Dipicolylamine Derivatives Bearing Pyrene and Anthracene as Molecular Probes for Cu and HS.

Two dipicolylamine (DPA) derivatives with the pyrene and anthracene groups, 1-(pyren-1-yl)-N, N-bis-(pyridine-2-ylmethyl)benzylamine (L1) and 1-(anthracen-9-yl)-N, N-bis-(pyridine-2-ylmethyl)benzylamine (L2) were synthesized, characterized, and their affinitive properties for metal ions were studied. The mass spectroscopy and Job's plots showed that L1 and L2 reacted with Cu and formed complexes [Cu(L1)(solvent)] (L1-Cu) and [Cu(L2)(solvent)] (L2-Cu), respectively. Both L1 and L2 were fluorescent probes recognizing Cu via the emission quenching and further detecting HS via the emission revival.

A Novel High-Conjugated Probe of 4-(Acridone-10-yl)-Phenylethyl Chloroformate (APE-Cl) for Rapid Detection of Amino Compounds Using HPLC with Fluorescence Detection.

The fluorescence detection of amino compounds and the evaluation of their content in environmental samples are vital, not only for assessing food quality but also for studying soil organic matter. Here, we present the synthesis and application of a novel fluorescent probe, 4-(9-acridone)benzylmethyl carbonochloride (APE-Cl), for detecting amino compounds via a chloroformate reaction with fluorescence detection. The complete derivatization reaction of APE-Cl with amino compounds can be accomplished in aqueous acetonitrile within 5 min at room temperature, using 0.

Time-varying intensity of ventilatory inefficiency and mortality in patients with acute respiratory distress syndrome.

Background: The association between bedside ventilatory parameters-specifically arterial carbon dioxide pressure (PaCO) and ventilatory ratio (VR)-and mortality in patients with acute respiratory distress syndrome (ARDS) remains a topic of debate. Additionally, the persistence of this association over time is unclear. This study aims to investigate the relationship between 28-day mortality in ARDS patients and their longitudinal exposure to ventilatory inefficiency, as reflected by serial measurements of PaCO and VR.

Rapid Video Analysis for Contraction Synchrony of Human Induced Pluripotent Stem Cells-Derived Cardiac Tissues.

Background: The contraction behaviors of cardiomyocytes (CMs), especially contraction synchrony, are crucial factors reflecting their maturity and response to drugs. A wider field of view helps to observe more pronounced synchrony differences, but the accompanied greater computational load, requiring more computing power or longer computational time.

Methods: We proposed a method that directly correlates variations in optical field brightness with cardiac tissue contraction status (CVB method), based on principles from physics and photometry, for rapid video analysis in wide field of view to obtain contraction parameters, such as period and contraction propagation direction and speed.

Trifluridine/Tipiracil (FTD/TPI) in Metastatic Colorectal Cancer in Hong Kong: A Territory-Wide Cohort Study.

Introduction: Randomized phase III trials showed that using trifluridine/tipiracil (FTD/TPI) in patients with pre-treated metastatic colorectal cancer (mCRC) conferred survival benefit versus placebo. Here, we investigated the effectiveness and safety of FTD/TPI and sought to identify prognostic factors among the mCRC population in Hong Kong.

Methods: A non-interventional, retrospective, multicenter cohort study enrolled patients with mCRC who received FTD/TPI in seven public hospitals in Hong Kong between 2016 and 2020.

Automatic segmentation model and machine learning model grounded in ultrasound radiomics for distinguishing between low malignant risk and intermediate-high malignant risk of adnexal masses.

Objective: To develop an automatic segmentation model to delineate the adnexal masses and construct a machine learning model to differentiate between low malignant risk and intermediate-high malignant risk of adnexal masses based on ovarian-adnexal reporting and data system (O-RADS).

Methods: A total of 663 ultrasound images of adnexal mass were collected and divided into two sets according to experienced radiologists: a low malignant risk set (n = 446) and an intermediate-high malignant risk set (n = 217). Deep learning segmentation models were trained and selected to automatically segment adnexal masses.

A randomized, crossover trial of one night of oxygen therapy for obstructive sleep apnea in patients with fibrotic interstitial lung disease.

Background And Objective: There is no satisfactory treatment for obstructive sleep apnea (OSA) in patients with interstitial lung disease (ILD) because of poor tolerance of positive airway pressure (PAP) therapy. Supplemental oxygen therapy has been shown to reduce hypoxemia and is well tolerated in patients with ILD. However, little is known about the effect of nocturnal oxygen supplementation (NOS) on OSA in patients with ILD.

Relational Victimization, Coping Styles and Depressive Symptoms: A Test of Bidirectional Associations in Adolescence.

Although evidence from previous studies suggests that adolescents with negative coping styles who experienced victimization are more likely to exhibit depressive symptoms, these associations have not yet been disentangled to separate between-person differences from within-person effects. To investigate the within-person bidirectional relationships among relational victimization, coping styles and depressive symptoms, this study conducted a four-wave random intercept cross-lagged panel model analysis. The final sample consisted of 1506 adolescents, 72.

The immune-related gene CD5 is a prognostic biomarker associated with the tumor microenvironment of breast cancer.

The occurrence and progression of breast cancer (BCa) are complex processes involving multiple factors and multiple steps. The tumor microenvironment (TME) plays an important role in this process, but the functions of immune components and stromal components in the TME require further elucidation. In this study, we obtained the RNA-seq data of 1086 patients from The Cancer Genome Atlas (TCGA) database.

Hepatoma cell-derived exosomal SNORD52 mediates M2 macrophage polarization by activating the JAK2/STAT6 pathway.

Background: A recent study revealed the oncogenic role of box C/D small nucleolar RNA 52 (SNORD52) in hepatocellular carcinoma (HCC) by facilitating the aggressive phenotypes of hepatoma cells. However, the potential role of exosomal SNORD52 in macrophage polarization during HCC progression remains poorly understood.

Methods: Exosomes were isolated from hepatoma cells.

Screening of obstructive sleep apnea and diabetes mellitus -related biomarkers based on integrated bioinformatics analysis and machine learning.

Background: The pathophysiology of obstructive sleep apnea (OSA) and diabetes mellitus (DM) is still unknown, despite clinical reports linking the two conditions. After investigating potential roles for DM-related genes in the pathophysiology of OSA, our goal is to investigate the molecular significance of the condition. Machine learning is a useful approach to understanding complex gene expression data to find biomarkers for the diagnosis of OSA.

Feasibility study for evaluating cervical intervertebral disc degeneration using axial diffusion tensor imaging.

Background: Intervertebral disc (IVD) degeneration is the main cause of neck pain. Although conventional magnetic resonance imaging can detect morphological changes in intervertebral disc degeneration, it cannot provide accurate and objective evaluations. Magnetic resonance diffusion tensor imaging (DTI) reflects the microstructural changes in tissues by describing the diffusion of water molecules.

A comprehensive pan-cancer analysis of RNF187 in human tumors.

Purpose: RING Finger 187 (RNF187) has recently emerged as a potential contributor to tumorigenesis. However, a comprehensive pan-cancer analysis of RNF187 in human tumors has not been undertaken until now.

Methods: Our study aims to investigate RNF187 expression across 33 different types of human tumors, utilizing data from the TCGA and GTEx databases.

Dye-sensitized upconversion nanoprobes with ultra-high signal-to-background ratio for visual and sensitive detection of nerve agent mimics.

An exciting upconversion nanoprobe conditioning strategy is proposed to improve the signal-to-background ratio (SBR) through a dye-sensitized strategy, in which the dye functions both as a recognition unit of the detection target and as a sensitizer to amplify the visible luminescence of the lanthanide-doped upconversion nanoparticles (UCNPs), instead of a quencher. The application of this dye-sensitized upconversion nanoprobe to the visual detection of nerve agent mimics diethoxy phosphatidylcholine (DCP) showed excellent detection performance, with up to 110-fold enhancement of the luminescence response of the probe in DCP solution and a detection limit as low as 2 nM. Finally, we performed visual detection of DCP solution and vapor by using test strips containing the probe.

Causal relationship between skin microbiota and Hidradenitis suppurativa: a two-sample Mendelian randomization study.

Background: Data from observational and clinical studies indicate an association between skin microbiota and hidradenitis suppurativa (HS). However, the causal relationship between skin microbiota and HS remains to be elucidated.

Methods: We obtained data on skin microbiota and HS from summary statistics of genome-wide association studies and applied Mendelian randomization (MR) statistical methods to assess causality.

Molecular structure characteristic of coals of different rank.

Context: Understanding the structural characteristics of coal at the molecular level is fundamental for its effective utilization. To explore the molecular structure characteristic, the long-flame coal from Daliuta (DLT), coking coal from Yaoqiao (YQ), and anthracite from Taixi (TX) were investigated using various techniques such as elemental analysis, Fourier transform infrared spectroscopy, solid-state C nuclear magnetic resonance spectroscopy, and X-ray photoelectron spectroscopy. Based on the structural parameters, the coal molecular model was constructed and optimized.

Aptamer proximal enzyme cascade reactions for ultrafast detection of glucose in human blood serum.

An innovative colorimetric sensing strategy was developed for the detection of glucose by the integration of glucose aptamer, glucose oxidase (GOx), and horseradish peroxidase (HRP), termed aptamer proximal enzyme cascade reactions (APECR). In the presence of glucose, aptamer binding enables GOx to catalyze glucose oxidation into HO efficiently. Subsequently, the adjacent HRP catalyzes the oxidation of the peroxidase substrate, 2,2'-biazobis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), utilizing the generated HO, resulting in a distinct color change.

Assessment of drivers' visual search patterns and cognitive load during driving in curved tunnels.

Objective: The objective of this study was to assess drivers' visual search patterns and cognitive load during driving in curved tunnels. Specifically, we aimed to investigate how different curved tunnel geometries (tunnel radii, turning directions) and zones (entrance, middle, exit) influence drivers' saccadic eye movements. This understanding can inform the development of safer tunnel designs and driving guidelines.

A Theoretical Study on Crossings Among Electronically Excited States and Laser Cooling of Group VIA (S, Se, and Te) Hydrides.

Various electronically excited states and the feasibility of direct laser cooling of SH, SeH, and TeH are investigated using the highly accurate ab initio and dynamical methods. For the detailed calculations of the seven low-lying Λ-S states of SH, we utilized the internally contracted multireference configuration interaction approach, considering the spin-orbit coupling (SOC) effects. Our calculated spectroscopic constants are in very good agreement with the available experimental results.

Associations of Exposure to 56 Serum Trace Elements with the Prevalence and Severity of Acute Myocardial Infarction: Omics, Mixture, and Mediation Analysis.

Several studies have reported associations between specific heavy metals and essential trace elements and acute myocardial infarction (AMI). However, there is limited understanding of the relationships between trace elements and AMI in real-life co-exposure scenarios, where multiple elements may interact simultaneously. This cross-sectional study measured serum levels of 56 trace elements using inductively coupled plasma mass spectrometry.

Association between preconception and early pregnancy exposure to fine particulate matter and nervous system anomalies: a nested case-control study.

Although several environmental factors may increase the risk of nervous system anomalies, the association between exposure to particulate matter with an aerodynamic diameter of ≤ 2.5 μm (PM) and nervous system anomalies is not completely understood. This study aimed to examine the association between expoure to PM and nervous system anomalies, including specific phenotypes during preconception and early pregnancy and determine the crucial time windows.

Change in sleep, gastrointestinal symptoms, and mood states at high altitude (4500m) for 6 months.

Purpose: This study aimed to investigate the alterations in sleep quality and sleep patterns among military personnel at altitudes ranging from 1500 to 4500 m, as well as the associated factors influencing their sleep.

Methods: This study employed a longitudinal prospective survey conducted over a period of six months, from November 2023 to June 2024. A total of 90 soldiers were recruited for participation.