Plasma D-Dimer Changes and Clinical Value in Acute Lower Extremity Deep Venous Thrombosis Treated with Catheter-Directed Thrombolysis.

Objective: This study sought to investigate the changes in plasma D-dimer levels during catheter-directed thrombolysis (CDT) in patients with acute lower extremity deep venous thrombosis (DVT), analyze imaging results, and assess their clinical implications.

Methods: We retrospectively analyzed 62 patients diagnosed with acute lower extremity DVT who underwent CDT between March 2019 and December 2022. Plasma D-dimer levels were measured before CDT, at regular intervals after CDT, and at the end of CDT.

The effect of saffron supplementation on liver and kidney function, blood glucose and pressure in patients with diabetes and prediabetes: A grade assessed systematic review and meta-analysis of randomized controlled trials.

Saffron has been traditionally used for various health benefits, but its effects on biomarkers of liver function, kidney function, and blood pressure in diabetes are not well understood. This meta-analysis aims to evaluate the impact of saffron supplementation on systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting blood glucose (FBG), liver enzymes (ALT, AST), and kidney function markers (BUN, creatinine) in patients with diabetes and prediabetes. A comprehensive search was conducted across multiple databases to identify randomized controlled trials (RCTs) assessing saffron/crocin supplementation on glycemic control, hepatic and renal function, and blood pressure regulation in patients with diabetes and prediabetes.

Multi-channel spatio-temporal graph attention contrastive network for brain disease diagnosis.

Dynamic brain networks (DBNs) can capture the intricate connections and temporal evolution among brain regions, becoming increasingly crucial in the diagnosis of neurological disorders. However, most existing researches tend to focus on isolated brain network sequence segmented by sliding windows, and they are difficult to effectively uncover the higher-order spatio-temporal topological pattern in DBNs. Meantime, it remains a challenge to utilize the structure connectivity prior in the DBNs analysis.

Clinical value of multi-slice spiral CT in evaluating preoperative TNN staging and postoperative recurrence and metastasis of colon carcinoma.

To evaluate the clinical value of multi-slice spiral CT in preoperative TNN staging and postoperative recurrence and metastasis of colon carcinoma, and to provide evidence for the reliability of CT in the diagnosis of colon carcinoma METHODS: 89 patients with colon carcinoma diagnosed pathologically in our hospital from July 2020 to April 2023 were selected retrospectively. The preoperative TNN staging and postoperative recurrence and metastasis were monitored by 64 row 128 layer spiral CT. The diagnostic coincidence rate, TNM staging coincidence rate and postoperative recurrent TNM staging accuracy were evaluated according to the pathological diagnosis RESULTS: The diagnostic coincidence rate of multi-slice spiral CT was 97.

Preparation of Anterolateral Thigh Flap from Polio-Affected Lower Limb: A Safe Surgical Option that Preserves Patient's Motor Function.

The anterolateral thigh (ALT) flap is a commonly used donor site for free tissue transfer, especially in head and neck reconstructions. The flap's success is primarily determined by the quality and quantity of its perforating vessels, which is why clinicians typically prefer harvesting from a healthy leg with intact vascular anatomy. Poliomyelitis typically causes unilateral lower limb paralysis, resulting in muscle atrophy and deformities.

High expression of ARPC1B promotes the proliferation and Apoptosis of clear cell renal cell carcinoma cells, leading to a poor prognosis.

Background: ARPC1B has been identified as a key regulator of malignant biological behavior in various tumors. However, its specific role in clear cell renal cell carcinoma (ccRCC) remains poorly understood. This study aims to evaluate the influence of ARPC1B on the prognosis and disease progression in ccRCC patients.

scRNA-seq reveals involvement of monocytes in immune response in SLE patients.

Background: Systemic Lupus Erythematosus (SLE) is a typical autoimmune disease characterized by a complex pathogenesis and a strong genetic predisposition. The study of inflammatory response in SLE monocytes is not very clear, and exploring the inflammatory factors of monocytes is beneficial to discover new diagnostic targets.

Results: Using scRNA-seq technology, we obtained the quantitative changes in circulating immune cells and various cellular immune metabolic profiles between SLE patients and healthy volunteers.

Effects of irisin on ovariectomy-induced depression, anxiety, and bodyweight growth in female mice.

Hormone replacement therapy (HRT) for postmenopausal syndrome (PMS) carries high risks of undesirable side effects. This study explores irisin as a potential alternative to HRT and investigates the underlying mechanisms. Ovariectomized (OVX) female mice was used as an animal model.

Effect of substitutive growth hormone therapy on myopia control among Chinese children.

Purpose: To explore the correlation between recombinant human growth hormone (rhGH) therapy and myopia progression, and to optimize the myopia control strategies in myopic children undergoing rhGH therapy.

Methods: This retrospective study included 27 myopic children receiving rhGH therapy and 57 myopic children in the control group, all of whom underwent myopia interventions. Axial length (AL) and refraction were measured by IOLMaster and an autorefractor after cycloplegia.

Construction of a fusant bacterial strain simultaneously degrading atrazine and acetochlor and its application in soil bioremediation.

Application of herbicide-degrading bacteria is an effective strategy to remove herbicide in soil. However, the ability of bacteria to degrade a herbicide is often severely limited in the presence of other pesticide. In this study, the atrazine-degrading strain Klebsiella varicola FH-1 and acetochlor-degrading strain Bacillus Aryabhatti LY-4 were used as parent strains to construct the recombinant RH-92 strain through protoplast fusion technology.

Identification of a functional CircRNA-miRNA-mRNA network and inhibitory effect of Hsa_circ_0001681 on gliomas.

Objective: Gliomas pose a significant global health challenge due to high rates of morbidity and mortality. Recent research has indicated that circular RNAs (circRNAs) may play a crucial role in gliomas. However, the specific impacts of circRNAs on gliomas development is poorly understood.

Sensitive and specific LAMP and multiplex qRT-PCR assays for detection of hypervirulent Klebsiella pneumoniae.

Hypervirulent Klebsiella pneumoniae (hvKP) pose significant challenges to clinical anti-infective treatment and has emerged as a major threat to global public health. In this study, we employed the loop-mediated isothermal amplification (LAMP) assays with OTG (orange to green) visual dye and multiplex quantitative real-time PCR (qRT-PCR) assay to rapidly detect hvKP. We determined the detection limits of the LAMP methods for K.

Rapid indirect detection of N-lactoyl-phenylalanine using dual DNA biosensors based on solution-gated graphene field-effect transistor.

As obesity rates continue to rise, there is an increasing focus on reducing obesity through exercise. People are becoming more aware of the importance of weight loss through physical activity. However, the effectiveness of exercise can vary significantly among individuals, making it challenging to evaluate its impact.

Identifying potential prognosis markers in relapsed multiple myeloma via integrated bioinformatics analysis and biological experiments.

Background: Almost all multiple myeloma (MM) patients will eventually develop disease that has relapsed with or become refractory to current therapeutic regimes. However, the pervious clinical parameters have been proved inaccurate for defining MM relapse, and molecular targets have become the focuses of interests. Prognostic predictions based on molecular targets have been more effective to this day.

Circulating tumour DNA in predicting and monitoring survival of patients with locally advanced rectal cancer undergoing multimodal treatment: long-term results from a prospective multicenter study.

Background: Neoadjuvant chemoradiotherapy (nCRT) is the standard for locally advanced rectal cancer (LARC). However, distant metastasis remains the primary cause of treatment failure. Early identification of high-risk individuals for personalized treatment may offer a solution.

Mitigating ice sheets and mountain glaciers melt with geoengineering.

The inadequacy of current emission reduction measures necessitates exploring innovative approaches to address the critical issue of ice sheet and mountain glacier melting. Geoengineering emerges as a potential solution to mitigate severe cryospheric changes. This review systematically examines geoengineering techniques tailored to ice sheets and mountain glaciers, analyzing their efficacy, risks, and limitations based on existing literature.

Ultrafiltration membrane modelling: Comparing two mathematical models by sensitivity and uncertainty analysis for Palermo and Corleone (Italy) water reuse case studies.

The new EU Urban Wastewater Treatment Directive requires stricter limits introducing quaternary treatments and poses significant challenges to achieving a sustainable environment. Advanced membrane-based treatment processes combined with mathematical models can be a good solution for facing the challenges above. Most existing literature on membrane filtration models primarily focuses on membrane bioreactors, lacking mechanistic models on ultrafiltration (UF) membranes.

Exposure to nano-polystyrene during pregnancy leads to Alzheimer's disease-related pathological changes in adult offspring.

Nanoplastics are common environmental pollutants. As of now, research has yet to explore how exposure to nanomaterials during gestation might influence the risk of developing Alzheimer's disease (AD) in offspring. Throughout the research, we assessed the AD pathology in adult offspring of mice prenatal 80 nm polystyrene nanoparticles (PS-NPs) exposure.

Discovery of phloridzin as a new antagonist for Di(2-ethylhexyl) phthalate-induced male reproductive toxicity based on the adverse outcome pathway network and drug-target gene set enrichment analysis.

Di(2-ethylhexyl) phthalate (DEHP) is a widespread ubiquitous phthalate environmental contaminant. The male reproductive toxicity (MRT) from exposure to DEHP and its main metabolite, mono(2-ethylhexyl) phthalate (MEHP), has been well documented. Fully elucidating its toxic mechanism and discovering effective antagonists are desirable means to reduce the health risks of DEHP.

Impact of leachate from boiled-water-treated plastic products on male reproductive health: Insights from transcriptomic and metabolomic profiling.

Given the extensive use of plastic materials in modern society, there is an escalating concern about the potential risks associated with exposure to plastic products. This study investigated the impact of plastic leachates from boiled-water-treated cups, including polypropylene (PP), high-density polyethylene (HDPE), low-density polyethylene (LDPE), polystyrene (PS), and polyethylene terephthalate (PET), on male reproductive health. Experimental mice were administered daily doses of the plastic leachates for 180 consecutive days.

Maternal exposure to deltamethrin during pregnancy and lactation impairs hippocampal learning and memory function of male offspring by ferroptosis.

Deltamethrin (DM), a broad-spectrum insecticide, is widely used in the world. It can exert direct action on the central nervous system to produce neurotoxicity. Exposure to DM can lead to iron metabolism disorder, oxidative stress and learning and memory dysfunction.

Aflatoxin B1 impairs the growth and development of chicken PGCs through oxidative stress and mitochondrial dysfunction.

Aflatoxins harm the reproductive system and gamete development in animals. Primordial germ cells (PGCs) in chickens, as ancestral cells of gametes, are essential for genetic transmission, yet the impact and mechanisms of aflatoxins on them remain elusive. This study systematically investigated the effects of aflatoxin B1 (AFB1) on chicken PGCs and their potential mechanisms using an in vitro culture model.

Cardiotoxicity of polystyrene nanoplastics and associated mechanism of myocardial cell injury in mice.

Aims: Nanoplastics (NPs) are emerging organic pollutants generated by plastic degradation and are ubiquitous in the environment. They can be accumulated through the food webs and enter the human body through dietary intake, posing health risks. The main target organs of NP accumulation are the lungs, liver, heart, and kidneys.

The association between screen time trajectories and the comorbidity of depression and anxiety.

Depression and anxiety are often comorbid among adolescents. Adolescent screen time changes over time. This study investigates the association between screen time trajectories and the comorbidity of depression and anxiety from a longitudinal perspective.

A predictive model of cognitive impairment risk in older adults with hypertension.

Background: Hypertension is one of the most common diseases in the world, impacting global life expectancy and associated with an increased risk of cognitive impairment.

Objective: This study aimed to develop a nomogram that accurately predicts the risk of cognitive impairment in hypertensive patients using the National Health and Nutrition Examination Study (NHANES).

Methods: A total of 1517 hypertensive patients from NHANES 2011-2014 were included in this study.