Scaling relations of CO hydrogenation and dissociation on single metal atom doped InO catalysts with promoted oxygen vacancy sites.

In this work, we conducted a computational study on single atom doped InO catalysts with 12 transition metals (Fe-Cu, Ru-Ag, Os-Au) through density functional theory (DFT) calculations, by investigating the dissociation of H, and the dissociation and hydrogenation of CO. From the thermodynamic-kinetic scaling relationships such as Brønsted-Evans-Polanyi (BEP) and transition-state scaling (TSS) relations, we establish the descriptors for the energy barriers and improve our understanding of the synergistic catalytic effect of oxygen vacancies and single atoms. We find that the adsorption energy of the H adatom on the perfect surface can serve as an effective descriptor for the dissociation energy barrier of H on this surface, and the formation energy of the oxygen vacancy can serve as an effective descriptor for the energy barrier of CO hydrogenation to HCOO as well as the energy barrier of CO direct dissociation.

Recent advancements in wearable sensors: integration with machine learning for human-machine interaction.

Wearable sensors have emerged as a transformative technology, enabling real-time monitoring and advanced functionality in various fields, including healthcare, human-machine interaction, and environmental sensing. This review provides a comprehensive overview of the latest advancements in wearable sensor technologies, focusing on innovations in sensor design, material flexibility, and integration with machine learning. We explore the feasibility of wearable electronics in achieving high-performance, flexible devices and discuss their potential to enhance human-machine interactions through intelligent data processing and decision-making.

Synthesis of MoC nanoparticles on N-doped carbon as an electrocatalyst for efficient electrocatalytic hydrogen evolution.

Molybdenum carbide (MoC) has emerged as a subject of considerable research interest as an intrinsically Pt-like electronic and cost-effective alternative to platinum-based catalysts for the sustainable hydrogen evolution reaction (HER). However, a high carbonization temperature can easily cause the agglomeration of nanoparticles. Therefore, we employed a zeolitic imidazolate framework (ZIF)-assisted synthesis strategy, obtaining MoC/CN-T nanoparticles by calcining the precursor Mo-ZIF at high temperature and low pressure.

Double cross-linked cellulose hydrogel-supported Fe species for efficient wound healing.

Traditional dressings often lack adequate skin structure support, which can lead to secondary damage, poor hemostasis, and an increased risk of inflammation due to wound adhesion. In this work, cellulose hydrogels were prepared by physical/chemical double cross-linking a 'sol-gel' strategy and further loaded with Fe to obtain a three-dimensional (3D) porous cellulose/Fe composite hydrogel (cellulose/Fe gel). The obtained cellulose/Fe gel featured a 3D porous nanofiber structure, excellent water absorption/moisture retention performance, and good mechanical stability.

Complete inhibition of localized corrosion in 5Cr steel under a water-saturated supercritical CO environment through Al microalloying.

To address the critical corrosion challenges faced by metal pipelines in carbon capture, utilization, and storage (CCUS) technologies, the study prepared a series of novel Fe-5Cr-(0-3)Al alloy steels. The corrosion resistance of these alloys in a water-saturated supercritical CO (sc-CO) environment was systematically investigated. The results revealed that increasing Al content significantly reduced the corrosion rate.

TRP channels and breast cancer: the role of TRPs in the pathophysiological development.

TRP channels play important roles in regulating various physiological and pathological processes, including the progression of cancer. Several TRP channels mediate tumour development. This review focuses on the role of TRP channels in the development of breast cancer, including their involvement in proliferation, apoptosis, autophagy, metastasis, and angiogenesis.

Identifying potential biomarkers and molecular mechanisms related to arachidonic acid metabolism in vitiligo.

Background: Numerous studies have reported that dysregulation of fatty acid metabolic pathways is associated with the pathogenesis of vitiligo, in which arachidonic acid metabolism (AAM) plays an important role. However, the molecular mechanisms of AAM in the pathogenesis of vitiligo have not been clarified. Therefore, we aimed to identify the biomarkers and molecular mechanisms associated with AAM in vitiligo using bioinformatics methods.

Change Fatigue Among Clinical Nurses and Related Factors: A Cross-sectional Study in Public Hospitals.

Objectives: To investigate the levels of change fatigue among clinical nurses in public hospitals and identify the potential contributing factors.

Design: A cross-sectional, multi-stage sampling study was conducted in accordance with the STROBE guideline.

Methods: This study surveyed 2,228 nurses in China from October to December 2023 using Wen Juan Xing (www.

Evaluating human exposure to antibiotic resistance genes.

Antibiotic resistance is an escalating global concern, leading to millions of annual fatalities. Antibiotic resistance genes (ARGs) present in bacteria equip them to withstand the effects of antibiotics. Intra- and interspecific ARGs transmission through horizontal gene transfer further exacerbates resistance dissemination.

Prevalence of bacteria, fungi, and virus coinfections with SARS-CoV-2 Omicron variant among patients with severe COVID-19 in Guangzhou, China, winter 2022.

The status of coinfection during the national outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron BA.5.2 or BF.

Epidemiology and genetic characterization of (X4)-positive and isolated from raw meat in Chengdu City, China.

The rapid spread of mobile tigecycline resistance presents a significant public health threat, particularly with the increasing prevalence of (X4)-positive Enterobacterales across various species. This study aimed to investigate the epidemic features and transmission dynamics of (X4)-positive (. ) through the analysis of 206 raw meats, including pork ( = 182), beef ( = 16), duck ( = 5), and chicken ( = 3).

Superior effectiveness and acceptability of saliva samples for the detection of SARS-CoV-2 in China.

In response to problems of poor sampling quality, low sensitivity, and high demand for medical personnel regarding the current severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) oropharyngeal (OP) swab sampling used in China, we aimed to evaluate the diagnostic performance and acceptability of saliva-based nucleic acid amplification tests (NAATs) in China. The results showed that, using nasopharyngeal (NP) swab results as the gold standard, the overall sensitivities for saliva specimens and OP swabs were 93.3 % and 85.

The multi-kingdom microbiome catalog of the chicken gastrointestinal tract.

Chicken is an important food animal worldwide and plays an important role in human life by providing meat and eggs. Despite recent significant advances in gut microbiome studies, a comprehensive study of chicken gut bacterial, archaeal, and viral genomes remains unavailable. In this study, we constructed a chicken multi-kingdom microbiome catalog (CMKMC), including 18,201 bacterial, 225 archaeal, and 33,411 viral genomes, and annotated over 6,076,006 protein-coding genes by integrating 135 chicken gut metagenomes and publicly available metagenome-assembled genomes (MAGs) from ten countries.

Genomic surveillance of emerging SARS-CoV-2 Omicron variations in Tianjin Municipality, China 2022.

The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has severely impacted public health. In 2022, the Omicron variant of SARS-CoV-2 rapidly became the dominant circulating variant in the local COVID-19 outbreaks in Tianjin Municipality, China. To gain a deeper understanding of the genetic variations of the Omicron variant in Tianjin, specimens from individuals who tested positive for SARS-CoV-2 between December 2021 and November 2022 were used for virus whole genome sequencing and phylogenetic analysis.

Intermittent fasting inhibits platelet activation and thrombosis through the intestinal metabolite indole-3-propionate.

Platelet hyperreactivity contributes significantly to thrombosis in acute myocardial infarction and stroke. While antiplatelet drugs are used, residual ischemic risk remains. Intermittent fasting (IF), a dietary pattern characterized by alternating periods of eating and fasting, has shown cardiovascular benefits, but its effect on platelet activation is unclear.

Circulating short-chain and branched short-chain fatty acids and the risk of incident type 2 diabetes: findings from the 4C study.

Previous studies suggested that fecal short-chain fatty acids (SCFAs) and branched short-chain fatty acids (BCFAs) are associated with glucose regulation. However, the potential relationship between circulating SCFAs and BCFAs with incident diabetes risk in both men and women remains unidentified in prospective cohort studies. In this study, we examined a panel of nine serum SCFAs and BCFAs in 3414 subjects with incident diabetes, and matched normoglycemic controls from the China Cardiometabolic Disease and Cancer Cohort study.

Causal Associations Between Chronic Obstructive Pulmonary Disease and Common Comorbidities: Evidence from Comprehensive Genetic Methods.

Background: Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory lung disease with high morbidity and mortality worldwide. Observational studies have shown correlations between common extrapulmonary comorbidities and COPD, but the existence of correlations does not necessarily prove a causal association. Therefore, causal relationships between diseases need to be explored by means of causal inference methods.

PGAM5 Modulates Macrophage Polarization, Aggravating Inflammation in COPD via the NF-κB Pathway.

Background: Chronic obstructive pulmonary disease (COPD) has emerged as a very consequential issue threatening human life and health; therefore, research on its pathogenesis is urgently needed. A prior investigation discovered a significant elevation in the phosphoglycerate mutase 5 (PGAM5) expression in the lung tissue of COPD smoking patients. This rise in expression is closely associated with COPD severity.

Identification and Experimental Validation of Biomarkers Related to MiR-125a-5p in Chronic Obstructive Pulmonary Disease.

Purpose: The miR-125a-5p has been reported influence the development of lung cancer, however, the link between it and chronic obstructive pulmonary disease (COPD) is still not well understood. Hence, this study was designed to investigate the molecular pathway by which miR-125a-5p related biomarkers were involved in COPD.

Patients And Methods: The differentially expressed genes (DEGs) and module genes related to COPD in GSE100153 were screened out by differential analysis and weighted gene co-expression network analysis, respectively.

Preparation and formation mechanism study of the long-term stable foamed sodium carboxymethyl cellulose loaded material.

A foamed sodium carboxymethyl cellulose (CMC) material was prepared under nitric acid conditions. Unlike traditional CMC materials, this foaming method is straightforward and does not require additional foaming agents. Owing to its high stability and load capacity, the foam can realize long-term quantitative storage and load a variety of metal ions; therefore, it has broad application prospects in the field of loaded materials for metal ions.

Coordination in strictly metric-free swarms: evidence for the existence of biological diversity.

Coordination serves as a crucial metric for analysing collective behaviour in complex systems. Given the prevalence of biological diversity, this study re-evaluated the coordination issue in strictly metric-free (SMF) swarms, incorporating both limited perceptual ranges and hierarchical dynamics. Initially, the study introduced a single-layer hierarchical SMF model that was optimized using differential evolution strategies.

Evaluation of gut microbiota alterations following orlistat administration in obese mice.

Background: The gut microbiota plays a pivotal role in various metabolic disorders. Orlistat has shown beneficial effects on weight loss and metabolism, but its direct impact on the gut microbiota has not been extensively reported. Thus, this study aimed to explore the effects of orlistat on the gut microbiota in mice with high-fat diet-induced obesity.

Up IGF-I via high-toughness adaptive hydrogels for remodeling growth plate of children.

The growth plate is crucial for skeletal growth in children, but research on repairing growth plate damage and restoring growth is limited. Here, a high-toughness adaptive dual-crosslinked hydrogel is designed to mimic the growth plate's structure, supporting regeneration and bone growth. Composed of aldehyde-modified bacterial cellulose (DBNC), methacrylated gelatin (GelMA) and sodium alginate (Alg), the hydrogel is engineered through ionic bonding and Schiff base reactions, creating a macroporous structure.

Artificial Intelligence Screening Tool for Obstructive Sleep Apnoea: A Study Based on Outpatients at a Sleep Medical Centre.

Purpose: Due to the lack of clear screening guidelines for different populations, identify strategies for obstructive sleep apnea (OSA) in the outpatient population are unclear, a large number of potential OSA outpatients have not been identified in time. The purpose of our study was to evaluate the applicability and accuracy of artificial intelligence sleep screening in outpatients and to provide a reference for OSA screening in different populations.

Methods: A type IV wearable artificial intelligence sleep monitoring (AISM) device was used to screen adults in the sleep clinic of the Sleep Medical Center for OSA screening, and the general demographic data of the patients were collected.

Genetic Overlap Between Obstructive Sleep Apnea and Ischemic Stroke: A Large-Scale Genome-Wide Cross-Trait Analysis.

Background: To further understand the complex relationship between Obstructive Sleep Apnea (OSA) and ischemic stroke, this study explores the role of genetic factors in the comorbidity of these two conditions.

Methods: Based on large-scale available Genome-Wide Association Studies (GWAS) for OSA and ischemic stroke, we conducted a multi-level cross-trait analysis. First, we utilized Linkage Disequilibrium Score Regression (LDSC) to analyze the genetic correlation between the two diseases.