Comprehensive analysis strategy of quality for traditional Chinese medicine compound based on fingerprint technology and quantitative prediction of spectra.

Traditional Chinese medicine compound (TCMC) comes from a wide range of sources, and the complexity of chemical composition leads to differences in quality. Improving quality evaluation standards is the focus as well as the difficulty in its development and application. The traditional fingerprint analysis method has certain limitations for the quality evaluation of TCMC and the judgment of superior and inferior products.

Magnetic field facilitated-colorimetric aptasensor for selective and sensitive detection of Staphylococcus aureus using aptamer-labeled Zn/Co ICPs nanoenzyme.

Colorimetric detection of pathogenic bacteria (such as S. aureus) in complex sample confronts challenges regarding sensitivity, selectivity, and accuracy. In this paper, a magnetic field facilitated (MFF)-colorimetric aptasensor was proposed for S.

Disease continuum centered on Parkinson's disease.

Parkinson's disease (PD), once viewed as a neurodegenerative disorder, is now increasingly recognized as part of a broader disease continuum, intricately linked to comorbidities across various organ systems. This study provides a snapshot of the disease continuum centered on PD, using a disease-wide association study (DWAS) involving 392,423 individuals-including 4,235 PD cases. This DWAS identifies disease clusters of PD comorbidities across the musculoskeletal, circulatory, digestive, and respiratory systems.

Circulating insulin-like growth factor-1 and the risk of multiple sclerosis: a prospective cohort study.

Background: Circulating insulin-like growth factor 1 (IGF-1) is positively associated with the risks of certain neurological disorders, including stroke, Alzheimer's disease, and Parkinson's disease. However, the association of IGF-1 with the risk of multiple sclerosis (MS) remains unclear.

Methods: A total of 348,324 participants at baseline were included from the UK biobank in this prospective study.

Nanozymes meet hydrogels: Fabrication, progressive applications, and perspectives.

Nanozyme, a class of emerging enzyme mimics, is the nanomaterials with enzyme-mimicking activity, which has obtained significant and widespread applications in various fields. However, they still face many challenges in practical applications (e.g.

Hydrosilylation of porous silicon: Unusual possibilities and potential challenges.

Among the many types of surface modifications on porous silicon (pSi), hydrosilylation stands out to be an important approach due to the formation of highly stable surface linkage through Si-C bonding. Since its conceptualization in 1998, hydrosilylation had gradually gained popularity for pSi surface modifications and had become an important approach for stabilizing pSi surfaces especially for biological applications. Over the past decade, significant advancements have been made in the hydrosilylation process for modifying porous silicon (pSi) surfaces.

Innovative strategy for full-scale polar components explicition and ultrasonic-assisted optimization of Astragalus membranaceus flower.

Traditional extraction under merely one specific solvent was confronted with incomplete phytochemical unscramble problem. In view of this, in order to obtain the overall chemical understanding, we attempted to use Astragalus membranaceus flower, an abundant exploitable resource, to screen a novel extraction mixing scheme via gradient solvents based on the ions' quantity detected in UHPLC-Q-TOF-MS/MS approach. Samples were firstly extracted by different concentration ethanol, and then, six mixing schemes were investigated and one scheme with maximum detected ions was screened out.

Illness behavior and its predictors in young and middle-aged colorectal cancer patients: A latent profile analysis.

Purpose: To describe the characteristics of sick role adaptation and understand the differences in young and middle-aged colorectal cancer (CRC) patients.

Methods: 225 colorectal cancer patients aged 18-59 admitting to a specialized oncology hospital in Guangzhou, China were involved from January to April 2022. Socio-demographic characteristics, disease-related characteristics, scores of Illness Behavior Questionnaire, Hospital Anxiety and Depression Scale, the Brief Illness Perception Questionnaire, Mishel Uncertainty in Illness Scale and Medical Coping Modes Questionnaire were applied to collect quantitative data.

CuS@Ag Heterostructure-based Surface Plasmonic Coupling Electrochemiluminescence Sensor for Glioma miRNA-124-3p Detection.

As an emerging class of extended crystalline organic materials, covalent organic framework (COF)-based aggregation-induced emission luminogen (AIE-gen) exhibited encouraging emissive properties. In this work, 4',4'',4‴,4‴'-(1,1,2,2-Ethenetetrayl)tetra(4-biphenylcarbaldehyde) (ETBC) as AIEgen was used to prepare AIE-COF (ET-COF-COOH) luminescent nanoprobe. ETBC and 1,3,5-Tris(4-aminophenyl)benzene (TAPB) had an extended π electronic system that allowed electron delocalization and overlapping transport.

Actinomycetes: Treasure trove for discovering novel antibiotic candidates.

Actinomycetes are an important source of secondary metabolites such as antibiotics and other active natural products. Many well-known antibiotics, such as streptomycin, oxytetracycline, and tetracycline, are produced by actinomycetes. Different types of antibiotics have distinct mechanisms of action against microorganisms: inhibit protein synthesis, inhibit nucleic acid synthesis, or inhibit cell wall synthesis.

Antiproliferative activity of selenium-enriched coumarin derivatives on the SK-N-SH neuroblastoma cell line: Mechanistic insights.

Thirty selenium-containing coumarin derivatives were synthesized and evaluated for inhibitory activity against 17 malignant tumor cell lines. Among these, compound 11i demonstrated the most potent inhibition of neuroblastoma SK-N-SH cells, with an IC of 2.5 ± 0.

Design and synthesis three novel series of derivatives using natural acetylcholinesterase inhibitor-RLMS as template and in vitro, in vivo and in silico activities verification.

Acetylcholinesterase (AChE) is a pivotal enzyme in nerve conduction, controlling its activity with its inhibitor (AChEI) is crucial for the treatment of Alzheimer's disease (AD). However, current AChEIs are associated with considerable adverse effects. Previous work has identified 2α,3β,19α,23-tetrahydroxy-12-ene-28-oic acid (RLMS) as a promising natural AChEI.

Heteroatom sulfur-doping in single-atom FeNC catalysts for durable oxygen reduction performance in zinc-air batteries.

Heteroatom doping into the transition metal-based catalysts is an effective strategy to improve the oxygen reduction reaction (ORR) kinetics. Herein, we proposed a one-step, soft template assisted, and green method for the synthesis of Sulfur (S) doped single atom FeNC catalyst. XAFS demonstrated that the Fe active sites in the FeNSC were more likely to possess the Fe-N configuration.

Sea urchin-like covalent organic frameworks/TiO heterostructure for enhanced photocatalytic CO conversion.

Photocatalytic reduction of CO to valuable chemicals is an effective strategy to address the environmental problems and energy crisis. Covalent organic frameworks (COFs) are emerging materials known for their excellent diverse properties, albeit limited by special synthetic methods, including high temperature (120 °C) and the necessity of inert gas atmosphere. Herein, a novel synthesis method under room temperature and air was optimized to form TpPa-COF (TP-COF) by p-phenylenediamine (Pa) and 2,4,6-triformyl phloroglucinol (Tp) through electrostatic self-assembly.

Flexible multifunctional Janus film towards self-healing, self-adhesive and streachable EMI shielding.

As smart electronic devices proliferate rapidly, concerns about electromagnetic radiation have become more prominent. Traditional electromagnetic shielding materials typically use three-dimensional porous foams, carbon structures, and film materials as their substrates. However, as electronic devices become more miniaturized, integrated, and precise, the large volume and limited functionality of foam materials have constrained their applications.

MOF-derived FeCe@Carbon catalysts for the efficient tetracycline degradation by activated persulfate: Preparation and mechanistic study.

Metal-organic frameworks (MOFs) derived materials are extensively utilized in wastewater treatment owing to their remarkable catalytic efficacy and durability. This study exploited iron-cerium-based bimetallic metal-organic framework (FeCe-MOF) as a sacrificial template, which was subsequently calcined at 700 °C to produce an iron-cerium-based bimetallic carbon nanospheres (FeCe@C). The FeCe@C has active sites of bimetallic Fe and Ce derivatives, demonstrating exceptional activation efficiency for persulfate, resulting in approximately 98.

Multifunctional (CoFe)(S)-ion-microneedle patch: Synergistic antimicrobial, anti-inflammatory and cell proliferation for accelerating wound healing.

Preventing bacterial infection and accelerating wound closure are critical for wound healing. Herein, a novel multifunctional polyvinyl alcohol-polyvinylpyrrolidone (PVA-PVP) microneedle (MN) patch embedded with enzyme-like activity (CoFe)(S) (CFS) nanoparticles and metal ions (Co and Fe) was systematically synthesized for the management of bacteria-infected wounds. CFS regulated redox homeostasis and achieved bacterial eradication while concomitantly alleviating oxidative damage.

Exosomes derived from colorectal cancer cells suppress B-cell mediated anti-tumor immunity.

Exosomes derived from cancer cells significantly influence the tumor immune microenvironment and can limit the efficacy of immunotherapy. However, the impact of exosomes on B cell-dependent anti-tumor immunity remains poorly understood. Here, we demonstrate that exosomes secreted by MC38 (MC38-Exos), a murine colorectal cancer cell line, induce B cells to adopt immunosuppressive phenotypes.

Investigation of the effects and mechanism of Total Glycosides of paeony against Radiation-Induced brain injury through network Pharmacology, molecular docking and experimental Verification.

Background: Total glucosides of paeony (TGP), derived from the dried root of Paeonia, is a popular treatment for immune diseases. Radiation induced brain injury (RBI) is a common side effect of brain radiation therapy, but the efficacy of TGP in treating RBI remains uncertain.

Purpose: To evaluate the protective effects of TGP against RBI and elucidate its underlying mechanisms using pharmacological network analysis, molecular docking, and experimental validation.

Hesperetin alleviates PM2.5-induced lung injury by inhibiting ferroptosis in an Nrf2-dependent manner.

Background: Fine particulate matter (PM2.5) is a global environmental problem that threatens public health because it can induce ferroptosis and cause lung injury. Hesperetin (Hes), a natural compound widely present in fruits and vegetables, can activate nuclear factor erythroid 2-related factor 2 (Nrf2), thereby exerting powerful antioxidant effects.

MiR-186-5p carried by M2 macrophage-derived exosomes downregulates TRPP2 expression in airway smooth muscle to alleviate asthma progression.

Bronchial asthma (asthma) is a chronic inflammatory disease of the airways that remains an unresolved problem. Reportedly M2 macrophages and exosomes play a role in inflammation, including asthma. We investigated the roles of M2 macrophage-derived exosomes (M2-Exos) effect in asthmatic progression by using ovalbumin (OVA) induced asthmatic mice model.

Notoginsenoside R1 alleviates blue light-induced corneal injury and wound healing delay by binding to and inhibiting TRIB1.

Background: With the escalating use of digital devices, blue light (BL) exposure has emerged as a critical concern due to its potential to cause ocular damage. This study explores the protective effects of notoginsenoside R1 (NR1), a bioactive compound from Panax notoginseng (Burkill) F.H.

Zyxin-a novel detrimental target, is inhibited by Saikosaponin A during allergic asthma.

Background: Allergic asthma is a heterogeneous disease involving numerous inflammatory cells. Mast cell (MC) plays a key role during allergic asthma. Saikosaponin A (SSA) inhibits MC activation and ameliorates allergic asthma, however, its underlying mechanism remains unclear.

Bushen Jiedu formula alleviates colorectal cancer progression through reducing lncRPPH1 in tumor-derived extracellular vesicles.

Background: The Bushen Jiedu Formula (BSJDF) is a traditional and effective chemical prescription of traditional Chinese medicine (TCM) administered due to its anti-cancer properties, particularly in colorectal cancer (CRC).

Purpose: This study proposes to explore the therapeutic benefits of BSJDF against metastasis in CRC and unravel its regulatory mechanisms related to the tumor microenvironment.

Study Design/methods: The combination of mass spectrometry and network pharmacology was used to analyze the involvement of BSJDF in anti-tumor progression.

Screening effective-component compatibility from Jinshui Chenfei formula for silicosis treatment by serum-pharmacochemistry and feedback system control.

Background: The unclear chemical composition and mechanisms of action pose challenges for new drug development and quality control of traditional Chinese medicine (TCM) formulas. To address this, the concept of effective-component compatibility (ECC) was proposed to represent drug combination with equivalent efficacy to TCM formulas, along with clear composition and dosage. However, previous strategies for screening ECC have often overlooked the synergistic effects of its components.