Targeting Neuroinflammation in Preterm White Matter Injury: Therapeutic Potential of Mesenchymal Stem Cell-Derived Exosomes.

Neuroinflammation is a key factor in the development of preterm white matter injury (PWMI), leading to glial cell dysfunction, arrest of oligodendrocyte maturation, and long-term neurological damage. As a potential therapeutic strategy, mesenchymal stem cells (MSCs) exhibit significant immunomodulatory and regenerative potential. Recent studies suggest that the primary mechanism of MSC action is their paracrine effects, particularly mediated by extracellular vesicles, with MSC-derived exosomes (MSC-Exos) being the key mediators.

PET Coordination Mechanism for the Detecting of Environmental Toxic Analytes: Current Approaches and Future Directions.

Fluorescence-based photoinduced electron transfer (PET) has garnered significant attention in the molecular recognition field in recent years because of its unique and desirable photophysical properties. Recent advancements in PET-based chemosensors have demonstrated their potential for real-time monitoring of pollutants such as heavy metals, pesticides, and organic contaminants in various environmental matrices. This review emphasizes the recent advancements in fluorogenic and chromogenic PET-based chemosensors based on Anthracene, Imidazole, Indole, Pyrrole, Thiazole, Naphthalene, Quinoline, Calix[4]arene, Fluorescein, Quantum Dots, Schiff base compounds and also focusing on their molecular design, sensing mechanisms, and photophysical properties reported from the year 2011 to 2024.

Do people with diabetes have a higher risk of developing postoperative endophthalmitis after cataract surgery? A systematic review and meta-analysis.

Purpose: Postoperative endophthalmitis (POE) is a rare but severe complication of cataract surgery. While diabetes mellitus may increase the risk of POE, the relationship remains unclear.

Methods: A systematic review and meta-analysis were conducted following PRISMA guidelines.

Development of colloidal gold test strip based on the BsVg819 gene fragment of vitellogenin of Bostrichthys sinensis for the detection of vitellogenin in multiple fish species.

As an environmental estrogen biomarker, the yolk precursor, vitellogenin (Vtg) is widely used in the assessment of estrogen pollution in aquatic environment. Currently, the detection of Vtg in plasma is mainly achieved by enzyme-linked immunosorbent assay (ELISA) method based on Vtg antibodies. However, due to differences in the immunological epitopes of Vtg from various species, Vtg antibodies have low universality.

Design Refinement of Catalytic System for Scale-Up Mild Nitrogen Photo-Fixation.

Ammonia and nitric acid, versatile industrial feedstocks, and burgeoning clean energy vectors hold immense promise for sustainable development. However, Haber-Bosch and Ostwald processes, which generates carbon dioxide as massive by-product, contribute to greenhouse effects and pose environmental challenges. Thus, the pursuit of nitrogen fixation through carbon-neutral pathways under benign conditions is a frontier of scientific topics, with the harnessing of solar energy emerging as an enticing and viable option.

Mapping glioma progression: single-cell RNA sequencing illuminates cell-cell interactions and immune response variability.

Background: Glioma, the most common primary cancer of the central nervous system, characterizes significant heterogeneity, presenting major challenges for therapeutic approaches and prognosis. In this study, the interactions between malignant glioma cells and macrophages/monocytes, as well as their influence on tumor progression and treatment responses, were explored using comprehensive single-cell RNA sequencing analysis.

Methods: RNA-seq data from the TCGA and CGGA databases were integrated and an in-depth analysis of glioma samples was performed using single-cell RNA sequencing, functional enrichment analysis, developmental trajectory analysis, cell-cell communication analysis, and gene regulatory network analysis.

The role of PD-L1 in EGFR-mutant non-small cell lung cancer.

Lung cancer remains the leading cause of cancer-related deaths globally. In China, nearly half of non-small cell lung cancer (NSCLC) patients carry epidermal growth factor receptor (EGFR) mutations. EGFR tyrosine kinase inhibitors (EGFR-TKIs) have significantly improved the prognosis for patients with EGFR mutations and are considered the preferred treatment for these individuals.

New Polyhydroxysteroids Derivatives from Starfish Asterias amurensis Induce Embryotoxicity in Marine Medaka.

In recent years, multiple population outbreaks of the Northern Pacific starfish (Asterias amurensis) have been documented off the coast of Qingdao. Starfish use chemosensation to regulate their life history and interactions with the environment, with their secondary metabolites serving as deterrents and dispersal agents against predators. While the eggs of marine fish are passive and susceptible, we hypothesized that the secondary metabolites of A.

The impact of combined Gua Sha and myofascial release techniques on upper limb dysfunction in patients with breast cancer and axillary web syndrome: a prospective case series study.

Objective: To investigate the effects of a combined Gua Sha and myofascial release approach on upper limb dysfunction in patients with breast cancer and axillary web syndrome (AWS).

Methods: In this prospective case series study, 30 patients with breast cancer diagnosed with AWS post-surgery were recruited. Participants underwent a 12-week intervention combining Gua Sha and myofascial release techniques.

A Novel Dual Latex Balloon Catheter for Temporarily Closing Acute Postinfarction Ventricle Septum Defect (VSD) in a Pig Model.

Acute postinfarction ventricular septum defect has a persistently high mortality rate due to unstable scars in the acute phase, which make surgery or occluder use unsuitable. Delayed closure increases the risk of irreversible hemodynamic deterioration. To address this, a dual latex balloon catheter was designed for temporary closure and tested in a pig model.

Problem-Based Learning-Standardized Preoperative Conversation Improves Neurosurgery Residents' Understanding of Cerebellopontine Angle Tumors.

This study aims to explore the effects of problem-based learning (PBL) and prescription-based preoperative talk (PPT) teaching methods in the teaching of tumors in cerebellopontine angle (CPA) of clinical neurosurgery residents.One hundred-thirty neurosurgery residents working in Qilu Hospital of Shandong University from September 2021 to June 2024 were randomly divided into two groups. The experimental group adopted the combination of PBL and PPT, referred to as PPP.

Mesh-reinforced reconstruction after abdominal wall desmoid tumor resection: a retrospective analysis of 16 cases.

Purpose: Managing the defect after abdominal wall desmoid tumor resection is challenging due to the wide excision required. This report aims to review our institutional experience with mesh-reinforced reconstruction following desmoid tumor resection in the abdominal wall.

Methods: We retrospectively reviewed patients who underwent abdominal wall desmoid tumor resection with mesh-reinforced reconstruction between April 2014 and January 2019.

Manipulating Interfacial Stability via Preferential Absorption for Highly Stable and Safe 4.6 V LiCoO Cathode.

Elevating the upper cutoff voltage to 4.6 V could effectively increase the reversible capacity of LiCoO (LCO) cathode, whereas the irreversible structural transition, unstable electrode/electrolyte interface and potentially induced safety hazards severely hinder its industrial application. Building a robust cathode/electrolyte interface film by electrolyte engineering is one of the efficient approaches to boost the performance of high-voltage LCO (HV-LCO); however, the elusive interfacial chemistry poses substantial challenges to the rational design of highly compatible electrolytes.

System metabolic engineering modification of Saccharomyces cerevisiae to increase SAM production.

S-adenosyl-L-methionine (SAM) is an important compound with significant pharmaceutical and nutraceutical applications. Currently, microbial fermentation is dominant in SAM production, which remains challenging due to its complex biosynthetic pathway and insufficient precursor availability. In this study, a multimodule engineering strategy based on CRISPR/Cas9 was established to improve the SAM productivity of Saccharomyces cerevisiae.

Investigating cuproptosis and mitochondrial dysfunction in brain cells: uncovering novel mechanisms and biomarkers for Parkinson's disease.

Parkinson's disease (PD) is a chronic neurodegenerative condition marked by the gradual degeneration of dopaminergic neurons, resulting in a range of disabling motor and non-motor symptoms. Despite advances, the molecular mechanisms underlying PD remain elusive, and effective biomarkers and therapeutic targets are limited. Recent studies suggest that mitochondrial dysfunction and dysregulated cellular metabolism are central to PD pathogenesis.

An electrochromism-equipped enzymatic biofuel cell system combined with hollow microneedle array for self-powered glucose sensing in interstitial fluid.

A disposable, self-powered enzymatic biofuel cell (BFC) sensor integrated with a hollow microneedle array (HMNA) for glucose monitoring in interstitial fluid (ISF) is reported. The HMNA enables painless and minimally invasive ISF extraction. The BFC uses dehydrogenase (GDH) in conjunction with NAD, diaphorase (DI), and vitamin K (VK) serving as electron transfer mediators as the anode catalyst and Prussian blue (PB) as the electrochromic cathode.

Causal relationship and potential common pathogenic mechanisms between hidradenitis suppurativa and related cancer.

Background: Hidradenitis suppurativa (HS) is a chronic, inflammatory and common skin disease. Observation studies have reported the association between HS and cancers, however no studies reported whether a causal relationship exists between HS and cancers. This study aimed to explore the causal relationship between HS and differential subtypes of cancers by conducting a bidirectional Mendelian randomization (MR) analysis.

The functions and modifications of tRNA-derived small RNAs in cancer biology.

Recent progress in noncoding RNA research has highlighted transfer RNA-derived small RNAs (tsRNAs) as key regulators of gene expression, linking them to numerous cellular functions. tsRNAs, which are produced by ribonucleases such as angiogenin and Dicer, are classified based on their size and cleavage positions. They play diverse regulatory roles at the transcriptional, post-transcriptional, and translational levels.

Starvation tolerance and effects on fitness of predatory mite Amblyseius orientalis.

Amblyseius orientalis Ehara (Mesostigmata: Phytoseiidae) has garnered significant attention as an effective predatory mite for controlling spider mites in fruit production in China. However, despite its considerable potential for pest management, A. orientalis may face food shortages during transportation and field application.

Single-cell RNA sequencing generates an atlas of normal tibia cartilage under mechanical loading conditions.

Chondrocytes in articular cartilage can secrete extracellular matrix to maintain cartilage homeostasis. It is well known that articular cartilage chondrocytes are sensitive to mechanical loading and that mechanical stimuli can be translated to biological processes. This study provides deep insight into the impact of mechanical loading on chondrocytes via single-cell RNA sequencing (scRNA-seq).

Self-disclosure and reproductive concerns among breast cancer female patients: the chain mediation model of couples' cancer-related communication problems and relationship intimacy.

Purpose: Reproductive concerns are prevalent in the female breast cancer patient population and increase existential distress. Although self-disclosure significantly correlated reproductive concerns, the exact mechanism of action is unknown. Based on previous theoretical studies on couples' cancer-related communication problems and intimacy in couples, this study constructed a chain mediation model to investigate whether the two variables mediate the relationship between self-disclosure and reproductive concerns.

Differences between children and young adults in the effects of difficulty and value of learning items on cognitive offloading strategies.

Cognitive offloading refers to the use of external tools to assist in memory processes.This study investigates the effects of item difficulty and value on cognitive offloading during a word-pair learning task, comparing children and young adults in a context where both cues coexist. In Experiment 1, we examined the impact of difficulty and value cues on cognitive offloading using a 2 (difficulty: easy vs.

Dietary risk factors in Crohn's disease and ulcerative colitis: a cohort study with paired healthy relatives as controls.

Purpose: Conflicting results have been reported on dietary factors in inflammatory bowel diseases (IBDs). Here, we compared the dietary intakes of IBD patients with those of paired healthy relatives (HRs), aiming to minimize the impact of genetic and environmental confounders.

Methods: Patients with Crohn's disease (CD, N = 45) and ulcerative colitis (UC, N = 20), their paired HRs (N = 45, N = 20) and healthy non-relative (HNR, N = 25, N = 55) controls were recruited.