Decarboxylase mediated oxalic acid metabolism is important to antioxidation and detoxification rather than pathogenicity in .

Oxalic acid (OA), an essential pathogenic factor, has been identified in several plant pathogens, and researchers are currently pursuing studies on interference with OA metabolism as a treatment for related diseases. However, the metabolic route in remains unknown. In this study, we describe D-erythroascorbic acid-mediated OA synthesis and its metabolic and clearance pathways in rice blast fungus.

Roles of the CDCA gene family in breast carcinoma.

Cell division cycle-associated (CDCA) genes are dysregulated in carcinomas. Our study aims to identify similarities and differences of the clinical roles of CDCAs in breast cancer (BRCA) and to explore their potential mechanisms. In GEPIA, compared to normal tissues, expressions of CDCAs were higher in BRCA and sub-types.

Feasibility, Acceptability, and Preliminary Efficacy of the Unified Protocol for Transdiagnostic Treatment of Emotional Disorders in Adolescents in China: A Pilot Study.

Currently, there is a lack of cost-effective and accessible intervention resources for Chinese adolescents with emotional disorders. The Unified Protocol for Transdiagnostic Treatment of Emotional Disorders in Adolescents (UP-A), which aims to apply transdiagnostic treatment principles to target core dysfunctions across a range of emotional disorders with a single protocol, could fill this gap. We first modified the UP-A for use in the Chinese cultural context and then assessed its feasibility, acceptability, and preliminary efficacy using a single-arm design.

A Randomized Comparison of Bioheart Sirolimus-Eluting Bioresorbable Scaffold and Everolimus-Eluting Stents: The BIOHEART-II Trial.

Background: First-generation bioresorbable scaffolds (BRS) increased risks of stent thrombosis and adverse events. The Bioheart scaffold is a new poly-L-lactic acid-based BRS.

Objectives: This study sought to evaluate the efficacy and safety of the BRS in patients with coronary artery disease.

Early and Late Outcomes With the Absorb Bioresorbable Vascular Scaffold: Final Report From the ABSORB Clinical Trial Program.

Background: The risk-benefit ratio of the Absorb bioresorbable vascular scaffold (BVS) may vary before and after 3 years, the time point of complete bioresorption of the poly-L-lactic acid scaffold.

Objectives: The aim of this study was to determine the time-varying outcomes of the Absorb BVS compared with cobalt-chromium everolimus-eluting stents (EES) from a large individual-patient-data pooled analysis of randomized trials.

Methods: The individual patient data from 5 trials that randomized 5,988 patients undergoing percutaneous coronary intervention to the Absorb BVS vs EES with 5-year follow-up were pooled.

Efficacy of light-transmitting eye shields for wound dressing in preventing pediatric emergence agitation following bilateral strabismus surgeries: a randomized clinical trial.

Background: Emergence agitation (EA) occurs in preschool children after ophthalmic surgery as eye shields induce visual disturbance. We aimed to investigate the efficacy of light-transmitting eye shields as an alternative to traditional medical gauze eye shields for wound dressing in terms of EA incidence following strabismus surgery.

Methods: We randomly assigned 70 preschool children undergoing bilateral strabismus surgery to receive either light-transmitting (LT group, n = 35) or medical gauze (MG group, n = 35) eye shields upon the completion of surgery.

The efficacy and safety of thymosin α1 for sepsis (TESTS): multicentre, double blinded, randomised, placebo controlled, phase 3 trial.

Objective: To evaluate whether the immunomodulatory drug thymosin α1 reduces mortality in adults with sepsis.

Design: Multicentre, double blinded, placebo controlled phase 3 trial.

Setting: 22 centres in China, September 2016 to December 2020.

Robot-Assisted Positioning for Percutaneous Endoscopic Interlaminar Discectomy.

Objective: During percutaneous endoscopic interlaminar discectomy (PEID), a range of technologies including medical robotics, visual navigation, and spatial registration have been proposed to expand the application scope and success rate of minimally invasive surgery. The use of robotic technology in surgery is conducive to improving accuracy and reducing risk. This study aims to introduce a precise and efficient targeting method tailored for robot-assisted positioning under C-arm fluoroscopy inPEID.

The Significance of Fractional Exhaled Nitric Oxide, Fractional Nasal Exhaled Nitric Oxide and Lung Function Tests in Children with Moderate-to-Severe Allergic Rhinitis.

Purpose: Fractional nasal exhaled NO (FnNO), fractional exhaled NO (FeNO) and lung function tests were performed in children with moderate-to-severe persistent allergic rhinitis (AR) to investigate the significance of the above indices in the assessment and diagnosis of children with AR.

Methods: A total of 135 children with persistent AR were selected and divided into moderate-to-severe and mild groups; serum total immunoglobulin E (IgE), peripheral blood eosinophil counts (EOS), FnNO, FeNO, and lung function tests were performed.

Results: Children in the moderate-to-severe group had increased levels of FnNO and FeNO and decreased levels of forced expiratory flow at 75% of forced vital capacity as a percentage of the predicted value (FEF75%) and maximum mid-term expiratory flow as a percentage of the predicted value (MMEF%) .

Neuroprotective effects of chitinase-1 and calcitonin gene-related peptide on Alzheimer's disease by promoting lysosomal function.

Background: The amyloid cascade hypothesis still dominates in Alzheimer's disease (AD), and the acceleration of the clearance efficiency of amyloid-β (Aβ) has been always considered as an effective treatment option to slow the occurrence and progression of AD.

Objective: This study aims to explore the role of zkscan3 and its related pathways in AD of the microglia-mediated pathogenesis, and whether the combined effect of drugs can exert neuroprotective function.

Methods: N9 mouse microglia and HT-22 mouse hippocampal neurons were randomly divided into 6 groups, qRT-PCR technique was used to detect the gene expression level of zkscan3 and the genes related to lysosome generation and function.

Successful oral RNA interference efficiency in the silkworm Bombyx mori through nanoparticle-shielded dsRNA delivery.

Double-stranded RNA (dsRNA) mediated RNA interference (RNAi) is a tool in functional gene study and pest control. However, RNAi efficiency in Lepidoptera is low compared to the RNAi sensitive Coleoptera. Previous studies on RNAi in the silkworm Bombyx mori, the lepidopteran model insect, were performed by injection only.

Genetic diversity and population structure of Oncomelania hupensis in Sichuan Province, China:implications for schistosomiasis control.

Schistosomiasis, caused by the infection with Schistosoma japonicum, remains a significant public health concern in China. As the sole intermediate host of S. japonicum, the breeding and spread of Oncomelania hupensis contribute significantly to the potential risk of disease occurrence and transmission.

Comparative analysis of optic disc and macular microvasculature in children with anisometropic amblyopia before and after treatment.

Purpose: To evaluate optic disc and macular microvasculature changes in children with anisometropic amblyopia before and after treatment.

Methods: In all, 60 children with unilateral anisometropic amblyopia between the ages of 6 and 12 were randomly selected from the ophthalmology clinic of Fuyang People's Hospital, while 60 children with non-amblyopia in the same age range were randomly selected as a normal control group. The right eye was uniformly taken in the control group with at least 6 months of follow-up.

Application of Raman Spectroscopy in the Non-invasive Diagnosis of Urological Diseases via Urine.

Objectives: The objective of this review is to provide a comprehensive overview of the utilization of Raman spectroscopy in urinary system diseases, highlighting its potential in non-invasive diagnostic methodologies for early diagnosis and prognostic assessment of urinary ailments.

Methods: We searched PubMed, Web of Science, and Google Scholar using 'raman,' 'bladder,' 'kidney,' 'prostate,' 'cancer,' 'infection,' 'stone or urinary calculi,' and 'urine or urinary,' along with 'AND' and 'OR' to refine our search. We excluded irrelevant articles and screened potential ones based on titles and abstracts before assessing the full texts for relevance and quality.

Real-World Evidence on Digital Therapeutics in Pediatric Amblyopia: Insights into Rapid Axial Elongation Risk.

Objective: To evaluate the impact of daily digital therapeutics (DTx) on the risk of rapid axial elongation (RAE) in children with amblyopia using real-world data.

Design: Retrospective cohort study.

Subjects: A total of 1,394 children aged 3 to 12 years with amblyopia, of which 477 received DTx.

Synthesis of an efficient demulsifier derived from cotton cellulose and its demulsification performance in oily wastewater.

Substantial amounts of oily wastewater are inevitably generated during petroleum extraction and petrochemical production, and the effective treatment of these O/W emulsions is crucial for environmental protection and resource recovery. The development of an environmentally friendly, cost-effective, and efficient demulsifier that operates effectively at low concentrations remains a significant challenge. This study introduces an eco-friendly ionic liquid demulsifier, Cotton Cellulose-Dodecylamine (CCDA), which demonstrates exceptional demulsification performance at low concentrations.

Highly sensitive, breathable, and superhydrophobic dome structure nonwoven-based flexible pressure sensor utilizing machine learning for handwriting recognition.

Wearable devices that incorporate flexible pressure sensors have shown great potential for human-machine interaction, speech recognition, health monitoring, and handwriting recognition.However, achieving high sensitivity, durability, wide detection range, and breathability through cost-effective fabrication remains challenging. Through ultrasound-assisted modification and impregnation-drying, dome-structured nonwovens/rGO/PDMS flexible pressure sensors were developed.

Design and theoretical calculation of chitosan derivatives: Amphiphilic chitosan micelles loaded with Chinese fir essential oil.

The unique structure of chitosan-based micelles can be loaded with essential oil, so it is significant to study the modification of chitosan and the interactions between chitosan and essential oil, while molecular dynamics (MD) simulation and density functional theory (DFT) provide a solution. In this study, three kinds of amphiphilic chitosan derivatives (CSDs) were constructed by grafting of different hydrophilic and hydrophobic groups. Amphiphilic chitosan micelles loaded with Chinese fir essential oil (CFEO) were prepared by self-assembly.

Enhancement of grape heat tolerance through VvbZIP36-mediated quercetin production.

Basic leucine zipper (bZIP) transcription factors serve as crucial regulators in plants' response to abiotic stress; however, its function in grapevine heat tolerance is still largely unknown. Here, we undertook a comprehensive investigation of grape genome, leading to the identification of 65 VvbZIP genes, among which 16 VvbZIPs were significantly induced under heat stress. Overexpression of VvbZIP36 enhanced heat tolerance in grape calli, while virus-induced gene silencing (VIGS) of VvbZIP36 reflected thermal sensitivity.

Highly compressible lamellar graphene/cellulose/sodium alginate aerogel via bidirectional freeze-drying for flexible pressure sensor.

Graphene exhibits exceptional electrical properties, and aerogels made from it demonstrate high sensitivity when used in sensors. However, traditional graphene aerogels have poor biocompatibility and sustainability, posing potential environmental and health risks. Moreover, the stacking of their internal structures results in low compressive strength and fatigue resistance, which limits their further applications.

Nanocellulose composites based on embedded europium-containing coordination polymers for the detection of antibiotics.

Developing sensitive and reliable methods for detecting antibiotics in water solutions is essential for protecting public health and the environment. Here, we report a novel fluorescent film with superior mechanical properties and detection response to ciprofloxacin (CIP), achieved through the in-situ growth of europium-based metal-organic frameworks on TEMPO-oxidized cellulose nanofibrils (TOCNF). Firstly, Eu(III) and 2,6-pyridinedicarboxylic acid (DPA) served as precursors, and a simple self-assembly strategy was employed to grow the composite film material (Eu-DPA@TOCNF) in situ on TOCNF, which exhibited characteristic emission peaks.

Preparation of soluble starch/zinc oxide nanocomposites by solid-phase reaction and study of their antibacterial properties.

Soluble starch/zinc oxide nanocomposites could be promising candidates for eco-friendly antimicrobial, food packaging, and a wide range of other utilization. In order to find a new way for the preparation of this kind of nanocomposites, an efficient and energy-saving reaction for the synthesis of soluble starch/zinc oxide nanocomposites has been investigated. The reaction was implemented in a solid state at room temperature without post-reaction calcination.

Ferulic acid mediates microbial fermentation of arabinoxylan to enhance host immunity by suppressing TLR4/NF-κB signaling.

The study was conducted to explore the relationship between arabinoxylan (AX) structure and microbial fermentation characteristics, and reveal molecular mechanism of AX on regulating immune function of the host. Results indicated that the group of wheat bran AX showed greater activity of feruloyl esterase, production of short chain fatty acids and ferulic acid compared with the blank group (P < 0.05).

Polydopamine-assisted ion-mediated hyaluronic acid grafting for effective construction of hemocompatible platform with cancer cell recognition.

Surfaces capable of specific biomolecule recognition are essential for cancer theranostics, biosensing, and tissue engineering. However, current grafting methods, critical for dictating the recognition efficiency and biocompatibility of biomaterials, especially hydrophilic polymers, struggle to balance high grafting density with ease of implementation. In pursuit of a simple, effective, and versatile solution, we introduced a polydopamine (PDA)-assisted Ca-mediated grafting strategy using hyaluronic acid (HA) as a model material.

Structural modification of whey protein isolate via electrostatic complexation with Tremella polysaccharides and its effect on emulsion stability at pH 4.5.

Emulsions play an important role in food systems by encapsulating and delivering active compounds, but maintaining their stability under various conditions can be challenging. This study explored how the concentrations of Tremella polysaccharides (TPs) (0-0.75 %) affects the structural of whey protein isolate (WPI) and the stability of their emulsions at pH 4.