Trauma exposure as a risk factor of major depressive disorder: A matched case-control study.

The association between childhood trauma (CT), stressful life events (SLE) and the onset and severity of major depressive disorder (MDD) has not been extensively studied. This study aimed to investigate the separate and combined association of CT and SLE with the onset and severity of MDD. A total of 503 patients with MDD and 503 controls were included.

Path analysis of the factors associated with postpartum depression symptoms in postpartum women.

Objectives: Postpartum depression (PPD) is widely acknowledged as a significant mental health problem for postpartum women, and several factors have been associated with PPD. This study aimed to assess the prevalence of PPD and explore the factors and relationships associated with PPD symptoms in postpartum women using path analysis. Furthermore, a new framework for PPD modeling for postpartum women was introduced.

EEG microstate analysis and machine learning classification in patients with obsessive-compulsive disorder.

Background: Microstate characterization of electroencephalogram (EEG) is a data-driven approach to explore the functional changes and interrelationships of multiple brain networks on a millisecond scale. This study aimed to explore the pathological changes of whole-brain functional networks in patients with obsessive-compulsive disorders (OCD) through microstate analysis and further to explore its potential value as an auxiliary diagnostic index.

Methods: Forty-eight OCD patients (33 with more than moderate anxiety symptoms, 15 with mild anxiety symptoms) and 52 healthy controls (HCs) were recruited.

Ultrabright aggregation-induced materials for the highly sensitive detection of Ag and T-2 toxin.

Heavy metals and mycotoxins are important contaminants in food pollution. Sensitive, reliable, and rapid detection of heavy metals and mycotoxins is crucial for human health. In this work, imidazole-functionalized aggregation-induced emission (AIE) molecule tetra-(4-pyridylphenyl) ethylene (TPPE) was used as a precise and specific probe for Ag detection, with a limit of detection (LOD) of 0.

YAP promotes fibrosis by regulating macrophage to myofibroblast transdifferentiation and M2 polarization in chronic pancreatitis.

Chronic pancreatitis (CP) is a clinical entity characterized by progressive inflammation and irreversible fibrosis of the pancreas, which ultimately leads to exocrine and/or endocrine insufficiency as well as an increased risk of pancreatic cancer. Currently, there are no specific or effective approved therapies for CP. Herein, we show that macrophage to myofibroblast transdifferentiation (MMT) and M2 macrophage polarization are associated with both human CP and CP experimental mouse models.

From policy to progress: Environmental taxation to mitigate air pollution in OECD countries.

Environmental taxes play a critical role in mitigating air pollution and fostering sustainability by internalizing the social costs of environmental damage. By imposing financial disincentives on polluters, these taxes encourage cleaner practices and technological innovation. Using panel ARDL models, this study examines the impact of environmental taxes on CO₂ emissions across 38 OECD countries, accounting for cross-sectional dependence, non-stationarity, and heterogeneity.

Effects of cadmium on female Drosophila melanogaster and its transgenerational inheritance effects.

Cadmium (Cd) is a silvery-white and shiny heavy metal that is common in daily life and can adversely affect the development, lifespan, and reproduction of organisms. In this study, Drosophila melanogaster (F) were cultured from eggs to adults in medium containing different Cd concentrations (0, 2.25, and 4.

Cooperation of Lactoplantibacillus plantarum and polyethylene microplastics facilitated the disappearance of tetracycline during anaerobic fermentation of whole plant maize.

In agricultural production systems, the harm of both antibiotics and microplastics (MPs) to human health has been an important and continuously concerned issue. A small bagged silage production system was designed to investigate the effects of Lactoplantibacillus plantarum, polyethylene (PE) -MPs and their mixture on the silage fermentation and chemical composition of Tetracycline (TET) -contaminated whole plant maize. In addition, the bacterial community of silage samples was analyzed by using next generation genome sequencing technology.

Long-term suppression of Microcystis aeruginosa by tannic acid: Risks of microcystin pollution and proteomic mechanisms.

Harmful algal blooms are a critical eco-environmental issue with severe impacts on aquatic ecosystems and human health. Tannic acid (TA) has been suggested as an effective algal bloom control, but the molecular mechanisms of its interaction with algae cells and its effects on algal toxin release remain unclear. This study tracked toxin production and release in the toxigenic species Microcystis aeruginosa (M.

Understanding pollutant-driven shifts of antibiotic resistome in activated sludge: A lab-scale study.

Non-antibiotic pollutants have been identified as contributors to the development of antibiotic resistance across various environments. Wastewater treatment plants, recognized as hotspots for antibiotic resistance genes (ARGs), have received extensive attention regarding the mechanisms driving resistance changes in activated sludge. However, the specific impacts of heavy metals and aromatic organics-common pollutants in industrial wastewater-on the resistome of activated sludge, as well as the underlying mechanisms driving these effects, remain underexplored.

Integrating machine learning, suspect and nontarget screening reveal the interpretable fates of micropollutants and their transformation products in sludge.

Activated sludge enriches vast amounts of micropollutants (MPs) when wastewater is treated, posing potential environmental risks. While standard methods typically focus on target analysis of known compounds, the identity, structure, and concentration of transformation products (TPs) of MPs remain less understood. Here, we employed a novel approach that integrates machine learning for the quantification of nontarget TPs with advanced target, suspect, and nontarget screening strategies.

Liquid crystal monomers in soil: Developing priority list based on the proposed soil health indicators.

Liquid crystal monomers (LCMs) are emerging pollutants that have attracted attention recently due to their unique chemical properties and wide applications. However, in-depth research on LCMs' potential risks to soil health remains blank. Therefore, 107 LCMs and nine soil health characterization proteins/enzymes were selected as research objects in this study.

Molecular-level insights of microplastic-derived soluble organic matter and heavy metal interactions in different environmental occurrences through EEM-PARAFAC and FT-ICR MS.

The interactions between microplastic-derived dissolved organic matter (MPs-DOM) and heavy metals (Cu, Pb, and Cd) regulate the complex environmental transport behavior of pollutants in terrestrial and aquatic environments. In this study, fluorescence excited emission matrix spectroscopy combined with parallel factor analysis (EEM-PARAFAC) and electrospray ionization coupled Fourier transform ion cyclotron resonance mass spectrometry (ESI FT-ICR MS) were employed to investigate the complexation mechanism of MPs-DOM with heavy metals, as well as the effects of different environmental occurrences of MPs-DOM on the transport behaviors of heavy metals in saturated porous medium. The findings demonstrated that MPs-DOM, particularly humic-like substances containing aromatic structures and various oxygen functional groups, could form stable complexes with heavy metals.

Efficient Hg(Ⅱ) removed by l-cysteine modified UiO-66 through chemical adsorption via a facile partial ligand replacement strategy.

In this work, UiO-66-l-cys with enhanced adsorption capacity for Hg(Ⅱ) in water was synthesized through a facile two-step partial ligand replacement strategy. The presence of the functional groups significantly enhanced the capacity of the material for Hg(Ⅱ). According to the Langmuir model, the maximum theoretical adsorption capacity was calculated to be 1321.

Design of a Co doped carbon Backbone with self-grown Au nanoparticles via a 'Triple Advantage' Strategy for sensitive dopamine detection.

In this study, a Co doped polyhedral carbon skeleton (Co CN) was prepared by nitrogen carbonization using ZIF-67 as a precursor. The Co CN features a rough surface with excellent electrical conductivity, and the Co atoms exhibit unique catalytic properties. Based on these characteristics, we used Co CN as a carrier to load Au nanoparticles (NPs) onto its surface through the linkage and reduction effects of polyoxometalates (POMs).

Short communication: Genomic prediction based on unbiased estimation of the genomic relationship matrix in pigs.

The traditional genomic relationship matrix (GRM) has shown to be a biased estimation of true kinship, which can affect subsequent genetic analyses. In this study, we employed an unbiased kinship (UKin) estimation method within the genomic best linear unbiased prediction framework to evaluate its prediction performance on both a simulated dataset and a Large White pig dataset. The simulated dataset encompasses six traits, 900 quantitative trait loci, and 36 000 single nucleotide polymorphisms (SNPs).

Cognitive function differs across healthy lifestyle behavior profiles: a 10-year population-based prospective cohort study.

Background: Modifiable lifestyle behaviors significantly influence the risk of cognitive impairment. However, the cumulative effects of multidimensional lifestyle profiles on cognitive function remain poorly understood, as most studies examine individual lifestyle behaviors in isolation. This study aimed to identify distinct profiles of individuals based on healthy lifestyle behaviors and to examine associations between these profiles and cognitive function in older Chinese adults.

New insights into the neurophysiological effects of heat stress on the Chinese mitten crab (Eriocheir sinensis).

Climate warming and frequent incidents of extreme high temperatures are serious global concerns. Heat stress induced by high temperature has many adverse effects on animal physiology, especially in aquatic poikilotherms. Chinese mitten crab (Eriocheir sinensis) is sensitive to high temperatures, this study evaluated the harmful effects of heat stress on the neurotoxicity, intestinal health, microbial diversity, and metabolite profiles.

Unveiling the mechanism of micro-and-nano plastic phytotoxicity on terrestrial plants: A comprehensive review of omics approaches.

Micro-and-nano plastics (MNPs) are pervasive in terrestrial ecosystems and represent an increasing threat to plant health; however, the mechanisms underlying their phytotoxicity remain inadequately understood. MNPs can infiltrate plants through roots or leaves, causing a range of toxic effects, including inhibiting water and nutrient uptake, reducing seed germination rates, and impeding photosynthesis, resulting in oxidative damage within the plant system. The effects of MNPs are complex and influenced by various factors including size, shape, functional groups, and concentration.

The relationship between serum uric acid and accelerated aging in middle-aged and older adults: a prospective cohort study based on CHARLS.

Objective: This study seeks to determine the association between serum uric acid (SUA) and accelerated aging among middle-aged and older adults in China, as well as assess the relationship between SUA trajectories and the risk of accelerated aging.

Methods: We utilized data from the China Health and Retirement Longitudinal Study (CHARLS), selecting middle-aged and older participants who completed follow-ups between 2011 and 2015. Biological age was estimated using the Klemera-Doubal method, and accelerated aging was determined by calculating the difference between an individual's biological age and their chronological age.

Improvement of the accuracy of breeding value prediction for egg production traits in Muscovy duck using low-coverage whole-genome sequence data.

Low-coverage whole genome sequencing (lcWGS) is an effective low-cost genotyping technology when combined with genotype imputation approaches. It facilitates cost-effective genomic selection (GS) programs in agricultural animal populations. GS based on lcWGS data has been successfully applied to livestock such as pigs and donkeys.

Effects of tannic acid on growth performance, intestinal health, and tolerance in broiler chickens.

This study investigated the optimal tannic acid dosage and assessed tolerance levels in broiler chickens. In experiment 1, 525 broilers were randomly divided into 5 treatment groups, the control group (CON group) and groups TA1 to TA4, corresponding to treatments of 0.025, 0.

Comprehensive Genetic Profile of Chinese Muscle-Invasive Bladder Cancer Cohort.

Objective: The aim of our study was to characterize the spectrum of mutations in muscle-invasive bladder cancer (MIBC) in the Chinese population, identifying mutational features and exploring potential therapeutic targets.

Methods: We collected samples from 62 Chinese patients with MIBC. For each patient, tumor tissues or blood samples were collected and sequenced by whole exome sequencing.

Validation of the Chinese version of the Epilepsy Anxiety Survey Instrument (EASI) and its brief version (brEASI) in Western China.

Objective: To translate and validate the Chinese version of the Epilepsy Anxiety Survey Instrument (EASI) and its brief version (brEASI) among Chinese people with epilepsy.

Methods: Adult outpatients from Sichuan Provincial People's Hospital were recruited. The type of anxiety disorder was determined via the Mini International Neuropsychiatric Interview (MINI).