Novel machine learning algorithm in risk prediction model for pan-cancer risk: application in a large prospective cohort.

Objective: To develop and validate machine-learning models that predict the risk of pan-cancer incidence using demographic, questionnaire and routine health check-up data in a large Asian population.

Methods And Analysis: This study is a prospective cohort study including 433 549 participants from the prospective MJ cohort including a male cohort (n=208 599) and a female cohort (n=224 950).

Results: During an 8-year median follow-up, 5143 cancers occurred in males and 4764 in females.

Circulating tumour cell clusters: isolation, biological significance and therapeutic implications.

Circulating tumour cells (CTCs) and CTC clusters are considered metastatic precursors due to their ability to seed distant metastasis. However, navigating the bloodstream presents a significant challenge for CTCs, as they must endure fluid shear forces and resist detachment-induced anoikis. Consequently, while a large number of cells from the primary tumour may enter the circulation, only a tiny fraction will result in metastasis.

Machine learning based on blood test biomarkers predicts fast progression in advanced NSCLC patients treated with immunotherapy.

Objective: Fast progression (FP) represents a desperate situation for advanced non-small cell lung cancer (NSCLC) patients undergoing immune checkpoint inhibitor therapy. We aimed to develop a predictive framework based on machine learning (ML) methods to identify FP in advanced NSCLC patients using blood test biomarkers.

Methods And Analysis: We extracted data of 1546 atezolizumab-treated patients from four multicentre clinical trials.

Hypoxia and hypotension following industrial-grade anhydrous ethanol ablation of the vein of Marshall in the treatment of atrial fibrillation: a case report.

This case presents a patient who experienced hypoxia and hypotension following the infusion of industrial-grade anhydrous ethanol into the vein of Marshall (VOM) during atrial fibrillation radiofrequency ablation. The hypotension lasted for at least three days, requiring dopamine support, while hypoxia persisted for over a week. The prolonged nature of these symptoms posed a diagnostic challenge.

The complete chloroplast genome and phylogenetic analysis of (Meisn.) Migo (Polygonaceae).

is a plant distributed at meadow or wetland. Our study reports the complete chloroplast genome. The chloroplast genome of is a typical tetrameric structure with a total length of 159,843 bp, containing a large single-copy (LSC) region of 84,350 bp, a small single-copy (SSC) region of 13,151 bp, and two inverted repeat regions (IRs) of 31,171 bp.

Corrigendum to "Hydrogen peroxide as a mitigation against sp. Bloom" [Aquaculture, Volume 577, 15 December 2023, 739932].

[This corrects the article DOI: 10.1016/j.aquaculture.

Can intelligent virtual assistants improve cognitive function in older adults? A two-wave mediation study.

Objectives: This study aims to investigate whether social networks and physical exercise mediate the relationship between new and constant use of intelligent virtual assistants (IVAs) and cognitive function in older adults in China and explore the potential differences across living arrangements and education levels.

Methods: This study utilized nationally representative longitudinal data from 2018 to 2020, including a sample of 8343 older adults aged 60-80. A path-analytic model was employed to examine the relationship between IVAs use and cognitive function, as well as the mediating roles of social networks and physical exercise.

Alterations of the Intestinal Mucosal Barrier and Gut Fungal Microbiome in Asymptomatic HIV-Infected Patients.

Damage to the intestinal mucosal barrier and dysbiosis of the gut microbiota are critical factors in HIV progression, reciprocally influencing each other. Besides bacteria, the fungal microbiota, a significant component of the gut, plays a pivotal role in this dysregulation. This study aims to investigate changes in the gut mucosal barrier and mycobiota during the initial stages of HIV infection, focusing on the involvement of intestinal fungi and their secretions in mucosal damage.

Asymmetric photoreactions catalyzed by chiral ketones.

Asymmetric catalytic reactions are essential for synthesizing chiral drugs and fine chemicals, with their stereoselectivity influenced significantly by interactions between catalysts and substrates. Ketone catalysts have garnered considerable attention in the realm of asymmetric photoreactions because of their highly controllable structures, ease of availability, and environmental friendliness. This review highlights the application of various reported ketone catalysts in a range of asymmetric photoreactions, including [2 + 2] photocycloaddition, photoderacemization, photochemical rearrangement, asymmetric electrophilic amination, and asymmetric alkylation of aldehydes.

Revolutionizing medical education: Surgery takes the lead in virtual reality research.

Objectives: Advancements in technology have spurred a transformative shift in medical education, with virtual reality (VR) emerging as a powerful tool for enhancing the learning experience. This study analyses the publications of VR in medical education, focusing on differences within different medical specialties.

Design: Using specific search terms, all studies published on VR in medical education listed in the Web of Science databases were included.

Network analysis of fatigue symptoms in Chinese patients with advanced cancer.

Objective: This study was aimed at investigating the network structures of fatigue symptoms in patients with advanced cancer, with a focus on identifying the central symptom-an aspect crucial for targeted and effective fatigue symptom management.

Methods: In this cross-sectional study, patients with advanced cancer were recruited from the cancer treatment center of a tertiary hospital in China between January and December of 2022. Symptom occurrence and severity were assessed with the Cancer Fatigue Scale.

Takeaway food consumption and depressive symptoms in Chinese university students: mediating effects of physical activity.

Background: The consumption of takeaways is becoming increasingly prevalent. Despite this, the relationship between takeaway food consumption and depressive symptoms in Chinese populations has not been clarified. Furthermore, the factors that mediate the association between takeaway frequency and depressive symptoms are unknown.

Network analysis of autism traits and problematic mobile phone use and their associations with depression among Chinese college students.

The current study employed network analysis to examine the relationship between symptoms from factor level about autism traits and problematic mobile phone use (PMPU) and to explore their associations with depression. We measured the above three variables in 949 college students in China with Autism Spectrum Quotient (AQ), Smartphone Addiction Scale (SAS), Center for Epidemiological Studies Depression Scale (CES-D). Central and bridge symptoms were pinpointed through the examination of centrality index.

Effects of internet-based cognitive behavioral therapy on anxiety and depressive symptoms among patients with cardiovascular and cerebrovascular diseases: a systematic review and meta-analysis.

Background: This study aimed to evaluate the effectiveness of Internet-based Cognitive Behavioral Therapy (ICBT) in reducing anxiety and depressive symptoms among patients with cardiovascular diseases (CVDs) and to explore how intervention characteristics, such as module number and program duration, influence treatment outcomes.

Methods: A systematic review and meta-analysis were conducted by searching eight databases, including PubMed, Embase, and Cochrane Library, for randomized controlled trials (RCTs) published up to December 2023. Studies involving adult CVD patients with anxiety or depressive symptoms who underwent ICBT interventions were included.

Establishment and validation a relapse prediction model for bipolar disorder.

Background: The recurrence rate of bipolar disorder (BD) is relatively high. Assessing the risk of relapse in patients with BD can assist in identifying populations at high risk for recurrence, and early feasible interventions can improve patient' prognoses. Therefore, it is important to establish and validate predictive models for relapse risk in patients with BD.

Enhanced computerized cognitive remediation therapy improved cognitive function, negative symptoms, and GDNF in male long-term inpatients with schizophrenia.

Objective: Negative and cognitive symptoms present significant challenges in patients with schizophrenia, and cognitive remediation is a promising approach to alleviate these symptoms. This study aimed to explore the efficacy of computerized cognitive remediation therapy (CCRT) on psychiatric symptoms, cognitive deficits, and serum levels of brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF) in patients with schizophrenia.

Materials And Methods: Forty male long-term institutionalized inpatients with schizophrenia were assigned to either a CCRT group (n = 20) or a control group (n = 20).

Molecular mechanism of aberrant decidualization in adenomyosis leading to reduced endometrial receptivity.

Patients with adenomyosis not only experience a decrease in quality of life as a result of dysmenorrhea and severe monthly flow but they are also rendered infertile. Pregnancy rates are still low among women with adenomyosis, even with assisted reproduction. According to the current study, endometrial receptivity is primarily responsible for the lower conception rate among patients with adenomyosis.

Citrate: a key signalling molecule and therapeutic target for bone remodeling disorder.

Bone remodeling is a continuous cyclic process that maintains and regulates bone structure and strength. The disturbance of bone remodeling leads to a series of bone metabolic diseases. Recent studies have shown that citrate, an intermediate metabolite of the tricarboxylic acid (TCA) cycle, plays an important role in bone remodeling.

The Rs724030 variant is associated with islet function and women waist-to-hip ratio in healthy subjects.

Objective: This study aims to investigate the associations between rs724030 A>G variant and prediabetes risk, along with their correlations with clinical features, including plasma glucose and serum insulin levels during oral glucose tolerance test (OGTT), islet function, insulin resistance, and plasma lipid levels. In particular, we investigated whether there are sex dimorphisms in the impact of this variant on islet function/insulin resistance.

Methods: We included 3415 glucose-tolerant healthy and 1744 prediabetes individuals based on OGTT.

Mendelian randomization studies of risk and protective factors for osteoporosis: a systematic review and meta-analysis.

Background: Mendelian randomization is believed to attenuate the biases inherent in observational studies, yet a meta-analysis of Mendelian randomization studies in osteoporosis has not been conducted thus far. This study aims to evaluate the connection between potential causal factors and the risk of osteoporosis by synthesizing evidence from Mendelian randomization studies.

Methods: The databases PubMed, Web of Science, and Embase were systematically searched for Mendelian randomization studies investigating factors influencing osteoporosis up to May 2024.

Development and evaluation of optimized PCR and indirect ELISA for the detection of in dairy cows.

Introduction: () is a Gram-negative opportunistic pathogen, whose increasing virulence and antibiotic resistance negatively impact dairy cow health and productivity, raising concerns in livestock health management. To mitigate this risk, rapid and reliable diagnostic methods for detection are essential. Currently, detection methods for are underdeveloped, prompting us to develop both pathogenic and serological detection methods, including an optimized PCR technique and an indirect enzyme-linked immunosorbent assay (I-ELISA).

Safety profile of EZH2 inhibitors for cancer: a systematic review and meta-analysis.

Objective: To evaluate the safety profiles of EZH2-targeted inhibitors in cancer treatment, focusing on treatment-related adverse events (TRAEs) across various clinical trials.

Methods: We conducted a systematic review and meta-analysis using data from clinical trials involving EZH2 inhibitors reported up to May 31, 2024. Databases searched included PubMed, Embase, CENTRAL (Cochrane Central Register of Controlled Trials), and ClinicalTrials.

Correlation of diabetes and adverse outcomes in hospitalized COVID-19 patients admitted to a tertiary hospital in China during a small-scale COVID-19 outbreak.

Background: The aim of this study was to investigate the impact of diabetes on mortality and adverse outcomes in COVID-19 patients and to analyse the associated risk factors.

Methods: This is a retrospective cohort study in 500 hospitalized patients with COVID-19 infection (214 with diabetes and 286 without diabetes) admitted to a tertiary hospital in China from December 2022 to February 2023. Demographic information, clinical characteristics and outcomes were collected.

A New Strain of Preponderant Amphitriploid Clone Juvenile With Integrated Genomes Partly From White Crucian Carp () Requires Low Dietary Protein.

This study was carried out to search for the protein requirement of a new strain of preponderant amphitriploid clone, which integrated genomes partly from white crucian carp (). Seven groups of fish (body weight: 9.73 ± 0.