Risk of increasing soil nitrous oxide emissions by chemical oxidation modification on biochar.

Biochar is widely recognized as a soil amendment capable of mitigating soil nitrous oxide (NO) emissions. However, the effects of biochar modification, particularly through chemical oxidation, remain relatively unexplored. This study modified wood and corn straw biochars using HO and acid (HSO/HNO).

Immune mechanisms in multiple sclerosis: CD3 levels on CD28+ CD4+ T cells link antibody responses to human herpesvirus 6.

Compelling evidence suggests a significant association between antibody-mediated immune responses and multiple sclerosis (MS). However, the exact causal relationships between these immune responses and MS remain unclear. In this study, we conducted a comprehensive examination of the link between antibody-mediated immune responses and MS via Mendelian randomization (MR) analysis to identify specific infectious pathogens potentially involved in the onset and progression of MS.

TLR3 as an emerging molecule facilitating pyroptosis in the context of rheumatoid arthritis: A study combined bioinformatics and experimental validation.

Background: Rheumatoid arthritis (RA) is an inflammatory disease of the joints mediated by immune cells. As an immune-related mode of cell death, pyroptosis has yet to be fully understood in RA. This research identified novel pyroptosis-related markers in RA and confirmed its functional significance in RA.

Case report: Vulvar metastasis after lung metastasis in cervical squamous cell carcinoma, a case report and literature review.

Introduction And Importance: Cervical cancer is highly correlated with high-risk human papillomavirus (HPV) infection, accounting for approximately 70 % of cases. However, false-negative HPV test results can occur, complicating early detection.

Case Presentation: We introduce a rare case of cervical cancer with lung metastasis followed by vulvar metastasis.

Improving hemodialysis patient depression outcomes with acupuncture: A randomized controlled trial.

Objective: To evaluate the efficacy and safety of acupuncture as a supplementary treatment for mild to moderate depression in hemodialysis patients.

Method: This multicenter, randomized, controlled, single-masked trial included 64 hemodialysis patients aged 18-75 divided into two groups. One group received genuine acupuncture, while the other received sham acupuncture over 12 weeks.

CmTGA8-CmAPX1/CmGSTU25 regulatory model involved in trehalose induced cold tolerance in oriental melon seedlings.

Plants have developed complex regulatory networks to adapt to various stresses, including cold stress. Trehalose (Tre), known as the "sugar of life," plays a crucial role in enhancing cold tolerance by triggering antioxidation. However, the underlying regulatory mechanisms remain unclear.

U(VI) removal by zerovalent manganese modified corn straw biochar in acidic wastewater: Efficiency, characteristics and mechanism.

The chemical and radiological toxicity of uranium can present a significant risk to both human health and environmental safety. Thus, ZVMn-BC was synthesized through borohydride reduction aimed at investigating its performance in removing U(VI) in acidic environment (pH = 3). Several batch experiments were conducted to assess the sorption capability under various operational conditions and the relevant experimental data were investigated by kinetics, isotherms and thermodynamic equations.

Modelling assisted phytoextraction of heavy metals from tannery origin leachate.

The toxic tannery solid waste leachate (TSWL) containing heavy metals is generated after the percolation of rainwater in openly dumped tannery solid waste (TSW) which poses a serious threat to the surroundings by leaching down and bioaccumulation. For its management, the phytoextraction potential of Pistia stratiotes L. and Spirodela polyrhiza L.

Photochemical bomb: Precision nuclear targeting to activate cGAS-STING pathway for enhanced bladder cancer immunotherapy.

Activating the cGAS-STING pathway presents a promising strategy to enhance the innate immunity and combat the immunosuppressive tumor microenvironment. One key mechanism for triggering this pathway involves the release of damaged DNA fragments caused by nuclear DNA damage. However, conventional cGAS-STING agonists often suffer from limited nucleus-targeting efficiency and potential biotoxicity.

Enhanced chemiluminescence of luminol via InS/MXene composite as a novel Co-reactant accelerator for UV-filter Benzophenone-3 determination.

In this study, a novel In₂S₃/MXene composite was developed as a co-reactant accelerator to enhance the chemiluminescence (CL) performance of the classical luminol-H₂O₂ system. The In₂S₃ and MXene heterojunction catalyzed the CL reaction through synergistic effect, facilitating the generation of reactive oxygen species and increasing CL intensities. This enhanced system was applied for the first time to detect an ultraviolet (UV) filter-benzophenone-3 (BP-3) by leveraging its light absorption property.

Reliable and specific biosensing on single- and double-stranded aptamer functionalized remote dual-gate organic field-effect transistors: A comparison.

Organic field-effect transistors (OFETs) integrated with commercial transistors are promising sensing platforms characterized by enhanced device uniformity, functional diversity, and electrical output stability. Aptamers with charged backbones and a high affinity for target molecules are anticipated to mitigate the limitations imposed by Debye screening in physiological environments with high ionic strength, thereby facilitating specific biological recognition in complex surroundings. This study presents two reliable OFET aptasensors for vascular endothelial growth factor (VEGF) and offers a systematic comparison of their performance.

Artificial intelligence enhanced microfluidic system for multiplexed point-of-care-testing of biological thiols.

Cysteamine (CA) serves as a cystine-depleting agent employed in the management of cystinosis and a range of other medical conditions. Monitoring blood CA levels at the point of care is imperative due to the risk of toxicity associated with elevated CA dosages. An additional significant challenge is presented by the intricate composition of human plasma and the presence of various interfering biological thiols, which possess similar structures or properties.

Magnetic field facilitated-colorimetric aptasensor for selective and sensitive detection of Staphylococcus aureus using aptamer-labeled Zn/Co ICPs nanoenzyme.

Colorimetric detection of pathogenic bacteria (such as S. aureus) in complex sample confronts challenges regarding sensitivity, selectivity, and accuracy. In this paper, a magnetic field facilitated (MFF)-colorimetric aptasensor was proposed for S.

Disease continuum centered on Parkinson's disease.

Parkinson's disease (PD), once viewed as a neurodegenerative disorder, is now increasingly recognized as part of a broader disease continuum, intricately linked to comorbidities across various organ systems. This study provides a snapshot of the disease continuum centered on PD, using a disease-wide association study (DWAS) involving 392,423 individuals-including 4,235 PD cases. This DWAS identifies disease clusters of PD comorbidities across the musculoskeletal, circulatory, digestive, and respiratory systems.

Circulating insulin-like growth factor-1 and the risk of multiple sclerosis: a prospective cohort study.

Background: Circulating insulin-like growth factor 1 (IGF-1) is positively associated with the risks of certain neurological disorders, including stroke, Alzheimer's disease, and Parkinson's disease. However, the association of IGF-1 with the risk of multiple sclerosis (MS) remains unclear.

Methods: A total of 348,324 participants at baseline were included from the UK biobank in this prospective study.

Illness behavior and its predictors in young and middle-aged colorectal cancer patients: A latent profile analysis.

Purpose: To describe the characteristics of sick role adaptation and understand the differences in young and middle-aged colorectal cancer (CRC) patients.

Methods: 225 colorectal cancer patients aged 18-59 admitting to a specialized oncology hospital in Guangzhou, China were involved from January to April 2022. Socio-demographic characteristics, disease-related characteristics, scores of Illness Behavior Questionnaire, Hospital Anxiety and Depression Scale, the Brief Illness Perception Questionnaire, Mishel Uncertainty in Illness Scale and Medical Coping Modes Questionnaire were applied to collect quantitative data.

CuS@Ag Heterostructure-based Surface Plasmonic Coupling Electrochemiluminescence Sensor for Glioma miRNA-124-3p Detection.

As an emerging class of extended crystalline organic materials, covalent organic framework (COF)-based aggregation-induced emission luminogen (AIE-gen) exhibited encouraging emissive properties. In this work, 4',4'',4‴,4‴'-(1,1,2,2-Ethenetetrayl)tetra(4-biphenylcarbaldehyde) (ETBC) as AIEgen was used to prepare AIE-COF (ET-COF-COOH) luminescent nanoprobe. ETBC and 1,3,5-Tris(4-aminophenyl)benzene (TAPB) had an extended π electronic system that allowed electron delocalization and overlapping transport.

Flexible multifunctional Janus film towards self-healing, self-adhesive and streachable EMI shielding.

As smart electronic devices proliferate rapidly, concerns about electromagnetic radiation have become more prominent. Traditional electromagnetic shielding materials typically use three-dimensional porous foams, carbon structures, and film materials as their substrates. However, as electronic devices become more miniaturized, integrated, and precise, the large volume and limited functionality of foam materials have constrained their applications.

Phenylboronic acid functionalized magnetic ferroferric oxide nanoparticles and capillary electrophoresis for efficient isolation of flavonoid compounds from leaves of Lonicera japonica Thunb.

Flavonoids are bioactive components in natural products, which possess anti-inflammatory, antibacterial, antioxidant, and cardiovascular protective properties. However, due to the complexity and low content of the components in these samples, developing rapid and sensitive methods for the isolation and extraction of flavonoids still remains a challenge in medical and food science. Herein, a 4-formylphenylboronic acid functionalized magnetic FeO nanomaterial (FeO@FPBA) was synthesized and applied as a sorbent of magnetic solid-phase extraction (MSPE) to covalently extract flavonoids from leaves of Lonicera japonica Thunb.

Stable and affordable phosphonates removal by iron scrap packed-bed anode electrocoagulation under realistic conditions: Mechanism and passivation mitigation over long-term operation.

Iron electrocoagulation (Fe-EC) exhibits broad application in water remediation towards various pollutants, including emerging organic phosphorus compounds (i.e., phosphonates).

Effects of microplastics on energy accumulation in a migratory shorebird in the coastal wetlands of the Yellow Sea, China.

Microplastic pollution has emerged as a significant environmental concern at the global level, potentially threatening biodiversity conservation and human wellbeing. As an important biological group with a wide global distribution, migratory shorebirds face considerable stress due to plastic and microplastic pollution. However, few studies have explored the ecotoxic impact of microplastic pollution on migratory shorebirds.

Multi-signal fluorescent probe for simultaneous differentiation and imaging of Hg, Cys, Hcy, and GSH in living cells and zebrafish.

The Mercury (II) ion (Hg²⁺) is a toxic heavy metal that threatens biological systems by inducing oxidative stress and disrupting the redox balance. Biothiols such as cysteine (Cys), homocysteine (Hcy), and glutathione (GSH) are critical in maintaining redox homeostasis and are implicated in numerous physiological and pathological processes. Understanding the complex interactions between Hg²⁺ and biothiols requires molecular tools capable of simultaneous detection.

Phthalate esters decreased nutritional value of rice grains via redirecting glycolytic carbon flow from grain quality formation toward antioxidative defense.

The prevalence and persistence of phthalate esters (PAEs) in agricultural soils has garnered global attention. Assessing their potential impacts on crop yield and quality necessitates a thorough understanding of their risks. In this study, we elucidated the carbon flow-dependent mechanisms of the decreased grain quality upon exposure to PAEs through a soil-based rice cultivation experiment.

Transcriptome analysis unveils the mechanisms of oxidative stress, immunotoxicity and neurotoxicity induced by benzotriazole UV stabilizer-328 in zebrafish embryos.

As an emerging pollutant, ultraviolet stabilizer-328 (UV-328) has been frequently detected in aquatic environments and attracted great attention. Nevertheless, the toxicity and mechanisms of UV-328 to aquatic organisms are still not fully understood. In particular, the immunotoxicity and neurotoxicity of UV-328 to aquatic organisms and their mechanisms have not been reported yet.

Joint exposure to multiple air pollutants and residual cardiovascular risk in hypertension.

Background: Despite the widespread availability of antihypertensive medications, residual cardiovascular risk of hypertension remained high. Limited studies have investigated the link between air pollution, particularly joint exposure to multiple air pollutants, with residual cardiovascular risk of hypertension.

Methods: 1981 hypertensive patients (≥ 18 years) from an ongoing longitudinal cohort in China, were enrolled between 2013 and 2019.