Interconnected Lamellar 3D Semiconductive PCP for Rechargeable Aqueous Zinc Battery Cathodes.

2D electronically conductive porous coordination polymers/metal-organic frameworks (2D EC-MOFs) of M-HHTPs (HHTP = 2,3,6,7,10,11-hexahydroxytriphenylene; M = Co, Ni, Cu, etc.) have received extensive attention due to their ease of preparation, semiconductive properties, and tunability based on the choice of metal species. However, slight shifts between layers attenuate their specific surface area and stability.

Superior Active and Durable Air Electrode for Protonic Ceramic Cells by Metal-Oxide Bond Engineering.

Protonic ceramic cells (PCCs) have been identified as promising energy conversion devices, offering flexible fuel options and reduced operating consumption at intermediate temperatures. However, the application of traditional cobalt-based perovskite air electrodes in PCCs is hindered by their insufficient durability and high coefficient of thermal expansion. In this study, a straightforward metal-oxygen bond engineering is conducted, introducing a single-phase perovskite, BaLa(FeZn)NO (BLFZN0.

A Novel Missense Mutation of the ABL1 Gene in a Child With Congenital Heart Defects and Skeletal Malformations Syndrome.

Congenital heart defects and skeletal malformations syndrome (CHDSKM) is a rare autosomal dominant genetic disorder characterized by specific clinical features, including dysmorphic facial traits, congenital heart defects, skeletal abnormalities, joint issues, and failure to thrive. The novelty of this case lies in the identification of a novel mutation in the ABL1 gene, expanding the genetic spectrum associated with this syndrome. A 5.

Unraveling the Microenvironment and the Pathogenic Axis of HIF-1α-Visfatin-Fibrosis in Autoimmune Pancreatitis Using a Single-Cell Atlas.

Autoimmune pancreatitis (AIP) is identified as a severe chronic immune-related disorder in pancreas, including two subtypes. In this study, pancreatic lesions in patients diagnosed as either type 1 AIP or type 2 AIP are examined, and these patients' peripheral blood at single-cell level. Furthermore, flow cytometry, immunofluorescence, and functional assays are performed to verify the identified cell subtypes.

Structural insights into substrate transport and drug inhibition of the human vesicular monoamine transporter 2 (VMAT2).

Vesicular monoamine transporter 2 (VMAT2) is a proton-monoamine antiporter that is widely expressed in central and peripheral neurons and plays a crucial role in loading monoamine neurotransmitters into secretory vesicles. Dysfunction of VMAT2 causes many neuropsychiatric disorders, such as depression and Parkinson's disease. Consequently, VMAT2 is a valid and important therapeutic target.

Interventions for Compassion Fatigue, Burnout, and Secondary Traumatic Stress in Nurses: A Systematic Review and Network Meta-Analysis.

This study uses network meta-analysis to evaluate the relative effectiveness of different interventions (behavioral, psychological, and comprehensive) in alleviating compassion fatigue, burnout, and secondary traumatic stress, as well as in improving compassion satisfaction among nurses, aiming to provide evidence-based insights for enhancing nurses' mental health and care quality. Compassion fatigue in nurses negatively affects their mental health, patient care quality, and healthcare efficiency. Various interventions (psychological, behavioral, and integrated) target this issue, but evidence on their effectiveness is inconclusive.

The role and mechanism of hepatocyte nuclear factor 1β in the occurrence and development of different human tumors: A pan-cancer analysis.

Carcinomatosis is one of the leading threats to human public fitness. HNF1B is a critical transcription element in vertebrate proliferation and oncogenesis, which has been shown to play roles in reactive oxygen species (ROS) metabolism. Our previous results have identified HNF1B as a tumor suppressor that could inhibit the malignant progression of prostate cancer.

Microneedles at the Forefront of Next Generation Theranostics.

Theranostics, combining therapeutic and diagnostic functions, marks a revolutionary advancement in modern medicine, with microneedle technology at its forefront. This review explores the substantial developments and multifaceted applications of microneedles, which have evolved from basic transdermal drug delivery devices to sophisticated diagnostic and therapeutic platforms. Microneedles enhance access to biomarkers via interstitial fluid, enabling real-time monitoring of physiological conditions, such as glucose and hormone levels, thus facilitating continuous health tracking.

Microneedle Array-Based Dermal Interstitial Fluid Biopsy for Cancer Diagnosis: Advances and Challenges.

Current early cancer diagnostic technologies, such as imaging, molecular tests, endoscopic techniques, and biopsies, face considerable challenges in low-and middle-income countries (LMICs) due to high costs, procedural complexity, and limited resource access. Microneedle-based liquid biopsy for skin interstitial fluid (ISF) offers a practical and minimally invasive alternative for cancer diagnosis in these settings. This review systematically examines ISF liquid biopsy methods for their effectiveness in capturing cancer biomarkers directly from the skin and assesses their potential to address diagnostic needs in low-resource environments.

Overcoming Energy Storage-Loss Trade-Offs in Polymer Dielectrics Through the Synergistic Tuning of Electronic Effects in π-Conjugated Polystyrenes.

Achieving high-performance dielectric materials remains a significant challenge due to the inherent trade-offs between high energy storage density and low energy loss. A central difficulty lies in identifying a suitable dipolar unit that can enhance the polarity and dielectric constant of the material while effectively suppressing the high energy losses associated with polarization relaxation, charge injection, and conduction. To address this, a novel strategy is proposed that introduces electron-donating and electron-withdrawing substituents on the benzene ring of polystyrene-based polymers, creating bulky dipole groups that are resistant to reorientation under an electric field.

LncRNA TUG1 Repressed Angiogenesis by Promoting the Ubiquitination of HuR and Inhibiting Its Nuclear Translocation in Cerebral Ischemic Reperfusion Injury.

Unlabelled: Although both Taurine Upregulated Gene 1(TUG1) and Human Antigen R (HuR) play significant regulatory roles in Cerebral Ischemic Reperfusion Injury (CIRI), their potential pro-angiogenesis mechanisms in CIRI remain unclear.

Methods: Herein, the biological roles of TUG1 and HuR in angiogenesis are first confirmed. Following that, HuR-binding VEGFA mRNAs are identified via the Fluorescence In Situ Hybridization (FISH), RNA Immunoprecipitation (RIP), and Cross-Linking Immunoprecipitation (CLIP) assays.

Single-Cell Landscape of Bronchoalveolar Lavage Fluid Identifies Specific Neutrophils during Septic Immunosuppression.

Sepsis-induced immunosuppression is related to increased susceptibility to secondary infections and death. Lung is the most vulnerable target organ in sepsis, but the understanding of the pulmonary immunosuppression state is still limited. Here, single-cell RNA sequencing of bronchoalveolar lavage fluid (BALF) is performed to map the landscape of immune cells, revealing a neutrophil-driven immunosuppressive program in the lungs of patients with immunosuppressive sepsis.

Bioinspired Disordered Aerogel for Omnidirectional Terahertz Response.

The structural disorder of the black butterfly assists in capturing sunlight across a wider spectral and angular range, injecting infinite vitality for omnidirectional and stimuli-responsive wave-absorbing materials. Here, the disordered micro-pores responding to terahertz (THz) waves through electromagnetic simulations, and then prepared via ice templating technology are analyzed and optimized. The customized disordered aerogel makes possible perfect terahertz response property with incidence-angle-insensitive and ultra-broadband.

Spray-Assisted Fabrication of Cellulose Photonic Pigments on Superhydrophobic Surfaces.

Photonic pigments, especially those based on naturally-derived building blocks like cellulose nanocrystals (CNCs), are emerging as a promising sustainable alternative to absorption-based colorants. However, the proposed manufacturing methods for CNC pigments, via either grinding films or emulsion-based production, usually require several processing steps. This limits their commercialization by increasing the costs, timescales, and environmental impacts of production.

Practice of ABO antibody titration in a transplant center: From tube method to manual gel column testing to automated column agglutination technology.

Background And Objectives: High-quality ABO antibody titre testing is required for ABO-incompatible haematopoietic stem cell transplantation and kidney transplantation. To assess the feasibility of automated ABO titration as an alternative to manual and semi-automatic titration during the peri-transplant period, a comparative study was conducted internally in a transfusion medicine laboratory.

Materials And Methods: This study was performed in two stages.

Efficient Spin-Light-Emitting Diodes With Tunable Red to Near-Infrared Emission at Room Temperature.

Spin light-emitting diodes (spin-LEDs) are important for spin-based electronic circuits as they convert the carrier spin information to optical polarization. Recently, chiral-induced spin selectivity (CISS) has emerged as a new paradigm to enable spin-LED as it does not require any magnetic components and operates at room temperature. However, CISS-enabled spin-LED with tunable wavelengths ranging from red to near-infrared (NIR) has yet to be demonstrated.

DNA Polymerase IV dinB Favors the Adaptive Fitness of mcr-carrying Bacteria Through a Negative Feedback Regulatory Mechanism.

The plasmid-borne resistance gene mcr drastically undermines the effectiveness of colistin, posing a substantial threat to public health. Although several key plasmid elements that balance mcr-1 persistence and bacterial growth are identified, the regulatory interactions between mcr-1 and host bacteria remain poorly understood. Using a genome-wide CRISPRi crRNA library, it is identified that DNA polymerase IV, dinB, is essential for controlling the fitness cost associated with mcr-1 in Escherichia coli.

Dexmedetomidine Blocks NCOA4-Dependent Ferritinophagy to Confer Ferroptosis Resistance in Lung Ischemia Reperfusion Injury via Targeting NRF2.

Lung ischemia reperfusion injury (LIRI) represents an evitable but significant pathologic complication post pulmonary transplantation. Dexmedetomidine (Dex) that is extensively applied as an anesthetic adjuvant in the intensive care setting has increasingly presented outstandingly protective effect on LIRI. This article concerns the elaborate role of Dex in ferroptosis after LIRI and the correlative downstream mechanism.

CAV1 Exacerbates Renal Tubular Epithelial Cell Senescence by Suppressing CaMKK2/AMPK-Mediated Autophagy.

Renal proximal tubular epithelial cell (PTEC) senescence and defective autophagy contribute to kidney aging, but the mechanisms remain unclear. Caveolin-1 (CAV1), a crucial component of cell membrane caveolae, regulates autophagy and is associated with cellular senescence. However, its specific role in kidney aging is poorly understood.

Effects of Static and Low-Frequency Magnetic Fields on Gene Expression.

Substantial research over the past two decades has established that magnetic fields affect fundamental cellular processes, including gene expression. However, since biological cells and subcellular components exhibit diamagnetic behavior and are therefore subjected to very small magnetic forces that cannot directly compete with the viscoelastic and bioelectric intracellular forces responsible for cellular machinery functions, it becomes challenging to understand cell-magnetic field interactions and to reveal the mechanisms through which these interactions differentially influence gene expression in cells. The limited understanding of the molecular mechanisms underlying biomagnetic effects has hindered progress in developing effective therapeutic applications of magnetic fields.

Synergistic Entropy Engineering with Oxygen Vacancy: Modulating Microstructure for Extraordinary Thermosensitive Property in ReNbO Materials.

The pursuit of high precision and stability simultaneously in high-temperature thermistor fields is longstanding. However, most spinel or perovskite-structured thermosensitive materials struggle to tolerate prolonged high-temperature environments at the expense of sensitivity and stability. Here, a novel entropy engineering strategy involving vacancies is proposed to balance sensitivity and stability for fergusonite-structured ReNbO (Re is a rare earth element) material in extreme environments.

Ethyl 2,4-dioxovalerate triggers aggregation and tunneling preference of Formosan subterranean termites (Blattodea: Rhinotermitidae) and enhances the effectiveness of fipronil.

Our previous study shows that Coptotermes formosanus (Blattodea: Rhinotermitidae) preferred to stay on filter paper treated with ethyl 2,4-dioxovalerate, a metabolite in the soil fungus Trichoderma virens. Here, we hypothesized that adding ethyl 2,4-dioxovalerate in sand could trigger aggregation and tunneling preferences of C. formosanus and improve the effectiveness of liquid termiticide.

Exploration of Multidimensional Structural Optimization and Regulation Mechanisms: Catalysts and Reaction Environments in Electrochemical Ammonia Synthesis.

Ammonia (NH) is esteemed for its attributes as a carbon-neutral fuel and hydrogen storage material, due to its high energy density, abundant hydrogen content, and notably higher liquefaction temperature in comparison to hydrogen gas. The primary method for the synthetic generation of NH is the Haber-Bosch process, involving rigorous conditions and resulting in significant global energy consumption and carbon dioxide emissions. To tackle energy and environmental challenges, the exploration of innovative green and sustainable technologies for NH synthesis is imperative.

Hierarchical Self-Assembly of Short Peptides: Nanostructure Formation, Function Tailoring, and Applications.

This article explores the hierarchical self-assembly of short peptides, which refers to the structured spatial arrangements of these molecules over long distances. This phenomenon is commonly found in nature and has important implications for biological structure and function. Short peptides are preferred for self-assembly because they have the ability to spontaneously create various nanostructures.