Layered Double Hydroxide Nanosheets Incorporated Hierarchical Hydrogen Bonding Polymer Networks for Transparent and Fire-Proof Ceramizable Coatings.

In recent decades, annual urban fire incidents, including those involving ancient wooden buildings burned, transportation, and solar panels, have increased, leading to significant loss of human life and property. Addressing this issue without altering the surface morphology or interfering with optical behavior of flammable materials poses a substantial challenge. Herein, we present a transparent, low thickness, ceramifiable nanosystem coating composed of a highly adhesive base (poly(SSS-co-HEMA)), nanoscale layered double hydroxide sheets as ceramic precursors, and supramolecular melamine di-borate as an accelerator.

Ultrasound-guided radiofrequency ablation for isthmus papillary thyroid microcarcinoma: a prospective 2 years of follow-up study.

To explore the safety and clinical efficacy of radiofrequency ablation (RFA) for papillary thyroid microcarcinoma (PTMC) located in the isthmus. This prospective study enrolled patients with single isthmus PTMC admitted to General Surgery Department of 983rd Hospital of Joint Logistic Support Force of PLA from 2017 to 2022. After ablation, the ultrasound and contrast-enhanced ultrasound (CEUS) were performed to follow up the outcomes at 1, 3, 6, 12, 18, and 24 months.

Efficacy of an Online Self-compassion Group Intervention for Sexual Minority Men Living with HIV: A Pilot Randomized Controlled Trial.

Sexual minority men living with HIV face challenges affecting their quality of life and medication adherence. While self-compassion has shown promise in improving quality of life, targeted interventions for this group remain limited. This pilot study evaluated the efficacy of an online self-compassion group intervention on quality of life and medication adherence among sexual minority men living with HIV.

Nutraceutical Impact of Pumpkin Seed Oil on Expression Levels of EZH-2 and KRT-14 Genes against DSS-induced Inflammatory Bowel Disease in the Rat Model.

Inflammatory bowel disease is a collection of intestinal disorders that cause inflammation in the digestive tract. Prolonged inflammation in the gastrointestinal tract is a major risk factor for colorectal cancer. The objective of this study was to fucus on gene expression levels of (KRT-14; associated with epithelial cell integrity) and enhancer of zeste homolog-1 (EZH-2; involved in cellular proliferation) in a IBD rat model in order to rule out impact of nutraceuticals (pumpkin seed oil; PSO) as a complementary approach to conventional treatments of IBD.

Genetic Improvement of rice Grain size Using the CRISPR/Cas9 System.

Rice grain size influences both grain yield and quality, making it a significant target for rice genetic improvement. In recent years, numerous genes related to grain size with differential effects have been cloned. The clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) gene editing system is a convenient tool for modifying genes.

PSMA PET/CT based multimodal deep learning model for accurate prediction of pelvic lymph-node metastases in prostate cancer patients identified as candidates for extended pelvic lymph node dissection by preoperative nomograms.

Purpose: To develop and validate a prostate-specific membrane antigen (PSMA) PET/CT based multimodal deep learning model for predicting pathological lymph node invasion (LNI) in prostate cancer (PCa) patients identified as candidates for extended pelvic lymph node dissection (ePLND) by preoperative nomograms.

Methods: [Ga]Ga-PSMA-617 PET/CT scan of 116 eligible PCa patients (82 in the training cohort and 34 in the test cohort) who underwent radical prostatectomy with ePLND were analyzed in our study. The Med3D deep learning network was utilized to extract discriminative features from the entire prostate volume of interest on the PET/CT images.

The protection of UCK2 protein stability by GART maintains pyrimidine salvage synthesis for HCC growth under glucose limitation.

Overexpression of uridine-cytidine kinase 2 (UCK2), a key enzyme in the pyrimidine salvage pathway, is implicated in human cancer development, while its regulation under nutrient stress remains to be investigated. Here, we show that under glucose limitation, AMPK phosphorylates glycinamide ribonucleotide formyltransferase (GART) at Ser440, and this modification facilitates its interaction with UCK2. Through its binding to UCK2, GART generates tetrahydrofolate (THF) and thus inhibits the activity of integrin-linked kinase associated phosphatase (ILKAP) for removing AKT1-mediated UCK2-Ser254 phosphorylation under glucose limitation, in which dephosphorylation of UCK2-Ser254 tends to cause Trim21-mediated UCK2 polyubiquitination and degradation.

Sleep characteristics and intervertebral disc degeneration risk: an observational and Mendelian randomization study.

Objectives: Sleep disorders are considered a risk factor for aging and skeletal degeneration, but their impact on intervertebral disc degeneration (IDD) remains unclear. The aim of this study was to assess associations between sleep characteristics and IDD, and to identify potential causal relationships.

Methods: Exposure factors included six unhealthy sleep characteristics: insomnia, short sleep duration (< 7 h), long sleep duration (≥ 9 h), evening chronotype, daytime sleepiness, and snoring.

Human breast milk-derived exosomes and their positive role on neonatal intestinal health.

Although the role of breast milk in promoting neonatal growth and maintaining intestinal homeostasis is well established, underlying mechanisms by which it protects the intestine from damage remain to be elucidated. Human breast milk-derived exosomes (HMDEs) are newly discovered active signaling vesicles with a diameter of 30-150 nm, which are key carriers of biological information exchange between mother and child. In addition, due to their ability to cross the gastrointestinal barrier, low immunogenicity, good biocompatibility and stability, HMDEs play an important role in regulating intestinal barrier integrity in newborns.

NLRP7 maintains the genomic stability during early human embryogenesis via mediating alternative splicing.

Genomic instability is the main cause of abnormal embryo development and abortion. NLRP7 dysfunctions affect embryonic development and lead to Hydatidiform Moles, but the underlying mechanisms remain largely elusive. Here, we show that NLRP7 knockout affects the genetic stability, resulting in increased DNA damage in both human embryonic stem cells and blastoids, making embryonic cells in blastoids more susceptible to apoptosis.

Assessment of stigma among patients living with Parkinson's disease: an exploratory study.

Objective: This cross-sectional study aims to assess the levels of stigma among patients with Parkinson's disease (PD) and identify the demographic and clinical factors influencing both internal and external stigma.

Materials And Methods: A total of 200 patients diagnosed with PD were recruited from Beijing Tiantan Hospital between June 2023 and June 2024 using convenience sampling. Data were collected through face-to-face interviews, including demographic information, disease severity assessed via the Movement Disorder Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS), and stigma levels measured using the 24-item Stigma Scale for Chronic Illness (SSCI).

Association of long-term weight management pharmacotherapy with multiple health outcomes: an umbrella review and evidence map.

Background: Multiple meta-analyses (MAs) have demonstrated that six pharmacotherapies, including orlistat, liraglutide, phentermine/topiramate, naltrexone/bupropion, semaglutide, and tirzepatide, improve weight loss and weight maintenance. However, few studies have synthesized and evaluated the quality of this evidence.

Objective: To identify the relevant MAs of randomized clinical trials (RCTs) that explored the association between the six pharmacotherapies and obesity-related health outcomes and adverse events (AEs).

Empowering wastewater treatment with step scheme heterojunction ternary nanocomposites for photocatalytic degradation of nitrophenol.

The ongoing challenge of water pollution necessitates innovative approaches to remove organic contaminants from wastewater. In this work, new two-dimensional S-scheme heterojunction photocatalysts BiO/CdS and MoS/BiO/CdS that are intended for the effective photocatalytic destruction of 4-nitrophenol, a dangerous organic pollutant, are synthesized and characterized. Utilizing a solvothermal method, successfully generated these ternary nanocomposites, which were characterized through various techniques including X-ray diffraction (XRD), scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS), high resolution transmission electronmicroscopy (HRTEM), Brunauer-Emmett-Telle (BET) and diffuse reflectance spectroscopy (DRS).

Longitudinal MRI evaluation of the efficacy of non-enhanced lung cancer brain metastases.

Brain metastases (BM) are the most prevalent intracranial malignancies. Approximately 30-40% of cancer patients develop BM at some stage of their illness, presenting with a high incidence and poor prognosis. Our clinical findings indicate a significant disparity in the efficacy between non-enhanced and enhanced lung cancer BM.

Fitness and adaptive evolution of a Rhodococcus sp. harboring dioxin-catabolic plasmids.

Catabolic plasmids are critical factors in the degradation of recalcitrant xenobiotics, such as dioxins. Understanding the persistence and evolution of native catabolic plasmids is pivotal for controlling their function in microbial remediation. Here, we track the fitness and evolution of Rhodococcus sp.

The difference of oropharyngeal microbiome during acute respiratory viral infections in infants and children.

Acute respiratory infections (ARI) with multiple types of viruses are common in infants and children. This study was conducted to assess the difference of oropharyngeal microbiome during acute respiratory viral infection using whole-genome shotgun metagenomic sequencing. The overall taxonomic alpha diversity did not differ by the types of infected virus.

Research on noise-induced hearing loss based on functional and structural MRI using machine learning methods.

Noise-induced hearing loss (NIHL) is a common occupational condition. The aim of this study was to develop a classification model for NIHL on the basis of both functional magnetic resonance imaging (fMRI) and structural magnetic resonance imaging (sMRI) by applying machine learning methods. fMRI indices such as the amplitude of low-frequency fluctuation (ALFF), fractional amplitude of low-frequency fluctuation (fALFF), regional homogeneity (ReHo), degree of centrality (DC), and sMRI indices such as gray matter volume (GMV), white matter volume (WMV), and cortical thickness were extracted from each brain region.

Global, regional, and national burden of esophageal cancer using the 2019 global burden of disease study.

Esophageal cancer, with its aggressive nature and high mortality, poses diverse epidemiological challenges worldwide. Over the past three decades, esophageal cancer has exhibited a substantial global burden, marked by a significant increase in absolute numbers, contrasting with a decline in age-standardized metrics. Prevalence nearly doubled, reaching 0.

London dispersion forces and steric effects within nanocomposites tune interaction energies and chain conformation.

The interplay between attractive London dispersion forces and steric effects due to repulsive forces resulting from the Pauli principle often determines the geometry and stability of nanostructures. Aromatic polyimides (PI) and carbon nanotubes (CNT) were chosen as building blocks as two components in the hetero delocalized electron nanostructures. Two PIs, having the same diamine part and different linkage substituents between two phenyl rings of dianhydride part, one linked with ether bond (C-O-C) (OPI), the other with C-(CF3)2 (FPI), were investigated.

Herb-disease association prediction model based on network consistency projection.

A growing number of biological and clinical reports indicate the usefulness of herbs in the treatment of complex human diseases, giving an essential supplement for modern medicine. Similar to drugs, the use of experimental validation to identify related diseases of given herbs is both expensive and time-consuming. Such validation is even more difficult because each herb always contains several components.

Towards evaluating and building versatile large language models for medicine.

In this study, we present MedS-Bench, a comprehensive benchmark to evaluate large language models (LLMs) in clinical contexts, MedS-Bench, spanning 11 high-level clinical tasks. We evaluate nine leading LLMs, e.g.

A cross-sectional study on the association between physical activity and the risk of colon cancer based on NHANES 2007-2018.

Colon cancer poses a significant threat to global health, and studies have shown a correlation between physical activity (PA) and the incidence of colon cancer. However, existing research has not quantitatively analyzed PA to evaluate its impact on the risk of colon cancer comprehensively. Data related to the study were obtained from the NHANES database for participants aged 20 and above between 2007 and 2018.

Association between ABCB4 variants and intrahepatic cholestasis of pregnancy.

The ABCB4 gene encodes multidrug resistance protein 3(MDR3), which is a phosphatidylcholine(PC) transfer enzyme that transfers lecithin from the inner part of the phospholipid bilayer to the extracellular bile. The occurrence of intrahepatic cholestasis of pregnancy(ICP) is closely related to ABCB4 variants, but there is limited research on this topic in southern Anhui, China. We sequenced ABCB4 in pregnant women with ICP and healthy pregnant women to explore the relationship.

Mechano-gated iontronic piezomemristor for temporal-tactile neuromorphic plasticity.

In bioneuronal systems, the synergistic interaction between mechanosensitive piezo channels and neuronal synapses can convert and transmit pressure signals into complex temporal plastic pulses with excitatory and inhibitory features. However, existing artificial tactile neuromorphic systems struggle to replicate the elaborate temporal plasticity observed between excitatory and inhibitory features in biological systems, which is critical for the biomimetic processing and memorizing of tactile information. Here we demonstrate a mechano-gated iontronic piezomemristor with programmable temporal-tactile plasticity.