Non-Luminal Disease Score for Everolimus in Patients with Hormone Receptor‑positive and Human Epidermal Growth Factor Receptor 2-Negative Advanced Breast Cancer: A Multicenter and Retrospective Study.

Purpose: This study aims to explore the role of the non-luminal disease score (NOLUS) for everolimus in patients with hormone receptor-positive and human epidermal growth factor receptor 2-negative (HR+/HER2-) advanced breast cancer (ABC).

Methods: NOLUS has previously been established as an algorithm: NOLUS (0-100) = - 0.45 × ER(%) - 0.

Association between body esteem and sugar-sweetened beverage intake among Chinese undergraduate students: a cross-sectional study.

Background: High intake of sugar-sweetened beverages has been linked to a range of physical, psychological, and emotional issues. Although there were various factors influencing sugar-sweetened beverage intake, the relationship between body esteem and sugar-sweetened beverage intake remains unclear. This study aimed to investigate the association between three dimensions of body esteem (body esteem-appearance, body esteem-attribution, and body esteem-weight) and the likelihood of high sugar-sweetened beverage intake.

Characterization of the volatile compounds in tea ( L.) flowers during blooming.

Tea flower, with characteristic flavor formed during blooming, are a significant tea resource. However, studies on the volatile compounds of tea flower and their aroma characteristics during flowering are scarce. In this study, the odor characteristics of tea flower during blooming were comprehensively investigated by GC-MS, PCA, ACI determination and sensory evaluation.

Efficacy and safety of post-discharge oral nutritional supplements for patients with gastric cancer undergoing gastrectomy: a meta-analysis of randomized controlled trials.

Objectives: To report the first and largest systematic review and meta-analysis of randomized controlled trials (RCT) to evaluated the efficacy and safety of post-discharge oral nutritional supplements (ONS) for patients with gastric cancer undergoing gastrectomy.

Design: Systematic review and meta-analysis.

Eligibility Criteria For Selecting Studies: RCT which evaluated the efficacy and/or safety of post-discharge ONS for patients with gastric cancer undergoing gastrectomy.

Berberine alleviates enterotoxigenic -induced intestinal mucosal barrier function damage in a piglet model by modulation of the intestinal microbiome.

Introduction: Enterotoxic (ETEC) is the main pathogen that causes diarrhea, especially in young children. This disease can lead to substantial morbidity and mortality and is a major global health concern. Managing ETEC infections is challenging owing to the increasing prevalence of antibiotic resistance.

Risk prediction models for feeding intolerance in patients with enteral nutrition: a systematic review and meta-analysis.

Background: Although more risk prediction models are available for feeding intolerance in enteral-nourishment patients, it is still unclear how well these models will work in clinical settings. Future research faces challenges in validating model accuracy across populations, enhancing interpretability for clinical use, and overcoming dataset limitations.

Objective: To thoroughly examine studies that have been published on feeding intolerance risk prediction models for enteral nutrition patients.

Mediation of endothelial activation and stress index in the association between vitamin B turnover rate and diabetic retinopathy: an analysis of the National Health and Nutrition Examination Survey.

Aim: This study aimed to explore the association between the ratio of 4-pyridoxine (4-PA) to pyridoxal 5'-phosphate (PLP) (4-PA/PLP) and diabetic retinopathy (DR) and further assess the mediating effect of Endothelial Activation and Stress Index (EASIX) on the association between 4-PA/PLP and DR.

Methods: In this cross-sectional study, 1,698 patients with diabetes from the National Health and Nutrition Examination Survey were included. According to the median, 4-PA/PLP was categorized into a high-level group (≥0.

Integrating attention mechanism and boundary detection for building segmentation from remote sensing images.

Accurate building segmentation has become critical in various fields such as urban management, urban planning, mapping, and navigation. With the increasing diversity in the number, size, and shape of buildings, convolutional neural networks have been used to segment and extract buildings from such images, resulting in increased efficiency and utilization of image features. We propose a building semantic segmentation method to improve the traditional Unet convolutional neural network by integrating attention mechanism and boundary detection.

Light-Programmable g-CN Microrobots with Negative Photogravitaxis for Photocatalytic Antibiotic Degradation.

Microrobots enhance contact with pollutants through their movement and flow-induced mixing, substantially improving wastewater treatment efficiency beyond traditional diffusion-limited methods. g-CN is an affordable and environmentally friendly photocatalyst that has been extensively researched in various fields such as biomedicine and environmental remediation. However, compared to other photocatalytic materials like TiO and ZnO, which are widely used in the fabrication of micro- and nanorobots, research on g-CN for these applications is still in its early stages.

Integrating single-cell RNA-seq and bulk RNA-seq to explore prognostic value and immune landscapes of methionine metabolism-related signature in breast cancer.

Background: Neoadjuvant, endocrine, and targeted therapies have significantly improved the prognosis of breast cancer (BC). However, due to the high heterogeneity of cancer, some patients cannot benefit from existing treatments. Increasing evidence suggests that amino acids and their metabolites can alter the tumor malignant behavior through reshaping tumor microenvironment and regulation of immune cell function.

Mindray CL-900i assay: An effective assay for hepatitis B surface antigen screening with superior specificity.

Objectives: The chemiluminescence immunoassay automated Abbott ARCHITECT hepatitis B surface antigen (HBsAg) screening assay is globally recognized for its superior sensitivity but notably low specificity. This mandates positive results confirmation by another confirmatory assay, such as the widely used Abbott ARCHITECT HBsAg neutralizing assay. This study aimed to evaluate the performance of the new chemiluminescence immunoassay, Mindray CL-900i HBsAg screening assay in comparison to the ARCHITECT neutralizing/confirmatory assay.

The graded heat-health risk forecast and early warning with full-season coverage across China: a predicting model development and evaluation study.

Background: Due to global climate change, high temperature and heatwaves have become critical issues that pose a threat to human health. An effective early warning system is essential to mitigate the health risks associated with high temperature and heatwaves. However, most of the current heatwave early warning systems are not adequately developed based on the heat-health risk model, and the health impact of hot weather has not been well managed in most countries.

Therapeutic potential of rutin in premenstrual depression: evidence from and studies.

Introduction: Premenstrual dysphoric disorder (PMDD) is a cyclical mood disorder that severely affects the daily life of women of reproductive age. Most of the medications being used clinically have limitations such as low efficacy, side effects, and high cost, so there is an urgent need to discover safer and more effective medications. Rutin is a natural flavonol glycoside with various pharmacological properties including antidepressant.

Discussion on the optimization of personalized medication using information systems based on pharmacogenomics: an example using colorectal cancer.

Pharmacogenomics (PGx) is a powerful tool for clinical optimization of drug efficacy and safety. However, due to many factors affecting drugs in the real world, PGx still accounts for a small proportion of actual clinical application scenarios. Therefore, based on the information software, pharmacists use their professional advantages to integrate PGx into all aspects of pharmaceutical care, which is conducive to promoting the development of personalized medicine.

accelerates methicillin-resistant eradication by promoting migration and activation of neutrophils.

Background: (Lanata) is generally used to treat pustule infection in Inner Mongolia folk medicine and is called "the holy medicine for pustule." However, the pharmacological mechanism of Lanata in treating pustule infection is still unclear.

Aims: This study aimed to investigate the therapeutic effects of Lanata on skin infection and explore the underlying mechanisms.

Polydatin protects against DSS-induced ulcerative colitis via Nrf2/Slc7a11/Gpx4-dependent inhibition of ferroptosis signalling activation.

Introduction: Ulcerative colitis (UC), a form of inflammatory irritable bowel disease, is characterized by a recurrent and persistent nonspecific inflammatory response. Polydatin (PD), a natural stilbenoid polyphenol with potent properties, exhibits unexpected beneficial effects beyond its well-documented anti-inflammatory and antioxidant activities. In this study, we presented evidence that PD confers protection against dextran sodium sulfate (DSS)-induced ulcerative colitis.

Multi-target regulatory effects of rhaponticin in a rat model of hepatic fibrosis revealed by non-targeted metabolomics.

Introduction: Hepatic fibrosis (HF), a progressive chronic liver disease, is a serious threat to global public health. The lack of preventive and therapeutic strategies has created an urgent need for effective anti-fibrosis agents. There is growing evidence that natural products might provide safe and effective interventions for HF.

Decoding nature: multi-target anti-inflammatory mechanisms of natural products in the TLR4/NF-κB pathway.

Natural products are valuable medicinal resources in the field of anti-inflammation due to their significant bioactivity and low antibiotic resistance. Research has demonstrated that many natural products exert notable anti-inflammatory effects by modulating the Toll-like receptor 4 (TLR4) and nuclear factor kappa B (NF-κB) signaling pathways. The research on related signal transduction mechanisms and pharmacological mechanisms is increasingly being discovered and validated.

Hydroxysafflor yellow A: a natural pigment with potential anticancer therapeutic effect.

Hydroxysafflor yellow A (HSYA), a natural pigment with a chalcone structure extracted from (Safflower), has been widely proven to have good efficacy on cardiovascular diseases, atherosclerosis, cancer, and diabetes. However, no study has reported on the anticancer mechanisms of Hydroxysafflor yellow A (HSYA), a principal bioactive compound in safflower. This review discusses recent developments in the physicochemical properties and sources, pharmacological effects and mechanisms, pharmacokinetic progress, and safety of HSYA, focusing on the involvement of HSYA in the regulation of related pathways and mechanisms of apoptosis, autophagy, and the tumor immune microenvironment in a variety of cancers.

Current status and prospects of traditional Chinese medicine combined with stem cell therapy for chronic kidney disease.

Renal fibrosis is one of the main pathological features of chronic kidney disease (CKD), and its treatment has been a hot research topic. Recent studies have shown that stem cell therapy can repair renal pathological changes and slow the progression of CKD. In addition, a large number of experiments have confirmed that traditional Chinese medicine (TCM), especially Chinese medicine compound preparations, has the advantage of multitargeting interventions to improve renal fibrosis.

DNA methylation inhibitors adverse reaction characteristic analysis: an analysis based on the European spontaneous adverse event reporting system.

Introduction: DNA methylation inhibitors have been approved for the prevention of Acute Myeloid Leukemia (AML), and their safety profile is not fully characterized. This study was aimed at evaluating the adverse drug reactions (ADRs) of DNA methylation inhibitors by analyzing the individual case safety reports (ICSRs) collected in the EudraVigilance (EV) database.

Materials And Methods: The EV database managed by the European Medicines Agency was adopted.