Progress in research on organic photovoltaic acceptor materials.

In the past two decades, organic solar cells (OSCs) have begun to attract attention as the efficiency of inorganic solar cells gradually approaches the theoretical limit. In the early development stage of OSCs, p-type conjugated polymers and n-type fullerene derivatives were the most commonly used electron donors and acceptors. However, with further research, the shortcomings of fullerene materials have become increasingly apparent.

Correction: Three-dimensional TiNbO anchored on carbon nanofiber core-shell arrays as an anode for high-rate lithium ion storage.

[This corrects the article DOI: 10.1039/C9RA10485B.].

Shearinines U-Y, indole diterpenoids from an entomogenous fungus, sp.

Five new indole diterpenoids, shearinines U-Y (2-6), and the known compound 22,23-dehydro-shearinine A (1) were isolated from cultures of the entomogenous fungus sp. Their structures were elucidated primarily by NMR experiments. The absolute configurations of 2-6 were assigned by electronic circular dichroism calculations, respectively.

Effect of oxalic acid treatment on the oxidation efficiency of maize stover cellulose and controllable preparation of nanocellulose.

Corn stover was used as raw material, and purification, oxalic acid treatment, oxidation treatment, and ultrasonic treatment were performed to realize the preparation of corn stover nanocellulose with low energy consumption. The effects of oxalic acid concentration (1 wt%, 2 wt%, 3 wt%, 4 wt%, and 5 wt%) on the purity, morphology, crystalline structure and oxidation efficiency of corn stover cellulose during oxalic acid treatment were investigated. The controllable preparation of corn stover nanocellulose was achieved by changing the parameter conditions of ultrasonic treatment.

Metal-free photocatalyst with reduced graphene oxide-doped graphitic carbon nitride homojunctions for efficient antibacterial applications.

Bacterial infections are a major global health challenge, posing severe risks to human well-being. Although numerous strategies have been developed to combat bacterial pathogens, their practical application is often hindered by operational constraints. Photocatalytic materials have emerged as promising candidates for bacterial disinfection and food preservation due to their efficiency and sustainability.

Synergistic effect of scattered rare metals on Pt/CeO for propane oxidative dehydrogenation with CO.

The oxidative dehydrogenation of propane with CO (CO-ODP) is a green industrial process for producing propene. Cerium oxide-supported platinum-based (Pt/CeO) catalysts exhibit remarkable reactivity toward propane and CO due to the unique delicate balance of C-H and C[double bond, length as m-dash]O bond activation. However, the simultaneous activation and cleavage of C-H, C-C, and C-O bonds on Pt/CeO-based catalysts may substantially impede the selective activation of C-H bonds during the CO-ODP process.

Cu/CuO/NH-MIL-88B (Fe) heterojunction as the photocatalyst to remove hexavalent chromium heavy metal ions in water.

This work aimed at addressing the problem of hexavalent chromium pollution in the water environment, designing and preparing the Cu/CuO/NH-MIL-88B (Fe) heterojunction material with NH-MIL-88B (Fe) as the carrier, Cu/CuO was loaded on NH-MIL-88B (Fe) by light-assisted reduction. The loading of CuO effectively improves the visible light absorption capacity of the composite material. The SPR effect of Cu improves the separation and transfer of photogenerated carriers in the composite material.

iRGD-Targeted Biosynthetic Nanobubbles for Ultrasound Molecular Imaging of Osteosarcoma.

Purpose: Osteosarcoma is the most common primary malignant tumor of the bone. However, there is a lack of effective means for early diagnosis due to the heterogeneity of tumors and the complexity of tumor microenvironment. αvβ3 integrin, a crucial role in the growth and spread of tumors, is not only an effective biomarker for cancer angiogenesis, but also highly expressed in many tumor cells.

A Multifunctional MIL-101-NH(Fe) Nanoplatform for Synergistic Melanoma Therapy.

Background: Melanoma is an aggressive form of skin cancer, and single-modality treatments often fail to prevent tumor recurrence and metastasis. Combination therapy has emerged as an effective approach to improve treatment outcomes.

Methods: In this study, we developed a multifunctional nanoplatform, MIL@DOX@ICG, utilizing MIL-101-NH(Fe) as a carrier to co-deliver the chemotherapeutic agent doxorubicin (DOX) and the photosensitizer indocyanine green (ICG).

Development and Evaluation of Aloperine-Loaded Nanostructured Lipid Carriers for the Treatment of Pulmonary Arterial Hypertension.

Objective: This study focuses on the development and evaluation of nanostructured lipid carriers (NLCs) loaded with aloperine as a potential therapeutic approach for the treatment of pulmonary arterial hypertension.

Methods: The NLCs were designed to enhance the solubility, stability, and bioavailability of aloperine, a compound with vasodilatory and anti-inflammatory properties. Through a series of experiments including single-factor experimentation, transmission electron microscopy, high-performance liquid chromatography, in vivo pharmacokinetics, and tissue distribution studies, we assessed the physicochemical properties, drug release profiles, and in vitro and in vivo performance of this novel nanocarrier.

Enhancing Periodontal Ligament Regeneration via PDLSC Delivery Using Electrospun PCL/Collagen/Cellulose Acetate Scaffolds and Collagen Hydrogel Incorporated with Curcumin-Loaded ZIF-8 Nanoparticles.

Background: Regenerating periodontal ligament (PDL) tissue is a vital challenge in dentistry that aims to restore periodontal function and aesthetics. This study explores a tissue engineering strategy that combines polycaprolactone (PCL)/collagen/cellulose acetate electrospun scaffolds with collagen hydrogels to deliver curcumin-loaded ZIF-8 nanoparticles fand periodontal ligament stem cells (PDLSCs).

Methods: Scaffolds were fabricated via electrospinningand collagen hydrogels incorporated PDLSCs and curcumin-loaded ZIF-8 nanoparticles (CURZIF-8) were developed using cross-linking.

The Role of Thickening Agent Proportions in Optimizing Nanoemulsion Gel for Dermatophytosis Treatment.

Background: Adjusting thickening agent proportions in nanoemulsion gel (NG) balances its transdermal and topical delivery properties, making it more effective for dermatophytosis treatment.

Methods: Carbomer 940 and α-pinene were used as model thickening agent and antifungal, respectively. A series of α-pinene NGs (αNG1, αNG2, αNG3) containing 0.

Novel Nanozyme-Based Multicomponent in situ Hydrogels with Antibacterial, Hypoxia-Relieving and Proliferative Properties for Promoting Gastrostomy Tube Tract Maturation.

Purpose: Gastrostomy is the commonly used enteral feeding technology. The clinical risks caused by tube dislodgement and peristomal site infection are the common complications before complete tract maturation after gastrostomy. However, there is currently no relevant research to promote gastrostomy wound treatment and tract maturation.

The protective effect of zinc oxide nanoparticles on boar sperm during preservation at 17 °C.

More than 90% of spermatozoa of boars in pork producing countries is stored in liquid at 17 °C; however, the quality of these spermatozoa is affected by bacterial breeding and oxidative damage. This study analyzed sperm quality and sperm capacitation after storage to study the effects of the effects of ZnO nanoparticles (ZnO NPs) supplementation on seminal plasma (SP)-free sperm preservation. We investigated the effects of adding 20, 50, 100 and 200 μg/mL of ZnO NPs to a seminal free boar sperm diluent over a 7-day period at 17 °C to assess the changes in non-capacitated/capacitated sperm quality parameters, antioxidant capacity, ATP content and extent of protein tyrosine phosphorylation.

Structural characterization and phylogenetic analysis of the chloroplast genome of var. balansae (gagnep.) N. Jacobsen 1991.

is a popular ornamental aquatic plant for aquarists, although only six species are found in China. Destruction of the natural habitats of for human activities has led to a decline in its numbers. In this report, we sequenced and annotated the chloroplast genome for the first time.

Clinical Characteristics and Risk Factors for Multidrug-Resistant Complex Bacteremia in a Chinese Tertiary Hospital: A Decade Review (2013-2022).

Objective: This study aimed to analyze the antimicrobial resistance profiles, clinical characteristics and risk factors of bacteremia caused by complex (ECC) strains.

Methods: We retrospectively collected clinical data from patients diagnosed with ECC bacteremia between 2013 and 2022 in a tertiary hospital in Jiangsu. Subgroup analyses were performed based on multidrug resistance (MDR), nosocomial acquisition, polymicrobial bacteremia, and mortality.

Impact of Herpesvirus Detection via Metagenomic Next-Generation Sequencing in Patients with Lower Respiratory Tract Infections.

Purpose: This study aimed to investigate the impact of herpesvirus detection by metagenomic next-generation sequencing (mNGS) of bronchoalveolar lavage fluid (BALF) on lower respiratory tract infections (LRTIs) patients' lung microbiome composition and prognosis.

Patients And Methods: We initially enrolled 234 hospitalized patients with LRTIs who underwent BALF mNGS between February 2022 and May 2023. The study analyzed the clinical manifestations and the pulmonary microbial composition between herpesvirus detection (HD) and non-herpesvirus detection (non-HD) group.

Application of Short Peptide Enteral Nutrition in Mechanically Ventilated Critically Ill Children with Severe Pneumonia and Its Impact on Patient Recovery.

Objective: To explore the application of short-peptide enteral nutrition formulation in mechanically ventilated pediatric patients with severe pneumonia and its impact on rehabilitation outcomes, providing practical clinical evidence for the nutritional support strategy in critically ill pneumonia children.

Methods: This study retrospectively analyzed the clinical data of 90 neonatal pneumonia patients undergoing mechanical ventilation from May 2022 to December 2023. The patients were divided into an experimental group receiving short peptide enteral nutrition formulation via nasogastric tube and a control group receiving whole-protein enteral nutrition formulation via nasogastric tube.

Compassionate Use of Omadacycline in a Down Syndrome Pre-Schooler With Critically Ill Atypical Pneumonia Caused by Macrolide-Resistant Mycoplasma Pneumoniae.

Background: Rapid and accurate identification of causative organisms and prompt initiation of pathogen-targeted antibiotics are crucial for managing atypical pneumonia. The widespread application of targeted next-generation sequencing (t-NGS) in clinical practice demonstrates significant targeted advantages in rapid and accurate aetiological identification and antimicrobial resistance genes detection, particularly for difficult-to-culture, rare, or unexpected pathogens. An alarming surge of acquired macrolide resistance (MR) in (MP) presents a substantial challenge for the clinical selection of pathogen-targeted antibiotics worldwide, especially for fluoroquinolone-restricted pediatric patients with limited options available.

A New Risk Score Based on Lipid Indicators for Patients with Advanced Hepatocellular Carcinoma.

Background: The prognosis is extremely troubling in advanced hepatocellular carcinoma (HCC). Prognostic scores have been developed. Yet, the positive predictive values might appear inadequate.

A Machine Learning Model for Predicting Prognosis in HCC Patients With Diabetes After TACE.

Purpose: Type II diabetes mellitus (T2DM) has been found to increase the mortality of patients with hepatocellular carcinoma (HCC). Therefore, this study aimed to establish and validate a machine learning-based explainable prediction model of prognosis in patients with HCC and T2DM undergoing transarterial chemoembolization (TACE).

Patients And Methods: The prediction model was developed using data from the derivation cohort comprising patients from three medical centers, followed by external validation utilizing patient data extracted from another center.

Insulin Resistance Mediates the Association Between Vitamin D and Non-Alcoholic Fatty Liver Disease.

Background: Vitamin D (VD) deficiency and insulin resistance (IR) increase the risk of non-alcoholic fatty liver disease (NAFLD), but few studies have explored the potential mechanisms by which IR mediates the association between VD and the pathogenesis of NAFLD at the genetic level using publicly available databases.

Methods: This is a cross-sectional study, and we utilized the National Health and Nutrition Examination Survey (NHANES) dataset, as well as data from GSE200765 obtained from the Gene Expression Omnibus (GEO) website. A total of 723 individuals who had completed liver ultrasound examination and the detection of VD levels were included in the final analysis.

Role of Huangqin Qingre Chubi Capsule in the Reduction of the Risk of Re-Admission in Patients With Ankylosing Spondylitis: A Cohort Study.

Objective: This study evaluates whether Huangqin Qingre Chubi Capsule (HQC), a traditional Chinese medicine (TCM) compound, is associated with the risk of re-admission in patients with ankylosing spondylitis (AS).

Methods: In this study, we retrospectively collected the clinical data of 1,296 AS patients. Patients were allocated into HQC and non-HQC groups.