Lithium Bond-Mediated Molecular Cascade Hydrogel for Injury-Free and Repositionable Adhesive Bioelectronic Interfaces.

Flexible bioelectronic interfaces with adhesive properties are essential for advancing modern medicine and human-machine interactions. However, achieving both stable adhesion and non-damaging detachment remains a significant challenge. In this study, a lithium bond-mediated molecular cascade hydrogel (LMCH) for bioelectronic interfaces is designed, which facilitates robust adhesion at the tissue level and permits atraumatic detachment for repositioning as required.

Carboxyl-CNTs Act as "Defensive Shield" to Boost Proton Insertion for Stable and Fast-Charging Aqueous Zn-Mn Batteries.

Proton insertion mechanism with fast reaction kinetics is attracting more and more attention for high-rate and durable aqueous Zn─MnO batteries. However, hydrated Zn insertion reaction accompanied with Jahn-Teller effect and Mn disproportionation generally leads to sluggish rate capability and irreversible structure transformation. Here, carboxyl-carbon nanotubes supported α-MnO nanoarrays (C─MnO) cathode is successfully fabricated by a convent grinding process for high-performance Zn batteries.

Loss of N-6 adenine-specific DNA methyltransferase 1 leads to meiotic prophase abnormalities and male sub-fertility in mice.

Mammalian sexual reproduction critically relies on the generation of haploid gametes following a specialized cell division process known as meiosis. Here, we demonstrate that N-6 Adenine-Specific DNA methyltransferase 1 (N6AMT1) plays a crucial role in the progression of meiosis during spermatogenesis, as follows. N6AMT1 was expressed in germ cells throughout the entire process of spermatogenesis, with a peak in mRNA levels in spermatocytes at the prophase I stage of meiosis.

March2 Alleviates Aortic Aneurysm/Dissection by Regulating PKM2 Polymerization.

Background: Aortic aneurysm/dissection (AAD) is a life-threatening disease lacking effective pharmacological treatment. Protein ubiquitination plays a pivotal role in cardiovascular diseases. However, the possible contribution of the E3 ubiquitin ligase March2 (membrane-associated RING finger protein 2) to the cause of AAD remains elusive.

Efficient estimation of the cox model when incorporating the subgroup restricted mean survival time.

The restricted mean survival time has been widely used in the field of medical research because of its clear physical and simple clinical interpretation. In this paper, we propose an efficient estimation that incorporates the auxiliary restricted mean survival information into the estimation of the proportional hazard (PH) model. Compared to conventional models that do not incorporate available auxiliary information, the proposed method improves efficiency in estimating regression parameters by utilizing the double empirical likelihood method.

Effects of tea polyphenols disinfectant on microbial communities and potential pathogenic bacteria in water.

The structural and abundance changes in water disinfected by tea polyphenols were investigated in high-abundance microbial communities (HAMC), medium-abundance microbial communities (MAMC), and low-abundance microbial communities (LAMC), also included the interactions within and between these communities. The antibacterial effect of tea polyphenols was observed at concentrations of 20-300 mg/L. If the tea polyphenols concentration is greater than or equal to 200 mg/L, it can continue to inhibit the growth of bacteria, and keep the total number of bacteria in 48 hours no more than100 CFU/ml, and this reflected the continuity of tea polyphenols disinfectant in the pipe network.

Root morphology, exudate patterns, and mycorrhizal symbiosis are determinants to improve phosphorus acquisition in alfalfa.

Differences in phosphorus (P) utilisation efficiency (PUtE) and/or yield are closely linked to differences in root functional traits under low soil P availability. However, our understanding of how soil P availability mediates the intraspecific variation in root functional traits for breeding high-P efficiency genotypes to increase PUtE and yield remains limited. We investigated that plant growth parameters and pivotal root functional traits associated with P acquisition in 20 alfalfa genotypes with contrasting P efficiencies and supplied with low, medium or high levels of P.

Intratumoral Injection of R848 and Poly(I:C) Synergistically Promoted Antitumour Immune Responses by Reprogramming Macrophage Polarization and Activating DCs in Lung Cancer.

Introduction: Immunotherapy has rapidly become a primary treatment option for many lung cancer patients because of its success in treating this prevalent and deadly disease. However, the success of immunotherapy relies on overcoming the immunosuppressive tumour microenvironment, making remodelling this environment a potential strategy for lung cancer therapy. Research suggests that Toll-like receptor (TLR) agonists can impede tumour growth by promoting the conversion of tumour-associated macrophages into an M1-like state or enhancing dendritic cell development.

Cascade-Responsive Nanoprodrug Disrupts Immune-Fibroblast Communications for Potentiated Cancer Mechanoimmunotherapy.

The abnormal tumor mechanical microenvironment due to specific cancer-associated fibroblasts (CAFs) subset and low tumor immunogenicity caused by inefficient conversion of active chemotherapeutic agents are two key obstacles that impede patients with desmoplastic tumors from achieving stable and complete immune responses. Herein, it is demonstrated that FAP-αCAFs-induced stromal stiffness accelerated tumor progression by precluding cytotoxic T lymphocytes. Subsequently, a cascade-responsive nanoprodrug capable of re-educating FAP-αCAFs and amplifying tumor immunogenicity for potentiated cancer mechanoimmunotherapy is ingeniously designed.

Heteroatom Introduction and Electrochemical Reconstruction on Heterostructured Co-Based Electrocatalysts for Hydrogenation of Quinolines.

Electrocatalytic hydrogenation (ECH) of quinoline provides an eco-friendly and prospective route to achieve the highly value-added generation of 1,2,3,4-tetrahydroquinoline (THQ). Co element has been proven to be the efficient catalytic site for ECH of quinoline, but the rational regulation of the electronic structure of active Co site to improve the activity is still a challenge. Herein, the hierarchical core-shell structure consisting of NiCo-MOF nanosheets encapsulated Cu(OH) nanorods (Cu(OH)@CoNi-MOF) is constructed.

Flexible Patterned Fuel Cell Patches Stimulate Nerve and Myocardium Restoration.

The distribution of electrical potentials and current in exogenous electrostimulation has significant impacts on its effectiveness in promoting tissue repair. However, there is still a lack of a flexible, implantable power source capable of generating customizable patterned electric fields for in situ electrostimulation(electrical stimulation). Herein, this study reports a fuel cell patch (FCP) that can provide in situ electrostimulation and a hypoxic microenvironment to promote tissue repair synergistically.

Nanofibrous Hydrogel with Highly Salt-Resistant Radial/Vertical-Combined Structure for Efficient Solar Interfacial Evaporation.

Hydrogel-based solar interfacial evaporators, featuring various channels such as random, unidirectional, and radial array, are considered effective for seawater desalination owing to their porous structure, lower evaporation enthalpy, and controllable water transport capacity. However, each individual array structure has its own strengths and limitations, influencing water transportation, thermal management, and salt rejection. By combining the benefits of each array configuration into a single evaporator, the evaporation performance can be maximized.

Impregnating Lattice Sulfur into Iron Crystal Allows Anaerobic Degradation of Extracellular Antibiotic Resistance Genes.

Lattice sulfur-impregnated nanoscale zerovalent iron (S-nFe) has been recognized as a promising groundwater remediation agent. However, little information is available on its reactivity with ubiquitous extracellular antibiotic resistance genes (eARGs) in anaerobic groundwater, and how S content and speciation affect their interactions. Here, the efficient anaerobic degradation of eARGs by S-nFe (6 log within 5 min), resulting in completely inhibited transformation is showed.

Controlled Modulation of Intrinsic Electron Response in C/CoT Nanoplates Toward Multispectral Excitation Devices.

Electromagnetic materials with adjustable dielectric and magnetic properties are constantly sought after in electronic and industrial fields. In this study, an innovative strategy that customizes anchored Co-based nanoparticles to optimize the electronic behaviors is proposed for the first time, enabling a controllable and high-efficiency evolution of the macroscopic electromagnetic response of Co-based (C/CoT) nanoplates across the X-ray, light in the solar band and gigahertz band. Specifically, in the gigahertz band, the C/Co and C/CoSe nanoplates with high-power loss capabilities can effectively attenuate and convert electromagnetic energy into heat energy, which not only prevents space electromagnetic radiation but also powers energy for various electromagnetic devices such as thermoelectric generators and microwave actuators.

Dual-Carriers of Tartary Buckwheat-Derived Exosome-Like Nanovesicles Synergistically Regulate Glucose Metabolism in the Intestine-Liver Axis.

The utilization of plant-derived exosome-like nanovesicles (ELNs) as nanocarriers for oral delivery of bioactives has garnered significant attention. However, their distinctive lipid membrane composition may result in elevated membrane permeability within the gastrointestinal environment, leading to the leakage of carried bioactives. Inspired by the concept of projectile design, Tartary buckwheat-derived ELNs (TB-ELNs) based dual-carriers are fabricated by loading chlorogenic acid (CGA) into the cores and bonding selenium nanoparticles (SeNPs) to the lipid membrane.

Crystalline CoP@ Amorphous WP Coaxial Nanowire Arrays as Bifunctional Electrocatalyst for Water Splitting.

The crystalline CoP@ amorphous WP core-shell nanowire arrays are oriented grown on the Ni foam (CoP@WP/NF). The amorphous WP shell provides more active sites, and the interface charge coupling accelerates the kinetic of the catalytic reaction, making the CoP@WP/NF catalysts excellent activity. In acidic, only 13 and 97 mV overpotentials are needed to reach 10 mA cm and 100 mA cm, respectively, which are the lowest overpotentials among all reported Transition metal phosphide (TMP) catalysts, of course, much lower than that of the Pt/C catalyst (31 mV at 10 mA cm, 120 mV at 100 mA cm).

Integration of Photodiagnosis and Therapy Guided by Micro/Nanorobots.

Micro/Nanorobots(MNRs)integrated with phototherapy represent an emerging approach to cancer treatment and hold significant potential for addressing bacterial infections, neurological disorders, cardiovascular diseases, and related conditions. By leveraging micro/nanoscale motor systems in conjunction with phototherapy, these robots enable real-time guidance and monitoring of therapeutic processes, improving drug delivery precision and efficiency. This integration not only enhances the effectiveness of phototherapy but also minimizes damage to surrounding healthy tissues.

Underlying characteristic aroma of white tea from diverse geographical origins and its prediction.

Background: White tea, an agriculturally distinctive product, exhibits significant aroma variations across different regions. Nevertheless, the mechanisms driving these differences, and distinguishing methods suitable for specific origins, have been scarcely reported. In this study, we analyzed the aroma characteristics and volatile components of 100 white tea samples from ten regions, utilizing sensory evaluation, headspace solid-phase microextraction-gas chromatography-mass spectrometry and chemometrics, then established a discrimination model.

Tetramethylurea Based Intermediate Phase Engineering for Efficient and Stable Perovskite Solar Cells.

Perovskite solar cells (PSCs) are emerging photovoltaic devices renowned for their high efficiency and low cost. Efficient and stable PSCs depend on high-quality perovskite films, which are strongly influenced by the excellent nucleation and growth. The choice of solvent is critical for the crystallization behavior of perovskite films.

Testing syndemic models along pathways to psychotic spectrum disorder: implications for population-level preventive interventions.

Background: Population-level preventive interventions are urgently needed and may be effective for psychosis due to social determinants. We tested three syndemic models along pathways from childhood adversity (CA) to psychotic spectrum disorder (PSD) and their implications for prevention.

Methods: Cross-sectional data from 7461 British men surveyed in 5 population subgroups.

p16INK4a Deletion Alleviated Obesity-Associated Kidney Fibrosis by Regulating Metabolic Reprogramming and the Inflammasome Pathway.

Recent research has revealed a close association between obesity and various metabolic disorders, including renal metabolic diseases, but the mechanism is still unknown. This study explored the role of p16INK4a in obesity-related kidney fibrosis and evaluated its potential as a therapeutic target. Using wild-type (WT) mice and p16 KO mice, we fed both groups a high-fat diet (HFD) for 6 months.

Engineering Bi/V/Mo-Based Multicomponent Heterostructure Electrocatalyst Toward Robust Lithium-Sulfur Batteries and Mechanistic Insights into the Self-Reconstruction.

The sluggish reaction kinetics and formidable shuttle effect of soluble lithium polysulfides (LiPSs) are thorny problems for the future industrialization of lithium-sulfur (Li-S) batteries. Therefore, exploring efficient electrocatalysts to capture LiPSs and accelerate their conversion is highly desirable yet tremendously challenging. Herein, a high-efficiency Bi/BiO/VMoN@rGO electrocatalyst with multifunctional active sites and multilevel heterointerfaces is elaborately designed for Li-S batteries.

Residual Al Adatoms Driven Epitaxy of AlGaN QWs for High-Performance UV LEDs.

AlGaN-based ultraviolet (UV) light-emitting diodes (LEDs) experience a notable reduction in efficiency within the 280-330 nm wavelength range, known as the "UVB gap". Given the extensive applications of UV LEDs in this wavelength range, it is imperative to bridge this efficiency gap. In this study, a strategy facilitated by the presence of residual Al adatoms is introduced to simultaneously improve the integration of Ga-adatoms and the migration of Al/Ga-adatoms during the growth of low-Al-composition AlGaN quantum wells (QWs) even at high temperatures comparable to those used for high-Al-composition AlGaN quantum barriers.

Prevalence of co-morbid anxiety and depression in pregnancy and postpartum: a systematic review and meta-analysis.

The prevalence of co-morbid anxiety and depression varies greatly between research studies, making it difficult to understand and estimate the magnitude of this problem. This systematic review and meta-analysis aim to provide up-to-date information on the global prevalence of co-morbid anxiety and depression in pregnant and postpartum women and to further investigate the sources of heterogeneity. Systematic searches of eight electronic databases were conducted for original studies published from inception to December 10, 2024.

Large Language Model-Based Critical Care Big Data Deployment and Extraction: Descriptive Analysis.

Background: Publicly accessible critical care-related databases contain enormous clinical data, but their utilization often requires advanced programming skills. The growing complexity of large databases and unstructured data presents challenges for clinicians who need programming or data analysis expertise to utilize these systems directly.

Objective: This study aims to simplify critical care-related database deployment and extraction via large language models.