Deep learning of noncontrast CT for fast prediction of hemorrhagic transformation of acute ischemic stroke: a multicenter study.

Background: Hemorrhagic transformation (HT) is a complication of reperfusion therapy following acute ischemic stroke (AIS). We aimed to develop and validate a model for predicting HT and its subtypes with poor prognosis-parenchymal hemorrhage (PH), including PH-1 (hematoma within infarcted tissue, occupying < 30%) and PH-2 (hematoma occupying ≥ 30% of the infarcted tissue)-in AIS patients following intravenous thrombolysis (IVT) based on noncontrast computed tomography (NCCT) and clinical data.

Methods: In this six-center retrospective study, clinical and imaging data from 445 consecutive IVT-treated AIS patients were collected (01/2018-06/2023).

Impact of Cement Distribution on the Efficacy of Percutaneous Vertebral Augmentation for Osteoporotic Fractures: Assessment with an MRI-Based Reference Marker.

Background: No studies have evaluated the impact of the cement distribution as classified on the basis of the fracture bone marrow edema area (FBMEA) in magnetic resonance imaging (MRI) on the efficacy of percutaneous vertebral augmentation (PVA) for acute osteoporotic vertebral fractures.

Methods: The clinical data of patients with acute, painful, single-level thoracolumbar osteoporotic fractures were retrospectively analyzed. The bone cement distribution on the postoperative radiograph was divided into 4 types according to the distribution of the FBMEA on the preoperative MRI.

Volume and Distribution of Early Knee Effusion After TKA with a PEEK-Based Knee Prosthesis: Correlation with Changes in Serum Inflammation Marker Levels, Knee Functional Score, and Range of Motion.

Background: Early knee effusion is a common phenomenon after total knee arthroplasty (TKA), with potential clinical implications. Unlike traditional alloy knee prostheses, the polyetheretherketone (PEEK) knee system has radiographic transparency on magnetic resonance (MR) scans, which allows analysis of prosthetic knee effusion. We aimed to identify the distribution and volume of knee effusion after TKA with the PEEK prosthesis with use of MR imaging and to analyze whether dynamic changes in effusion were correlated with serum inflammatory marker changes and knee function recovery.

Density functional theory study of hydrogen and oxygen reactions on NiO(100) and Ce doped NiO(100).

Context: This study aims to reveal the reaction mechanisms of H and O on the NiO(100) and Ce-doped NiO(100) surfaces using the density functional theory (DFT) combined with the on-site Coulomb correction (DFT + U) method. It was found that H and O react favorably on the reduced surfaces of both materials. However, after the oxygen vacancy is filled, the activation energy for the reaction between H₂ and lattice oxygen increases.

Trypanosomosis and Transhumance: Contributions to Contemporary Conflicts Between Farmers and Herdsmen Along the Tsetse Fly Belts: Mathematical Modeling and Systematic Field Analysis Approach.

Conflicts within the tsetse fly belt revealed a strong correlation between the dynamics of bovine trypanosomosis and the insurgency involving farmers and herders in Nigeria and parts of West Africa. This study examined the history, causes and influence of farmers-herdsmen conflicts on banditry, terrorism and food security as it relates to the epidemiology of African animal trypanosomosis (AAT). A combination of literature database searches, semi-structured questionnaires, and mathematical modeling was employed.

Carotenoid profile in maternal and cord plasma and its trends in breast milk during lactation: a comparative study among three cities in northern China.

Increasing evidence suggests that carotenoids play an important role in visual and cognitive development during early life. This study aimed to depict the carotenoid profile in maternal/cord plasma and breast milk in three northern cities of China while investigating the association between dietary carotenoid intake and breast milk carotenoid levels. We enrolled 990 lactating mothers from three urban northern Chinese cities to collect breast milk (including colostrum, transitional milk, early mature milk, middle mature milk, and late mature milk).

Dysregulation of the molecular clock by blood-borne factors in Alzheimer's disease patients.

Background: Circadian disruptions are increasingly recognized in Alzheimer's disease (AD) patients and may influence disease onset and progression. This study examines how AD pathology affects blood-borne factors that regulate circadian rhythms.

Methods: Eighty-five participants from the Sino Longitudinal Study on Cognitive Decline were enrolled: 35 amyloid-beta negative normal controls (Aβ- NCs), 23 amyloid-beta positive normal controls (Aβ+ NCs), 15 patients with amnestic mild cognitive impairment (aMCI), and 12 with Alzheimer's disease dementia (ADD).

Modular Engineering of Lysostaphin with Significantly Improved Stability and Bioavailability for Treating MRSA Infections.

Methicillin-resistant (MRSA) is a refractory pneumonia-causing pathogen due to the antibiotic resistance and the characteristics of persisting inside its host cell. Lysostaphin is a typical bacteriolytic enzyme for degrading bacterial cell walls via hydrolysis of pentaglycine cross-links, showing potential to combat multidrug-resistant bacteria. However, there are still grand challenges for native lysostaphin because of its poor shelf stability and limited bioavailability.

The role of skin microbiota in lichen planus from a Mendelian randomization perspective.

Lichen planus is a chronic skin lesion characterized by pruritic violaceous papules, which has a high risk of morbidity. Skin microbiota plays an important role in the maintenance of cutaneous mucosal barrier and human health and immune homeostasis. Studies have shown that skin microbiota may play a role in the pathogenesis of lichen planus, but it is not yet clear.

Aptamer-Driven Multifunctional Nanoplatform for Near-Infrared Fluorescence Imaging and Rapid Inactivation of .

() is a prominent pathogen responsible for intestinal infections, primarily transmitted through contaminated food and water. This underscores the critical need for precise and biocompatible technologies enabling early detection and intervention of bacterial colonization . Herein, a multifunctional nanoplatform (IR808-Au@ZIF-90-Apt) was designed, utilizing an -specific aptamer to initiate cascade responses triggered by intracellular ATP and GSH.

A novel hybrid deep learning framework based on biplanar X-ray radiography images for bone density prediction and classification.

Unlabelled: This study utilized deep learning for bone mineral density (BMD) prediction and classification using biplanar X-ray radiography (BPX) images from Huashan Hospital Medical Checkup Center. Results showed high accuracy and strong correlation with quantitative computed tomography (QCT) results. The proposed models offer potential for screening patients at a high risk of osteoporosis and reducing unnecessary radiation and costs.

Palladium-catalyzed allylic C-H alkylation of terminal olefins with 3-carboxamide oxindoles.

A novel palladium-catalyzed allylic C-H alkylation of terminal olefins with 3-carboxamide oxindoles is described. A variety of new 3-carboxamide-3-allylation oxindoles with an all-carbon quaternary center were obtained in moderate to good yields (up to 99%). In addition, the asymmetric version of this reaction was also explored, providing moderate enantioselectivity.

Complete genome sequence of strain SOCE 003, a marine bacterium isolated from the surface seawater of Dapeng Bay.

is a heterotrophic bacterium commonly found in diverse marine environments. Here, we report the complete genome sequence of strain SOCE 003, which is 5,154,101 bp long, encoding 5,524 annotated protein-coding genes, 39 tRNAs, and 8 rRNAs. This genome information will help us understand the ecology of .

A reciprocity calibration of hydrophones in a non-anechoic water tank: Method and realization.

To measure the electroacoustic parameters of transducers in the continuous sound field in a limited water area, a reciprocity calibration method of hydrophones using a spatial sampling average method in a non-anechoic tank was developed. The sound propagation in the non-anechoic tank under the impedance boundary condition, with a sound source producing continuous sound, is introduced based on the Helmholtz equation and Green's function. The reciprocity constant is given using the spatial sampling average sound pressure, and the three-transducer reciprocity calibration procedure was established.

A low-frequency broadband ring transducer driven by the flextensional structure.

The flextensional transducer (FT) is a typical low-frequency transmitting transducer that is capable of high-power operation due to its capacity for displacement amplification. This article uses the structural configuration of the class IV FT as the basis for designing a ring transducer, which is a circular structure comprising a multitude of class IV flextensional structures as well as circular acoustic radiation structures. The flextensional structure drives the circular acoustic radiation structure, which in turn generates sound waves at low frequencies.

Effects of leading-edge serration shape on noise reduction in rod-airfoil interactions.

Leading-edge serrations inspired by owls exhibit the capability to control airfoil-turbulence interaction noise, but the design principle of the serration shape is still an open issue. To this end, we designed five types of serration shapes with different combinations of curvature, namely, triangular, ogee, anti-ogee, feather-like, and anti-feather-like. These curves are applied to serrated modifications with different bluntness levels (sharp or blunt) and amplitudes (0.

Complete genome sequence of GL-4.

A cellulase-producing was previously isolated from the intestinal tract of domestic bamboo rat and identified as GL-4. In this study, we present the complete genome sequence of GL-4. The genome is 4,271,214 bp long, with a guanine-cytosine content of 43.

Side group topological structure modified orbital and condensed state characteristics enhance the electrical anti-breakdown performance of polyolefin.

As an effective method to enhance the dielectric performance of polyolefin materials, polar side group modification has been extensively applied in the insulation and energy storage materials of electrical and electronic systems. In this work, two side groups with different topological structures were adopted, namely, vinyl acetate (VAc, aliphatic chain) and -vinyl-pyrrolidone (NVP, saturated ring), to modify polypropylene (PP) chemical grafting, and the effects of structural topology of the polar side group on the microscopic and macroscopic characteristics of PP, particularly on its electrical anti-breakdown ability, were investigated. Experimental results showed that the side group structural topology directly affected the crystallization and thermal properties of PP.

WF2020 isolated from fermented pickles promotes longevity and health in JNK and p38 MAPK pathways.

, a potential probiotic for use in food and feed production, can exert anti-aging effects in a strain-specific manner. However, the molecular mechanisms underlying its anti-aging effects remain poorly understood. This study explored the effects of WF2020 (WF2020), isolated from Chinese fermented pickles, on longevity and health and investigated the underlying mechanisms in .

Apelin-13 inhibits ischemia-reperfusion mediated podocyte apoptosis by reducing m-TOR phosphorylation to enhance autophagy.

Podocytes are essential to maintain the normal filtration function of glomerular basement membrane, which could be injured by ischemia-reperfusion. As complicated function of autophagy in terminal differentiated podocytes, autophagy dysfunction might contribute to I/R induced renal dysfunction following glomerular filtration membrane (GFM) injuries. Meanwhile, apelin-13, an endogenous polypeptide, has been proved to be effective in regulating autophagy and apoptosis in podocytes.

A Serial MRI-based Deep Learning Model to Predict Survival in Patients with Locoregionally Advanced Nasopharyngeal Carcinoma.

Purpose To develop and evaluate a deep learning-based prognostic model for predicting survival in locoregionally- advanced nasopharyngeal carcinoma (LA-NPC) using serial MRI before and after induction chemotherapy (IC). Materials and Methods This multicenter retrospective study included 1039 LA-NPC patients (779 male, 260 female, mean age 44 [standard deviation: 11]) diagnosed between April 2009 and December 2015. A radiomics- clinical prognostic model (Model RC) was developed using pre-and post-IC MRI and other clinical factors using graph convolutional neural networks (GCN).