Bibliometric Analysis of Neuroinflammation and Postoperative Cognitive Dysfunction.

Background: The occurrence and development of postoperative cognitive dysfunction (POCD) are closely linked to neuroinflammation. This bibliometric analysis aims to provide novel insights into the research trajectory, key research topics, and potential future development trends in the field of neuroinflammation-induced POCD.

Methods: The Web of Science Core Collection (WoSCC) database was searched to identify publications from 2012 to 2023 on neuroinflammation-induced POCD.

, a new species causing sooty spot of kiwifruit in China.

is a large cosmopolitan genus of plant pathogenic fungi that are commonly associated with leaf and fruit spots as well as blights on a wide range of plant hosts. is a member of this genus, causing sooty spot on kiwifruit worldwide. With the expansion of kiwifruit cultivation, the incidence of sooty spot has become severe in Fengxin County, Jiangxi Province, China.

Amino-Acid-Induced Circularly Polarized Luminescence of Octahedral Lanthanide Cage.

Chiral metal organic cage compounds with excellent circularly polarized luminescent performance have broad application prospects in many fields. Herein, two lanthanide complexes with luminescent properties in the form of racemic hexagonal octahedral cages were synthesized using a tri (β-diketone) ligand. Eu6(C21H6F15O6)8(H2O)6 exhibited red light emission with high quantum yields of 61%.

Recent developments in pillar[5]arene-based nanomaterials for cancer therapy.

Nanomaterials possess unique size characteristics, enabling them to cross tissue gaps, penetrate the blood-brain barrier and endothelial cells, and release drugs at the cellular level. Additionally, the surface of nanomaterials is readily functionalized, endowing them with good biocompatibility, low biotoxicity, and specific targeting. All these advantages render nanomaterials broad application prospects in tumor therapy.

Zebrafish as a Visible Neuroinflammation Model for Evaluating the Anti-Inflammation Effect of Curcumin-Loaded Ferritin Nanoparticles.

It is crucial to inhibit the neuroinflammation response as it is a prominent factor contributing to the pathogenesis of neurodegenerative disorders. However, the limited development of neuroinflammation models dramatically hinders the efficiency of nanomedicine discovery. In recent years, the optically transparent zebrafish model provided unique advantages for imaging of the whole body, allowing the progression of the disease to be visualized.

Inflammation alters the expression and activity of the mechanosensitive ion channels in periodontal ligament cells.

Background: Periodontal ligament cells (PDLCs) possess mechanotransduction capability, vital in orthodontic tooth movement (OTM) and maintaining periodontal homeostasis. The study aims to elucidate the expression profiles of mechanosensitive ion channel (MIC) families in PDLCs and how the inflammatory mediator alters their expression and function, advancing the understanding of the biological process of OTM.

Methods And Methods: Human PDLCs were cultured and exposed to TNF-α.

Proteomics: An In-Depth Review on Recent Technical Advances and Their Applications in Biomedicine.

Proteins hold pivotal importance since many diseases manifest changes in protein activity. Proteomics techniques provide a comprehensive exploration of protein structure, abundance, and function in biological samples, enabling the holistic characterization of overall changes in organisms. Nowadays, the breadth of emerging methodologies in proteomics is unprecedentedly vast, with constant optimization of technologies in sample processing, data collection, data analysis, and its scope of application is steadily transitioning from the bench to the clinic.

Calcium-magnesium synergy in reducing cadmium bioavailability and uptake in rice plants.

The synergistic application of calcium (Ca) and magnesium (Mg) was investigated to mitigate cadmium (Cd) uptake and translocation in rice grown in Cd-contaminated soil. A pot experiment was conducted using different Ca:Mg molar ratios (Ca1:Mg2, Ca2:Mg1, and Ca1:Mg1) to evaluate their effect on Cd uptake. The results showed that the Ca1:Mg1 treatment achieved the highest reduction in grain Cd content (54.

Unraveling the Differential Efficiency of Dorsal and Ventral Pathways in Visual Semantic Decoding.

Visual semantic decoding aims to extract perceived semantic information from the visual responses of the human brain and convert it into interpretable semantic labels. Although significant progress has been made in semantic decoding across individual visual cortices, studies on the semantic decoding of the ventral and dorsal cortical visual pathways remain limited. This study proposed a graph neural network (GNN)-based semantic decoding model on a natural scene dataset (NSD) to investigate the decoding differences between the dorsal and ventral pathways in process various parts of speech, including verbs, nouns, and adjectives.

Enhanced Osteoporosis Treatment via Nano Drug Coating Encapsulating GG.

Osteoporosis is the most common systemic skeletal disorder, particularly associated with aging and postmenopausal women. With the growing knowledge about the gut-bone axis, the therapeutic strategies for osteoporosis have been shifted toward regulating gut microbiota to promote positive bone metabolism. Although GG (LGG) is widely reported to positively regulate bone metabolism by restoring the dysbiotic microbiome, oral administration is associated with sensitivity to gastric fluid and low bioavailability.

Pacific Proving Grounds-Derived U and U: Potential Tracers for Western North Pacific Ocean Dynamics.

U and U are proven to be useful tracers to investigate upper-ocean hydrodynamics due to their source-specific isotopic ratios and conservative behaviors in the open ocean. However, their application in the Pacific Ocean has been limited by scarce observations and unclear source-term information. Here, we present our observations of U and U in the western North Pacific Subtropical Gyre (NPStG), showing the presence of a source of anthropogenic U featured by a low U/U ratio (∼1 × 10), which is an order of magnitude lower than the global fallout signature (∼2 × 10).

Pandemic or "Plandemic"?: The Mediating Role of Epistemic Justification Strategies in the Relationship Between COVID-19 Conspiracy Beliefs and COVID-19 Vaccine Conspiracy Beliefs.

Background: In today's post-truth times, where personal feelings and beliefs have become increasingly important, determining what is accurate knowledge has become an important skill. This is especially important during uncertainty crises (e.g.

LOGOWheat: deep learning-based prediction of regulatory effects for noncoding variants in wheats.

Identifying the regulatory effects of noncoding variants presents a significant challenge. Recently, the accumulation of epigenomic profiling data in wheat has provided an opportunity to model the functional impacts of these variants. In this study, we introduce Language of Genome for Wheat (LOGOWheat), a deep learning-based tool designed to predict the regulatory effects of noncoding variants in wheat.

Gengnianchun Against HO-Induced Oxidative Damage in KGN Cells via miR-548m/FOXO3 Signaling.

Gengnianchun (GNC) is a traditional remedy used for diminished ovarian reserve, but its underlying mechanisms remain unclear. This study aimed to explore these mechanisms in human granulosa-like cancer (KGN) cells pretreated with medicated rat serum (MRS) before HO exposure. MRS pretreatment significantly alleviated HO-induced cell damage, including improvements in cell viability, superoxide dismutase and GSH-Px activities, and Bcl-2 expression.

Costs of Influenza Illness and Acute Respiratory Infections by Household Income Level: Catastrophic Health Expenditures and Implications for Health Equity.

Background: Seasonal influenza illness and acute respiratory infections can impose a substantial economic burden in low- and middle-income countries (LMICs). We assessed the cost of influenza illness and acute respiratory infections across household income strata.

Methods: We conducted a secondary analysis of data from a prior systematic review of costs of influenza and other respiratory illnesses in LMICs and contacted authors to obtain data on cost of illness (COI) for laboratory-confirmed influenza-like illness and acute respiratory infection.

Miniscope Imaging of Nucleus Accumbens Neural Activity in Freely Behaving Rats: Virus Injection, Gradient Index Lens Implantation, Recording Strategies, and Analytical Methods.

In vivo calcium imaging in freely moving rats using miniscopes provides valuable information about the neural mechanisms of behavior in real time. A gradient index (GRIN) lens can be implanted in deep brain structures to relay activity from single neurons. While such procedures have been successful in mice, few reports provide detailed procedures for successful surgery and long-term imaging in rats, which are better suited for studying complex human behaviors.

Study on Highly Sensitive Capacitive Pressure Sensor Based on Silk Fibroin-Lignin Nanoparticles Hydrogel.

Silk fibroin (SF) hydrogel has been proven to have excellent applications in the field of pressure sensors, but its sensing performance still needs improvement. A flexible hydrogel prepared from natural macromolecular materials was developed, and lignin nanoparticles (LNPs) were introduced during the preparation of the SF hydrogel. When LNPs account for 3% of SF, the sensing unit of the SF-LNPs hydrogel exhibits high stress sensitivity (1.

AutoGP: An Intelligent Breeding Platform for Enhancing Maize Genomic Selection.

In the face of climate change and the growing global population, there is an urgent need to accelerate the development of high-yielding crop varieties. To this end, vast amounts of genotype-to-phenotype data have been collected, and many machine learning (ML) models have been developed to predict phenotype from a given genotype. However, the requirement for high densities of single-nucleotide polymorphisms (SNPs) and the labor-intensive collection of phenotypic data are hampering the use of these models to advance breeding.

Unequal Effects of the Lockdown on Mental Health in Shanghai: The Moderating and Mediating Role of Neighborhood Environment and Online Social Connections.

The COVID-19 pandemic profoundly impacted population mental health worldwide. Few studies examined how the neighborhood environment and online social connections might influence the social gradient in mental health during the pandemic lockdown. We aim to examine the moderating and mediating role of neighborhood environment and online social connections in the association between socioeconomic status (SES) and mental health outcomes.

Correlates Between Temporomandibular Disorder Symptom Severity, Psychological Distress, Well-Being, and Oral Health-Related Quality of Life: Insights From Chinese Young Adults.

Background: There is limited understanding of how temporomandibular disorder (TMD) symptoms, psychological distress, and well-being are related to each other and to OHRQoL in Chinese young adults.

Objectives: This study aimed to identify correlations between TMD symptom severity, psychological status, and OHRQoL while also examining factors associated with low OHRQoL.

Methods: Participants, recruited from a major university in the capital city, completed a survey that included demographics, the Chinese versions of the expanded five TMD symptoms (5Ts) screener, Depression, Anxiety, Stress Scales-21 (DASS-21), Ryff's Scales of Psychological Well-being-18 (SPWB-18), and Oral Health Impact Profile for TMDs (OHIP-TMD).

Cardiovascular Therapy Benefits of Novel Antidiabetic Drugs in Patients With Type 2 Diabetes Mellitus Complicated With Cardiovascular Disease: A Network Meta-Analysis.

Objective: Provide an evidence-based basis for the selection of cardiovascular benefit drugs in Type 2 diabetes mellitus (T2DM) patients with cardiovascular disease (CVD).

Methods: Conduct a comprehensive search of all relevant literature from PubMed, Embase, Web of Science, Cochrane Library, and Clinical Trials.gov from their establishment until December 13, 2023, and select randomized controlled trials (RCTs) that meet the pre-established inclusion and exclusion criteria.

Cellular Senescence Contributes to the Dysfunction of Tight Junctions in Submandibular Glands of Aging Mice.

The current mechanism by which aging reduces salivary secretion is unknown. This study investigates the mechanism of aging-related submandibular (SMG) dysfunction and evaluates the therapeutic potential of dental pulp stem cell-derived exosomes (DPSC-exos). We found that the stimulated salivary flow rate was significantly reduced in naturally aging and D-galactose-induced aging mice (D-gal mice) compared to control mice.

Effect of Inter-Generational Living Arrangement and Digital Exclusion on Unmet Healthcare Needs Among Older Adults: Findings From Two National Cohort Studies.

Aim: To analyse how refined living arrangements, in the context of digital access, affect elderly healthcare resource utilisation and satisfaction with healthcare needs.

Design: A prospective cohort study. The study reporting is conformed to the STROBE checklist.