of geological characteristics and potential factors of formation damage in coalbed methane reservoir in Northern Qinshui basin.

Given the suboptimal physical properties and distinctive geological conditions of deep coalbed methane reservoirs, any reservoir damage that occurs becomes irreversible. Consequently, the protection of these deep coalbed methane reservoirs is of paramount importance. This study employs experimental techniques such as scanning electron microscopy, X-ray diffraction, and micro-CT imaging to conduct a comprehensive analysis of the pore structure, mineral composition, fluid characteristics, and wettability of coal seams 3# and 15# in the northern Qinshui Basin of China.

Clinical significance of PCT, CRP, IL-6, NLR, and TyG Index in early diagnosis and severity assessment of acute pancreatitis: A retrospective analysis.

To evaluate the clinical utility of PCT, CRP, IL-6, NLR, and TyG index in improving the early diagnosis and severity assessment of acute pancreatitis (AP). This retrospective study included 137 AP patients and 30 healthy controls from Hunan Provincial People's Hospital (January 2021-September 2023). Univariate and multivariate logistic regression analyses assessed the associations between biomarkers and severe acute pancreatitis (SAP).

Trends, global comparisons, and projections of early onset colorectal cancer burden in China based on GBD study 2021.

This study aimed to analyze the trends of early-onset colorectal cancer (EOCRC) among individuals aged 15 to 49 in China from 1990 to 2021 and compare them with global patterns using data from the Global Burden of Disease (GBD) study. The analysis focused on age-standardized incidence rates (ASIR), prevalence rates (ASPR), mortality rates (ASMR), and disability-adjusted life years (DALYs). Joinpoint regression was used to determine the average annual percentage change (AAPC), and the ARIMA model was employed to forecast trends from 2022 to 2050.

Lymphocyte-C-reactive protein ratio upon admission to predict disease progression and ICU admission in adult patients with diabetic ketoacidosis.

This study aimed to investigate whether lymphocyte-C-reactive protein ratio (LCR) upon admission can predict disease progression and intensive care unit (ICU) admission in adult patients with diabetic ketoacidosis (DKA). A single-center retrospective study was conducted, including adult DKA patients admitted to the First Affiliated Hospital of Harbin Medical University between March 2018 and March 2023. Multiple demographic and clinical data were collected from the medical records upon admission and during hospitalization.

A Markov decision optimization of medical service resources for two-class patient queues in emergency departments via particle swarm optimization algorithm.

In the modern healthcare system, the rational allocation of emergency department (ED) resources is crucial for enhancing emergency response efficiency, ensuring patient safety, and improving the quality of medical services. This paper focuses on the issue of ED resource allocation and designs a priority sorting system for ED patients. The system classifies patients into two queues: urgent and routine.

LINC00626 drives tamoxifen resistance in breast cancer cells by interaction with UPF1.

Although tamoxifen is commonly utilized as adjuvant therapy for Estrogen Receptor alpha (ERα)-positive breast cancer patients, approximately 30-50% of individuals treated with tamoxifen experience relapse. Therefore, it is essential to investigate additional factors besides ERα that influence the estrogen response. In this study, cross-analysis of databases were performed, and the results revealed a significant association between LINC00626 and ERα signaling as well as increased expression levels of this gene in tamoxifen-resistant cells.

A noninvasive hyperkalemia monitoring system for dialysis patients based on a 1D-CNN model and single-lead ECG from wearable devices.

This study aimed to develop a real-time, noninvasive hyperkalemia monitoring system for dialysis patients with chronic kidney disease. Hyperkalemia, common in dialysis patients, can lead to life-threatening arrhythmias or sudden death if untreated. Therefore, real-time monitoring of hyperkalemia in this population is crucial.

TOPSIS prefabricated building construction evaluation based on interval-valued Pythagorean fuzzy numbers based on prospect theory.

Prefabricated buildings have a series of advantages such as high efficiency, energy savings, and environmental protection, and are being strongly promoted by the Chinese government. However, due to the late start of prefabricated buildings in China, the installation process of prefabricated components is relatively complex, leading to difficulties in quality and safety control. A novel evaluation methodology integrating the technique for order preference by similarity to ideal solution (TOPSIS) with prospect theory and interval-valued Pythagorean fuzzy numbers (IVPFNs) is proposed.

Contributing factors to postoperative surgical site infections in pituitary neuroendocrine tumors undergoing endonasal transsphenoidal resection.

Pituitary Neuroendocrine Tumors (PitNETs), often treated via endonasal transsphenoidal resection, present a risk for postoperative surgical site infections (SSIs), including intracranial infections such as meningitis. Identifying the risk factors associated with these infections is crucial for improving surgical outcomes and patient care. A retrospective study was conducted at a medical center from June 2020 to June 2023.

Correlation between neutrophil percentage-to-albumin ratio and all-cause and cerebrovascular mortality among hypertension patients.

Neutrophil percentage-to-albumin ratio (NPAR) is a novel inflammatory biomarker and correlated with the progression and clinical outcomes of many diseases. This investigation aimed to clarified the association between NPAR and mortality risk among hypertension patients. The database of the National Health and Nutrition Examination Survey provided the patient data for hypertension.

Optical semantic communication through multimode fiber: from symbol transmission to sentiment analysis.

We propose and validate a novel optical semantic transmission scheme using multimode fiber (MMF). By leveraging the frequency sensitivity of intermodal dispersion in MMFs, we achieve high-dimensional semantic encoding and decoding in the frequency domain. Our system maps symbols to 128 distinct frequencies spaced at 600 kHz intervals, demonstrating a seven-fold increase in capacity compared to conventional communication encoding.

Assessment of environmental impacts of heavy metal pollution in rice in Nanning, China.

Nowadays rice has become one of the world's staple foods. Rice in southern China is also a staple food for everyone, however, with the development of China's industrialization model, many industrial areas may be contaminated by heavy metals, leading to contamination of the agricultural areas. With the development of recent years, Nanning has become a heavily industrial development area, and rice is also a favourite staple food.

3D numerical modeling of the deformation and failure mechanisms of batter pile groups subjected to fault ruptures.

Fault ruptures induced by earthquakes pose a significant threat to constructions, particularly underground structures such as pile foundations. Among various foundation types, batter pile foundations are widely used due to their ability to resist inclined forces. To gain new insights into the response of batter pile groups to fault ruptures caused by earthquakes, this study investigates the deformation and failure mechanisms of batter pile groups due to the propagation of normal and reverse fault ruptures using 3D numerical modeling.

VCP downstream metabolite glycerol-3-phosphate (G3P) inhibits CD8T cells function in the HCC microenvironment.

CD8T cells within the tumor microenvironment (TME) are often functionally impaired, which limits their ability to mount effective anti-tumor responses. However, the molecular mechanisms behind this dysfunction remain incompletely understood. Here, we identified valosin-containing protein (VCP) as a key regulator of CD8T cells suppression in hepatocellular carcinoma (HCC).

Identification of molecular characteristics in polycystic ovary syndrome using single-cell and transcriptome analysis.

Polycystic Ovary Syndrome (PCOS) is a complex endocrine disorder affecting women of childbearing age, and we aimed to reveal its underlying molecular mechanisms. Gene expression profiles from GSE138518 and GSE155489, and single-cell RNA sequencing (scRNA-seq) data from PRJNA600740 were collected and subjected to bioinformatics analysis to identify the complex molecular mechanisms of PCOS. The expression of genes was detected by RT-qPCR.

[Guiding significance of intra-articular sagittal reduction in the treatment of tibial plateau fractures].

Tibial plateau fracture is a fracture involving the proximal articular surface of the tibia, and its injury mechanism is complex, the fracture morphology is different, and it is often accompanied by different degrees of soft tissue injury, which is difficult to diagnose and treat. In recent years, the research hotspot has focused on solving the reduction and fixation of the posterior lateral column of the tibial plateau, because it has been clinically found that the residual sagittal plane after tibial plateau fracture is insufficient reduction or loss of reduction leads to knee joint dysfunction. The posterior inclination angle of the tibial plateau is an important parameter to describe the sagittal alignment of the tibia.

[Zero-incision treatment of supracondylar humeral fractures in extremely unstable Gartland type Ⅳ children by percutaneous prying combined with modified rotary reduction with Kirschner wire].

Objective: To investigate the clinical efficacy of percutaneous prying combined with modified rotary reduction with needle in the treatment of supracondylar fracture of humerus in Gartland type Ⅳ children, and to evaluate the postoperative elbow joint function, the incidence of elbow varus deformity and the application prospect of this technique.

Methods: A total of 98 children diagnosed with Gartland type Ⅳ supracondylar humeral fractures between June 2020 and January 2023 were included in this study, comprising of 57 males and 41 females. The age ranged from 2 to 14 years old with an average of (6.