Chemical Composition of Royle Ex Wight and Its Potential Role in Ameliorating Colitis.

Royle ex Wight, commonly known as "Baishouwu," has been traditionally used in China for its medicinal and dietary benefits. Despite its long history of use, the potential therapeutic effects of in the treatment of colitis have not been fully investigated. This study aims to evaluate the effects of the water extract of root on colitis and elucidate its potential mechanisms of action.

Ellagic Acid Modulates Necroptosis, Autophagy, Inflammations, and Stress to Ameliorate Nonalcoholic Liver Fatty Disease in a Rat Model.

Nonalcoholic fatty liver disease (NAFLD) is considered one of the most common metabolic disorders worldwide. Although the pathoetiology of NAFLD is not fully elucidated, recent evidence suggests the involvement of stress, inflammation, and programmed death in the onset and progression of the disease. This investigation aimed to evaluate the effects of ellagic acid (EA), a known herbal antioxidant, on a high-fat diet (HFD)-induced animal model of NAFLD by evaluating the status of lipid profile, necroptosis (RIPK1, RIPK3, and MLKL), autophagy (LC3, ATG5, and BECN1), inflammation (TNF-α, IL-6, IL-4, and IL-10), and stress (SOD, CAT, GR, GPx, and MDA).

Therapeutic effects and mechanisms of Juanbilijieqing fang in ameliorating gouty arthritis in a murine model.

This study aims to assess the safety, efficacy, and mechanisms of Juanbilijieqing Fang in a mouse model of gouty arthritis. C57BL/6 mice were allocated into six groups: control, gouty arthritis model, and treatment groups receiving varying doses of Juanbilijieqing Fang (low, medium, high), along with a positive control group treated with febuxostat. Gouty arthritis was induced via MSU crystal injection following a high-fat diet.

ALKBH5 knockdown suppresses gastric cancer progression by reducing the expression of long non-coding RNA TUG1.

Purpose: This study aimed to explore the relationship between m6A demethylase ALKBH5 and long noncoding RNA TUG1 (TUG1), as well as their effects on proliferation, migration, and angiogenesis in gastric cancer (GC) cells.

Methods: The Cancer Genome Atlas (TCGA) database was utilized to analyze the relative expression levels of ALKBH5, TUG1, and vascular endothelial growth factor A (VEGFA). Survival analyses of TUG1, ALKBH5, and VEGFA were performed using the Gene Expression Profiling Interactive Analysis (GEPIA) and Kaplan-Meier databases.

Short-Wave Infrared Optoelectronics with Colloidal CdHgSe/ZnCdS Core/Shell Nanoplatelets.

Colloidal semiconductor nanocrystals (NCs) are an efficient and cost-effective class of nanomaterials for optoelectronic applications. Advancements in NC-based optoelectronic devices have resulted from progress in synthetic chemistry, adjustable surface properties, and optimized device architectures. Semiconductor nanoplatelets (NPLs) stand out among other NCs due to their precise growth control, yielding uniform thickness with submonolayer roughness.

Personality traits, mindfulness, and perceived stress in Chinese adults: a sequential explanatory mixed-methods approach.

Background: This study explores how personality traits and mindfulness facets interact to influence perceived stress, focusing on a Chinese adult sample. It aims to address gaps in understanding the combined effects of dispositional and mindfulness factors on stress.

Methods: A sequential explanatory mixed-methods design was employed.

The characteristic of poverty-alleviation behavioral strategies of the rural poor population and their relationship with socio-demographic factors.

Objective: The primary objective of this study is to investigate the fundamental patterns and characteristics of poverty-alleviation behavior strategies among rural poor population. It aims to examine the association between the key socio-demographic characteristics of these populations and their poverty-alleviation strategies, thereby identifying the individual and sociocultural factors related to these behaviors.

Methods: This study employs a questionnaire designed to assess poverty-alleviation behavior strategies among rural poor population.

The impact of moral judgment on bystanders' interpersonal trust: the mediating role of trustworthiness.

Interpersonal trust is the premise and foundation of encouraging cooperation in this age of rapid progress. The purpose of this study was to investigate how moral judgment affects bystanders' interpersonal trust and its internal mechanisms when there are ethical transgressions. The moral judgment of the evaluators was divided into three categories-opposition, neutrality and approval-on the basis of the moral transgressions of the offenders.

The effect of the teacher-student relationship on the academic adjustment of returned migrant children: the chain mediating role of school attitude and resilience.

Introduction: Returned migrant children have not received widespread attention in China, and research on their academic adjustment is still limited. Teachers are important individuals who influence the academic development of returned migrant children, and the aim of the study is to analyze the mechanism by which the teacher-student relationship affects their academic adjustment.

Methods: This study followed a sample of 1921 returned migrant children across 8 counties in central and western China, using an academic adjustment scale, a teacher-student relationship scale, a school attitude scale, and a resilience scale.

Fostering learning engagement: the impact of different interpersonal relationships from the perspective of positive youth development.

Learning engagement is a crucial factor affecting the quality of learning and holds significant value in promoting student development and enhancing teaching quality. By using time-lagged data from four schools and considering intentional self-regulation, this study integrates three types of relationships (parent-child, teacher-student, and peer relationships) into the same research framework to examine their impacts on learning engagement and the underlying mechanisms among high school students. The findings reveal that parent-child, teacher-student, and peer relationships all significantly positively affect high school students' learning engagement.

The impact of goods and services tax increase on economic crime: Evidence from China's tobacco tax hike.

Introduction: Despite the acknowledged interconnection between socioeconomic environment and economic crime, research on the relationship between Goods and Services Tax (GST) and economic crime is scarce because of their complicated relationship. This study examines the impact of the GST increase on the illicit tobacco trade.

Methods: Based on China's tobacco excise tax shock in 2015, this study employs a difference-in-difference (DID) method to analyze the impact of the GST increase on economic crime.

Causal Relationship between Helicobacter Pylori Antibodies and Immune Thrombocytopenia: A Mendelian Randomization Study.

Background: Previous observational studies have suggested a potential causal relationship between Helicobacter pylori () infection and immune thrombocytopenia (ITP). However, the evidence for causal inference remains contentious, and the underlying mechanisms require further investigation. To delve deeper into the relationship between and ITP, we conducted a Mendelian randomization (MR) analysis.

Intraoperative Administration of Esketamine is Associated with Reduced Opioid Consumption After Laparoscopic Gynecological Surgery: A Randomized Controlled Trial.

Purpose: To explore the postoperative opioid-sparing effect and incidence of adverse events of different dosages of intraoperative esketamine administration in patients undergoing laparoscopic gynecological surgery.

Patients And Methods: Patients undergoing elective gynecological laparoscopic operation was enrolled and randomly allocated to lower-dose esketamine group, higher-dose esketamine group, or control group. Patients in the two intervention groups received esketamine doses of 0.

UPLC-MS/MS Method for Givinostat in Rat Plasma: Development, Validation, in vivo Pharmacokinetics Study and in vitro Metabolic Stability Research.

Background: Givinostat, a potent histone deacetylase (HDAC) inhibitor, is promising for the treatment of relapsed leukemia and myeloma.

Purpose: This study aimed to develop and verify a quick assay for the measurement of givinostat concentration using ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) with eliglustat as the internal standard (IS), establishing a basic pharmacokinetic profile for its pre-clinical application and metabolic stability in vitro.

Methods: Sample preparation was performed via protein precipitation using acetonitrile.

Risk Prediction of Liver Injury in Pediatric Tuberculosis Treatment: Development of an Automated Machine Learning Model.

Purpose: Drug-induced liver injury (DILI) is one of the most common and serious adverse drug reactions related to first-line anti-tuberculosis drugs in pediatric tuberculosis patients. This study aims to develop an automatic machine learning (AutoML) model for predicting the risk of anti-tuberculosis drug-induced liver injury (ATB-DILI) in children.

Methods: A retrospective study was performed on the clinical data and therapeutic drug monitoring (TDM) results of children initially treated for tuberculosis at the affiliated Changsha Central Hospital of University of South China.

Advances in Selenium and Related Compounds Inhibiting Multi-Organ Fibrosis.

Selenium (Se), a critically essential trace element, plays a crucial role in diverse physiological processes within the human body, such as oxidative stress response, inflammation regulation, apoptosis, and lipid metabolism. Organ fibrosis, a pathological condition caused by various factors, has become a significant global health issue. Numerous studies have demonstrated the substantial impact of Se on fibrotic diseases.

A prognostic nomogram of non-small cell lung cancer based on tumor marker inflammatory nutrition score.

Background: Patients diagnosed with non-small cell lung cancer (NSCLC) usually have a poor prognosis, so it is critical to identify effective biomarkers for prognosis prediction. The aim of this study is to establish a nomogram to evaluate the prognostic significance of blood markers in patients with NSCLC and provide reference for clinical work.

Methods: A total of 486 patients with NSCLC who were admitted to hospital from January 2009 to December 2019 were retrospectively analyzed.

Development of an AI model for predicting hypoxia status and prognosis in non-small cell lung cancer using multi-modal data.

Background: Prognosis prediction is crucial for non-small cell lung cancer (NSCLC) treatment planning. While tumor hypoxia significantly impacts patient outcomes, identifying hypoxic genomic markers remains challenging. This study sought to identify hypoxic computed tomography (CT) radiomic features and create an artificial intelligence (AI) model for NSCLC through the integration of multi-modal data.

Mapping the evolution and frontiers of : a bibliometric analysis and literature review.

Background And Objective: While bibliometric studies of single journals have been conducted, bibliometric mapping has not yet been used to analyze the literature published by the (). This study aimed to comprehensively review all publications of from its inception to 2024 and provide a detailed overview of its main publication characteristics.

Methods: This study analyzed publications from spanning 2012 to 2024 using CiteSpace, VOSviewer, and the 'Bibliometrix' package in R.

Osimertinib as a neoadjuvant therapy in resectable EGFR-mutant non-small cell lung cancer: a real-world, multicenter retrospective study.

Background: Osimertinib, a third-generation tyrosine kinase inhibitor (TKI), has been authorized for use in patients with epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC). This study aimed to evaluate the effectiveness and safety of neoadjuvant osimertinib in individuals with resectable locally advanced NSCLC harboring EGFR mutation.

Methods: Ten centers located in mainland China took part in a single-arm, real-world, multicenter retrospective study (registration number: ChiCTR2100049954).

Health-related quality of life analysis from ENTER, a randomized, controlled phase III trial of whole-brain radiotherapy with and without concurrent erlotinib in NSCLC with brain metastases.

Background: Health-related quality of life (HRQoL) is critical for patients with lung cancer due to poor prognosis. We presented patient-reported outcomes in patients with non-small cell lung cancer (NSCLC) brain metastases (BM) who received whole-brain radiotherapy (WBRT) in combination with erlotinib or WBRT alone in the phase 3 ENTER study.

Methods: The patients' HRQoL was assessed by using the European Organization for Research and Treatment of Cancer 30-item Core Quality of Life Questionnaire (EORTC QLQ-C30).

Radiomicsmetabolic signature profiles for advanced non-small cell lung cancer with chemoimmunotherapy by reflecting biological function and survival.

Background: Resistance to chemoimmunotherapy in patients with advanced non-small cell lung cancer (NSCLC) necessitates effective prognostic biomarkers. Although F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) has shown potential for efficacy assessment, it has been mainly evaluated in immuno-monotherapy setting, lacking elaborations in the scenarios of immunotherapy combined with chemotherapy. To tackle this dilemma, we aimed to build a non-invasive PET/CT-based model for stratifying tumor heterogeneity and predicting survival in advanced NSCLC patients undergoing chemoimmunotherapy.