The role of defatted hydrolyzed egg yolk powder in protecting DHA algal oil.

This study comprehensively investigated DHA algal oil emulsions and microcapsules prepared with different egg yolk hydrolysates (DHYP). Dual-enzyme (phospholipase A1 and protease) treatment enhanced emulsion stability by boosting protein adsorption, reducing particle size, and increasing zeta potential. For microcapsules, EF-DUAL, treated with dual-enzymes, had improved solubility, dispersibility, and wall material compactness, effectively protecting DHA from oxidation.

Chemometrics-powered spectroscopic techniques for the measurement of food-derived phenolics and vitamins in foods: A review.

Foods are rich in various bioactive compounds, like phenolics, and vitamins, which play important physiological roles in the human body. The analysis of phenolics and vitamins in plant and animal-based foods is a topic of growing interest. Compared with conventional methods, the chemometrics-powered infrared, Fourier transform-near infrared and mid-infrared, ultraviolet-visible, fluorescence, and Raman spectroscopy offer a reliable, low-cost, and nondestructive means to determine phenolics and vitamins.

Differentiation of Citri Reticulatae Pericarpium varieties via HPLC fingerprinting of polysaccharides combined with machine learning.

To accurately and reliably distinguish different varieties of Citri Reticulatae Pericarpium (CRP), we propose a novel classification strategy combining polysaccharide fingerprinting and machine learning (ML). First, extraction conditions are optimized using the one-variable-at-a-time method and response surface methodology, and the extraction yield of total polysaccharides reaches 25.15%, with different varieties exhibiting different anti-oxidant abilities.

Structural and physicochemical properties and changes in vitro digestion and fermentation of soluble dietary fiber from tea residues modified by fermentation.

The aim of this study was to investigate the structure, physicochemical properties, and changes in vitro digestion and fermentation between unfermented tea residue dietary fiber (UDF) and fermented tea residue soluble dietary fiber (FSDF). The results showed that soluble dietary fiber in FSDF was increased from 2.54 % to 15.

Analysis of the antioxidant efficacy substances in fermented black mulberry juice and their preventive effects on oxidative stress in C2C12 cells.

This study evaluated the in vitro antioxidant activity and bioactive compound content of mixed-strain lactic acid bacteria-fermented black mulberry juice (FBMJ) and its protective effects against oxidative stress using physicochemical experiments and a cellular oxidative stress model. We also performed preliminary analyses of polysaccharide structures in FBMJ and identified the dynamic changes in the phenolic profiles of FBMJ during the fermentation process. The results indicated that FBMJ polyphenols can improve cell vitality and prevent HO-induced oxidative stress by reducing intracellular reactive oxygen species concentrations and regulating mitochondrial membrane potential.

Lipidomic profiling reveals the protective mechanism of nitrogen-controlled atmosphere on brown rice quality during storage.

Rice, a globally important staple, requires effective preservation methods to maintain its quality during extended storage. This study explored the efficacy of nitrogen-controlled atmosphere (NCA) storage in preserving the quality of brown rice during a one-year period using UHPLC-MS/MS based lipidomic profiling. A total of 1013 lipids were identified and categorized into five main groups.

Thiol-modified hyaluronic acid and hydroxyl radical-induced oxidation synergistically enhance the gelling capacity of ginkgo seed proteins.

The objective of this work was to investigate the effect of synthetic thiol-modified hyaluronic acid (HASH) on the gelation properties of ginkgo seed protein isolate (GSPI) under non-oxidizing (NOX) or oxidizing (OX) conditions. Under NOX conditions, HASH mediated the disruption of disulfide bonds, leading to a dose-dependent dissociation of GSPI. Conversely, in OX conditions, hydroxyl radical-induced oxidation facilitated the formation of interprotein disulfide bonds.

Analysis key aroma compounds based on the aroma quality and infusion durability of jasmine tea.

The quality of jasmine tea is closely related to the aroma of the tea infusion and the brew durability of the tea leaves. In this study, the aroma components of jasmine tea infusions subjected to multiple brewings were investigated using sensory evaluation, headspace solid-phase microextraction gas chromatography-mass spectrometry (HS-SPME-GC-MS), and headspace gas chromatography-ion mobility spectrometry (HS-GC-IMS). 179 and 73 volatile compounds were identified by HS-SPME-GC-MS and HS-GC-IMS.

Health-related quality of life and symptoms in patients with previously untreated, locally advanced or metastatic non-squamous non-small cell lung cancer treated with sintilimab or placebo plus pemetrexed and platinum (ORIENT-11): A randomized, double-blind, phase 3 trial.

Background: In the phase 3 ORIENT-11 study, sintilimab plus pemetrexed-platinum provided statistically significant longer overall survival and progression-free survival versus placebo plus pemetrexed-platinum as first-line treatment in patients with locally advanced or metastatic non-squamous non-small cell lung cancer (NSCLC). Here, we report the patient-reported outcomes (PRO) analysis findings in ORIENT-11.

Methods: PROs were measured using the European Organization for Research and Treatment of Cancer Quality of Life of Cancer Patients Questionnaire Core 30 items (EORTC QLQ-C30) and the Lung Cancer Symptom Scale (LCSS) questionnaire.

Cellular heterogeneity and communication networks in gastric cancer: Single-cell analysis reveals β-hydroxybutyrylation-associated genes and immune infiltration characteristics.

Gastric cancer is characterized by high heterogeneity, with its complex microenvironment and intercellular communications playing critical roles in disease progression and treatment responses. In this study, we utilized single-cell sequencing to dissect the intricate landscape of gastric cancer, identifying diverse cell populations and their interactions. We focused on the role of β-hydroxybutyrylation (Kbhb)-associated genes and their impact on the tumor microenvironment.

Triglyceride-glucose index and triglyceride-glucose-body mass index as prognostic factors for early stage breast cancer patients receiving neoadjuvant chemotherapy.

Background: Insulin resistance (IR) is closely associated with the risk of breast cancer. The triglyceride-glucose (TyG) index and the triglyceride-glucose-body mass index (TyG-BMI) are considered surrogate indicators of IR; however, their prognostic value in breast cancer patients has not been discussed. The purpose of this study is not only to explore whether the TyG index and the TyG-BMI can predict the chemotherapy response and long-term prognosis of breast cancer patients receiving neoadjuvant chemotherapy (NACT) but also to investigate the possible mediating mechanism and to analyze the relationship between TyG-related enzyme expression and drug resistance and prognosis.

Comparative analysis of cis-cutting and retro-cutting techniques in gastric tube fabrication for preventing postoperative anastomotic leakage after esophagectomy.

Objective: The construction of a gastric-tube-substitute esophagus is a common method for digestive tract reconstruction after esophagectomy. However, the incidence of postoperative anastomotic leakage remains high. This study aims to compare the effectiveness of 2 gastric tube fabrication methods-cis-cutting and retro-cutting-in reducing postoperative anastomotic leakage.

Theoretical insights on the double ESIPT mechanism and fluorescence properties of HBIo chromophore.

2-{[3-(1H-benzoimidazol-2-yl)-2-hydroxy-5-methylbenzylidene] amino}-benzoic acid (HBIo) based on proton transfer can serve as the fluorescent probe for detecting heavy metal ions. The excited-state intramolecular proton transfer (ESIPT) reaction mechanism of the HBIo chromophore with an intramolecular asymmetric double hydrogen bond in different solvents are investigated. The reaction barrier of the ESIPT along hydrogen bond O1-H2···N3 is higher than that of ESIPT along O4-H5···N6, which indicates that the double ESIPT is a stepwise process.

The influence of the position and quantity of thiophene or acetylene groups on the photoelectric properties of dye-sensitized solar cells.

To investigate the influence of the position and quantity of thiophene or acetylene groups on the photoelectric properties of dye-sensitized solar cells (DSSCs), density functional theory (DFT) were employed to simulate five zinc porphyrin dye molecules (T-3, T-3-D, T-3-A, T-3-AD, and T-3-ace). The optimized geometry indicated that T-3-ace possessed superior planar properties, attributed to incorporating the acetylene groups, facilitating the charge transfer process. The lower lowest unoccupied molecular orbital (LUMO) energy levels of T-3-ace and T-3-D suggested that introducing thiophene or acetylene groups on the donor side enhanced the electron absorption capability of the dyes.

A molecular sensor for selective recognition of Fe by a functional seven-nuclear Zn(II) cluster compound formed from a quinoline-modified half-salamo-type Precursor.

In this paper, we designed and synthesized a novel based on quinoline modification half-salamo-type Zn(II) complex([Zn(L)(μ-OCH)]·(ClO)), namely ZP. The structure of ZP was determined by X-ray single-crystal diffraction, in which the Zn(II) ions displayed in two different coordination modes, ultimately forming a highly symmetric heptanuclear structure. The Zn(II) complex probe modified by quinoline luminescent group has excellent luminescence properties and selectively recognizes Fe in aqueous solution.

A highly sensitive and colorimetric fluorescent sensor for visualizing Zn in aqueous solution.

A new colorimetric fluorescent sensor QPEBT was developed by merging the N,N-di(2-picolyl)ethane-1,2-diamine and 2,2'-bithiophene moieties into the quinolimide backbone. QPEBT could sensitively detect Zn through the remarkable fluorescence enhancement with distinct color changes from light orange to pink in visible light and from ginger to orange-yellow in 365 nm UV irradiation. The 1:1 stoichiometry between QPEBT and Zn was verified by the spectra titrations, Job's and HRMS analyses, and theoretical calculations.

Struggling over water, losing it through evaporation: The case of Afghanistan and Iran.

Prolonged droughts and rising water demand have worsened water disputes in the transboundary Helmand basin, shared by Afghanistan and Iran. While both countries have built water storage reservoirs to mitigate water shortages, evaporative losses from these reservoirs reduce their effectiveness. This issue intensifies challenges over water shortages in the region without reliable monitoring data.

Enhancement of aerobic sludge granulation by quorum sensing signaling molecules mediated by biomimetic bacterial extracellular vesicles.

The addition of exogenous quorum sensing signaling molecules to the activated sludge system enables rapid sludge granulation. However, signaling molecules exposed to the environment are easily degraded, and their quorum sensing effects cannot be maintained in the long term. Therefore, they must be frequently added, which leads to an increase in operational costs.

Application of bio-electrochemical systems for phosphorus resource recovery: Progress and prospects.

This review focuses on applying bio-electrochemical systems (BES) for phosphorus (P) recovery. Microbial fuel cells (MFCs) degrade pollutants to generate electricity and recover P, with the structure and electrode materials playing a significant role in P recovery efficiency. Microbial electrolysis cells (MECs) recover P while simultaneously producing hydrogen or methane, with factors such as voltage and pH influencing performance.

Risk of increasing soil nitrous oxide emissions by chemical oxidation modification on biochar.

Biochar is widely recognized as a soil amendment capable of mitigating soil nitrous oxide (NO) emissions. However, the effects of biochar modification, particularly through chemical oxidation, remain relatively unexplored. This study modified wood and corn straw biochars using HO and acid (HSO/HNO).

Machine learning unveils the role of biochar application in enhancing tea yield by mitigating soil acidification in tea plantations.

Biochar, a widely utilized soil amendment in environmental applications, has been employed to enhance tea cultivation. This study utilized three machine learning models to investigate the effects of biochar on tea growth and yield, with the random forest (RF) model demonstrating superior performance (R = 0.8768, Root Mean Square Error = 6.

Intracalvariosseous injection: an approach for central nervous system drug delivery through skull bone marrow with a preclinical research in stroke.

Background: Central nervous system (CNS) accessibility constitutes a major hurdle for drug development to treat neurological diseases. Existing drug delivery methods rely on breaking the blood-brain barrier (BBB) for drugs to penetrate the CNS. Researchers have discovered natural microchannels between the skull bone marrow and the dura mater, providing a pathway for drug delivery through the skull bone marrow.

Immune checkpoint inhibitors mediate myocarditis by promoting macrophage polarization via cGAS/STING pathway.

Background: Immune checkpoint inhibitors has opened up new avenues for cancer treatment, but serious cardiac injury has emerged in their use. A large number of data have shown that abnormal activation of cytosolic DNA-sensing cyclic GMP-AMP synthase-interferon gene activator pathway is closely related to cardiovascular inflammation and autoimmune diseases. However, the pathophysiological function of the cGAS-STING cascade in myocarditis induced by Immune checkpoint inhibitors is unclear.

Immune mechanisms in multiple sclerosis: CD3 levels on CD28+ CD4+ T cells link antibody responses to human herpesvirus 6.

Compelling evidence suggests a significant association between antibody-mediated immune responses and multiple sclerosis (MS). However, the exact causal relationships between these immune responses and MS remain unclear. In this study, we conducted a comprehensive examination of the link between antibody-mediated immune responses and MS via Mendelian randomization (MR) analysis to identify specific infectious pathogens potentially involved in the onset and progression of MS.

TLR3 as an emerging molecule facilitating pyroptosis in the context of rheumatoid arthritis: A study combined bioinformatics and experimental validation.

Background: Rheumatoid arthritis (RA) is an inflammatory disease of the joints mediated by immune cells. As an immune-related mode of cell death, pyroptosis has yet to be fully understood in RA. This research identified novel pyroptosis-related markers in RA and confirmed its functional significance in RA.