Configurational control of low-symmetry heteroleptic metal-organic cages with asymmetric ligands.

Low-symmetry metal-organic cages (MOCs) can better mimic the structure of biological enzymes compared to high-symmetry MOCs, due to their unique internal cavities that resemble the specialized and irregular active sites of enzymes. In this study, two low-symmetry heteroleptic MOCs with six Pd(ii) centers, PdL L and PdL L , were successfully constructed by combining two strategies: asymmetric ligand assembly and multi-ligand co-assembly. Crystallographic characterization and analysis revealed that PdL L is a mixture of potentially 16 isomers.

Mechanism and dynamics of photoswitchable flavoprotein charge-transfer complexes.

Because of their diverse uses in biological science and engineering, continued effort has been made to expand the pool of photoswitchable protein systems. A recent study demonstrated that in monomeric sarcosine oxidase (MSOX), photoexcitation of a charge-transfer (CT) complex formed by a flavin cofactor and a nonreactive ligand (, methylthioacetate) induces the ligand to reversibly change conformation, with implications for the development of flavin-dependent fast photochromic proteins. However, the factors that control the underlying switching mechanism and dynamics remain largely unexplored.

Efficient energy transfer from organic triplet states to Mn dopants for dynamic tunable multicolor afterglow in 1D hybrid cadmium chloride.

Metal ion-doped organic-inorganic hybrid metal halides have emerged as promising room-temperature phosphorescence (RTP) materials owing to their tunable afterglow properties and significant potential in information security applications. However, optimizing RTP performance and achieving dynamic control over afterglow colors remain challenging in 1D hybrid systems, primarily because of the inefficient energy transfer from RTP-active organic components to external emissive sites. Herein, we report a novel 1D hybrid metal halide benchmark material, [(NBP)CdClHO] (NBP-Cd, NBP = -benzylpiperidone), and a series of Mn-doped derivatives, NBP-Cd:Mn (where represents doping levels from 1% to 50%).

Predictive value of early neutrophil-to-lymphocyte ratio and C-reactive protein in pediatric steroid-sensitive nephrotic syndrome.

Objective: This study aims to investigate the predictive value of early neutrophil-to-lymphocyte ratio (NLR) and C-reactive protein (CRP) levels for relapse and adverse prognosis within one year in children diagnosed with steroid-sensitive nephrotic syndrome (SSNS).

Methods: This study included a total of 145 pediatric patients diagnosed with steroid-sensitive nephrotic syndrome (SSNS) between January 2016 and December 2021. We collected early neutrophil-to-lymphocyte ratio (NLR) and C-reactive protein (CRP) levels, along with relevant clinical data, and conducted a one-year follow-up of the patients.

High sperm DNA stainability might not be an accurate predictive indicator of male fertility and assisted reproductive technology outcomes.

Background: The clinical need for assisted reproduction continued to increase, so did the need for predictive markers of assisted reproductive technology (ART) outcomes. Among all the markers, sperm DNA integrity was paid more and more attention in the assessment of male fertility in recent years, but its clinical value remains still in doubt.

Methods: We conducted a retrospective cohort study.

Serum A20 level is associated with bone mineral density in male patients with type 2 diabetes mellitus.

Background: A20, also known as TNF-α-induced protein 3 (TNFAIP3), is a crucial negative regulator of inflammation and immune responses. Emerging evidence suggests that A20 is involved in the regulation of glucose metabolism and plays a significant role in bone metabolic diseases by inhibiting nuclear factor (NF)-κB activation. However, the potential relationship between serum A20 level and bone mineral density (BMD) in patients with type 2 diabetes mellitus (T2DM) has not been explored.

Bone mineral density and sex hormone binding globulin as potential mediators of the causal effect of urolithiasis on osteoporosis risk: a Mendelian randomization.

Objective: Osteoporosis (OP) and urolithiasis (UL) are two metabolic diseases that are prevalent globally. Previous observational studies have found a relationship between these two diseases that increases the risk of each other, but whether there is a direct causal link is still unclear. Currently, research on the mechanisms of these two diseases mainly focuses on external factors such as diet and environment.

Thyroid hormone replacement therapy in dialysis/renal insufficiency patients.

Dialysis/renal insufficiency patients are often accompanied by hypothyroidism due to renal damage, the mechanisms of which are complex. The use of thyroid hormone replacement therapy in such patients has become an important clinical issue. This article reviews the mechanism of hypothyroidism in dialysis/renal insufficiency patients and describes the importance and precautions of thyroid hormone replacement therapy to provide a reference for clinical diagnosis and treatment.

Mediates Immunosuppression of the Tumor Microenvironment in Non-Small Cell Lung Cancer.

Background: Studies have demonstrated that histone deacetylase 1 () enables cancer cells to evade killing mediated by cytotoxic T lymphocytes. However, there are no studies on the immunological aspects of in non-small cell lung cancer (NSCLC).

Methods: In this research, we used the Cancer Genome Atlas (TCGA) public database combined with tissue microarray (TMA) to investigate expression and prognosis in NSCLC.

Non-destructive analysis of composition using hyperspectral imaging and machine learning.

Background: is a widely used medicinal fungus whose quality is influenced by various factors, making traditional chemical detection methods complex and economically challenging. This study addresses the need for fast, noninvasive testing methods by combining hyperspectral imaging with machine learning to predict polysaccharide and ergosterol levels in cap and powder.

Methods: Hyperspectral images in the visible near-infrared (385-1009 nm) and short-wave infrared (899-1695 nm) ranges were collected, with ergosterol measured by high-performance liquid chromatography and polysaccharides assessed via the phenol-sulfuric acid method.

Coupling of chromatography with surface-enhanced Raman spectroscopy: trends and prospects.

Surface-enhanced Raman spectroscopy is a powerful analytical technique for the determination of analytes with the advantages of sensitivity, portability, and simplicity, able to provide structural information for the identification of compounds. However, when it comes to the analysis of complex samples, matrix components may interfere with the analyte quantification. To overcome this shortcoming, a number of approaches have been proposed, such as extraction techniques.

Discovery of triazole derivatives for biofilm disruption, anti-inflammation and metal ion chelation.

In the face of bacterial hazards to human health and resistance to multiple antibiotics, there is an urgent need to develop new antibiotics to meet the challenge. In this paper, the triazolyl heterocyclic (3-amino-1,2,4-triazole, ) was synthesised efficiently using thiourea as starting material. Finally, the end product was obtained by aldehyde-amine condensation reaction and the structures of all compounds were determined by spectral analysis.

Adaptive neoadjuvant endocrine therapy screens out prime population of ribociclib intensive adjuvant therapy.

The latest data from the NATALEE trial showed the absolute 3-year invasive disease-free survival benefit was 4.9% between the experimental and control groups. That is to say, in the intermediate-risk hormone receptor positive/human epidermal growth factor receptor-2 negative subgroup, there are also some patients with primary resistance to ribociclib.

Improving neuroblastoma risk prediction through a polygenic risk score derived from genome-wide association study-identified loci.

Objective: Neuroblastoma is the most common extracranial solid tumor in children and has complex genetic underpinnings. Previous genome-wide association studies (GWASs) have identified many loci associated with neuroblastoma susceptibility; however, their application in risk prediction for Chinese children has not been systematically explored. This study seeks to enhance neuroblastoma risk prediction by validating these loci and evaluating their performance in polygenic risk models.

Clinicopathological and molecular features of HR /HER2 breast cancer patients with distinct endocrine resistance patterns.

Objective: Recurrence continues to be a pivotal challenge among hormone receptor-positive (HR)/human epidermal growth factor receptor 2-negative (HER2) breast cancers. In the international consensus guidelines, HR/HER2 breast cancer relapse patterns are divided into three distinct types: primary resistant, secondary resistant, and endocrine sensitive. However, owing to the lack of cohorts with treatment and follow-up data, the heterogeneity among different recurrence patterns remains uncharted.

Prophylactic hyperthermic intraperitoneal chemotherapy in patients with locally advanced gastric cancer after curative surgery: Final results of a phase II trial.

Objective: The trial was designed to evaluate the efficacy of prophylactic hyperthermic intraperitoneal chemotherapy (HIPEC) with cisplatin for patients with locally advanced gastric cancer (LAGC).

Methods: Between March 2015 and November 2016, a phase II clinical trial was performed. Fifty consecutive patients with LAGC were randomly assigned to two groups: the experimental group (radical gastrectomy + HIPEC with cisplatin + adjuvant chemotherapy) and the control group (radical gastrectomy + adjuvant chemotherapy).

Integrated analysis of single-cell and bulk transcriptomes uncovers clinically relevant molecular subtypes in human prostate cancer.

Objective: Prostate cancer (PCa) is a complex disease characterized by diverse cellular ecosystems within the tumor microenvironment (TME) and high tumor heterogeneity, which challenges clinically stratified management and reinforces the need for novel strategies to fight against castration-resistant PCa (CRPC).

Methods: We performed single-cell RNA sequencing (scRNA-seq) on 10 untreated primary PCa tissues and integrated public scRNA-seq resources from three normal prostate tissues, two untreated primary PCa tissues, and six CRPC tumors to portray a comprehensive cellular and molecular interaction atlas of PCa. We further integrated the single-cell and bulk transcriptomes of PCa to establish a molecular classification system.

Deep learning-based multi-task prediction of response to neoadjuvant chemotherapy using multiscale whole slide images in breast cancer: A multicenter study.

Objective: Early predicting response before neoadjuvant chemotherapy (NAC) is crucial for personalized treatment plans for locally advanced breast cancer patients. We aim to develop a multi-task model using multiscale whole slide images (WSIs) features to predict the response to breast cancer NAC more finely.

Methods: This work collected 1,670 whole slide images for training and validation sets, internal testing sets, external testing sets, and prospective testing sets of the weakly-supervised deep learning-based multi-task model (DLMM) in predicting treatment response and pCR to NAC.

CT-based radiomics-deep learning model predicts occult lymph node metastasis in early-stage lung adenocarcinoma patients: A multicenter study.

Objective: The neglect of occult lymph nodes metastasis (OLNM) is one of the pivotal causes of early non-small cell lung cancer (NSCLC) recurrence after local treatments such as stereotactic body radiotherapy (SBRT) or surgery. This study aimed to develop and validate a computed tomography (CT)-based radiomics and deep learning (DL) fusion model for predicting non-invasive OLNM.

Methods: Patients with radiologically node-negative lung adenocarcinoma from two centers were retrospectively analyzed.

Composite score of PD-1 CD8 tumor-infiltrating lymphocytes and CD57 CD8 tumor ascites lymphocytes is associated with prognosis and tumor immune microenvironment of patients with advanced high-grade serous ovarian cancer.

Objective: The expression of programmed death 1 (PD-1) on CD8 T cells is associated with their activation and exhaustion, while CD57 serves as a senescence marker. The impact of PD-1 and CD57CD8 T cells on the prognosis of patients with advanced high-grade serous ovarian cancer (HGSOC) remain unclear.

Methods: We assessed the percentages of PD-1 and CD57CD8 T cells in tumor-infiltrating lymphocytes (TILs, n=85) and tumor ascites lymphocytes (TALs, n=87) using flow cytometry.

Genomic characterization and antifungal properties of YF, a promising biocontrol agent against pathogen of codonopsis root rot.

Root rot, a destructive soil-borne disease, poses a significant threat to a wide range of economically important crops. Codonopsis, a high-value medicine plant, is particularly susceptible to substantial production losses caused by -induced root rot. In this study, we identified a promising biocontrol agent for codonopsis root rot, YF.

Understanding the microbiome-crop rotation nexus in karst agricultural systems: insights from Southwestern China.

Understanding how soil properties and microbial communities respond to crop rotation is essential for the sustainability of agroecosystems. However, there has been limited research on how crop rotation alters below-ground microbial communities in soils with serious bacterial wilt within the karst agricultural system. This study investigated the effects of continuous planting of corn, tobacco, and tobacco-corn rotation on soil microbial communities in the karst regions of Southwestern China.

Discovery of novel mycoviruses from fungi associated with mango leaf spots.

Mango () is a commercially significant fruit crop cultivated globally. However, leaf spot diseases are common in mango orchards, which severely impact the yield. Mycoviruses hold promise as potential biocontrol agents.

Remediation of antimony-contaminated soil using food waste organic fertilizer and rhizosphere microbial response mechanism.

Antimony pollution poses a significant threat to both the ecological environment and the health of people living in mining regions. Using organic fertilizers is an efficient approach for the remediation of heavy metal contamination in soil. This study aimed to explore how food waste organic fertilizer (FF) can remediate antimony-contaminated soil and the associated rhizosphere microbial response mechanism.