Comprehensive genomic analysis of SmbHLH genes and the role of SmbHLH93 in eggplant anthocyanin biosynthesis.

SmbHLH93can activate the expression of SmCHS, SmANS, SmDFR and SmF3H.Overexpression of SmbHLH93promotes anthocyanin biosynthesis. SmbHLH93can interact with SmMYB1 to promote anthocyanin accumulation.

Genetic dissection of foxtail millet bristles using combined QTL mapping and RNA-seq.

QTL mapping of two RIL populations in multiple environments revealed a consistent QTL for bristle length, and combined with RNA-seq, a potential candidate gene influencing bristle length was identified. Foxtail millet bristles play a vital role in increasing yields and preventing bird damage. However, there is currently limited research on the molecular regulatory mechanisms underlying foxtail millet bristle formation, which constrains the genetic improvement and breeding of new foxtail millet varieties.

Research progress of early brain Injury in subarachnoid hemorrhage from 2004 to 2024: a bibliometric analysis.

Early brain injury (EBI) after subarachnoid hemorrhage (SAH) is a clear correlation with poor prognosis. In the past 20 years, the research on EBI has increased rapidly. However, there is a lack of bibliometric analysis related to EBI.

Membranes of Polymer of Intrinsic Microporosity PIM-1 for Gas Separation: Modification Strategies and Meta-Analysis.

Polymers of intrinsic microporosity (PIMs) have received considerable attention for making high-performance membranes for carbon dioxide separation over the last two decades, owing to their highly permeable porous structures. However, challenges regarding its relatively low selectivity, physical aging, and plasticisation impede relevant industrial adoptions for gas separation. To address these issues, several strategies including chain modification, post-modification, blending with other polymers, and the addition of fillers, have been developed and explored.

Centriolar cap proteins CP110 and CPAP control slow elongation of microtubule plus ends.

Centrioles are microtubule-based organelles required for the formation of centrosomes and cilia. Centriolar microtubules, unlike their cytosolic counterparts, are stable and grow very slowly, but the underlying mechanisms are poorly understood. Here, we reconstituted in vitro the interplay between the proteins that cap distal centriole ends and control their elongation: CP110, CEP97, and CPAP/SAS-4.

The interactive role of microRNA and other non-coding RNA in hepatitis B (HBV) associated fibrogenesis.

One of the outstanding features of chronic hepatitis B infection (CHB) is its strong association with liver fibrosis. CHB induced inflammation and injury trigger multiple biochemical and physical changes that include the promotion of a wide range of cytokines, chemokines and growth factors that activate hepatic stellate cells (HSCs) CHB induced activation of hepatic stellate cells (HSCs) is regarded as a central event in fibrogenesis to directly promote the synthesis of myofibroblasts and the expression of a range of materials to repair injured liver tissue. Fibrogenesis is modulated by the mainstream epigenetic machinery, as well as by non-coding RNA (ncRNA) that are often referred to as an ancillary epigenetic response to fine tune gene expression.

Post-transplant cyclophosphamide versus anti-thymocyte globulin in haploidentical stem cell transplantation: a systematic review and meta-analysis.

Post-transplant cyclophosphamide (PTCy) and anti-thymocyte globulin (ATG) are mainstay prophylactic treatment options for graft-versus-host disease (GVHD), widely used in haploidentical stem cell transplantation. Due to a lack of prospective studies, a number of retrospective comparisons have yielded different conclusions as to which prophylaxis regimen is superior. We performed a meta-analysis of these studies to get more informed and comprehensive decisions from clinicians.

Nanoenzyme-based sensors for the detection of anti-tumor drugs.

Natural enzymes are a class of biological catalysts that can catalyze a specific substrate. Although natural enzymes have catalytic activity, they are susceptible to the influence of external environment such as temperature, and storage requirements are more stringent. Since the first discovery of magnetic FeO nanoparticles with peroxidase-like activity in 2007, the research on nanoenzymes has entered a rapid development stage.

Combining resistance indicators, metabolomes and transcriptomes to reveal correlations in disease and cold resistance in tea plant and analyze the key domain NB-ARC.

Integration of resistance indicators, metabolomes, and transcriptomes to elucidate that there is a positive correlation between disease susceptibility and cold tolerance in tea plants. The flavonoid pathway was found to be the major metabolic and transcriptional enrichment pathway. A key domain NB-ARC was identified through joint analysis, along with analysis of key domains within the NB-ARC protein.

Comparison of the efficacy of the modified internal brace and the arthroscopic Broström-Gould procedure for chronic lateral ankle instability.

Purpose: To compare the efficacy of an internal brace and the arthroscopic Broström-Gould procedure for chronic lateral ankle instability (CLAI).

Methods: The clinical data of 71 patients who were diagnosed with chronic lateral ankle instability between May 2020 and May 2022 were retrospectively analyzed. The American Orthopedic Foot and Ankle Society (AOFAS) scale, Foot and Ankle Ability Measure (FAAM), and Visual Analogue Scale (VAS) were used to assess clinical outcomes.

Compressed Sensing-Based Cine-MRI for Location of Dysphagia and Swallowing Function assessment in Patients with Head and Neck Cancer: A Comparative Study.

Cine magnetic resonance imaging (Cine-MRI) may evaluate the swallowing function and locations of patients with dysphagia, which requires very fast imaging speed. Compressed sensing is a technique that allows for faster MRI imaging by sampling fewer data points and reconstructing the image via optimization techniques, crucial for capturing the rapid movements involved in swallowing. This study aimed to analyze swallowing function and locations in patients with head and neck cancer and healthy individuals using Cine-MRI based on compressed sensing.

Autophagy Attenuates Oxidative Stress-Induced Collagen Degradation in Vaginal Fibroblasts: Implications for Pelvic Organ Prolapse.

Introduction And Hypothesis: The relationship between autophagy and pelvic organ prolapse (POP) remains unknown. The aim of this novel experimental study, utilizing tissue samples derived from women undergoing gynecological surgery, is to investigate the role of autophagy in mitigating collagen degradation in human vaginal fibroblasts induced by oxidative stress, with particular emphasis on its implications in the pathogenesis of POP. Exploring the role of autophagy in protecting against collagen degradation and cellular senescence in human vaginal fibroblasts under oxidative stress may offer new insights into therapeutic strategies for conditions such as POP.

RNA-Seq transcriptomic landscape profiling of spontaneously hypertensive rats in youth treated with a ARNI versus ARB.

Angiotensin receptor-neprilysin inhibitor (ARNI) and angiotensin II receptor blockers (ARB) are antihypertension medications that improve cardiac remodeling and protect the heart. However, at the early stage of hypertension, it is still unclear how these two drugs affect the transcriptomic profile of multiple organs in hypertensive rats and the transcriptomic differences between them. We performed RNA sequencing to define the RNA expressing profiles of the eight tissues (atrium, ventricle, aorta, kidney, brain, lung, white fat, and brown fat) in spontaneously hypertensive rats (SHRs) and SHRs treated with ARNI or ARB.

Identification of catechin species using a colorimetric and fluorescence dual-mode sensor array based on peroxidase-like PtNi bunched nanoparticles.

Catechins in tea, as promoters of human health, have attracted widespread attention. Herein, a dual-signal mode (colorimetric and fluorescence) sensor array for catechin species fingerprinting was built based on PtNi bunched nanoparticle (PtNi-BNP)--phenylenediamine (OPD)-HO system. PtNi-BNPs catalyze the reaction between OPD and HO to produce oxidized OPD (oxOPD) with both colorimetric (yellow) and fluorescent properties.

Palladium-Catalyzed Oxidative Allene-Allene Cross-Coupling.

Direct cross-coupling reactions between two similar unactivated partners are challenging but constitute a powerful strategy for the creation of new carbon-carbon bonds in organic synthesis. [4]Dendralenes are a class of acyclic branched conjugated oligoenes with great synthetic potential for the rapid generation of structural complexity, yet the chemistry of [4]dendralenes remains an unexplored field due to their limited accessibility. Herein, we report a highly selective palladium-catalyzed oxidative cross-coupling of two allenes with the presence of a directing olefin in one of the allenes, enabling the facile synthesis of a broad range of functionalized [4]dendralenes in a convergent modular manner.

High-Entropy Aqueous Electrolyte Induced Formation of Water-Poor Zn2+ Solvation Structures and Gradient Solid-Electrolyte Interphase for Long-Life Zn-Metal Anodes.

Electrolyte engineering has emerged as an effective strategy for stabilizing Zn-metal anodes. However, a single solute or solvent additive is far from sufficient to meet the requirements for electrolyte cycling stability. Here, we report a new-type high-entropy electrolyte composed of equal molar amounts of Zn(OTf)2 and LiOTf, along with equal volumes of H2O, triethyl phosphate, and dimethyl sulfoxide, which enhances electrolyte stability by increasing solvation entropy.

Qualitative and Quantitative Analyses of 1-Aminocyclopropane-1-carboxylic Acid Concentrations in Plants Organs Using Phenyl Isothiocyanate Derivatization.

1-Aminocyclopropane-1-carboxylic acid (ACC) is a direct precursor of phytohormone ethylene. We used a phenyl isothiocyanate (PITC) derivatization modification method combined with spectrographic analysis to isolate and identify three products of the derivatization reactions of ACC and PITC. The MRM mode of UPLC-MS/MS was used to establish the analysis of 6-phenyl-5-thioxo-4,6-diazaspiro[2.

SDSPT2s:SDSPT2 with Selection.

As an approximation to SDSCI [static-dynamic-static (SDS) configuration interaction (CI), a minimal MRCI; , , 1481], SDSPT2 [ , , 2696] is a CI-like multireference (MR) second-order perturbation theory (PT2) that treats single and multiple roots in the same manner. This feature permits the use of configuration selection over a large complete active space (CAS) to end up with a much reduced reference space ̃, which is connected only with a small portion (̃) of the full first-order interacting space connected to . The most expensive portion of the reduced interacting ̃ space (which involves three active orbitals) can further be truncated by partially bypassing its generation followed by an integral-based cutoff.

Accelerating Fock Build via Hybrid Analytical-Numerical Integration.

A hybrid analytical-numerical integration scheme is introduced to accelerate the Fock build in self-consistent field (SCF) and time-dependent density functional theory (TDDFT) calculations. To evaluate the Coulomb matrix [], the density matrix is first decomposed into two parts, the superposition of atomic density matrices and the rest = -. While [] is evaluated analytically, [] is evaluated fully numerically [with the multipole expansion of the Coulomb potential (MECP)] during the SCF iterations.

Prolonged grief disorder symptoms and posttraumatic growth among Chinese shidu parents: A latent transition analysis.

Objective: Chinese shidu parents (bereaved parents who have lost the only child) may experience prolonged grief disorder, as well as posttraumatic growth (PTG). This study aimed to examine their latent classes and transition patterns of prolonged grief disorder symptoms and PTG.

Method: Based on a longitudinal design, 265 shidu parents completed the Prolonged Grief Scale-Revised and Short Form of Posttraumatic Growth Inventory for Chinese Shidu Parents twice with an interval of about 5 months.

Switching CO2 Electroreduction toward C2+ Products and CH4 by Regulate the Protonation and Dimerization in Platinum/Copper Catalysts.

Copper (Cu)-based catalysts exhibit distinctive performance in the electrochemical CO2 reduction reaction (CO2RR) with complex mechanism and sophisticated types of products. The management of key intermediates *CO and *H is a necessary factor for achieving high product selectivity, but lack of efficient and versatile strategies. Herein, we designed Pt modified Cu catalysts to effectively modulate the competitive coverage of those intermediates.

Modulation of magnesium intake on the association between vitamin D deficiency and severe hepatic steatosis in overweight and obese individuals.

This study aimed to explore the association between serum vitamin D and/or dietary magnesium intake levels and severe hepatic steatosis. This cross-sectional study collected data from 2,874 individuals in the NHNAES database between 2017 and 2018. Variables were subjected to weighted univariate logistic regression analysis, and variables with p<0.

The effect of propolis supplementation on blood pressure: a systematic review and meta-analysis of controlled trials.

Introduction: The current meta-analysis aimed to determine the efficacy of propolis supplementation on hypertension.

Evidence Acquisition: The systematic review and meta-analysis. were undertaken on five online databases to find clinical trials assessing the effects of propolis on systolic blood pressure (SBP) and diastolic blood pressure (DBP) markers up to October 2023.

Experiment-Guided Refinement of Milestoning Network.

Milestoning is an efficient method for calculating rare event kinetics by constructing a continuous-time kinetic network that connects the reactant and product states. Its accuracy depends on both the quality of the underlying force fields and the trajectory sampling. The sampling error can be effectively controlled through various methods.