Synergistic influences of BMP9 and NGF on the osteogenic differentiation of C3H10T1/2 mesenchymal stem cells.

Background: Bone morphogenetic protein 9 (BMP9) and nerve growth factor (NGF) are critical factors influencing osteogenic differentiation in mesenchymal stem cells (MSCs). While BMP9 has been recognized for its potent osteogenic capabilities, NGF's role in bone tissue engineering is less understood. This investigation delineated the synergistic link of BMP9 with NGF in driving osteogenic differentiation in C3H10T1/2 MSCs.

LINC02363: a potential biomarker for early diagnosis and treatment of sepsis.

Background: Sepsis remains a leading cause of global morbidity and mortality, yet early diagnosis is hindered by the limited specificity and sensitivity of current biomarkers.

Aim: The aim of this study was to identify lncRNAs that play a key role in sepsis and provide potential biomarkers for the diagnosis and treatment of sepsis.

Methods: Transcriptomic data from sepsis patients were retrieved from the Chinese National Genebank (CNGBdb).

Predicting anastomotic leak in patients with esophageal squamous cell cancer treated with neoadjuvant chemoradiotherapy using a nomogram based on CT radiomic and clinicopathologic factors.

Background: Anastomotic leak (AL) is a common complication in patients with operable esophageal squamous cell carcinoma (ESCC) treated with neoadjuvant chemoradiotherapy (NCRT) and radical esophagectomy. Therefore, this study aimed to establish and validate a nomogram to predict the occurrence of AL.

Methods: Between March 2016 and December 2022, ESCC patients undergoing NCRT and radical esophagectomy were retrospectively collected in China.

Effects of psychosocial factors on postpartum depression: a half-longitudinal mediation analysis of cognitive reactivity.

Background: The prevention and treatment of perinatal depression are currently the focus of perinatal health care, with cognitive reactivity confirmed to be an important predictor. However, how cognitive reactivity mediates the relationship between psychosocial factors (e.g.

Long-read RNA sequencing enables full-length chimeric transcript annotation of transposable elements in lung adenocarcinoma.

Background: Transposable elements (TEs), which constitute nearly half of the human genome, have long been regarded as genomic "dark matter". However, their reactivation in tumor cells, resulting in the production of TE-chimeric transcripts (TCTs), has emerged as a potential driver of cancer progression. The complexity and full extent of these transcripts remain elusive, largely due to the limitations of short-read next-generation sequencing technologies.

Horizontal impact of extensive incisor retraction on alveolar bone.

Objective: To explore the horizontal impact of extensive incisor retraction on alveolar bone and to investigate the relationship of changes in alveolar bone thickness (ΔBT) with horizontal retraction distance of the incisal edge (HRD) and horizontal retraction distance of alveolar ridge crest (HRD') in orthodontic treatment.

Materials And Methods: This retrospective study included 84 patients who underwent orthodontic extraction treatment, involving extensive incisor retraction (≥ 3 mm). Pre-treatment (T0) and post-treatment (T1) cone-beam computed tomography (CBCT) data were collected.

Association of LHCGR rs2293275 genotype with ovarian aging in Chinese women: a multicenter population-based study.

Objective: To evaluate the association between the LHCGR rs2293275 (N312S) genotype and ovarian aging phenotypes in Han Chinese women, focusing on diminished ovarian reserve (DOR) and primary ovarian insufficiency (POI).

Study Design: This multicenter population-based study included 1,240 women aged 18-40 years diagnosed with DOR (n = 711) or POI (n = 529), alongside 72,846 ethnically and regionally matched controls from the Han Chinese Genomes Database (PGG.Han).

Long-term mortality impact of postoperative hyperactive delirium in older hip fracture surgery patients.

Background: Postoperative hyperactive delirium is a common and serious complication in older patients undergoing surgery, but the association between delirium and mortality remains controversial. Compared to other delirium subtypes, hyperactive delirium is characterized by more overt clinical manifestations, facilitating accurate detection and evaluation. This study aimed to clarify this association by comparing long-term mortality between patients with and without postoperative hyperactive delirium, using propensity score matching for robust analysis.

Risk prediction and early intervention strategies for persistent SARS-CoV-2 infection in patients with non-Hodgkin lymphoma: a retrospective cohort study.

Background: Patients with non-Hodgkin lymphoma (NHL) face heightened mortality and accelerated disease progression when persistently infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This critical situation underscores the urgent need to identify risk factors and establish early intervention strategies tailored to this vulnerable population. The primary aim of this study was to investigate the risk factors associated with persistent SARS-CoV-2 infection in NHL patients during the COVID-19 pandemic.

Associations between serum ferritin levels and gestational diabetes mellitus among a non-anemic population.

Background: Studies have shown a strong correlation between excess iron and the development of gestational diabetes mellitus (GDM), though iron is an essential trace element during pregnancy. This study aims to investigate the precise relationship between iron storage levels during late pregnancy and the development of GDM, trying to find out ways to meet pregnant iron storage requirements and reduce GDM risk simultaneously.

Methods: A non-anemic population consisting of 9,512 healthy singleton pregnant women were included in this study.

The serum gamma-glutamyl transpeptidase-to-platelet ratio predicts HELLP syndrome.

Background: HELLP (Hemolysis, elevated liver enzymes, and low platelets) syndrome is a dangerous obstetric condition that is in great need of simple and inexpensive non-invasive early predictors, but it has been poorly studied. This study was conducted to investigate the predictive role of serum gamma-glutamyl transpeptidase to platelet ratio (GPR) during pregnancy in HELLP syndrome and its adverse pregnancy outcomes.

Methods: This was a retrospective study in a tertiary hospital.

Omega-6 polyunsaturated fatty acids and their metabolites: a potential targeted therapy for pulmonary hypertension.

Pulmonary hypertension (PH) is a progressive and life-threatening cardiopulmonary disease that is not uncommon. The modulation of the pulmonary artery (PA) involves various fatty acids, including omega-6 polyunsaturated fatty acids (ω-6 PUFAs) and ω-6 PUFAs-derived oxylipins. These lipid mediators are produced through cyclooxygenase (COX), lipoxygenase (LOX), cytochrome P450 (CYP450), and non-enzymatic pathways.

Detection and co-occurrence of Acanthamoeba and Klebsiella pneumoniae in freshwater river systems of Taichung, Taiwan.

Background: This study focuses on the detection and co-occurrence of Acanthamoeba and Klebsiella pneumoniae in freshwater river systems. Both microorganisms are known for their pathogenic potential, with Acanthamoeba capable of causing infections such as amoebic keratitis, and K. pneumoniae being a common cause of community infections.

Next-generation sequencing-based population genetics unravels the evolutionary history of Rhodomyrtus tomentosa in China.

Background: Rhodomyrtus tomentosa (Ait.) Hassk. is useful for its ornamental, medicinal, and ecological characteristics, and is considered a "Neglected and Underutilized Crop Species".

The comparative study of the efficacy of recombinant human brain natriuretic peptide combined with vasoactive medications for elderly patients with heart failure and hypotension receiving injections.

Background: Heart failure (HF) in elderly patients with concurrent hypotension presents a therapeutic challenge due to limited standard HF therapies' applicability. Recombinant human brain natriuretic peptide (rhBNP) and vasoactive medications have shown potential in HF management, but their combined efficacy in elderly patients with HF and hypotension remains understudied.

Methods: This retrospective cohort study included elderly HF patients with hypotension who received rhBNP alone (Group A, n = 68), rhBNP with dobutamine (Group B, n = 74), or rhBNP with dopamine (Group C, n = 71).

Double balloon catheter induction of labor in pregnant women with COVID-19 infection.

Background: To identify the effectiveness and safety induction using a double-balloon catheter in the setting of Coronavirus disease 2019 (COVID-19) infection.

Methods: This retrospective study included 577 COVID-19-afected women who underwent induction of labor with a double balloon catheter or spontaneously started delivery between December 7, 2022, and June 20, 2023; 154 women underwent induction of labor (double balloon catheter, study group) and 423 women underwent spontaneous started delivery (control group). Maternal and neonatal outcomes and complications during labor were assessed and compared.

Older adult's acceptance and uptake of referral after screening for cognitive impairment: a cross-sectional study in China.

Background: Previous studies have shown that the referral situation after cognitive screening is not optimistic. However, little is known about the situation in China. The current study assessed the cognitive function of older adults with an Eight-item Ascertain Dementia (AD8) score of ≥ 2 in a community health center and investigated their willingness to accept referrals.

Clinical comparison of vaginal misoprostol combined with a foley balloon versus vaginal misoprostol alone for inducing labor: a prospective cohort study.

Objective: To compare the induction-to-delivery time and maternal satisfaction associated with vaginal misoprostol combined with a Foley balloon to those associated with vaginal misoprostol alone for labor induction.

Methods: This was a prospective cohort study involving singleton full-term pregnant women with fetuses who were observed in the cephalic position; these patients were divided into a combination group (25 µg vaginal misoprostol combined with a Foley balloon, n = 94) and a misoprostol group (25 µg vaginal misoprostol, n = 105). The primary outcome was the induction-to-delivery time, and the secondary outcomes included maternal satisfaction, mode of delivery and neonatal conditions.

Capillary refill time and tissue oxygen saturation as factors influencing lower limb ischemia in VA-ECMO: a case-control study.

Background And Objectives: Venous-Arterial Extracorporeal Membrane Oxygenation (VA-ECMO) is a pivotal means for rapid cardiopulmonary support, yet it may result in lower limb ischemia. This study aims to explore the high-risk factors for lower limb ischemia following VA-ECMO.

Methods: 117 patients who received VA-ECMO treatment at Guangxi Zhuang Autonomous Region People's Hospital from June 2022 to December 2023 were divided into lower limb ischemia group and non ischemia group for case-control analysis.

Application of chain body temperature management checklist in robotic surgery for urology: a randomised controlled trial.

Objective: To explore the management effect of a chain temperature management checklist in preventing hypothermia in patients undergoing urological robotic surgery during the perioperative period.

Methods: A total of 152 patients undergoing urological robotic surgery were enrolled in this study between March and September 2021 and again between March and September 2022. All patients were randomly divided into the control group (n = 76) and the intervention group (n = 76).

Epimedium brevicornum Maxim alleviates diabetes osteoporosis by regulating AGE-RAGE signaling pathway.

Objectives: Epimedium brevicornum Maxim (EP) has a history of utilization in Chinese traditional medicine for the treatment of bone diseases. However, the precise mechanism by which EP extract (EPE) operates in Diabetes osteoporosis (DOP) remains ambiguous. The study was aimed to explore the effects and underlying mechanisms of EPE on DOP, with particular emphasis on the AGE-RAGE pathway.

Transcriptomic and metabolomic analysis reveal the cold tolerance mechanism of common beans under cold stress.

Background: Common bean (Phaseolus vulgaris L.) is a thermophilic crop, and exposure to cold stress can significantly impact their yield and quality. To elucidate the impact of cold stress on cold-tolerant 'Wei Yuan' (WY) and cold-sensitive 'Bai Bu Lao' (BBL) of common bean, the mechanism of cold tolerance was studied by physiological and biochemical and multi-omics analysis.

Intraoperative isotonic balanced versus hypotonic crystalloids on postoperative sodium homeostasis in small children undergoing major neurosurgery: a randomized controlled trial.

Background: Whether intraoperative isotonic balanced maintenance fluid is associated with less variation in sodium homeostasis in small children undergoing major neurosurgery remains unknown.

Methods: Patients aged up to 6 years undergoing major neurosurgery were randomly assigned to receive either isotonic balanced solution (IB) or 0.2% hypotonic solution (H) as intraoperative maintenance fluid.

Insulin resistance-induced mitochondrial dysfunction and pyroptosis in trophoblasts: protective role of metformin.

Background: Gestational diabetes mellitus (GDM) affects up to 14% of pregnancies globally, with insulin resistance (IR) playing a critical but often underappreciated role in its pathogenesis. Yet the specific impact of insulin at IR levels on mitochondrial function and pyroptosis in first-trimester trophoblasts remains unclear. Metformin use in GDM pregnancies is rising, but its impact on placental mitochondrial function is uncertain.

Traceability of septic shock caused by phocaeicola vulgatus: a rare case report.

Background: Phocaeicola vulgatus (P.vulgatus) is a member of Bacteroides fragilis Group(BFG). Septic shock caused by P.