The Characteristics, Sources, and Health Risks of Volatile Organic Compounds in an Industrial Area of Nanjing.

This study investigates the chemical complexity and toxicity of volatile organic compounds (VOCs) emitted from national petrochemical industrial parks and their effects on air quality in an industrial area of Nanjing, China. Field measurements were conducted from 1 December 2022, to 17 April 2023, focusing on VOC concentrations and speciations, diurnal variations, ozone formation potential (OFP), source identification, and associated health risks. The results revealed an average total VOC (TVOC) concentration of 15.

Challenges of E-Waste Dismantling in China.

Electronic and electrical products have deeply permeated all aspects of life, bringing a lot of convenience to individuals. However, the generation of e-waste after their end-of-life has resulted in serious risks both to the ecological environment and human health due to a lack of scientific and effective recycling and treatments. As two major types of components in e-waste, heavy metals and plastics can not only directly enter the human body via inhalation, ingestion, and skin absorption, but also accumulate in the human body indirectly through the food chain.

Disentangling the Relationship Between Urinary Metal Exposure and Osteoporosis Risk Across a Broad Population: A Comprehensive Supervised and Unsupervised Analysis.

: Limited evidence links urinary metal exposure to osteoporosis in broad populations, prompting this study to cover this knowledge gap using supervised and unsupervised approaches. : This study included 15,923 participants from the National Health and Nutrition Examination Survey (NHANES) spanning from 1999 to 2020. Urinary concentrations of nine metals-barium (Ba), cadmium (Cd), cobalt (Co), cesium (Cs), molybdenum (Mo), lead (Pb), antimony (Sb), thallium (Tl), and tungsten (Tu)-were measured using inductively coupled plasma mass spectrometry (ICP-MS).

Annual and Seasonal Variability of Trichloromethane in Drinking Water of Kunshan City 2016-2022 and Associated Health Risks.

This study aimed to evaluate the annual pollution characteristics of trichloromethane (TCM) in Kunshan City's tap water from 2016 to 2022. This research analyzed 566 tap water samples from centralized water supply units, utilizing the GB 5749-2006 Sanitary Standard for Drinking Water as the evaluation benchmark. Data analysis employed non-parametric tests and Spearman's correlation analysis using Excel 2017 and SPSS 26.

Oxidative Stress and Keap1-Nrf2 Pathway Involvement in Bisphenol A-Induced Liver Damage in Rats.

Bisphenol A (BPA), extensively utilized in the manufacture of epoxy resins and polycarbonate plastics, is prevalent in the environment. Its exposure has been associated with an increased risk of hepatic lesions; however, the underlying mechanisms and the spectrum of its effects remain poorly understood. This study investigates the role of the Keap1-Nrf2 signaling pathway in regulating BPA-induced hepatotoxicity in vivo using a rat model.

The Impact of Blood Lead and Its Interaction with Occupational Factors and Air Pollution on Hypertension Prevalence.

Large-scale epidemiological studies on the association of blood lead levels with blood pressure and hypertension prevalence are still limited, particularly among lead-exposed workers. The evidence is even more scarce on the interaction of blood lead levels with occupational variables and ambient air pollution levels. We developed mixed-effect models based on a large group of lead-exposed workers (N = 22,002).

Distribution of Polycyclic Aromatic Hydrocarbons and Pesticides in Danjiangkou Reservoir and Evaluation of Ecological Risk.

The Danjiangkou Reservoir is the largest artificial freshwater lake in Asia. This study investigated the spatiotemporal distribution of pesticides and polycyclic aromatic hydrocarbons (PAHs) in the Danjiangkou Reservoir to assess the ecological and human health risks associated with these pollutants. Twenty-three sampling sites in the Danjiangkou Reservoir each collected 23 surface water samples and 23 sediment samples.

Toxicity of Polystyrene Microplastics with Cadmium on the Digestive System of Tadpoles.

Microplastics pollution in freshwater systems is attracting increasing attention. However, our knowledge of its combined toxicity with heavy metals is scarce. In this study, was used as the model animal to study the combined poisoning mechanism of cadmium or microplastics on the digestive systems of tadpoles in freshwater.

Polystyrene Nanomicroplastics Aggravate Ammonia-Induced Neurotoxic Effects in Zebrafish Embryos.

The highly hazardous chemical ammonia has been proven to be absorbed by nanoparticles, thereby exerting highly toxic effects on aquatic organisms. As a ubiquitous pollutant in aquatic environments, polystyrene nanomicroplastics (PSNPs) have shown strong adsorption capacity due to their large surface area. Therefore, the potential joint effects of ammonia and PSNPs need to be clarified.

The Association Between Brominated Flame Retardants Exposure and Liver-Related Biomarkers in US Adults.

Emerging studies demonstrate that exposure to brominated flame retardants (BFRs) can have harmful effects on human health. Our study focused on the relationship between exposure to various BFRs and markers of liver function. To further explore the association between BFR exposure and liver function impairment, we used data from the National Health and Nutrition Examination Surveys (NHANES) for three cycles from 2009 to 2014, leaving 4206 participants (≥20 years of age) after screening.

The Relationship Between PM2.5 and Eight Common Lung Diseases: A Two-Sample Mendelian Randomization Analysis.

Air pollutants have both acute and chronic impacts on human health, affecting multiple systems and organs. While PM2.5 exposure is commonly assumed to be strongly associated with all respiratory diseases, this relationship has not been systematically analyzed.

Microplastic Particles Detected in Fetal Cord Blood, Placenta, and Meconium: A Pilot Study of Nine Mother-Infant Pairs in South China.

Microplastics (MPs) are emerging environmental pollutants. Pregnancy and infancy are sensitive windows for environmental exposure. However, few studies have investigated the presence of MPs in mother-infant pairs, or the exposure source.

The Efficacy and Safety of Roxadustat for Anemia in Hemodialysis Patients with Chronic Kidney Disease: A Meta-Analysis of Randomized Controlled Trials.

Background: Patients undergoing hemodialysis (HD) for chronic kidney disease (CKD) often encounter anemia. Roxadustat has not only undergone phase II-III clinical trials in patients suffering from CKD and undergoing HD; a number of post-marketing clinical studies have been conducted using the drug. This article was to assess the effectiveness and safety of roxadustat in managing anemia among patients with CKD undergoing HD.

Effect of Fenton-Based Processes on Arsenic Removal in the Presence of Humic Acid.

Geogenic arsenic (As) contamination in groundwater poses a significant public health risk in many regions worldwide. Previous studies have reported hydrogen peroxide (HO) concentrations ranging from 5.8 to 96 μmol L in rainwater, which may contribute to the oxidation and removal of As.

Global Trends and Hotspots in Non-Targeted Screening of Water Pollution Research: Bibliometric and Visual Analysis.

Non-targeted screening (NTS) technology has been showing significant potential in identifying contaminants of emerging concern (CECs) in water and has attracted great attention in academia in recent years. It is a method that analyzes samples without pre-selecting substances, enabling the detection and identification of unknown compounds, which is crucial for environmental health and public protection. This study uses the Bibliometrix package in R 4.

Microplastics Exposure Aggravates Synovitis and Pyroptosis in SLE by Activating NF-κB and NRF2/KEAP1 Signaling.

Microplastics (MPs) represent an emerging pollutant capable of entering the human body through the respiratory and digestive systems, thereby posing significant health risks. Systemic lupus erythematosus (SLE) is a complex autoimmune disease that affects multiple organ systems, often presenting with polyarticular joint manifestations. Despite its relevance, there is currently limited research on the impact of MPs on lupus arthritis.

Using Sediment Bacterial Communities to Predict Trace Metal Pollution Risk in Coastal Environment Management: Feasibility, Reliability, and Practicability.

The distribution of trace metals (TMs) in a continuous water body often exhibits watershed attributes, but the tidal gates of the coastal rivers may alter their transformation and accumulation patterns. Therefore, a tidal gate-controlled coastal river was selected to test the distribution and accumulation risks of Al, As, Cr, Cu, Fe, Mn, Ni, Sr, and Zn in the catchment area (CA), estuarine area (EA), and offshore area (OA). Associations between TMs and bacterial communities were analyzed to assess the feasibility of using bacterial parameters as ecological indicators.

Activated Sludge Combined with Pervious Concrete Micro-Ecosystem for Runoff Rainwater Collection and Pollutant Purification.

This study investigated the purification of pollutants in runoff rainwater by constructing a micro-ecosystem using waste-activated sludge (WAS) and riverbed sludge (RBS) as inoculums in combination with pervious concrete. The research results showed that the best hydraulic retention time (HRT) was 9 h. The COD and ammonia nitrogen (NH-N) removal of the waste-activated sludge ecosystem (WASE) was 62.

DEHP-Induced Glioblastoma in Zebrafish Is Associated with Circadian Dysregulation of PER3.

DEHP is a plasticizer that is widely found in our water environment and poses a significant risk to the environment and human health. Long-term exposure to DEHP can cause endocrine disruption and interfere with the organism's normal functioning. In order to explore the potential effects of DEHP on the development of biological brain tissues, this study used bioinformatics analysis to confirm the diagnostic and prognostic value of PER3 in gliomas and further validated the neurotoxicity of DEHP using methods such as behavioral experiments and molecular biology in zebrafish.

Correction: Wang et al. Integration of Transcriptomics and Lipidomics Profiling to Reveal the Therapeutic Mechanism Underlying (Sangzhi) Alkaloids for the Treatment of Liver Lipid Metabolic Disturbance in High-Fat-Diet/Streptozotocin-Induced Diabetic Mice. 2023, , 3914.

In the original publication [...

The Critical Role of Lipid Metabolism in Health and Diseases.

Lipids make up 10-20% of the human body and serve as crucial energy storage substances as well as essential components of cell membranes [...

A Systematic Review and Meta-Analysis of Type 2 Diabetes Prevention Through Lifestyle Interventions in Women with a History of Gestational Diabetes-A Summary of Participant and Intervention Characteristics.

: We aimed to review the effect of lifestyle interventions in women with a history of gestational diabetes mellitus (GDM) based on the participants and intervention characteristics. : We systematically searched seven databases for RCTs of lifestyle interventions published up to 24 July 2024. We included 30 studies that reported the incidence of type 2 diabetes mellitus (T2DM) or body weight.

Investigation into the Potential Mechanism of Radix Paeoniae Rubra Against Ischemic Stroke Based on Network Pharmacology.

Background: Radix Paeoniae Rubra (RPR), an edible and medicinal Traditional Chinese Medicine (TCM), is extensively employed in therapeutic interventions of cardiovascular and cerebrovascular diseases. However, the curative effect of RPR on ischemic stroke remains ambiguous. This work integrated network pharmacology, molecular docking, and experimental validation to explore the mechanisms of RPR in treating ischemic stroke.

Disease Burden Estimation of Hepatocellular Carcinoma Attributable to Dietary Aflatoxin Exposure in Sichuan Province, China.

Background: Aflatoxin B (AFB), AFB, AFG, and AFG are Group 1 human carcinogens, with AFB notably increasing hepatocellular carcinoma (HCC) risk. Sichuan Province, China, with its subtropical monsoon climate, is susceptible to AF contamination in various food items. However, the HCC disease burden attributable to lifetime chronic dietary AF intake in Sichuan has not been investigated.

Status of Inappropriate Complementary Feeding and Its Associated Factors Among Infants of 9-23 Months.

Inappropriate complementary feeding during the first two years of life significantly impacts children's health, increasing risks of malnutrition and illness. : This study investigates factors influencing early feeding patterns among 600 mothers of children aged 9-23 months in selected hospitals in Punjab, Pakistan. Using a structured questionnaire, data were collected and analyzed, with associations measured by odds ratios (ORs) and 95% confidence intervals (CIs).