Construction of benzimidazole- and indole-fused azabicyclo[3.1.0]hexanes bearing a cyano-containing quaternary center from vinylsulfonium salts through sequential [3 + 2]/[2 + 1] cyclization.

A sequential [3 + 2]/[2 + 1] annulation reactions of benzimidazole- and indole-derived acrylonitriles with vinylsulfonium salts have been developed for the first time, and shown to provide in yields of 32 to 98% a series of azabicyclo[3.1.0]hexanes containing each a cyano-substituted tetrasubstituted carbon stereocenter with >20 : 1 dr.

Directed Evolution of an Alginate Lyase from sp. for Seaweed Fertilizer Production from the Brown Seaweed .

An alginate lyase (FsAly7) from sp. was engineered by directed evolution to improve its optimum temperature and thermostability. The optimum temperature of the positive mutant mFsAly7 (FsAly7-Ser43Pro) was increased by 5 °C, and the thermal inactivation half-lives at 40 and 45 °C were 4.

LC-STH-13 ameliorates the progression of SLE in MRL/lpr mice by inhibiting the TLR9/NF-κB signaling pathway.

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease often treated with glucocorticoids, which can lead to complications such as osteoporosis and an increased infection risk. Hence, identifying safe and effective treatment strategies is crucial. has shown promise in improving immune disorders.

Self-assembled eumelanin nanoparticles enhance IFN-I activation and cilia-driven intercellular communication to defend against Tulane virus, a human norovirus surrogate.

Norovirus (NoV) infection is a leading cause of gastroenteritis and poses global health threats, with increasing incidence reported in immunocompromised individuals, which is further exacerbated by the globalization of the food industry. Eumelanin has demonstrated its potential in antiviral treatments, but its role in preventing viral infections remains underexplored. Therefore, in this study, we investigated the antiviral properties and potential mechanisms of self-assembled eumelanin nanoparticles (EmNPs) against Tulane virus (TuV), a surrogate with a similar infection mechanism to NoVs.

Tandem Versus Single Autologous Stem Cell Transplantation for High-Risk Multiple Myeloma in the Era of Novel Agents: A Real-World Study of China.

Background: This study compares the efficacy and safety of single autologous stem cell transplantation (ASCT) versus tandem ASCT for multiple myeloma (MM) patients in the era of novel agents.

Methods: A total of 112 high-risk MM patients were included (single ASCT, (n = 57) or tandem ASCT(n = 55) in this retrospective multicenter study. Responses and outcomes were evaluated.

Development of specific molecular markers for medicinal peony () with double flower.

In China, medicinal with double flowers (DFs) does not produce seeds, yet it possesses significantly higher paeoniflorin content compared with its single-flowered counterpart. The propagation of medicinal with DFs relies solely on rhizomes. However, due to economic motivations, the rhizomes of medicinal with single flowers (SFs) are often mixed with those of medicinal with DFs.

Non-Resonant Magnetic X-ray Scattering as a Probe of Ultrafast Molecular Spin-State Dynamics: An Ab Initio Theory.

With the advancement of high harmonic generation and X-ray free-electron lasers (XFELs) to the attosecond domain, the studies of the ultrafast electron and spin dynamics became possible. Yet, the methods for efficient control and measurement of the quantum state are to be further developed. In this publication, we propose using magnetic X-ray scattering (MXS) for resolving the molecular spin-state dynamics and establish a complete protocol to simulate MXS diffraction patterns in molecules with ab initio quantum chemistry based on the multiconfigurational method.

Growth window optimization for large-size quasi-two-dimensional Dion-Jacobson type perovskites.

Quasi-2D DJ type perovskites theoretically offer excellent properties for X-ray detection, but they often face issues such as phase segregation and small crystal size. In this study, we synthesized large single crystals of quasi-2D DJ type perovskite (3AMPY)(MA)PbBr using temperature-controlled crystallization. The resulting X-ray detector exhibited high resistivity (1.

Selenium-assisted copper-catalyzed synthesis of phosphoramide from secondary phosphine oxide involving the construction of N-P bonds.

In this study, phosphoramide compounds were successfully synthesized a series of reaction transformations from P(O)H compounds. The process began with the formation of P-Se-Ar bonds, facilitated by the synergistic effect of phenylboronic acid, selenium, and appropriate ligands in the presence of copper. Following this, nucleophilic substitution reactions with amine compounds were conducted to create P-N bonds.

Investigating the Role of TRPV4 and GPR35 Interaction in Endothelial Dysfunction in Aging Mice.

Endothelial dysfunction, characterized by a decline in endothelial physiological functions, is a significant aspect of cardiovascular aging, contributing notably to arterial stiffness, atherosclerosis, and hypertension. Transient receptor potential channel V4 (TRPV4), a key member of Ca-permeable channels, plays a crucial role in maintaining vascular functions. However, the role and mechanisms of TRPV4 in aging-related endothelial dysfunction remain incompletely understood.

A flexible 3D ordered SERS sensor for rapid and reliable detection of pesticide residues in fruits.

We fabricated flexible, three-dimensional (3D) ordered silicon nanowire (SiNW) arrays decorated with high-density silver nanoparticles (AgNPs) for the sensitive and reproducible detection of pesticide residues. These sensors demonstrated a detection limit of 10 M for methyl parathion (MPT) on curved surfaces.

Tunable band gaps and conduction band edges of CdS/ZnS heterostructures - a first-principles-based prediction.

CdS/ZnS heterostructures with tunable band gaps are promising photocatalysts for solar- or visible-light-driven H production through water splitting. To predict how the bandgap changes with the heterostructure composition, density functional theory calculations with meta-GGA correction are performed. It is found that the band gaps of CdS and ZnS are reduced by up to 14.

Elongator subunit Elp3 regulates reproduction in Tribolium castaneum by interacting with FOXO.

As the catalytic subunit of the Elongator complex, Elongator protein 3 (Elp3) plays a crucial role in multiple physiological processes, including growth, development and immune responses. Previous studies on Elp3 have focused on Caenorhabditis elegans, Drosophila melanogaster, Homo sapiens (human) or Mus musculus (mouse), whereas there are few reports on Elp3 in agricultural pests. Here, the role of TcElp3 in reproduction in the red flour beetle, Tribolium castaneum, was investigated, and the underlying mechanisms were explored.

Preliminary establishment and evaluation of a rapid detection method for GII human norovirus based on time-resolved fluorescence chromatography.

Human norovirus is the leading cause of non-bacterial gastroenteritis worldwide in all age groups. In this study, a rapid, high-sensitivity and quantitative detection method for VP1 protein of norovirus GII was developed based on time-resolved fluorescence microsphere immunochromatography. The optimal labeling amount and coated antibody concentration of norovirus monoclonal antibody were 10 μg and 1.

6-Indolo-[2,3-]-quinoxaline derivatives as promising bifunctional SHP1 inhibitors.

Dysfunction in the SHP1 enzyme can cause cancers and many diseases, so it is of great significance to develop novel small molecule SHP1 inhibitors. Through continuous monitoring of metabolic and targeted processes of SHP1 inhibitors in real-time, we can evaluate the effectiveness and toxicity of the inhibitors, further optimize drug design, and explore SHP1 biology. Indoloquinoxaline is an important class of N-containing heterocycle, which has been studied and applied in the pharmacological field and in optoelectronic materials.

circSIRT2/miR-542-3p/VASH1 axis regulates endothelial-to-mesenchymal transition (EndMT) in subretinal fibrosis in age-related macular degeneration models.

Neovascular age-related macular degeneration (nAMD), characterized by choroidal neovascularization (CNV), is one of the leading causes of severe visual impairment and irreversible vision loss around the world. Subretinal fibrosis (SRF) contributes to the incomplete response to anti-vascular endothelial growth factor (VEGF) treatment and is one of the main reasons for long-term poor visual outcomes in nAMD. Reducing SRF is urgently needed in the anti-VEGF era.

Stable Self-Powered Broadband PtSe/Si Pin Infrared Photodetector Based on a High-Quality Ultrapure Intrinsic Si Film Exfoliated by Si/SOI Wafer Bonding.

Two-dimensional (2D) PtSe has attracted significant attention in recent years owing to its exceptional optoelectronic properties. Currently, the contact interface of the PtSe/bulk 2D-three-dimensional (3D) p-n heterojunction exhibits numerous defects. Moreover, the n-type bulk materials serve as a carrier transport layer, resulting in serious recombination losses and deterioration of device stability.

Electrochemical stability of electrospun silicon/carbon nanofiber anode materials: a review.

Silicon (Si) is regarded as a promising anode material owing to its high specific capacity and low lithiation potential. The large volume change and the pulverization of silicon during the lithiation/delithiation process hinder its direct energy storage application. This review focuses on the electrospun silicon/carbon (Si/C) nanofiber anode materials for lithium-ion batteries for long-term stable energy storage.

Multi-scale numerical simulations of photothermal therapy for tumors based on PDA-coated gold nanoparticles.

This paper presents a multiscale computational model, 'micro-to-meso-to-macro', to simulate polydopamine coated gold nanoparticles (AuNP@PDA) for assisted tumor photothermal therapy (PTT). The optical properties, mainly refractive index, of the PDA unit molecules are calculated using the density functional theory (DFT) method in this multiscale model. Subsequently, the thermodynamic properties, including thermal conductivity and heat capacity, of the PDA cells and AuNP@PDA particles are calculated using molecular dynamics (MD) simulation.

Tenecteplase Thrombolysis for Stroke up to 24 Hours After Onset With Perfusion Imaging Selection: The CHABLIS-T II Randomized Clinical Trial.

Background: Whether it is effective and safe to extend the time window of intravenous thrombolysis up to 24 hours after the last known well is unknown. We aimed to determine the efficacy and safety of tenecteplase in Chinese patients with acute ischemic stroke due to large/medium vessel occlusion within an extended time window.

Methods: Patients with ischemic stroke presenting 4.

Recent Applications of Pillararene-Inspired Water-Soluble Hosts.

Pillararenes and their derivatives have emerged in supramolecular chemistry as unique macrocycles for applications in host-guest chemistry, materials science and biomimetics. Many variations have been conceived and synthesized in recent years and in this review, we relate progress in water-soluble versions: leaning towerarenes, extended-pillararenes, biphenarenes, helicarenes and octopusarenes. These are applied in targeted drug delivery, selective uptake and release of aromatic guests, fabrication of gold/silver and mesoporous silica nanoparticles, cell imaging, pollutant separation, biomedicine (e.

A multifunctional metal-based nanozyme for CT/PTI-guided photothermal/starvation/chemodynamic therapy against colon tumor.

Colon cancer is a major global health threat. Early detection and treatment are crucial for improving survival rates. Conventional methods, like colonoscopies and CT scans, have limitations, emphasizing the need for innovative strategies.

Strategies to Enhance the Therapeutic Efficacy of GLP-1 Receptor Agonists through Structural Modification and Carrier Delivery.

Diabetes is a metabolic disorder characterized by insufficient endogenous insulin production or impaired sensitivity to insulin. In recent years, a class of incretin-based hypoglycemic drugs, glucagon-like peptide-1 receptor agonists (GLP-1RAs), have attracted great attention in the management of type 2 diabetes mellitus (T2DM) due to their benefits, including stable glycemic control ability, a low risk of hypoglycemia, and weight reduction for patients. However, like other peptide drugs, GLP-1RAs face challenges such as instability, susceptibility to enzymatic degradation, and immunogenicity, which severely limit their clinical application.

Photoinduced synthesis of trisubstituted allylic molecules migratory allylation of olefins.

A transition-metal-free method to afford diverse trisubstituted allylic molecules migratory allylation of olefins under light irradiation is described. This system tolerated diverse -tosylhydrazones and olefinic boronic acids. Successful allylation of drugs and natural-product analogues was achieved.